6 completed, 4 recruiting, 2 not yet recruiting, 1 terminated. 5 Not applicable, 2 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 2, Not yet recruiting 1, Recruiting 1, Terminated 1 |
| Phase 3 | 2 | Not yet recruiting 1, Recruiting 1 |
| Phase 2 | 1 | Completed 1 |
Follow Radiation Necrosis: new trials by email Literature Review of Radiation Necrosis trials Research Report on Radiation Necrosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| [18F]FET PET for Differentiating Tumor Progression vs Treatment-Related Changes in Brain Metastases Floretyrosine F 18 ([18F]FET) - Brain Metastasis, Radiation Necrosis | Phase 3 | Not yet recruiting | Telix Pharmaceuticals (Innovations) Pty Limited | 381 | 2026-12-01 | 2026-11-12 |
| TENS of Auricular Vagal Nerve for Radiation Necrosis Transcutaneous auricular vagal nerve stimulation (taVNS), Sham - Radiation Necrosis, Cerebral Edema | Not applicable | Not yet recruiting | Virginia Commonwealth University | 40 | 2026-11-30 | 2026-11-12 |
| Early [18F]-FDG PET Dynamic Analysis in Brain Metastases After Radiotherapy. CT scan - Short Time Examination, Brain Metastases | Recruiting | Centre Hospitalier Universitaire, Amiens | 50 | 2026-05-18 | 2026-06-08 | |
| Microbiome Determinants of Adverse Effects of Stereotactic Radiosurgery Adverse Radiation Effects, Radiation Necrosis | Recruiting | University of Chicago | 150 | 2025-08-05 | 2026-08-18 | |
| Bevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic Cerebral Radiation Necrosis After Radiation for High-grade Glioma or Brain Metastases Bevacizumab, Dexamethasone - Radiation Necrosis, High Grade Glioma (III or IV) | Phase 3 | Recruiting | The Netherlands Cancer Institute | 408 | 2025-06-19 | 2026-07-13 |
| REMASTer: REcurrent Brain Metastases After SRS Trial Radiation Therapy, Steroid Therapy, Laser Interstitial Thermal Therapy - Brain Metastases, Radiation Necrosis | Not applicable | Recruiting | Monteris Medical | 261 | 2022-05-10 | 2026-10-20 |
| Dynamic F-DOPA PET for Differential Diagnosis Between Recurrence and Radionecrosis of Brain Metastasis early 18F-FDOPA uptake - Brain Metastases, Radiation Necrosis | Not applicable | Completed | Centre Hospitalier Universitaire, Amiens | 8 | 2022-02-01 | 2025-11-18 |
| Low-dose Intra-arterial Bevacizumab for Edema and Radiation Necrosis Therapeutic Intervention (LIBERTI) 25% Mannitol, Low-dose Intra-arterial Bevacizumab - Radiation Necrosis | Phase 2 | Completed | Norton Healthcare | 10 | 2016-11-23 | 2022-05-24 |
| Hyperbaric Oxygen Therapy for Treatment of Severe Radiation-Induced Complications Hyperbaric Oxygen Therapy (HBOT) - Radiation Injury, Radiation-Induced Complications | Not applicable | Completed | Institute of Oncology Ljubljana | 39 | 2016-05-19 | 2026-02-19 |
| Differentiation of Pseudoprogression and True Progression Through High Field Susceptibility Weighted Imaging and R2* Radiation Injury, Radiation Necrosis | Completed | Centre for Functional and Metabolic Mapping | 18 | 2014-07-01 | 2016-03-31 | |
| Laser Ablation After Stereotactic Radiosurgery Metastatic Brain Tumors, Progression | Completed | Monteris Medical | 44 | 2012-07-01 | 2024-04-15 | |
| The Role of Bevacizumab in the Treatment of Radiation Necrosis in Children With Central Nervous System Tumors Bevacizumab (Avastin®) - Radiation Necrosis | Not applicable | Terminated | University of Colorado, Denver | 7 | 2010-06-28 | 2021-05-19 |
| Diffusion Tensor MRI to Distinguish Brain Tumor Recurrence From Radiation Necrosis Glioma Tumor Recurrence, Radiation Necrosis | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 29 | 2006-01-27 | 2017-10-06 |
Brain Neoplasms (7) · Radiation Injuries (4) · Disease Progression (2) · Glioma (2) · Arteriovenous Malformations (1) · Brain Edema (1) · Central Nervous System Neoplasms (1) · Glioblastoma (1) · Neoplasm Metastasis (1) · Neurotoxicity Syndromes (1) · Recurrence (1)
Nervous System Diseases (10) · Brain Diseases (8) · Central Nervous System Diseases (8) · Neoplasms (8) · Neoplasms by Site (8) · Nervous System Neoplasms (8) · Central Nervous System Neoplasms (7) · Wounds and Injuries (4) · Disease Attributes (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Neoplasms by Histologic Type (2) · Neoplasms, Germ Cell and Embryonal (2) · Neoplasms, Glandular and Epithelial (2) · Neoplasms, Nerve Tissue (2)
Bevacizumab (3) · (18F)fluoroethyltyrosine (1) · Adrenal Cortex Hormones (1) · Dexamethasone (1) · Hyperbaric Oxygenation (1) · Mannitol (1) · Radiotherapy (1)
Centre Hospitalier Universitaire, Amiens (2) · Monteris Medical (2) · Centre for Functional and Metabolic Mapping (1) · Institute of Oncology Ljubljana (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Norton Healthcare (1) · Telix Pharmaceuticals (Innovations) Pty Limited (1) · The Netherlands Cancer Institute (1) · University of Chicago (1) · University of Colorado, Denver (1) · Virginia Commonwealth University (1)
United States (7) · France (2) · Canada (1) · Netherlands (1) · Slovenia (1)
Dieta Brandsma, MD, PhD (1) · Glenn Bauman, MD (1) · John K Park, M.D. (1) · Justin Fraser, MD (1) · Margaret Macy, MD (1) · Peter Fecci, MD (1) · Ravi S Menon, PhD (1) · Ryan Cleary, MD (1) · Shervin R Dashti, MD,PhD (1) · Veronica Chiang, MD (1)