54 completed, 17 terminated, 5 unknown, 4 withdrawn. 34 Phase 2, 33 Phase 1, 10 Not applicable, 7 Phase 3, 1 Early Phase 1.
Follow Recurrent Rectal Cancer: new trials by email Literature Review of Recurrent Rectal Cancer trials Research Report on Recurrent Rectal Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Preoperative Chemoradiotherapy and Toripalimab in Locally Recurrent Rectal Cancer PD-1 antibody (Toripalimab), Capecitabine, Oxaliplatin - Recurrent Rectal Cancer | Phase 2 | Not yet recruiting | Sixth Affiliated Hospital, Sun Yat-sen University | 44 | 2025-01-01 | 2024-12-27 |
| The Combination of Hypofractionated Radiotherapy and Immunotherapy in Locally Recurrent Rectal Cancer PD-1 antibody, Capecitabine, 5FU - Recurrent Rectal Cancer | Phase 2 | Unknown | Fudan University | 93 | 2022-11-30 | 2024-10-01 |
| PelvEx 4: Advanced Pelvic Malignancy and the Role of the Multi-disciplinary Team Meeting No specific intervention; cases are retrospective and patients have already been treated. - Multidisciplinary Communication, Locally Advanced Rectal Cancer | Unknown | St Vincent's University Hospital, Ireland | 12 | 2021-10-15 | 2021-10-13 | |
| Hypofractionated Pencil-Beam Scanning Intensity-modulated Proton Therapy (IMPT) in Recurrent Rectal Cancer Hypofractionated Pencil-Beam Scanning Intensity-modulated Proton Therapy, MEVION S250i Hyperscan and Adaptive Aperture Proton Therapy Machine - Recurrent Rectal Cancer | Not applicable | Terminated | Washington University School of Medicine | 15 | 2021-05-04 | 2025-09-29 |
| Induction Chemotherapy for Locally Recurrent Rectal Cancer Combination drug, Chemoradiotherapy, Surgery locally recurrent rectal cancer - Recurrent Rectal Cancer | Phase 3 | Recruiting | Catharina Ziekenhuis Eindhoven | 364 | 2020-11-13 | 2022-09-06 |
| CTV Exploration of 3D-PT Assisted CT-guided I-125 Seeds Implantation for Recurrent Rectal Cancer CTV - Recurrent Rectal Cancer, 125I Seeds Implantation | Unknown | Peking University Third Hospital | 60 | 2020-01-01 | 2021-01-14 | |
| SGM-101 in Locally Advanced and Recurrent Rectal Cancer SGM-101 - Rectal Cancer, Recurrent Rectal Cancer | Phase 2 / Phase 3 | Unknown | Leiden University Medical Center | 203 | 2019-10-22 | 2020-11-24 |
| Body Composition Manipulation in CoLorectal cancEr (BiCyCLE): Neuromuscular Electrical Stimulation (NMES) Microstim 2v2 Stimulator - Rectal Cancer, Colorectal Cancer | Not applicable | Unknown | London North West Healthcare NHS Trust | 46 | 2019-04-14 | 2021-10-29 |
| Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal Cancer That Has Spread to the Liver irinotecan-eluting beads, hepatic artery embolization - Liver Metastases, Mucinous Adenocarcinoma of the Colon | Phase 1 | Terminated | Fox Chase Cancer Center | 2 | 2016-01-29 | 2018-02-26 |
| Magnetic Resonance-Guided High Intensity Focused Ultrasound for Recurrent Rectal Cancer Magnetic resonance-guided focused ultrasound, Standard Radiation, Chemotherapy - Recurrent Rectal Cancer | Not applicable | Completed | William Chu, MD, MSc, FRCPC | 6 | 2015-04-01 | 2023-12-07 |
| Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer ziv-aflibercept, leucovorin calcium, fluorouracil - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 2 | Withdrawn | University of Southern California | 2015-03-01 | 2015-05-06 | |
| CPI-613 and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery 6,8-bis(benzylthio)octanoic acid, fluorouracil, pharmacological study - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 1 | Completed | Wake Forest University Health Sciences | 19 | 2015-01-06 | 2023-08-07 |
| Phase I Study of Neoadjuvant Radiotherapy With 5-Fluorouracil for Rectal Cancer intensity-modulated radiation therapy, fluorouracil, oxaliplatin - Mucinous Adenocarcinoma of the Rectum, Recurrent Rectal Cancer | Phase 1 | Completed | Virginia Commonwealth University | 14 | 2014-12-04 | 2021-07-20 |
| MEK Inhibitor MEK162 in Combination With Leucovorin Calcium, Fluorouracil, and Oxaliplatin in Treating Patients With Advanced Metastatic Colorectal Cancer MEK inhibitor MEK162, leucovorin calcium, fluorouracil - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 1 | Completed | City of Hope Medical Center | 26 | 2014-07-16 | 2026-10-19 |
| Genetic Mutations in Blood and Tissue Samples in Predicting Response to Treatment in Patients With Locally Advanced Rectal Cancer Undergoing Chemoradiation cytology specimen collection procedure, laboratory biomarker analysis - Mucinous Adenocarcinoma of the Rectum, Recurrent Rectal Cancer | Completed | Fox Chase Cancer Center | 43 | 2014-07-01 | 2024-05-02 | |
