88 completed, 22 unknown, 20 recruiting, 14 terminated. 54 Not applicable, 33 Phase 2, 19 Phase 3, 15 Phase 1, 4 Early Phase 1.
Follow Scleroderma: new trials by email Literature Review of Scleroderma trials Research Report on Scleroderma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Study on Systemic Sclerosis and the Validation of French-language Questionnaires Assessing Disability, Quality of Life, and Disease Status. Questionnaires - Scleroderma | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 200 | 2026-11-01 | 2026-10-22 | |
| Personalized Online Occupational Therapy Intervention for Adults With Scleroderma Personalized Online Occupational Therapy Intervention, Usual Care - Scleroderma, Scleroderma (Limited and Diffuse) | Not applicable | Completed | Universidad de Zaragoza | 24 | 2026-05-16 | 2026-10-14 |
| Clinical Study of EVM18001 in the Treatment of Refractory Autoimmune Diseases EVM18001 Injection - System Lupus Erythematosus(SLE), Scleroderma | Not applicable | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 12 | 2026-03-12 | 2026-03-13 |
| Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma Skin samples, Analysis of fibroblasts - Scleroderma | Recruiting | Centre Hospitalier Universitaire Dijon | 60 | 2026-01-26 | 2026-01-29 | |
| Evaluating Tools to Communicate Scleroderma Research Results to Patients - Trial #1 Plain-language summary, Dissemination Tool (Infographic) - Scleroderma, Systemic Sclerosis | Not applicable | Completed | Lady Davis Institute | 511 | 2025-12-05 | 2026-09-10 |
| Investigating the Effectiveness of the Biopsychosocial Model-Based Exercise Approach in Children and Adults Diagnosed With Scleroderma Cognitive Exercise Therapy Approach, Control group - Scleroderma, Scleroderma, Localized | Not applicable | Recruiting | Hacettepe University | 48 | 2025-12-04 | 2025-12-18 |
| A Phase 1/2 Study of PRO-203 in Healthy Volunteers and Participants With Systemic Sclerosis. PRO-203, Placebo - Healthy Volunteers, Systemic Sclerosis (SSc) | Phase 1 / Phase 2 | Recruiting | Prolium Bioscience, Inc | 44 | 2025-10-27 | 2026-10-09 |
| Patients Diagnosed With Scleroderma and Their Chewing and Swallowing Performance Questionnaire application for child and adult scleroderma patients - Systemic Sclerosis (SSc), Scleroderma | Recruiting | Hacettepe University | 50 | 2025-08-04 | 2025-09-19 | |
| Patients Diagnosed With Scleroderma: Physical Performance and Functionality Questionnaire and functionality application for child and adult scleroderma patients - Systemic Sclerosis (SSc), Scleroderma | Recruiting | Hacettepe University | 50 | 2025-08-04 | 2025-09-19 | |
| AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases. Allogeneic NK Cells - Refractory Rheumatoid Arthritis (RA), Idiopathic Inflammatory Myopathies (IIMs) | Phase 2 | Recruiting | Artiva Biotherapeutics, Inc. | 90 | 2025-07-09 | 2026-07-31 |
| RENEW-AI: Personalizing Scleroderma Management With an AI Health Coach RENEW-AI - Scleroderma | Not applicable | Completed | University of Michigan | 20 | 2025-05-19 | 2025-08-20 |
| Brain Boost Program to Improve Cognitive Function in People With Systemic Sclerosis Brain Boost group, Waitlist group - Scleroderma | Not applicable | Active not recruiting | University of Michigan | 66 | 2025-04-16 | 2026-04-28 |
| Efficacy and Safety of HN2301 in Autoimmune Diseases（AIDs） HN2301 injection - Systemic Lupus Erythematosus, Scleroderma | Phase 1 | Recruiting | Shenzhen MagicRNA Biotechnology Co., Ltd | 30 | 2025-03-16 | 2026-08-12 |
| Ultrasound and Electrophysiology Study of Hand in Systemic Sclerosis Patients and Contributors of Hand Dysfunction Scleroderma, Hand Functionality | Not yet recruiting | Assiut University | 45 | 2025-03-01 | 2025-01-15 | |
| Delving Into Participation Trends of Scleroderma Clinical Trials Scleroderma | Not yet recruiting | Power Life Sciences Inc. | 500 | 2025-03-01 | 2024-02-28 | |
| Tibulizumab Systemic Sclerosis Understanding and Response Evaluation (TibuSURE) Tibulizumab, Placebo - Systemic Sclerosis (SSc), Scleroderma | Phase 2 | Active not recruiting | Zura Bio Inc | 80 | 2025-02-06 | 2026-07-20 |
