6 completed, 5 unknown, 3 recruiting, 2 not yet recruiting. 7 Phase 2, 5 Not applicable, 3 Phase 3, 2 Phase 1.
Follow Spinocerebellar Ataxia Type 3: new trials by email Literature Review of Spinocerebellar Ataxia Type 3 trials Research Report on Spinocerebellar Ataxia Type 3
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Umbilical Cord Mesenchymal Stem Cells Therapy (19#iSCLife®-SA) for Patients With Spinocerebellar Ataxia Intravenous infusion, Intrathecal injection, umbilical cord mesenchymal stem cell - Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2 | Phase 2 | Not yet recruiting | Sclnow Biotechnology Co., Ltd. | 45 | 2026-12-31 | 2026-04-23 |
| Optimizing Parameters of Transcranial Temporal Interference Stimulation for Spinocerebellar Ataxia Type 3 Transcranial Temporal Interference Stimulation (tTIS) - Spinocerebellar Ataxia Type 3 | Not applicable | Not yet recruiting | First Affiliated Hospital of Fujian Medical University | 24 | 2026-08-07 | 2026-09-01 |
| A Safety and Pharmacokinetics Trial of VO659 in SCA1, SCA3 and HD VO659 - Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 3 | Phase 1 / Phase 2 | Recruiting | Vico Therapeutics B. V. | 68 | 2023-02-14 | 2026-08-19 |
| Priming Motor Learning Through Exercise in People With Spinocerebellar Ataxia High-Intensity Aerobic Exercise Prior to Balance Training, Low-Intensity Exercise Prior to Balance Training - Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2 | Not applicable | Unknown | Teachers College, Columbia University | 20 | 2023-02-06 | 2024-05-03 |
| Treatment of Transcranial Alternating Current Stimulation（tACS）on Cerebellar Ataxia Transcranial Alternating Current Stimulation - Spinocerebellar Ataxia Type 3, Multiple System Atrophy-cerebellar Type | Not applicable | Completed | First Affiliated Hospital of Fujian Medical University | 164 | 2022-08-07 | 2024-07-12 |
| STRIDES - a Clinical Research Study of an Investigational New Drug to Treat Spinocerebellar Ataxia SLS-005, Placebo - Spinocerebellar Ataxia Type 3 | Phase 2 / Phase 3 | Terminated | Seelos Therapeutics, Inc. | 23 | 2022-06-03 | 2024-04-24 |
| A Pharmacokinetics and Safety Study of BIIB132 in Adults With Spinocerebellar Ataxia 3 BIIB132, BIIB132-Matching Placebo - Spinocerebellar Ataxia Type 3 | Phase 1 | Terminated | Biogen | 8 | 2022-02-02 | 2023-08-04 |
| Study of CAD-1883 for Spinocerebellar Ataxia CAD-1883, Placebos - Spinocerebellar Ataxias, Spinocerebellar Ataxia Type 1 | Phase 2 | Withdrawn | Cadent Therapeutics | 2021-06-01 | 2021-04-08 | |
| Efficacy Of Oral Trehalose In Spinocerebellar Ataxia 3 Trehalose, Maltose - Spinocerebellar Ataxia Type 3 | Not applicable | Unknown | National University of Malaysia | 20 | 2020-02-24 | 2022-08-16 |
| Neuropsychiatry and Cognition in SCA3/MJD SCA3/MJD molecular diagnosis, Cognitive Testing, Psychiatric Evaluation - Spinocerebellar Ataxia Type 3, Machado-Joseph Disease | Unknown | Hospital de Clinicas de Porto Alegre | 144 | 2019-12-13 | 2021-01-19 | |
| Instrumented Data Exchange for Ataxia Study Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2 | Completed | University of Chicago | 128 | 2019-06-01 | 2024-08-05 | |
| Troriluzole in Adult Participants With Spinocerebellar Ataxia troriluzole, Placebo - Spinocerebellar Ataxias, Spinocerebellar Ataxia Type 1 | Phase 3 | Active not recruiting | Biohaven Pharmaceuticals, Inc. | 299 | 2019-03-08 | 2026-06-24 |
| Identification of Biomarkers in Spinocerebellar Ataxia 3 Specimen Collection - Spinocerebellar Ataxia Type 3 | Completed | University of Michigan | 22 | 2019-02-21 | 2023-11-22 | |
| Repetitive Transcranial Magnetic Stimulation in SCA3 Patients Active repetitive transcranial magnetic stimulation, Sham repetitive transcranial magnetic stimulation - Spinocerebellar Ataxia Type 3 | Not applicable | Completed | Ning Wang, MD., PhD. | 39 | 2018-12-17 | 2022-08-16 |
| Natural History of Oculomotor Neurophysiology in Ataxic and Pre-ataxic Carriers of SCA3/MJD Video-oculography, Clinical Scales, Genotyping - Spinocerebellar Ataxia Type 3, Machado-Joseph Disease | Unknown | Hospital de Clinicas de Porto Alegre | 95 | 2017-03-28 | 2020-07-09 | |
