7 completed, 2 terminated, 1 available, 1 recruiting. 6 Phase 2, 5 Phase 3, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 4, Terminated 2 |
| Phase 3 | 5 | Completed 1, Recruiting 1, Suspended 1, Terminated 1, Unknown 1 |
| Not applicable | 2 | Completed 2 |
Follow Recurrent Clostridium Difficile Infection: new trials by email Literature Review of Recurrent Clostridium Difficile Infection trials Research Report on Recurrent Clostridium Difficile Infection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| VE303 for Prevention of Recurrent Clostridioides Difficile Infection VE303, Placebo - Clostridium Difficile, Clostridium Difficile Infections | Phase 3 | Recruiting | Vedanta Biosciences, Inc. | 852 | 2024-05-20 | 2026-09-29 |
| Fecal Filtrate as a Treatment Option of Multiple Recurrent Clostridioides Difficile Infection Fecal filtrate transplantation, Conventional fecal microbiota transplantation - Clostridium Difficile Infection, Recurrent Clostridium Difficile Infection | Phase 3 | Unknown | University of Pecs | 238 | 2023-11-01 | 2023-05-19 |
| Dietary Optimization of Microbiome Recovery Following Fecal Microbiota Transplantation MEND diet, mNICE diet - Recurrent Clostridium Difficile Infection, Fecal Microbiota Transplant | Not applicable | Completed | University of Minnesota | 12 | 2023-05-01 | 2025-08-12 |
| Primary or Recurrent Clostridioides Difficile Infection Treatment With Capsules of Lyophilised Faecal Microbiota vs Fidaxomicin MBK-01, Fidaxomicin - Recurrent Clostridium Difficile Infection, Primary Clostridium Difficile Infection | Phase 3 | Completed | Mikrobiomik Healthcare Company S.L. | 93 | 2021-10-29 | 2025-03-25 |
| Penn Microbiome Therapy for Recurrent Clostridium Difficile Infection Penn Microbiome Therapy - 001, Penn Microbiome Therapy - 002, Penn Microbiome Therapy - 003 - Recurrent Clostridium Difficile Infection | Phase 2 | Terminated | University of Pennsylvania | 9 | 2020-01-13 | 2023-11-01 |
| Efficacy of Oral Vancomycin Prophylaxis for Prevention of Recurrent Clostridium Difficile Infection Vancomycin, Placebo - Recurrent Clostridium Difficile Infection, Clostridium Difficile Infection | Phase 2 | Completed | University of Wisconsin, Madison | 79 | 2018-05-21 | 2025-05-25 |
| Open-Label Extension of CP101 Trials Evaluating Oral Full-Spectrum Microbiota™ (CP101) in Subjects With Recurrence of Clostridium Difficile Infection CP101 - Clostridium Difficile Infection, Recurrent Clostridium Difficile Infection | Phase 2 | Completed | Finch Research and Development LLC. | 132 | 2018-05-01 | 2022-08-30 |
| Lyophilized Fecal Transplant vs Lyophilized Fecal Filtrate in Recurrent C Diff Infection LFMT, LSFF - Enterocolitis, Recurrent Clostridium Difficile Infection | Phase 2 | Completed | Dina Kao | 11 | 2018-02-14 | 2020-02-20 |
| Lyophilized Fecal Microbiota Transplantation for Recurrent Clostridioides Difficile Infection Lyophilized Fecal Microbiota Transplantation - Recurrent Clostridium Difficile Infection | Not applicable | Completed | Vancouver Island Health Authority | 158 | 2015-10-01 | 2024-09-23 |
| Microbiota Restoration Therapy for Recurrent Clostridium Difficile-associated Diarrhea RBX2660 (microbiota suspension) - Recurrent Clostridium Difficile Infection | Phase 2 | Completed | Rebiotix Inc. | 34 | 2013-08-01 | 2019-11-13 |
| Oral Vancomycin Followed by Fecal Transplant Versus Tapering Oral Vancomycin Vancomycin, Fecal Transplant - Recurrent Clostridium Difficile Infection, Laboratory Confirmed Clostridium Difficile Infection | Phase 2 / Phase 3 | Terminated | University Health Network, Toronto | 81 | 2010-10-01 | 2014-12-08 |
| BIO-K+ CL1285 for Prevention of Recurrent Clostridium Difficile Infection Lactobacillus acidophilus CL1285® and Lactobacillus casei, Placebo - Recurrent Clostridium Difficile Infection | Phase 3 | Suspended | Bio-K Plus International Inc. | 140 | 2010-06-01 | 2016-01-15 |
| Fecal Microbiota Transplantation (FMT): PRIM-DJ2727 Fecal Microbiota Transplantation (FMT) product PRIM-DJ2727 - Recurrent Clostridium Difficile Infection, Multidrug-resistant Klebsiella Pneumoniae Urinary Tract Infection | Available | Herbert DuPont, MD | 2026-03-09 |
Clostridium Infections (13) · Diarrhea (3) · Diabetes Insipidus, Neurogenic (1) · Dysentery (1) · Enterocolitis (1) · Enterocolitis, Pseudomembranous (1) · Fever (1) · Reinfection (1)
Bacterial Infections (13) · Bacterial Infections and Mycoses (13) · Gram-Positive Bacterial Infections (13) · Infections (13) · Pathological Conditions, Signs and Symptoms (4) · Digestive System Diseases (3) · Gastroenteritis (3) · Gastrointestinal Diseases (3) · Intestinal Diseases (3) · Signs and Symptoms (3) · Signs and Symptoms, Digestive (3) · Body Temperature Changes (1) · Diabetes Insipidus (1) · Disease Attributes (1) · Endocrine System Diseases (1)
Fecal Microbiota Transplantation (3) · Vancomycin (2) · Fidaxomicin (1)
Bio-K Plus International Inc. (1) · Dina Kao (1) · Finch Research and Development LLC. (1) · Herbert DuPont, MD (1) · Mikrobiomik Healthcare Company S.L. (1) · Rebiotix Inc. (1) · University Health Network, Toronto (1) · University of Minnesota (1) · University of Pecs (1) · University of Pennsylvania (1) · University of Wisconsin, Madison (1) · Vancouver Island Health Authority (1) · Vedanta Biosciences, Inc. (1)
United States (7) · Canada (5) · Hungary (2) · Spain (2) · Australia (1) · Belgium (1) · Brazil (1) · Bulgaria (1) · Czechia (1) · Denmark (1) · France (1) · Georgia (1) · Germany (1) · Ireland (1) · Israel (1)
Alexander Khoruts, MD (1) · Christine Lee, MD (1) · Cornelius J Foley, MD (1) · Dimitri Drekonja, MD (1) · Dina Kao, MD (1) · Ebbing Lautenbach, MD, MPH, MSCE (1) · Herbert DuPont, MD (1) · Javier Cobo, MD (1) · Nasia Safdar, MD PhD (1) · Susan Poutanen, MD MPH FRCPC (1) · Susy Hota, MD FRCPC (1) · Zain Kassam, MD, MPH (1)
PMID 24762631, PMID 26565008, PMID 28011612, PMID 33106983, PMID 33593430, PMID 34150673, PMID 40601321, PMID 41245385, PMID 42286373