| Evaluating the Effect of Questionnaire Context on the Reporting of Somatic Items Among People With Systemic Sclerosis Reordered PHQ-8 - Scleroderma, Systemic Sclerosis (SSc) | Not applicable | Completed | Lady Davis Institute | 851 | 2025-01-17 | 2025-09-09 |
| Vaccination Against Herpes Zoster in Patients With Inflammatory Rheumatic Diseases Shingrix, vaccination with 2 doses of Shingrix vaccine - Systemic Vasculitis, Spondylarthropathies | Phase 4 | Enrolling by invitation | Region Skane | 240 | 2024-12-17 | 2025-01-10 |
| Ultrasonic COmparison of Salivary Glands in Autoimmune Diseases (COUGAR) Sjogren Syndrome, Dry Syndrome | Not yet recruiting | University Hospital, Brest | 501 | 2024-12-01 | 2024-11-08 | |
| 6-minute Pegboard Ring Test in Patients With Scleroderma validity and reliability study - Systemic Sclerosis (SSc), Scleroderma | Unknown | Yasemin GEDIKLI | 50 | 2024-10-15 | 2024-09-19 |
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Scleroderma, Diffuse (165) · Scleroderma, Systemic (67) · Lung Diseases, Interstitial (17) · Arthritis, Rheumatoid (12) · Lupus Erythematosus, Systemic (11) · Autoimmune Diseases (10) · Sjogren's Syndrome (10) · Arthritis, Psoriatic (7) · Myositis (7) · Scleroderma, Localized (7) · digital ulcers (7) · Raynaud Disease (6) · Spondylitis, Ankylosing (6) · Hypertension, Pulmonary (5) · Motor Activity (5)
Skin and Connective Tissue Diseases (165) · Skin Diseases (164) · Connective Tissue Diseases (163) · Scleroderma, Systemic (98) · Respiratory Tract Diseases (29) · Lung Diseases (28) · Pathological Conditions, Signs and Symptoms (28) · Cardiovascular Diseases (24) · Immune System Diseases (24) · Vascular Diseases (24) · Musculoskeletal Diseases (22) · Pathologic Processes (22) · Joint Diseases (17) · Nervous System Diseases (17) · Autoimmune Diseases (15)
Cyclophosphamide (6) · Blood Specimen Collection (3) · Mycophenolic Acid (3) · Rituximab (3) · Botulinum Toxins, Type A (2) · Cognitive Behavioral Therapy (2) · Methylprednisolone Acetate (2) · Rehabilitation (2) · Surveys and Questionnaires (2) · Tablets (2) · anifrolumab (2) · fludarabine (2) · thymoglobulin (2) · Alemtuzumab (1) · Alginic Acid (1)
University of Michigan (13) · Johns Hopkins University (9) · Lady Davis Institute (8) · Istanbul University (6) · Assistance Publique - Hôpitaux de Paris (4) · Assiut University (4) · Duke University (4) · Hacettepe University (3) · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (3) · Bristol-Myers Squibb (2) · Cytori Therapeutics (2) · Elpen Pharmaceutical Co. Inc. (2) · Federal University of São Paulo (2) · Firat University (2) · Khon Kaen University (2)
United States (79) · Turkey (Türkiye) (17) · Canada (16) · France (15) · United Kingdom (9) · Brazil (5) · China (5) · Spain (5) · Germany (4) · Italy (4) · Poland (4) · India (3) · Mexico (3) · Romania (3) · Sweden (3)
Luc Mouthon, MD, PhD (3) · Brett Thombs, PhD (2) · Dana DiRenzo, MD (2) · David Launay, MD,PhD (2) · Dinesh Khanna, MD (2) · Houman Hemmati, MD (2) · Richard Burt, MD (2) · Susan Murphy (2) · Alexandre WS Silva, PhD (1) · Aman Sharma, MD (1) · Andrea Low (1) · Ankoor Shah, MD (1) · Arnold E. Postlethwaite, MD (1)
PMID 33481429, PMID 12355489, PMID 15692967, PMID 16738459, PMID 16790698, PMID 16840399, PMID 17469162, PMID 17485423, PMID 17717203, PMID 17901414, PMID 17974598, PMID 18512816, PMID 18641099, PMID 19207142, PMID 19776222, PMID 19892673, PMID 20392703, PMID 20576211, PMID 20740615, PMID 22470237, PMID 24092682, PMID 24459219, PMID 24559157, PMID 24850877, PMID 25274889, PMID 25452309, PMID 27077744, PMID 27179107, PMID 27267753, PMID 27469583, PMID 27757230, PMID 28012804, PMID 28038680, PMID 28081972, PMID 28378937, PMID 28426903, PMID 28544580, PMID 28552512, PMID 28619061, PMID 29037155, PMID 29099620, PMID 29121645, PMID 29198478, PMID 29325173, PMID 29342462, PMID 29381834, PMID 29444467, PMID 29741230, PMID 30277862, PMID 30428506
2023 (2), N01AR002251 (1), R01AR047219 (1), R01HL089758 (1), R01HL089901 (1), R01HL114910 (1), R21AR065089 (1), R21AR066305 (1), R34HL122558 (1), UM1AI109565 (1)