23 completed, 11 unknown, 2 terminated, 1 recruiting. 3 Not applicable, 2 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Completed 3 |
| Phase 3 | 2 | Completed 2 |
| Phase 4 | 1 | Unknown 1 |
Follow SIRS: new trials by email Literature Review of SIRS trials Research Report on SIRS
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early Severe Illness TrAnslational BioLogy InformaticS in Humans Phelebotomy, Broncheoalveolar Lavage, Tracheal Aspirate - Sepsis, ARDS | Recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 1000 | 2024-04-26 | 2025-10-06 | |
| A Blood Test to Diagnose Sepsis in Symptomatic Adults and Children Diagnostic Test: Blood specimen collection - Infections, Sepsis | Unknown | mProbe Inc. | 1100 | 2022-05-01 | 2022-03-29 | |
| Establishment of an ELISA for the Recognition of Procalcitonin Variants in Patients With Hyperprocalcitonemia. Procalcitonin-variants ELISA-Assay - Sepsis, Pre-Eclampsia | Completed | University Hospital Muenster | 30 | 2022-02-01 | 2024-06-04 | |
| Anti-inflammatory Action of Oral Clarithromycin in Community-acquired Pneumonia Tablets, Clarithromycin 500mg - Community-acquired Pneumonia, Sepsis | Phase 3 | Completed | Hellenic Institute for the Study of Sepsis | 278 | 2021-01-25 | 2023-12-12 |
| mSEP: Testing of Physiological and Immune-metabolic Blood Markers for Maternal Sepsis Blood test - Sepsis, Maternal Sepsis | Unknown | Cardiff University | 330 | 2020-10-12 | 2021-08-27 | |
| Validation of Molecular and Protein Biomarkers in Sepsis mRNA expression - Sepsis, Cardiac Arrest | Unknown | Public Health England | 270 | 2020-02-25 | 2020-03-05 | |
| SIRS in Cyanotic and Acyanotic Children in Cardiac Surgery Sevoflurane - SIRS, Pediatric Cardiac Surgery | Completed | Cukurova University | 197 | 2020-02-04 | 2021-03-15 | |
| Early Identification of Sepsis in Children IG, IPF, NRBC, CRP, PCT, presepsin - Sepsis, Shock, Septic | Unknown | Brno University Hospital | 100 | 2019-12-01 | 2019-12-03 | |
| The Role of Emergency Neutrophils and Glycans in Postoperative and Septic Patients Blood sampling - Sepsis, Septic Shock | Terminated | Göteborg University | 10 | 2019-09-04 | 2021-08-19 | |
| Efficacy of Intravenous In-line Filter in Patient Undergoing Cardiac Surgery In-line filtration, Standard care - SIRS | Not applicable | Completed | Mahidol University | 486 | 2019-01-03 | 2024-03-15 |
| Performance Evaluation of the Nanomix eLab® CRP, PCT, and LAC Assays With the Nanomix eLab System Nanomix eLab® System molecular diagnostic test (non-interventional) - Sepsis, SIRS | Completed | Nanomix | 184 | 2018-12-11 | 2021-08-23 | |
| Effects of Electrical Stimulation for Preventing Loss of Muscle Mass in Patients With SIRS, Sepsis and Septic Shock Experimental Electrical Stimulation, Sham Electrical Stimulation, Conventional Physiotherapy - Sepsis, Septic Shock | Not applicable | Completed | Hospital Sirio-Libanes | 36 | 2018-10-01 | 2024-10-29 |
| Evaluation of CDSS in Detection of SIRS and Sepsis in Pediatric Patients Clinical Decision-Support System - SIRS, Sepsis | Completed | Hannover Medical School | 177 | 2018-08-01 | 2019-08-14 | |
| Cytokine Hemoadsorption in ECMO Patients SIRS, Cytokine Storm | Completed | University Medical Centre Ljubljana | 25 | 2017-06-01 | 2021-05-25 | |
