56 completed, 18 recruiting, 13 unknown, 9 active not recruiting. 65 Not applicable, 2 Phase 2, 1 Early Phase 1, 1 Phase 3.
Follow Spina Bifida: new trials by email Literature Review of Spina Bifida trials Research Report on Spina Bifida
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Motor Imagery-Supported Thoracic Expansion in Children With Spina Bifida Thoracic Expansion Exercises, Motor Imagery-Supported Thoracic Expansion Exercises - Spina Bifida | Not applicable | Not yet recruiting | Karabuk University | 30 | 2026-10-12 | 2026-09-29 |
| tSCS in Children With Spina Bifida Transcutaneous stimulator - Spina Bifida, Myelomeningocele | Not applicable | Recruiting | Bailey Petersen | 20 | 2026-09-30 | 2026-09-15 |
| Clinical Investigation to Validate the Safety and Performance of the ABLE Kids Device in Pediatric Patients With Neurological Gait Disorders in a Clinical Setting ABLE Kids - Gait Impairment, Cerebral Palsy (CP) | Not applicable | Recruiting | ABLE Human Motion S.L. | 15 | 2026-09-01 | 2026-09-08 |
| Enema Device for Children With Spina Bifida Use of the foley catheter assistive device - Spina Bifida, Fecal Incontinence | Not applicable | Recruiting | University of Colorado, Denver | 20 | 2026-08-11 | 2026-09-03 |
| Coupled Gentamicin-Lactobacillus Rhamnosus in NLUTD Gentamicin, Lactobacillus Rhamnosus GG - Spinal Cord Injury, Neurogenic Bladder (NB) | Early Phase 1 | Not yet recruiting | Medstar Health Research Institute | 48 | 2026-08-01 | 2026-08-21 |
| Establishing the Preliminary Utility of a Novel Pediatric Manual Mobile Standing Wheelchair PedMMSWC Wheelchair User Testing, PedMMSWC Simulated Home, School, Community Environment - Spina Bifida | Not applicable | Recruiting | Optimal Mobility, Inc | 30 | 2026-06-18 | 2026-06-24 |
| Spina Bifida Healthcare Navigator Program Behavioral Treatment - Spina Bifida | Not applicable | Active not recruiting | University of Pittsburgh | 24 | 2026-04-15 | 2026-06-04 |
| Bowel Continence Across the Lifespan in People With Spina Bifida Retrograde Enema, Antegrade Enema - Spina Bifida, Neurogenic Bowel | Recruiting | David Chu | 943 | 2026-04-01 | 2026-09-24 | |
| Efficacy of Intravesical Oxybutynin in Children With Neurogenic Bladder Dysfunction Oxybutynin Hydrochloride, Placebo - Spina Bifida | Phase 3 | Recruiting | Central Hospital, Nancy, France | 60 | 2026-01-15 | 2026-04-14 |
| Transcutaneous Tibial Nerve Stimulation (TTNS) Treatment in Spina Bifida Pediatric Patients With Neurogenic Bladder Transcutaneous Tibial Nerve Stimulation (TTNS) treatment - Spina Bifida | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 12 | 2025-11-18 | 2026-02-12 |
| Comparing Digitally and Traditionally Made Ankle Foot Orthoses Part A First Wear Period: Traditional AFO(s), Part A First Wear Period: Digital AFO(s), Part A Second Wear Period: Traditional AFO(s) - Flaccid Paresis, Spastic Paresis | Not applicable | Recruiting | Holland Bloorview Kids Rehabilitation Hospital | 50 | 2025-09-05 | 2025-11-20 |
| Transcutaneous Spinal Stimulation for Children and Youth With Spina Bifida Transcutaneous stimulation - Myelomeningocele, Spina Bifida | Not applicable | Recruiting | Mayo Clinic | 30 | 2025-08-07 | 2025-10-14 |
| Autologous Human Umbilical Cord Tissue Patch for Postnatal Closure of Open Neural Tube Defects Autologous umbilical cord patch - Spina Bifida | Not applicable | Recruiting | The University of Texas Health Science Center, Houston | 15 | 2025-08-05 | 2026-09-24 |
| Plyometric vs Resistance Training for Trunk Balance in Children With Spina Bifida upper extremity plyometric exercises, upper extremity resistance exercises - Spina Bifida, Balance Changes | Not applicable | Completed | Okan University | 28 | 2025-03-01 | 2025-08-15 |
| High Intensity Exercise and Improving Physical Activity Among People With Neurologic Dysfunction Participate in high intensity exercise of at least 20 minutes in 60 minutes session of RPE greater than 6. - Cerebral Palsy (CP), Stroke | Not applicable | Completed | University of Hartford | 15 | 2025-02-24 | 2025-11-03 |
| Assessing Transition Practices for Children With Disabilities: Pathways to a Successful Adulthood Chart review, Semi-structured interview - Spina Bifida, Cerebral Palsy | Completed | Centre Hospitalier Universitaire de Saint Etienne | 128 | 2025-02-14 | 2026-07-16 | |
