13 completed, 9 unknown, 6 recruiting, 2 available. 11 Phase 1, 8 Not applicable, 8 Phase 2, 1 Phase 3.
Follow Limbal Stem Cell Deficiency: new trials by email Literature Review of Limbal Stem Cell Deficiency trials Research Report on Limbal Stem Cell Deficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Predictors of Visual Outcome in Patients Affected With Ocular Surface Diseases Neurotrophic Keratopathy, Exposure Keratopathy | Not yet recruiting | IRCCS San Raffaele | 1000 | 2026-07-01 | 2026-07-14 | |
| Multi-Center, Prospective, Non-Interventional Study in Subjects With Limbal Stem Cell Deficiency Non-interventional - Limbal Stem Cell Deficiency | Recruiting | Claris Biotherapeutics, Inc. | 500 | 2026-05-22 | 2026-08-06 | |
| Cultivated Limbal Epithelial Transplantation (CLET) for Limbal Stem Cell Deficiency (LSCD) Limbal Stem-cell Deficiency | Not yet recruiting | Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA | 30 | 2025-11-01 | 2025-05-16 | |
| Efficacy of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease Allogeneic Bone-Marrow Derived Mesenchymal Stromal Cells Secretome, Vehicle Control - Persistent Corneal Epithelial Defect, Corneal Epithelial Disorders | Phase 2 | Recruiting | University of Illinois Chicago | 24 | 2025-08-01 | 2026-10-28 |
| Association Between Limbal Function and Tear Proteomics in Chronic Ocular Diseases: Focusing on Glaucoma Glaucoma, Ocular Hypertension | Recruiting | National Taiwan University Hospital | 90 | 2025-07-08 | 2025-08-13 | |
| Implementation of a Protocol for the Transdifferentiation of Buccal Mucosal Epithelium Into Corneal Epithelium Conjunctival reconstruction - Limbal Stem Cell Deficiency | Not applicable | Unknown | University Hospital, Montpellier | 4 | 2024-06-19 | 2024-08-19 |
| Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Limbal Stem Cell Deficiency CSB-001 Ophthalmic Solution 0.1% - Limbal Stem Cell Deficiency | Phase 1 | Recruiting | Claris Biotherapeutics, Inc. | 75 | 2024-05-15 | 2026-08-13 |
| Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies Rare Diseases, Aniridia | Unknown | IRCCS Ospedale San Raffaele | 274 | 2024-05-01 | 2024-05-14 | |
| Treatment of LSCD With DM transplantation of a Descemet's Membrane corneal onlay, partial LSCD, transplantation of a Descemet's Membrane corneal onlay, total/near-total LSCD - Limbal Stem-cell Deficiency, Congenital Aniridia | Phase 1 | Completed | University of Minnesota | 19 | 2023-11-30 | 2026-01-08 |
| CDL Validation Study Eyes Dry Chronic, Chronic Conjunctivitis of Both Eyes | Completed | Occyo GmbH | 104 | 2022-04-22 | 2024-04-04 | |
| Labial Mucosal Epithelium Grafting for Corneal Limbus Substitution Labial mucosal epithelium grafting for corneal limbus substitution - Limbal Stem-cell Deficiency | Not applicable | Unknown | The S.N. Fyodorov Eye Microsurgery State Institution | 20 | 2021-07-01 | 2024-04-23 |
| Cultured Autologous Oral Mucosa Epithelial Sheet for the Treatment of Bilateral Limbal Stem Cell Deficiency FEMJA transplatation - Total Bilateral Limbal Cell Deficiency | Phase 1 / Phase 2 | Recruiting | Hospices Civils de Lyon | 40 | 2020-11-13 | 2025-12-16 |
| Stem Cell Therapy for Limbal Stem Cell Deficiency cLSC, Scleral contact lens (SCL) - Limbal Stem-cell Deficiency | Phase 1 | Active not recruiting | University of California, Los Angeles | 20 | 2020-09-30 | 2026-02-10 |
| The Effects of Allogeneic SLET Limbal Stem-cell Deficiency | Unknown | National Taiwan University Hospital | 30 | 2019-07-05 | 2019-07-18 | |
| The Effects of Autologous SLET Limbal Stem-cell Deficiency | Unknown | National Taiwan University Hospital | 30 | 2019-07-05 | 2019-07-16 | |
| Allogeneic ABCB5-positive Limbal Stem Cells for Treatment of LSCD LSC2 - Limbal Stem Cell Deficiency | Phase 1 / Phase 2 | Unknown | RHEACELL GmbH & Co. KG | 16 | 2019-07-04 | 2022-10-07 |
| Multiple Noninvasive Examination Modality to Evaluate the Severity of Ocular Surface Disorders Limbal Stem-cell Deficiency | Completed | National Taiwan University Hospital | 25 | 2018-06-08 | 2019-07-26 | |
| Corneal Epithelial Allograft From Living-related Donor for LSCD Corneal epithelial allograft, Limbal conjunctival allograft, Femtosecond laser - Limbal Stem Cell Deficiency | Not applicable | Completed | Chunxiao Wang | 20 | 2017-07-27 | 2020-02-28 |
| Corneal Epithelial Autograft for LSCD Corneal epithelial autograft, Limbal conjunctival autograft, Femtosecond laser - Limbal Stem Cell Deficiency | Not applicable | Unknown | Chunxiao Wang | 20 | 2017-07-25 | 2019-08-09 |
| Transplantation of Autologous Oral Mucosal Epithelial Stem Cell Sheet for Treating Limbal Stem Cell Deficiency Disease cultured autologous oral mucosal epithelial cell sheet - Limbal Stem Cell Deficiency | Phase 1 / Phase 2 | Unknown | He Eye Hospital | 7 | 2017-01-01 | 2017-01-10 |
Showing 20 of 35. Sign in to see all of them.
