39 completed, 13 terminated, 2 unknown, 1 active not recruiting. 23 Phase 1, 23 Phase 2, 4 Not applicable, 4 Phase 3, 2 Early Phase 1.
Follow Stage IV Colon Cancer: new trials by email Literature Review of Stage IV Colon Cancer trials Research Report on Stage IV Colon Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Encorafenib, Binimetinib, and Nivolumab in Treating Microsatellite Stable BRAF V600E Metastatic Colorectal Cancer Binimetinib, Encorafenib, Nivolumab - Metastatic Colon Adenocarcinoma, Metastatic Colorectal Adenocarcinoma | Phase 1 | Terminated | University of California, San Francisco | 2 | 2020-08-31 | 2023-01-09 |
| Canady Helios Cold Plasma Scalpel Treatment at the Surgical Margin and Macroscopic Tumor Sites Canady Helios Cold Plasma Scalpel - Recurrent Malignant Solid Neoplasm, Stage IV Breast Cancer | Not applicable | Unknown | Jerome Canady, M.D. | 20 | 2019-07-30 | 2021-08-09 |
| Phase 1b Study to Evaluate ATP128, VSV-GP128 and BI 754091, in Patients With Stage IV Colorectal Cancer ATP128, BI 754091, VSV-GP128 - Colorectal Cancer, MSS | Phase 1 | Active not recruiting | Amal Therapeutics | 96 | 2019-07-22 | 2025-01-29 |
| Dibenzyl Trisulphide (GUINEAHEN WEED) for Stage IV Cancer Dibenzyl trisulphide capsules, Stage IV Breast Cancer Placebo, Stage IV: Colon Cancer Placebo - Stage IV Prostate Cancer, Stage IV Colon Cancer | Early Phase 1 | Unknown | The University of The West Indies | 104 | 2018-10-01 | 2019-10-08 |
| Elevated Platelet Count as Prognostic Factor in Colorectal Cancer With Synchronous Liver Metastases Measurement of platelet count at diagnosis - Colorectal Cancer, Colorectal Carcinoma | Completed | Azienda Ospedaliera Universitaria Integrata Verona | 196 | 2018-01-01 | 2023-07-20 | |
| Health Care Coach Support in Reducing Acute Care Use and Cost in Patients With Cancer Best Practice, Laboratory Biomarker Analysis, Supportive Care - Acute Myeloid Leukemia, Brain Glioblastoma | Not applicable | Completed | Stanford University | 128 | 2017-08-08 | 2025-01-24 |
| A Retrospective Cohort Study Outcome of Treatment in Asymptomatic Stage 4 Colorectal Cancer primary tumor resection group - Stage IV Colon Cancer | Completed | Mahidol University | 135 | 2017-01-01 | 2020-04-06 | |
| Prospective Cohort Study Depending on the Use of Palliative Care for Advanced Stage of Cancer Patients Early palliative care, Routine hospice care - Stage IV Breast Cancer, Stage IV Pancreatic Cancer | Completed | Seoul National University Hospital | 444 | 2016-12-17 | 2021-03-17 | |
| Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal Cancer Undergoing Chemotherapy cytology specimen collection procedure, laboratory biomarker analysis, questionnaire administration - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Terminated | Fox Chase Cancer Center | 6 | 2013-10-01 | 2018-02-07 | |
| Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab panitumumab, irinotecan hydrochloride, fluorouracil - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 2 | Completed | John Hays | 16 | 2013-02-01 | 2025-02-05 |
| Aflibercept and FOLFOX6 Treatment for Previously Untreated Stage IV Colorectal Cancer aflibercept, oxaliplatin, leucovorin - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 2 | Completed | John Hays | 56 | 2012-11-14 | 2025-02-05 |
| Vaccine Therapy in Treating Patients With Colorectal, Stomach, or Pancreatic Cancer laboratory biomarker analysis, enzyme-linked immunosorbent assay, flow cytometry - Recurrent Colon Cancer, Recurrent Gastric Cancer | Phase 1 | Completed | City of Hope Medical Center | 12 | 2011-12-22 | 2026-10-19 |
| Radiolabeled Monoclonal Antibody Therapy, Combination Chemotherapy, and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer irinotecan hydrochloride, leucovorin calcium, fluorouracil - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 1 | Completed | City of Hope Medical Center | 3 | 2011-08-30 | 2026-10-16 |
| Study of AUY922 and Cetuximab in Patients With KRAS Wild-Type Metastatic Colorectal Cancer AUY922, Cetuximab - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 1 | Completed | Swedish Medical Center | 20 | 2011-02-01 | 2015-06-08 |
| Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors veliparib, capecitabine, oxaliplatin - Adenocarcinoma of the Pancreas, Adenocarcinoma of the Stomach | Phase 1 | Terminated | National Cancer Institute (NCI) | 16 | 2010-10-01 | 2014-04-02 |