| Astrocytic Markers and the Pre-ataxic Period of SCA3/MJD - BIGPRO Study Astrocytes Molecular Diagnosis, Clinical Scales - Baseline, Blood Draw - Baseline - Spinocerebellar Ataxia Type 3, Machado-Joseph Disease | Unknown | Hospital de Clinicas de Porto Alegre | 95 | 2017-03-18 | 2020-06-09 | |
| Safety and Efficacy of Lithium Carbonate in Patients With Spinocerebellar Ataxia Type 3 Lithium Carbonate, Placebo - Spinocerebellar Ataxia Type 3, Machado Joseph Disease | Phase 2 / Phase 3 | Completed | Hospital de Clinicas de Porto Alegre | 62 | 2011-05-01 | 2013-01-30 |
| Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Rare Disorders, Undiagnosed Disorders | Recruiting | Sanford Health | 20000 | 2010-07-01 | 2025-05-29 | |
| Pilot Study of Safety and Efficacy of Sodium Phenylbutyrate in Spinocerebellar Ataxia Type 3 Placebo, Sodium Phenylbutyrate - Spinocerebellar Ataxia Type 3 | Phase 2 | Withdrawn | Hospital de Clinicas de Porto Alegre | 2010-06-01 | 2012-08-17 | |
| Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias Genetic Testing, Blood Collection, Magnetic Resonance Imaging (MRI) Scan - Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2 | Recruiting | Lauren Moore | 1400 | 2010-04-01 | 2026-08-03 |
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Machado-Joseph Disease (21) · Spinocerebellar Ataxias (10) · Spinocerebellar Ataxia 10 (4) · Spinocerebellar ataxia 8 (4) · Ataxia (3) · Friedreich Ataxia (2) · Olivopontocerebellar Atrophy V (2) · Spinocerebellar Degenerations (2) · 3-Methylglutaconic Aciduria, Type V (1) · Achalasia Addisonianism Alacrimia syndrome (1) · Acrodysostosis (1) · Addison Disease (1) · Alagille Syndrome (1) · Alstrom Syndrome (1) · Amnesia, Transient Global (1)
Brain Diseases (21) · Central Nervous System Diseases (21) · Cerebellar Ataxia (21) · Cerebellar Diseases (21) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (21) · Dyskinesias (21) · Genetic Diseases, Inborn (21) · Heredodegenerative Disorders, Nervous System (21) · Nervous System Diseases (21) · Neurodegenerative Diseases (21) · Neurologic Manifestations (21) · Spinal Cord Diseases (21) · Spinocerebellar Degenerations (19) · Ataxia (18) · Spinocerebellar Ataxias (11)
4-phenylbutyric acid (1) · Blood Specimen Collection (1) · Genetic Testing (1) · Genotype (1) · Infusions, Intravenous (1) · Injections, Spinal (1) · Lithium Carbonate (1) · Magnetic Resonance Spectroscopy (1) · Maltose (1) · Specimen Handling (1) · Surveys and Questionnaires (1) · Transcranial Direct Current Stimulation (1) · Trehalose (1) · Varenicline (1)
Hospital de Clinicas de Porto Alegre (5) · First Affiliated Hospital of Fujian Medical University (2) · Biogen (1) · Biohaven Pharmaceuticals, Inc. (1) · Cadent Therapeutics (1) · Lauren Moore (1) · National University of Malaysia (1) · Ning Wang, MD., PhD. (1) · Sanford Health (1) · Sclnow Biotechnology Co., Ltd. (1) · Seelos Therapeutics, Inc. (1) · Teachers College, Columbia University (1) · University of Chicago (1) · University of Michigan (1) · University of South Florida (1)
United States (10) · Brazil (6) · China (4) · Germany (3) · United Kingdom (3) · Australia (2) · Israel (2) · Netherlands (2) · Portugal (2) · Canada (1) · Denmark (1) · France (1) · Malaysia (1) · South Korea (1) · Spain (1)
Laura B. Jardim, MD, PhD (2) · Chelsea E Macpherson, DPT (1) · Henry Paulson, MD (1) · Hong Jiang (1) · Jonas AM Saute, MD (1) · Laura B Jardim, MD PhD (1) · Laura B Jardim, PhD (1) · Laura Jardim (1) · Liana Rosenthal, MD, PhD (1) · Lori Quinn, PT, EdD (1) · Norlinah Mohamed Ibrahim, MRCP (1) · Sheng-Han Kuo, MD (1) · Theresa Zesiewicz, MD (1)
PMID 24399647, PMID 25449974, PMID 26297649, PMID 26644294, PMID 26943780, PMID 27848087, PMID 29057148, PMID 29089256, PMID 32982927, PMID 34115419, PMID 35962273, PMID 37179566, PMID 38489195, PMID 38615323, PMID 38814532, PMID 39806095, PMID 40532663, PMID 40679685, PMID 41445681
U01NS106670 (1)