11 active not recruiting, 11 recruiting, 7 completed, 2 suspended. 19 Not applicable, 8 Phase 2, 3 Phase 3, 2 Early Phase 1, 1 Phase 4.
Follow Stage I Prostate Cancer AJCC v8: new trials by email Literature Review of Stage I Prostate Cancer AJCC v8 trials Research Report on Stage I Prostate Cancer AJCC v8
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Magnetic Resonance-Guided Stereotactic Body Radiation Therapy for the Treatment of Prostate Cancer Biopsy Procedure, Computed Tomography, Electronic Health Record Review - Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8 | Not applicable | Not yet recruiting | City of Hope Medical Center | 20 | 2027-01-01 | 2026-08-17 |
| Testing the Effects of Exercise on Colorectal Cancer Development After Treatment With Pelvic Radiation Therapy for Prostate Cancer Aerobic Exercise, Biopsy Procedure, Biospecimen Collection - Colon Polyp, Colorectal Carcinoma | Not applicable | Recruiting | City of Hope Medical Center | 30 | 2026-12-16 | 2026-08-28 |
| CT- Versus MRI-Based Planning for High-Dose-Rate Prostate Brachytherapy for Prostate Cancer Magnetic Resonance Imaging, Questionnaire Administration - Prostate Carcinoma, Stage I Prostate Cancer AJCC v8 | Not applicable | Recruiting | Emory University | 100 | 2026-10-22 | 2026-11-02 |
| Image-Guidance and Online Adaptation With Stereotactic Body Radiation Therapy for the Treatment of Localized Prostate Cancer, MANTICORE Trial Biospecimen Collection, Computed Tomography, CT-guided Stereotactic Body Radiation Therapy - Localized Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8 | Not applicable | Recruiting | Jonsson Comprehensive Cancer Center | 186 | 2025-12-01 | 2026-02-05 |
| Feasibility and Effect of Wrapping Nerves With a Multi-Layer Perinatal Tissue Allograft During Prostatectomy Allografting, Survey Administration - Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8 | Not applicable | Recruiting | Mayo Clinic | 45 | 2025-08-14 | 2026-09-11 |
| Computed Tomography-Guided Stereotactic Body Radiation Therapy With Intrafraction Motion Monitoring for the Treatment of Localized Prostate Cancer, ILLUSION Trial Biospecimen Collection, Computed Tomography, CT-guided Stereotactic Body Radiation Therapy - Localized Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8 | Not applicable | Active not recruiting | Jonsson Comprehensive Cancer Center | 91 | 2025-06-27 | 2026-08-20 |
| Pembrolizumab With Androgen Deprivation Therapy and Radiotherapy for the Treatment of Patients With High Risk Localized Prostate Cancer Gonadotropin Releasing Hormone Agonists and Antagonists, Bicalutamide, Biopsy Procedure - High Risk Prostate Carcinoma, Localized Prostate Adenocarcinoma | Phase 2 | Withdrawn | OHSU Knight Cancer Institute | 2025-04-16 | 2025-09-23 | |
| Testosterone Replacement Therapy for the Treatment of Low Testosterone in Hypogonadal Men With Localized Prostate Cancer on Active Surveillance Biopsy of Prostate, Biospecimen Collection, Magnetic Resonance Imaging - Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8 | Phase 4 | Recruiting | Roswell Park Cancer Institute | 600 | 2025-01-15 | 2026-05-14 |
| Adaptive Radiation Therapy (ART) Stereotactic Ablative Body Radiotherapy (SABR) for Primary Localized Prostate Cancer Computed Tomography, Cone-Beam Computed Tomography, Image-Guided Adaptive Radiation Therapy - Localized Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8 | Not applicable | Recruiting | Mayo Clinic | 164 | 2024-08-15 | 2026-10-14 |
| Accuracy of 18F-rhPSMA-7.3 PET/ MRI for Prediction of Lymph Node Metastasis in Localized High-Risk Prostate Cancer Bilateral Pelvic Lymph Node Dissection, Biospecimen Collection, Bone Scan - Localized Prostate Carcinoma, Oligometastatic Prostate Carcinoma | Not applicable | Recruiting | Mayo Clinic | 50 | 2024-06-11 | 2026-04-06 |
| Vitamin D for Prostate Endocrine Therapy Biospecimen Collection, D Vitamin, Dual X-ray Absorptiometry - Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8 | Phase 3 | Recruiting | University of Rochester | 240 | 2023-12-14 | 2026-01-15 |
| Focal Ablation With Focal Cryotherapy or HIFU for the Treatment of Men With Localized Prostate Cancer Cryosurgery, High-Intensity Focused Ultrasound Ablation, Survey Administration - Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8 | Not applicable | Recruiting | University of California, Davis | 100 | 2023-11-09 | 2026-06-30 |
| Online Dietary and Resistance Training to Improve Physical Function in Older Cancer Survivors, E-PROOF Trial Exercise Intervention, Informational Intervention, Nutritional Assessment - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Not applicable | Completed | Ohio State University Comprehensive Cancer Center | 75 | 2023-08-28 | 2026-01-02 |
