106 completed, 52 recruiting, 45 unknown, 41 terminated. 136 Phase 2, 91 Phase 1, 42 Not applicable, 17 Phase 3, 8 Early Phase 1.
Follow Soft Tissue Sarcoma: new trials by email Literature Review of Soft Tissue Sarcoma trials Research Report on Soft Tissue Sarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma Proton Therapy (Adaptive) - Pediatric Solid Tumors, Rhabdomyosarcoma | Not applicable | Recruiting | St. Jude Children's Research Hospital | 100 | 2026-08-20 | 2026-08-21 |
| Propranolol Plus Standard Radiation Therapy Before Surgery for the Treatment of Patients With Soft Tissue Sarcoma Biopsy, Biospecimen Collection, Computed Tomography - Soft Tissue Sarcoma | Phase 1 | Withdrawn | Roswell Park Cancer Institute | 2026-05-15 | 2025-08-26 | |
| Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors Methionine-Reduced Diet - Adenocarcinoma, Basal Cell Carcinoma | Early Phase 1 | Recruiting | University of California, Irvine | 25 | 2026-05-01 | 2026-07-31 |
| Preoperative Immunonutrition in Patients With Bone and Soft Tissue Sarcomas Forticare Advanced oral nutritional supplement - Bone Sarcoma, Soft Tissue Sarcoma | Not applicable | Recruiting | St. Anne's University Hospital Brno, Czech Republic | 100 | 2026-04-01 | 2026-05-27 |
| Application of Contrast-enhanced Ultrasound in Monitoring Soft Tissue Sarcoma Response to Neoadjuvant Radiotherapy Definity, Contrast-Enhanced Ultrasound - Soft Tissue Sarcoma | Early Phase 1 | Recruiting | Thomas Jefferson University | 10 | 2026-03-23 | 2026-04-14 |
| Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization Autologous total tumor mRNA loaded DOTAP liposome vaccine - Melanoma, Soft Tissue Sarcoma | Phase 1 | Suspended | University of Florida | 18 | 2026-03-17 | 2026-09-17 |
| Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors 68Ga-NNS309, 177Lu-DFC413 - Pancreatic Ductal Adenocarcinoma, Non-Small Cell Lung Cancer | Phase 1 | Recruiting | Novartis Pharmaceuticals | 180 | 2025-11-24 | 2026-10-09 |
| Safety and Efficacy of DIT309 in Advanced Bone and Soft Tissue Sarcomas DIT309 cell injection - Osteosarcoma, Soft Tissue Sarcoma | Phase 1 | Suspended | Tcelltech Inc. | 15 | 2025-11-06 | 2026-10-14 |
| Prospective Phase I/II Study Evaluating the Safety and Efficacy of Preoperative Carbon Ion Radiotherapy in Patients With Soft Tissue Sarcoma : The SARCOMA-01 Trial by the Severance sARCOma Multidisciplinary Team Carbon-Ion Radiotherapy (CIRT) - Soft Tissue Sarcoma | Not applicable | Not yet recruiting | Yonsei University | 60 | 2025-11-01 | 2025-11-26 |
| SATURN-STS: Phase II Study of Neoadjuvant Atezolizumab With Doxorubicin, Concurrent Atezolizumab With Pre-operative Radiation Therapy and Adjuvant Atezolizumab in Patients With High-risk Surgically Resectable Extremity and Truncal Soft Tissue Sarcoma Atezolizumab, Doxorubicin Hydrochloride - Soft Tissue Sarcoma | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 50 | 2025-09-11 | 2026-05-22 |
| Outcomes Following Limb Sparing Surgery for Soft Tissue Sarcoma Surgical resection with or without radiotherapy and/or chemotherapy - Soft Tissue Sarcoma | Recruiting | Amsterdam UMC | 150 | 2025-04-24 | 2025-12-19 | |
| A Study of MT-4561 in Patients With Various Advanced Solid Tumors MT-4561 - Head and Neck Squamous Cell Carcinoma (HNSCC), Non-small Cell Lung Cancer (NSCLC) | Phase 1 / Phase 2 | Recruiting | Tanabe Pharma America, Inc. | 27 | 2025-04-18 | 2025-12-11 |
| tislelizUMaB in canceR Patients With molEcuLar residuaL Disease Tislelizumab, Blood sampling, Placebo - Cancer, Lung Cancer | Phase 3 | Recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 717 | 2025-04-16 | 2025-05-13 |
| Preoperative 5-Day Radiotherapy for Soft Tissue Sarcoma Hypofractionated Radiation Therapy - Soft Tissue Sarcoma | Phase 2 | Recruiting | Medical University of South Carolina | 40 | 2025-04-01 | 2026-03-30 |
| Preliminary Clinical Study of Entinostat in Children With Malignant Soft Tissue Sarcoma Harboring PAX-family Gene Abnormalities Entinostat, VAC/VTC chemotherapy - Soft Tissue Sarcoma | Phase 1 | Recruiting | Beijing Tongren Hospital | 16 | 2025-03-15 | 2026-10-22 |
| Neoadjuvant Intralesional Injection of Talimogene Laherparepvec Talimogene Laherparepvec, Neoadjuvant Radiation, Surgery - Soft Tissue Sarcoma, Sarcoma,Soft Tissue | Phase 2 | Active not recruiting | John Rieth | 2 | 2025-03-03 | 2026-07-17 |