| Early Detection of Glycocalyx Damage in Emergency Room Patients GlycoCheck™-System - Sepsis, SIRS | Completed | University Hospital Muenster | 260 | 2017-04-03 | 2020-04-02 | |
| Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal CytoSorb - Pancreatitis, Acute, SIRS | Phase 4 | Unknown | Technical University of Munich | 30 | 2017-03-15 | 2017-03-17 |
| CD64 and Antibiotics in Human Sepsis Antibiotic Resistant Infection, Critical Illness | Completed | University of Ulm | 64 | 2016-09-01 | 2024-12-10 | |
| The Ward Study for SeptiCyte® Lab to Distinguish Between Infection-positive and Infection-negative SIRS SeptiCyte Lab molecular diagnostic test (non-interventional) - Sepsis, SIRS | Terminated | Immunexpress | 66 | 2015-06-01 | 2018-03-01 | |
| The Role of Ninjurin-1 During Systemic Inflammation Ninj1 Expression, SIRS | Completed | Dr. Patrick Meybohm, M.D. | 30 | 2014-02-01 | 2014-09-03 | |
| Utility of Presepsin in Distinguishing Between Sepsis and SIRS SIRS, Sepsis | Completed | Mochida Pharmaceutical Company, Ltd. | 226 | 2014-01-01 | 2018-08-21 |
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Sepsis (29) · Shock, Septic (9) · Infections (6) · Critical Illness (5) · Inflammation (4) · Disease (3) · Systemic Inflammatory Response Syndrome (3) · Death (2) · Heart Arrest (2) · Multiple Organ Failure (2) · Multiple Trauma (2) · Shock (2) · Acute Kidney Injury (1) · Bacteremia (1) · Cognition Disorders (1)
Pathologic Processes (33) · Pathological Conditions, Signs and Symptoms (33) · Inflammation (28) · Systemic Inflammatory Response Syndrome (28) · Infections (26) · Shock (10) · Disease Attributes (6) · Respiratory Tract Diseases (5) · Lung Diseases (4) · Cardiovascular Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Respiratory Tract Infections (3) · Urogenital Diseases (3) · Digestive System Diseases (2) · Heart Diseases (2)
Blood Specimen Collection (1) · Clarithromycin (1) · Gastroscopy (1) · Gene Expression (1) · Hematologic Tests (1) · Sevoflurane (1) · Tablets (1)
Chinese PLA General Hospital (5) · University of Ulm (3) · University Hospital Muenster (2) · Ake Norberg (1) · Baxter Healthcare Corporation (1) · Brno University Hospital (1) · Cardiff University (1) · Charite University, Berlin, Germany (1) · Cukurova University (1) · Dr. Patrick Meybohm, M.D. (1) · Fondation Hôpital Saint-Joseph (1) · Göteborg University (1) · Hannover Medical School (1) · Hellenic Institute for the Study of Sepsis (1) · Hospital Sirio-Libanes (1)
Germany (9) · China (6) · United States (4) · Sweden (2) · United Kingdom (2) · Austria (1) · Brazil (1) · Canada (1) · Czechia (1) · Denmark (1) · France (1) · Greece (1) · Japan (1) · Slovenia (1) · Switzerland (1)
Lixin Xie, MD (2) · Manfred Weiss, MD, MBA (2) · Aleks Leligdowicz, MD PhD (1) · Anna Karlsson-Bengtsson, Prof (1) · Claudia Spies, MD Prof. (1) · Evangelos J Giamarellos-Bourboulis, MD, PhD (1) · Jia Huang (1) · Kristian Kofoed, MD (1) · Lixin Xie, Dr (1) · Manfred Weiss, MD (1) · Michael Marschollek, PhD (1) · Mitchell Levy, MD (1) · Narongrit Kantathut, MD (1)
PMID 11786196, PMID 17362525, PMID 22023777, PMID 22339896, PMID 22809118, PMID 23372690, PMID 23425763, PMID 25553245, PMID 26370823, PMID 27846908, PMID 30681551, PMID 30952998, PMID 31221891, PMID 33602206, PMID 36115679, PMID 36301921, PMID 38184008, PMID 39636188, PMID 41934919, PMID 41998704, PMID 42704050