| Short-Infusion Ziv-aflibercept in Treating Patients With Metastatic Colorectal Cancer Receiving Combination Chemotherapy ziv-aflibercept, leucovorin calcium, irinotecan hydrochloride - Recurrent Colon Cancer, Recurrent Rectal Cancer | Not applicable | Withdrawn | City of Hope Medical Center | 2014-01-01 | 2014-07-21 | |
| Family Caregiver Palliative Care Intervention in Supporting Caregivers of Patients With Stage II-IV Gastrointestinal, Gynecologic, Urologic and Lung Cancers educational intervention, telephone-based intervention, quality-of-life assessment - Healthy Subject, Localized Transitional Cell Cancer of the Renal Pelvis and Ureter | Not applicable | Completed | City of Hope Medical Center | 200 | 2013-10-29 | 2026-10-01 |
| Comprehensive Gene Sequencing in Guiding Treatment Recommendations Patients With Metastatic or Recurrent Solid Tumors cytology specimen collection procedure, laboratory biomarker analysis - Recurrent Breast Cancer, Recurrent Colon Cancer | Completed | Ohio State University Comprehensive Cancer Center | 150 | 2013-09-03 | 2021-10-28 | |
| Irinotecan and Alisertib in Treating Patients With Advanced Solid Tumors or Colorectal Cancer irinotecan hydrochloride, alisertib - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 1 | Completed | University of California, Davis | 17 | 2013-08-01 | 2019-01-04 |
| PET-MRI in Diagnosing Patients With Colon or Rectal Cancer positron emission tomography, computed tomography, magnetic resonance imaging - Recurrent Colon Cancer, Recurrent Rectal Cancer | Not applicable | Completed | Case Comprehensive Cancer Center | 15 | 2013-04-01 | 2021-05-18 |
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Rectal Neoplasms (82) · Colonic Neoplasms (69) · Pancreatic Neoplasms (12) · Breast Neoplasms (9) · Carcinoma, Non-Small-Cell Lung (9) · Stomach Neoplasms (8) · Carcinoma, Hepatocellular (7) · Salivary Gland Neoplasms (7) · Breast Neoplasms, Male (6) · Carcinoma, Ovarian Epithelial (6) · Colorectal Neoplasms (6) · Carcinoma, Renal Cell (5) · Esthesioneuroblastoma, Olfactory (5) · Gallbladder Neoplasms (5) · Squamous Cell Carcinoma of Head and Neck (5)
Digestive System Diseases (81) · Digestive System Neoplasms (81) · Gastrointestinal Diseases (81) · Intestinal Diseases (81) · Intestinal Neoplasms (81) · Neoplasms by Site (81) · Rectal Diseases (81) · Gastrointestinal Neoplasms (79) · Neoplasms (79) · Colorectal Neoplasms (76) · Colonic Diseases (68) · Neoplasms by Histologic Type (16) · Endocrine Gland Neoplasms (14) · Endocrine System Diseases (14) · Neoplasms, Glandular and Epithelial (13)
Fluorouracil (23) · Leucovorin (20) · Oxaliplatin (17) · Irinotecan (15) · Bevacizumab (12) · Cetuximab (11) · Capecitabine (9) · Erlotinib Hydrochloride (6) · Radiation (4) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (3) · Floxuridine (3) · Fluorodeoxyglucose F18 (3) · Radiotherapy (3) · aflibercept (3) · Dasatinib (2)
National Cancer Institute (NCI) (42) · City of Hope Medical Center (8) · Fox Chase Cancer Center (3) · Ohio State University Comprehensive Cancer Center (3) · University of Southern California (2) · Abramson Cancer Center at Penn Medicine (1) · Alliance for Clinical Trials in Oncology (1) · Case Comprehensive Cancer Center (1) · Catharina Ziekenhuis Eindhoven (1) · Fudan University (1) · John Hays (1) · Leiden University Medical Center (1) · London North West Healthcare NHS Trust (1) · National Institutes of Health Clinical Center (CC) (1) · Peking University Third Hospital (1)
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Marwan Fakih (3) · Jeffrey Wong (2) · Wells Messersmith (2) · William Schelman (2) · Afsaneh Barzi (1) · Alain Mita (1) · Alessio Pigazzi (1) · Allyson Ocean (1) · Amit Oza (1) · Antonius Miller (1) · Axel Grothey, MD (1) · Betty Ferrell (1) · Bruce Giantonio (1) · Caio Rocha Lima, MD (1) · Cathy Eng (1)
PMID 17634125, PMID 20048179, PMID 21208843, PMID 22472035, PMID 24583822, PMID 24987057, PMID 25384705, PMID 25965900, PMID 26062933, PMID 26611425, PMID 30850872, PMID 32201506, PMID 32375690, PMID 32641862, PMID 32692450, PMID 33993383, PMID 34526100, PMID 38053659, PMID 38897584
P30CA014520 (3), U01CA062491 (3), U10CA025224 (3), N01CM17003 (2), N01CM62201 (2), N01CM62202 (2), P30CA006927 (2), P30CA068485 (2), U01CA070095 (2), U10CA021115 (2), U10CA032102 (2), N01CM00038 (1), N01CM00099 (1), N01CM17101 (1), N01CM17102 (1)