16 completed, 2 terminated, 1 withdrawn. 7 Not applicable, 7 Phase 1, 4 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 7 |
| Phase 1 | 7 | Completed 5, Terminated 1, Withdrawn 1 |
| Phase 2 | 4 | Completed 3, Withdrawn 1 |
| Phase 3 | 1 | Completed 1 |
Follow Stage IIIA Colon Cancer: new trials by email Literature Review of Stage IIIA Colon Cancer trials Research Report on Stage IIIA Colon Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Encorafenib, Binimetinib, and Nivolumab in Treating Microsatellite Stable BRAF V600E Metastatic Colorectal Cancer Binimetinib, Encorafenib, Nivolumab - Metastatic Colon Adenocarcinoma, Metastatic Colorectal Adenocarcinoma | Phase 1 | Terminated | University of California, San Francisco | 2 | 2020-08-31 | 2023-01-09 |
| Health Care Coach Support in Reducing Acute Care Use and Cost in Patients With Cancer Best Practice, Laboratory Biomarker Analysis, Supportive Care - Acute Myeloid Leukemia, Brain Glioblastoma | Not applicable | Completed | Stanford University | 128 | 2017-08-08 | 2025-01-24 |
| CPI-613 and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery 6,8-bis(benzylthio)octanoic acid, fluorouracil, pharmacological study - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 1 | Completed | Wake Forest University Health Sciences | 19 | 2015-01-06 | 2023-08-07 |
| Programs to Support You During Chemotherapy (Pro-You) Yoga Skills Training (YST), questionnaire administration, fatigue and depressive symptom assessment and management - Depressive Symptoms, Fatigue | Not applicable | Completed | Vanderbilt-Ingram Cancer Center | 3 | 2014-08-01 | 2015-06-23 |
| Family Caregiver Palliative Care Intervention in Supporting Caregivers of Patients With Stage II-IV Gastrointestinal, Gynecologic, Urologic and Lung Cancers educational intervention, telephone-based intervention, quality-of-life assessment - Healthy Subject, Localized Transitional Cell Cancer of the Renal Pelvis and Ureter | Not applicable | Completed | City of Hope Medical Center | 200 | 2013-10-29 | 2026-10-01 |
| Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal Cancer Undergoing Chemotherapy cytology specimen collection procedure, laboratory biomarker analysis, questionnaire administration - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Terminated | Fox Chase Cancer Center | 6 | 2013-10-01 | 2018-02-07 | |
| Irinotecan and Alisertib in Treating Patients With Advanced Solid Tumors or Colorectal Cancer irinotecan hydrochloride, alisertib - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 1 | Completed | University of California, Davis | 17 | 2013-08-01 | 2019-01-04 |
| PET-MRI in Diagnosing Patients With Colon or Rectal Cancer positron emission tomography, computed tomography, magnetic resonance imaging - Recurrent Colon Cancer, Recurrent Rectal Cancer | Not applicable | Completed | Case Comprehensive Cancer Center | 15 | 2013-04-01 | 2021-05-18 |
| Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery Akt Inhibitor MK2206, Laboratory Biomarker Analysis, Pharmacological Study - Colon Mucinous Adenocarcinoma, Colon Signet Ring Cell Adenocarcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 18 | 2013-03-01 | 2019-09-20 |
| Adherence to Survivorship Care Guidelines in Health Care Providers for Non-Small Cell Lung Cancer and Colorectal Cancer Survivor Care educational intervention, medical chart review - Adenocarcinoma of the Lung, Mucinous Adenocarcinoma of the Colon | Not applicable | Completed | Fox Chase Cancer Center | 1440 | 2013-01-01 | 2017-04-06 |
| Survivorship Care Planning in Patients With Colorectal or Non-Small Cell Lung Cancer educational intervention, questionnaire administration, quality-of-life assessment - Stage I Colon Cancer, Stage I Rectal Cancer | Not applicable | Completed | City of Hope Medical Center | 30 | 2013-01-01 | 2013-12-18 |
| Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies oxaliplatin, irinotecan hydrochloride, leucovorin calcium - Acinar Cell Adenocarcinoma of the Pancreas, Adenocarcinoma of the Gallbladder | Phase 1 | Completed | University of Chicago | 79 | 2012-03-26 | 2020-05-08 |
| Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors Gamma-Secretase Inhibitor RO4929097, Cediranib Maleate, Pharmacological Study - Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2010-05-01 | 2014-12-23 |
| Single Incision Laparoscopic Surgery in Treating Patients With Colorectal Disease therapeutic laparoscopic surgery - Adenomatous Polyp, Crohn Disease | Not applicable | Completed | Ohio State University Comprehensive Cancer Center | 10 | 2010-05-01 | 2017-12-06 |
| Erlotinib Hydrochloride in Treating Patients With Stage I-III Colorectal Cancer or Adenoma erlotinib hydrochloride, placebo, laboratory biomarker analysis - Adenomatous Polyp, Recurrent Colon Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 45 | 2008-07-01 | 2015-01-06 |
| SB-715992 in Treating Patients With Advanced or Metastatic Colorectal Cancer ispinesib, laboratory biomarker analysis - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 64 | 2005-01-01 | 2015-03-02 |
| A Phase I, Pharmacological, and Biological Study of OSI-774 in Combination With FOLFOX 4 (5-FU, Leucovorin, and Oxaliplatin) and Bevacizumab (Avastin) in Patients With Advanced Colorectal Cancer erlotinib hydrochloride, fluorouracil, leucovorin calcium - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2003-06-01 | 2013-09-30 |
| Irinotecan Compared With Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer irinotecan hydrochloride, oxaliplatin, leucovorin calcium - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 3 | Completed | National Cancer Institute (NCI) | 560 | 1999-11-01 | 2013-05-03 |
| Pan FGFR Kinase Inhibitor BGJ398 and Combination Chemotherapy in Treating Patients With Untreated Metastatic Pancreatic Cancer Fluorouracil, Irinotecan Hydrochloride, Laboratory Biomarker Analysis - Colon Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma | Phase 1 / Phase 2 | Withdrawn | Roswell Park Cancer Institute | 2016-05-20 |
Colonic Neoplasms (19) · Rectal Neoplasms (18) · Pancreatic Neoplasms (5) · Carcinoma, Non-Small-Cell Lung (4) · Carcinoma, Renal Cell (3) · Colorectal Neoplasms (3) · Stomach Neoplasms (3) · Adenomatous Polyps (2) · Breast Neoplasms (2) · Melanoma (2) · Ovarian Neoplasms (2) · Urinary Bladder Neoplasms (2) · Adenocarcinoma of Lung (1) · Adenomatous Polyposis Coli (1) · Astrocytoma (1)
Colonic Diseases (19) · Digestive System Diseases (19) · Digestive System Neoplasms (19) · Gastrointestinal Diseases (19) · Gastrointestinal Neoplasms (19) · Intestinal Diseases (19) · Intestinal Neoplasms (19) · Neoplasms (19) · Neoplasms by Site (19) · Rectal Diseases (18) · Colorectal Neoplasms (16) · Neoplasms by Histologic Type (6) · Neoplasms, Glandular and Epithelial (6) · Endocrine Gland Neoplasms (5) · Endocrine System Diseases (5)
Fluorouracil (5) · Irinotecan (4) · Oxaliplatin (4) · Early Intervention, Educational (3) · Leucovorin (3) · Methods (3) · Erlotinib Hydrochloride (2) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (1) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · Bevacizumab (1) · Fluorodeoxyglucose F18 (1) · MK 2206 (1) · MLN 8237 (1) · Magnetic Resonance Spectroscopy (1) · Nivolumab (1)
National Cancer Institute (NCI) (6) · City of Hope Medical Center (2) · Fox Chase Cancer Center (2) · Case Comprehensive Cancer Center (1) · Ohio State University Comprehensive Cancer Center (1) · Roswell Park Cancer Institute (1) · Stanford University (1) · University of California, Davis (1) · University of California, San Francisco (1) · University of Chicago (1) · Vanderbilt-Ingram Cancer Center (1) · Wake Forest University Health Sciences (1)
United States (18) · Canada (1)
Betty Ferrell (1) · Caio Rocha Lima, MD (1) · Chloe E Atreya, MD, PhD (1) · Crystal Denlinger, MD (1) · David Renton, MD (1) · Edmund Kopetz (1) · Efrat Dotan (1) · Hedy Kindler (1) · Henry Pitot (1) · Manali Patel (1) · Raj Paspulati, MD (1) · Sebastien Hotte (1) · Stephanie Sohl (1) · Syma Iqbal, MD (1) · Thomas Semrad (1)
PMID 33993383, PMID 34749008, PMID 35771552
N01CM00039 (1), N01CN35160 (1), P30CA006927 (1), P30CA012197 (1), P30CA016056 (1), P30CA016672 (1), P30CA068485 (1), P30CA093373 (1), U01CA070095 (1), U01CA132123 (1), U10CA025224 (1)