3 completed, 3 terminated, 1 active not recruiting. 3 Phase 1, 2 Phase 2, 1 Early Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Active not recruiting 1, Completed 1, Terminated 1 |
| Phase 2 | 2 | Completed 1, Terminated 1 |
| Early Phase 1 | 1 | Terminated 1 |
| Phase 3 | 1 | Completed 1 |
Follow Stage IIIB Rectal Cancer AJCC v7: new trials by email Literature Review of Stage IIIB Rectal Cancer AJCC v7 trials Research Report on Stage IIIB Rectal Cancer AJCC v7
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer Capecitabine, Fluorouracil, Leucovorin - Locally Advanced Rectal Adenocarcinoma, Metastatic Rectal Adenocarcinoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 3 | 2019-05-14 | 2024-05-23 |
| Ferumoxytol-Enhanced MRI in Imaging Lymph Nodes in Patients With Locally Advanced Rectal Cancer Contrast-enhanced Magnetic Resonance Imaging, Ferumoxytol - Locally Advanced Rectal Carcinoma, Stage III Rectal Cancer AJCC v7 | Early Phase 1 | Terminated | OHSU Knight Cancer Institute | 2 | 2018-04-27 | 2021-09-10 |
| Trametinib and Trifluridine and Tipiracil Hydrochloride in Treating Patients With Colon or Rectal Cancer That is Advanced, Metastatic, or Cannot Be Removed by Surgery Laboratory Biomarker Analysis, Trametinib, Trifluridine and Tipiracil Hydrochloride - Metastatic Colon Carcinoma, Metastatic Colorectal Carcinoma | Phase 1 | Completed | City of Hope Medical Center | 26 | 2018-04-11 | 2024-04-08 |
| S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery Cetuximab, Irinotecan Hydrochloride, Laboratory Biomarker Analysis - Colon Adenocarcinoma, ERBB2 Gene Amplification | Phase 2 | Completed | SWOG Cancer Research Network | 240 | 2017-11-27 | 2026-02-10 |
| Ropidoxuridine in Treating Patients With Advanced Gastrointestinal Cancer Undergoing Radiation Therapy Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis, Pharmacological Study - Advanced Bile Duct Carcinoma, Stage II Esophageal Cancer AJCC v7 | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 19 | 2016-02-01 | 2026-09-15 |
| Radiation Therapy and Capecitabine With or Without Curcumin Before Surgery in Treating Patients With Rectal Cancer Capecitabine, Curcumin, Laboratory Biomarker Analysis - Rectal Mucinous Adenocarcinoma, Rectal Signet Ring Cell Adenocarcinoma | Phase 2 | Terminated | M.D. Anderson Cancer Center | 22 | 2008-08-11 | 2023-09-28 |
| Comparison of Adjuvant Chemotherapy Regimens in Treating Stage II/III Rectal Cancer Radiotherapy, Fluorouracil, Leucovorin Calcium - Rectal Mucinous Adenocarcinoma, Rectal Signet Ring Cell Adenocarcinoma | Phase 3 | Completed | National Cancer Institute (NCI) | 225 | 2003-10-15 | 2018-12-04 |
Rectal Neoplasms (7) · Colonic Neoplasms (3) · Colorectal Neoplasms (1) · Esophageal Neoplasms (1) · Liver Neoplasms (1) · Stomach Neoplasms (1)
Digestive System Diseases (7) · Digestive System Neoplasms (7) · Gastrointestinal Diseases (7) · Gastrointestinal Neoplasms (7) · Intestinal Diseases (7) · Intestinal Neoplasms (7) · Neoplasms (7) · Neoplasms by Site (7) · Rectal Diseases (7) · Colorectal Neoplasms (6) · Colonic Diseases (3) · Esophageal Diseases (1) · Head and Neck Neoplasms (1) · Liver Diseases (1) · Stomach Diseases (1)
Radiotherapy (3) · Capecitabine (2) · Fluorouracil (2) · Irinotecan (2) · Leucovorin (2) · Oxaliplatin (2) · Radiation (2) · 2C4 antibody (1) · Cetuximab (1) · Curcumin (1) · Ferrosoferric Oxide (1) · PF-05280014 (1) · Platinum (1) · Radiotherapy, Intensity-Modulated (1) · Trastuzumab (1)
National Cancer Institute (NCI) (3) · City of Hope Medical Center (1) · M.D. Anderson Cancer Center (1) · OHSU Knight Cancer Institute (1) · SWOG Cancer Research Network (1)
United States (7) · Puerto Rico (1)
Al Benson (1) · Alexander Guimaraes (1) · Jillian R. Gunther, PHD (1) · Kanwal Raghav (1) · Marwan G Fakih (1) · Nageshwara V Dasari (1) · Timothy J Kinsella (1)
PMID 35738999, PMID 36636059, PMID 39761503, PMID 41397917
P30CA033572 (1), U10CA021115 (1), U10CA180888 (1), UM1CA186688 (1)