| LiSWT for Nerve Sparing Radical Prostatectomy ED Nerve-Sparing Prostatectomy, Medical Device Usage and Evaluation, Duplex Ultrasound - Erectile Dysfunction, Localized Prostate Carcinoma | Not applicable | Completed | Thomas Jefferson University | 8 | 2023-07-06 | 2025-07-15 |
| rhPSMA-73 PET-MRI Imaging for the Detection of Prostate Cancer Among Men Who Are Otherwise Candidates for Active Surveillance Biopsy of Prostate, Decipher Prostate Cancer Test, Flotufolastat F-18 Gallium - Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8 | Early Phase 1 | Recruiting | Northwestern University | 40 | 2023-06-07 | 2026-07-02 |
| Time-Restricted Eating Versus Nutritional Counseling for the Reduction of Radiation or Chemoradiation Tx Side Effects in Patients With Prostate, Cervical, or Rectal Cancers Biospecimen Collection, Informational Intervention, Quality-of-Life Assessment - Localized Prostate Carcinoma, Locally Advanced Cervical Carcinoma | Phase 2 | Active not recruiting | City of Hope Medical Center | 49 | 2023-03-23 | 2026-10-20 |
| RElugolix VErsus LeUprolide Cardiac Trial Radiation therapy, Leuprolide, Relugolix - Biochemically Recurrent Prostate Carcinoma, Localized Prostate Carcinoma | Phase 2 | Active not recruiting | Emory University | 94 | 2022-06-06 | 2026-02-12 |
| MRI-guided Transurethral Urethral Ultrasound Ablation for the Treatment of Low to Intermediate Grade Prostate Cancer MRI-Guided Transurethral Ultrasound Ablation, Questionnaire Administration, Digital Rectal Examination - Prostate Carcinoma, Stage I Prostate Cancer AJCC v8 | Not applicable | Recruiting | Mayo Clinic | 100 | 2022-04-06 | 2026-07-22 |
| Robot-Assisted Radical Prostatectomy With or Without Vesicopexy in Patients With Prostate Cancer Quality-of-Life Assessment, Questionnaire Administration, Radical Prostatectomy - Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8 | Not applicable | Suspended | University of Southern California | 196 | 2021-10-27 | 2026-06-01 |
| Neoadjuvant Dietary Intervention in Intermediate Risk Prostate Cancer Dietary Intervention, Radical Prostatectomy - Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8 | Not applicable | Active not recruiting | M.D. Anderson Cancer Center | 12 | 2021-08-27 | 2026-09-18 |
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Prostatic Neoplasms (36) · Colorectal Neoplasms (4) · Breast Neoplasms (1) · Carcinoma, Renal Cell (1) · Colonic Polyps (1) · Erectile Dysfunction (1) · Gastrointestinal Neoplasms (1) · Neoplasms (1) · Ovarian Neoplasms (1) · Rectal Neoplasms (1) · Urinary Bladder Neoplasms (1) · Urogenital Neoplasms (1) · Uterine Cervical Neoplasms (1)
Genital Diseases (36) · Genital Diseases, Male (36) · Genital Neoplasms, Male (36) · Male Urogenital Diseases (36) · Neoplasms by Site (36) · Prostatic Diseases (36) · Urogenital Diseases (36) · Neoplasms (35) · Urogenital Neoplasms (35) · Digestive System Diseases (5) · Digestive System Neoplasms (5) · Gastrointestinal Diseases (5) · Intestinal Diseases (5) · Intestinal Neoplasms (5) · Rectal Diseases (5)
Magnetic Resonance Spectroscopy (10) · Specimen Handling (10) · Biopsy (4) · Radiotherapy (4) · Radiation (3) · Brachytherapy (2) · Exercise Test (2) · Leuprolide (2) · Nutrition Assessment (2) · Observation (2) · Radiosurgery (2) · Watchful Waiting (2) · apalutamide (2) · relugolix (2) · Absorptiometry, Photon (1)
Mayo Clinic (6) · City of Hope Medical Center (5) · M.D. Anderson Cancer Center (5) · University of Southern California (3) · Emory University (2) · Jonsson Comprehensive Cancer Center (2) · OHSU Knight Cancer Institute (2) · Roswell Park Cancer Institute (2) · NRG Oncology (1) · National Cancer Institute (NCI) (1) · Northwestern University (1) · Ohio State University Comprehensive Cancer Center (1) · Rutgers, The State University of New Jersey (1) · Thomas Jefferson University (1) · University of California, Davis (1)
United States (35) · Canada (1)
Dalnim Cho (2) · Ram A. Pathak, MD (2) · Ahmed Aly (1) · Amar Kishan (1) · Amar W. Kishan, MD (1) · Arthur Hung (1) · Ashley E Ross (1) · Clayton S Lau (1) · David A Woodrum, MD, PhD (1) · David Woodrum, MD, PhD (1) · Gregory Idos (1) · Gurkamal S Chatta (1) · Hooman Djaladat, MD (1) · Jessica L Krok-Schoen, PhD (1) · Juan Chipollini (1)
PMID 34461975, PMID 34741653, PMID 36435952, PMID 38421243, PMID 39390760, PMID 40177325, PMID 41706486, PMID 41833067, PMID 42077327
P30CA033572 (5), P30CA014089 (3), P30CA138292 (2), P30CA015083 (1), P30CA015704 (1), P30CA016042 (1), P30CA016672 (1), P30CA023074 (1), P30CA060553 (1), P30CA072720 (1), P30CA093373 (1), P50CA140388 (1), R01CA218093 (1), R01CA258349 (1), R21AG078258 (1)