| Investigative Analysis of Soft Tissue Sarcoma Clinical Trials: An Observational Study Soft Tissue Sarcoma | Not yet recruiting | Power Life Sciences Inc. | 500 | 2025-03-01 | 2024-02-28 | |
| Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue Sarcoma Biopsy, Chest Computed Tomography, Chest Radiography - Adult Pleomorphic Rhabdomyosarcoma, AJCC Grade 2 Sarcoma | Not applicable | Not yet recruiting | ECOG-ACRIN Cancer Research Group | 1582 | 2025-01-28 | 2024-07-30 |
| Quantitative Margin Assessment Using High-resolution Positron Emission Tomography - Computed Tomograhy XEOS AURA 10 - Oral Cancer, Osteosarcoma | Not applicable | Not yet recruiting | University Medical Center Groningen | 30 | 2025-01-01 | 2024-12-10 |
| DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations Capmatinib - Solid Tumour, Haematological Malignancy | Phase 2 / Phase 3 | Recruiting | Cancer Research UK | 30 | 2024-11-19 | 2025-11-24 |
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Sarcoma (297) · Osteosarcoma (32) · Bone Neoplasms (30) · Rhabdomyosarcoma (25) · Breast Neoplasms (23) · Sarcoma, Ewing (23) · Melanoma (22) · Neoplasms (19) · Neoplasm Metastasis (16) · Ovarian Neoplasms (16) · Carcinoma, Non-Small-Cell Lung (15) · Leiomyosarcoma (14) · Sarcoma, Synovial (13) · Wilms Tumor (12) · Colorectal Neoplasms (11)
Neoplasms by Histologic Type (295) · Neoplasms, Connective and Soft Tissue (295) · Neoplasms (278) · Neoplasms by Site (98) · Neoplasms, Connective Tissue (56) · Neoplasms, Glandular and Epithelial (49) · Neoplasms, Nerve Tissue (48) · Neuroectodermal Tumors (43) · Urogenital Diseases (43) · Urogenital Neoplasms (43) · Female Urogenital Diseases (42) · Female Urogenital Diseases and Pregnancy Complications (42) · Skin Diseases (41) · Skin and Connective Tissue Diseases (41) · Neoplasms, Bone Tissue (38)
Doxorubicin (31) · Gemcitabine (17) · Radiotherapy (17) · Ifosfamide (11) · pembrolizumab (10) · Docetaxel (9) · Radiation (9) · Surgical Procedures, Operative (9) · Trabectedin (9) · anlotinib (7) · Nivolumab (6) · olaratumab (6) · Magnetic Resonance Spectroscopy (5) · pazopanib (5) · talimogene laherparepvec (5)
Eli Lilly and Company (8) · Sun Yat-sen University (8) · University Health Network, Toronto (8) · M.D. Anderson Cancer Center (7) · Institut Claudius Regaud (5) · Memorial Sloan Kettering Cancer Center (5) · Second Affiliated Hospital, Zhejiang University, School of Medicine (5) · Washington University School of Medicine (5) · Centre Leon Berard (4) · Grupo Espanol de Investigacion en Sarcomas (4) · National Cancer Institute (NCI) (4) · Brown University (3) · Centre Oscar Lambret (3) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (3) · Fox Chase Cancer Center (3)
United States (158) · China (39) · France (35) · Canada (26) · Germany (26) · Italy (22) · Spain (18) · United Kingdom (17) · Poland (12) · Belgium (11) · Netherlands (10) · Australia (9) · Denmark (9) · Switzerland (8) · Israel (7)
John Rieth, MD (4) · Albiruni Razak, M.D. (3) · Kristen Ganjoo, MD (3) · Antonio Casado (2) · Brian A Van Tine, M.D., Ph.D. (2) · Claudia Valverde (2) · Gerlinde Egerer, MD (2) · Gina D'Amato, MD (2) · Josefina Cruz (2) · Leighton Elliott, MD (2) · Mia Weiss, M.D. (2) · Mohammed Milhem, MD (2)
PMID 31401903, PMID 32827353, PMID 27621408, PMID 32713836, PMID 35115306, PMID 35135810, PMID 18286501, PMID 20932656, PMID 21937277, PMID 22152120, PMID 23922114, PMID 24048627, PMID 24554062, PMID 24618336, PMID 24885755, PMID 25185097, PMID 25680558, PMID 25928327, PMID 26874885, PMID 26880867, PMID 27245095, PMID 27255678, PMID 27367154, PMID 27387325, PMID 28214655, PMID 28447475, PMID 28651927, PMID 28667207, PMID 28988646, PMID 29929092, PMID 30217671, PMID 31400383, PMID 31537562, PMID 31772984, PMID 31987969, PMID 32259228, PMID 32767659, PMID 32813609, PMID 32840417, PMID 32859662, PMID 33203665, PMID 33292545, PMID 33305087, PMID 33632930, PMID 33686452, PMID 33775123, PMID 33927108, PMID 33932507, PMID 34330766, PMID 34519839
2015 (4), 2009 (2), 2016 (2), U10CA180886 (2), 2004 (1), 2005 (1), 2008 (1), 2014 (1), 2017 (1), 2019 (1), 2023 (1), 2025 (1), P30CA012197 (1), P30CA013330 (1), P30CA015704 (1)