| Panobinostat and Fluorouracil Followed By Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer Who Did Not Respond to Previous Fluorouracil-Based Chemotherapy panobinostat, fluorouracil, leucovorin calcium - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 1 | Terminated | University of Southern California | 7 | 2010-10-01 | 2015-05-27 |
| Chemoembolization Using Irinotecan in Treating Patients With Liver Metastases From Metastatic Colon or Rectal Cancer irinotecan-eluting beads, hepatic artery embolization - Liver Metastases, Mucinous Adenocarcinoma of the Colon | Phase 1 | Terminated | Fox Chase Cancer Center | 4 | 2010-10-01 | 2021-12-20 |
| High-Dose Cholecalciferol in Treating Patients Receiving Combination Chemotherapy and Bevacizumab as First-Line Therapy For Metastatic Colorectal Cancer leucovorin calcium, bevacizumab, cholecalciferol - Stage IV Colon Cancer, Stage IV Rectal Cancer | Phase 2 | Terminated | Roswell Park Cancer Institute | 10 | 2010-08-01 | 2014-07-21 |
| RO4929097 and Capecitabine in Treating Patients With Refractory Solid Tumors gamma-secretase/Notch signalling pathway inhibitor RO4929097, capecitabine, laboratory biomarker analysis - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2010-06-01 | 2014-11-07 |
| RO4929097 in Treating Patients With Metastatic Colorectal Cancer gamma-secretase/Notch signalling pathway inhibitor RO4929097, laboratory biomarker analysis - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 37 | 2010-05-01 | 2014-05-20 |
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Colonic Neoplasms (56) · Rectal Neoplasms (48) · Breast Neoplasms (12) · Pancreatic Neoplasms (12) · Stomach Neoplasms (11) · Carcinoma, Non-Small-Cell Lung (9) · Carcinoma, Hepatocellular (7) · Carcinoma, Ovarian Epithelial (7) · Colorectal Neoplasms (7) · Salivary Gland Neoplasms (7) · Breast Neoplasms, Male (6) · Prostatic Neoplasms (6) · Squamous Cell Carcinoma of Head and Neck (6) · Appendiceal Neoplasms (5) · Carcinoma, Renal Cell (5)
Colonic Diseases (55) · Digestive System Diseases (55) · Digestive System Neoplasms (55) · Gastrointestinal Diseases (55) · Intestinal Diseases (55) · Intestinal Neoplasms (55) · Neoplasms by Site (55) · Gastrointestinal Neoplasms (54) · Neoplasms (54) · Colorectal Neoplasms (49) · Rectal Diseases (48) · Endocrine Gland Neoplasms (15) · Endocrine System Diseases (15) · Neoplasms by Histologic Type (15) · Carcinoma (13)
Fluorouracil (12) · Leucovorin (12) · Oxaliplatin (9) · Bevacizumab (7) · Cetuximab (7) · Irinotecan (7) · Capecitabine (5) · Erlotinib Hydrochloride (4) · Floxuridine (3) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (2) · Dasatinib (2) · Gene Expression Profiling (2) · Granulocyte-Macrophage Colony-Stimulating Factor (2) · Sorafenib (2) · Vorinostat (2)
National Cancer Institute (NCI) (31) · City of Hope Medical Center (3) · Fox Chase Cancer Center (2) · John Hays (2) · Roswell Park Cancer Institute (2) · Abramson Cancer Center at Penn Medicine (1) · Alliance for Clinical Trials in Oncology (1) · Amal Therapeutics (1) · Azienda Ospedaliera Universitaria Integrata Verona (1) · Burzynski Research Institute (1) · Gachon University Gil Medical Center (1) · Jerome Canady, M.D. (1) · Mahidol University (1) · National Institutes of Health Clinical Center (CC) (1) · Seoul National University Hospital (1)
United States (49) · Canada (3) · South Korea (2) · Belgium (1) · Germany (1) · Italy (1) · Jamaica (1) · Switzerland (1) · Thailand (1)
John Hays, MD (2) · Alain Mita (1) · Allyson Ocean (1) · Amit Oza (1) · Antonius Miller (1) · Axel Grothey, MD (1) · Bruce Giantonio (1) · Cathy Eng (1) · Chairat Supsamutchai, MD (1) · Charles Blanke (1) · Chloe E Atreya, MD, PhD (1) · Corrado Pedrazzani, MD (1) · David Solit (1) · Efrat Dotan (1) · Efrat Dotan, MD (1)
PMID 20048179, PMID 21208843, PMID 24583822, PMID 24987057, PMID 32201506, PMID 32641862, PMID 32692450, PMID 34749008, PMID 35771552, PMID 37509349, PMID 38314087, PMID 39582048
N01CM17003 (2), N01CM62201 (2), N01CM62202 (2), P30CA014520 (2), P30CA068485 (2), U01CA062491 (2), U10CA021115 (2), U10CA025224 (2), 2019 (1), N01CM00038 (1), N01CM00099 (1), N01CM17107 (1), N01CM62203 (1), N01CM62204 (1), N01CM62208 (1)