| QUALAS Validation in Dutch QUALAS survey - Spina Bifida | Recruiting | Erasmus Medical Center | 300 | 2024-12-09 | 2024-12-12 | |
| Effectiveness of Biofeedback Training in Children with Neurogenic Bladder and Bowel Disorder Wıth Spina Bifida Biofeedback exercise combined with breathing exercise, urotherapy educational group - Spina Bifida | Not applicable | Unknown | Hasan Kalyoncu University | 24 | 2024-10-21 | 2024-10-01 |
| Retrospective Study on the WalkOn AFO in Children or Teenagers With Neurological Pathologies Cerebral Palsy (CP), Spastic Paraplegia | Completed | Otto Bock France SNC | 65 | 2024-09-03 | 2025-09-24 | |
| The Study Aims to Improve the Accuracy of Detecting Spina Bifida During Early Ultrasound Scans. to Achieve This, an AI Model Has Been Developed to Provide Feedback About the Presence of Spina Bifida. a RCT Has Been Designed to Compare the Effectiveness of AI Feedback with No AI Feedback. Evaluation of XAI-assisted spina bifida diagnosis - Spina Bifida | Not applicable | Completed | Copenhagen Academy for Medical Education and Simulation | 38 | 2024-07-01 | 2024-12-04 |
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Spinal Dysraphism (105) · Cerebral Palsy (33) · Spinal Cord Injuries (24) · Urinary Bladder, Neurogenic (15) · Meningomyelocele (14) · Muscular Dystrophies (8) · Neural Tube Defects (8) · Multiple Sclerosis (6) · Stroke (6) · Brain Injuries (4) · Brain Injuries, Traumatic (4) · Musculoskeletal Diseases (4) · Arthritis, Juvenile (3) · Bone Diseases, Metabolic (3) · Down Syndrome (3)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (105) · Nervous System Malformations (105) · Congenital Abnormalities (103) · Nervous System Diseases (103) · Neural Tube Defects (97) · Central Nervous System Diseases (41) · Brain Diseases (35) · Brain Damage, Chronic (33) · Pathological Conditions, Signs and Symptoms (31) · Signs and Symptoms (27) · Neurologic Manifestations (24) · Trauma, Nervous System (24) · Wounds and Injuries (24) · Spinal Cord Diseases (22) · Female Urogenital Diseases and Pregnancy Complications (20)
Fetoscopy (3) · Health Resources (3) · Surveys and Questionnaires (3) · Blood Specimen Collection (2) · Urinary Sphincter, Artificial (2) · Administration, Intravesical (1) · Behavior Therapy (1) · Breathing Exercises (1) · Case-Control Studies (1) · Gentamicins (1) · Health Promotion (1) · Intermittent Urethral Catheterization (1) · Metformin (1) · Pamidronate (1) · Physical Therapy Modalities (1)
Rennes University Hospital (5) · McGill University (4) · University Hospital, Clermont-Ferrand (4) · Holland Bloorview Kids Rehabilitation Hospital (3) · University of Alabama at Birmingham (3) · University of Pittsburgh (3) · Central Hospital, Nancy, France (2) · Erasmus Medical Center (2) · Gillette Children's Specialty Healthcare (2) · Grand Valley State University (2) · Hydrocephalus and Neuroscience Institute (2) · Kenneth Peters, MD (2) · Mayo Clinic (2) · National Institutes of Health Clinical Center (CC) (2) · The University of Texas Health Science Center, Houston (2)
United States (48) · France (16) · Canada (12) · Turkey (Türkiye) (6) · Netherlands (3) · Belgium (2) · Denmark (2) · Norway (2) · South Korea (2) · Spain (2) · India (1) · Pakistan (1)
Dana Anaby, PhD (4) · Christelle Destinval, MD (2) · Jogi Pattisapu, MD (2) · Ramen Chmait, MD (2) · Ruben Quintero, MD (2) · Thomas C Bulea, Ph.D. (2) · Adrienne Kovacs, PhD,CPsych (1) · Ahmet Baschat, MD (1) · Amanda Garver, DO (1) · Amy McPherson, PhD (1) · Andi Saptono, Ph.D. (1) · Andrew Chon (1) · Ariane Marelli, MD,MPH,FRCPC (1)
PMID 17199857, PMID 21035565, PMID 21306277, PMID 21950393, PMID 22609118, PMID 24987412, PMID 25641449, PMID 25923030, PMID 26149636, PMID 29146566, PMID 30837255, PMID 31464189, PMID 31518302, PMID 31518315, PMID 32883297, PMID 34743701, PMID 35505001, PMID 36347777, PMID 36799340, PMID 37002023, PMID 38207160, PMID 38457177, PMID 38969555, PMID 38976710, PMID 39352737, PMID 41178302, PMID 41442093, PMID 41464320, PMID 41847996, PMID 42504464
K23DK119368 (1), R01DK084034 (1), R01DK110749 (1), R01HD039081 (1), R44HD118822 (1)