Corneal Diseases (5) · Aniridia (4) · Corneal Injuries (2) · Corneal Neovascularization (2) · Keratitis (2) · Pemphigoid, Benign Mucous Membrane (2) · Stevens-Johnson Syndrome (2) · Burns, Chemical (1) · Cataract (1) · Corneal Opacity (1) · Dry Eye Syndromes (1) · Ectrodactyly-cleft lip-palate syndrome (1) · Eye Injuries (1) · Glaucoma (1)
Eye Diseases (35) · Corneal Diseases (30) · Congenital Abnormalities (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Eye Abnormalities (4) · Eye Diseases, Hereditary (4) · Genetic Diseases, Inborn (4) · Iris Diseases (4) · Uveal Diseases (4) · Wounds and Injuries (4) · Conjunctival Diseases (3) · Skin Diseases (3) · Skin Diseases, Vesiculobullous (3) · Skin and Connective Tissue Diseases (3) · Chemically-Induced Disorders (2)
Transplantation (1)
National Taiwan University Hospital (4) · Chunxiao Wang (2) · Claris Biotherapeutics, Inc. (2) · Royan Institute (2) · BRIM Biotechnology Inc. (1) · CHU de Quebec-Universite Laval (1) · CellSeed France S.A.R.L. (1) · Chang Gung Memorial Hospital (1) · He Eye Hospital (1) · Hospices Civils de Lyon (1) · IRCCS Ospedale San Raffaele (1) · IRCCS San Raffaele (1) · Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA (1) · Instituto de Oftalmología Fundación Conde de Valenciana (1) · Klinikum Chemnitz gGmbH (1)
United States (9) · Taiwan (5) · Belgium (2) · China (2) · France (2) · Germany (2) · Austria (1) · Canada (1) · India (1) · Iran (1) · Italy (1) · Mexico (1) · Russia (1) · South Korea (1) · Spain (1)
Alireza Baradaran, MD (2) · Marzieh Ebrahimi, PhD (2) · Ting Huang, M.D.Ph.D. (2) · Wei-Li Chen, phD (2) · Yizhi Liu, M.D.Ph.D. (2) · Adisak Wongkajornsilp, M.D., Ph.D. (1) · Ali R Djalilian, MD (1) · Boris E Malyugin, MD PhD Prof (1) · Carina Koppen, MD, PhD (1) · David Hui-Kang Ma, MD, PhD (1) · Friedrich Kruse, Prof. Dr. (1) · Gerd U. Auffarth, Prof.Dr.med. (1) · Hamid Gorabi, PhD (1) · Hamid Gourabi, PhD (1) · Hossein Baharvand, PhD (1)
PMID 15377551, PMID 16458679, PMID 16989763, PMID 17251457, PMID 19373264, PMID 19458337, PMID 21097786, PMID 21571372, PMID 21652025, PMID 21850186, PMID 22328817, PMID 22850415, PMID 23087419, PMID 23405945, PMID 23767776, PMID 23892486, PMID 24589151, PMID 25075515, PMID 26451369, PMID 26704459, PMID 26817481, PMID 27824126, PMID 27911610, PMID 28758321, PMID 29800578, PMID 30578758, PMID 30716697, PMID 32077779, PMID 34620226, PMID 35922868, PMID 40038272, PMID 40152603, PMID 41503585
3UH3EY031809-04S1 (1), R01EY021797 (1)