11 completed, 3 terminated, 2 unknown, 1 withdrawn. 17 Phase 2, 5 Phase 1, 4 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 17 | Completed 11, Terminated 3, Unknown 2, Withdrawn 1 |
| Phase 1 | 5 | Completed 3, Terminated 1, Withdrawn 1 |
| Phase 3 | 4 | Completed 2, Terminated 1, Unknown 1 |
Follow Pulmonary Emphysema: new trials by email Literature Review of Pulmonary Emphysema trials Research Report on Pulmonary Emphysema
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Two Different Doses of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% in Participants With Alpha1-Antitrypsin Deficiency Alpha-1 15%, Liquid Alpha1-Proteinase Inhibitor (Human) - Alpha1-Antitrypsin Deficiency | Phase 1 / Phase 2 | Completed | Grifols Therapeutics LLC | 17 | 2021-12-16 | 2026-10-08 |
| Allogeneic MSC Treatment for Pulmonary Emphysema Allogeneic MSC, Placebo - Pulmonary Emphysema, Mesenchymal Stromal Cells | Phase 2 | Unknown | Leiden University Medical Center | 30 | 2019-06-25 | 2021-06-09 |
| Clinical Study of the Efficacy and Safety of the Application of Allogeneic Mesenchymal (Stromal) Cells of Bone Marrow, Cultured Under the Hypoxia in the Treatment of Patients With Severe Pulmonary Emphysema Mesenchymal stem cells, Reference therapy: 400 mL of 0.9% NaCl solution - Pulmonary Emphysema | Phase 1 / Phase 2 | Withdrawn | Federal Research Clinical Center of Federal Medical & Biological Agency, Russia | 2014-03-01 | 2018-01-09 | |
| Low Cost Biological Lung Volume Reduction Therapy for Advanced Emphysema Bronchoscopic Lung volume reduction - Pulmonary Emphysema | Phase 2 | Completed | Mansoura University | 15 | 2013-04-01 | 2015-11-11 |
| A Continuation Study of the AeriSeal® System Administered at 3 to 4 Sites During a Single Treatment Session for Lung Volume Reduction in Patients With Advanced Emphysema AeriSeal System - Pulmonary Emphysema, Chronic Obstructive Pulmonary Disease(COPD) | Phase 2 / Phase 3 | Terminated | Aeris Therapeutics | 18 | 2011-03-01 | 2013-11-14 |
| AeriSeal® System for Lung Volume Reduction in Patients With Advanced Emphysema AeriSeal System - Pulmonary Emphysema, COPD | Phase 2 / Phase 3 | Completed | Aeris Therapeutics | 20 | 2010-08-01 | 2011-10-21 |
| AeriSeal System for Lung Volume Reduction AeriSeal System - Emphysema, Chronic Obstructive Pulmonary Disease (COPD) | Phase 1 / Phase 2 | Completed | Aeris Therapeutics | 55 | 2009-11-01 | 2013-06-26 |
| Unilateral Versus Bilateral Endoscopic Lung Volume Reduction A Comparative Case Study IBV Implantation - Pulmonary Emphysema | Phase 2 / Phase 3 | Unknown | Heidelberg University | 20 | 2009-09-01 | 2011-04-27 |
| A Pilot Study to Evaluate the ROX Anastomotic Coupler System in Patients With Chronic Obstructive Pulmonary Disease ROX Anastomotic Coupler System (ACS) - Chronic Obstructive Pulmonary Disease | Phase 2 | Completed | ROX Medical, Inc. | 49 | 2009-09-01 | 2014-04-21 |
| PROCHYMAL™ (Human Adult Stem Cells) for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) Prochymal™, Placebo - Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema | Phase 2 | Completed | Mesoblast, Inc. | 62 | 2008-03-20 | 2026-03-11 |
| US Biologic Lung Volume Reduction (BLVR) Phase 2 Emphysema Study Biologic Lung Volume Reduction (BLVR) - 20 mL Hydrogel - Pulmonary Emphysema, Chronic Obstructive Pulmonary Disease | Phase 2 | Completed | Aeris Therapeutics | 22 | 2007-08-01 | 2011-10-24 |
| Phase II/III Study of an Alpha-1 Proteinase Inhibitor (Kamada-API) in Individuals With Alpha-1 Antitrypsin Deficiency Kamada-API - Alpha 1-Antitrypsin Deficiency | Phase 2 / Phase 3 | Completed | Kamada, Ltd. | 50 | 2007-03-01 | 2007-10-17 |
| US 10 mL Biologic Lung Volume Reduction (BLVR) Phase 2 Emphysema Study BLVR Treatment - Pulmonary Emphysema | Phase 2 | Completed | Aeris Therapeutics | 20 | 2007-02-01 | 2011-10-24 |
| Netherlands 10 mL Bronchoscopic Lung Volume Reduction (BLVR) Phase 1/2 Emphysema Study - Initial Formulation BLVR Hydrogel - Pulmonary Emphysema | Phase 2 | Terminated | Aeris Therapeutics | 5 | 2005-05-01 | 2010-01-18 |
| Israeli 10 mL Bronchoscopic Lung Volume Reduction (BLVR) Phase 1/2 Emphysema Study - Initial Formulation BLVR Hydrogel - Pulmonary Emphysema | Phase 1 / Phase 2 | Terminated | Aeris Therapeutics | 4 | 2005-01-01 | 2008-03-06 |
| Yoga for Treating Shortness of Breath in Chronic Obstructive Pulmonary Disease (COPD) yoga - Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive | Phase 1 / Phase 2 | Completed | National Center for Complementary and Integrative Health (NCCIH) | 36 | 2003-01-01 | 2006-08-18 |
| Randomized Comparison of Awake Nonresectional Versus Nonawake Resectional Lung Volume Reduction Surgery awake nonresectional LVRS, Nonawake resectional LVRS - Pulmonary Emphysema | Phase 2 | Completed | University of Rome Tor Vergata | 60 | 2002-12-01 | 2007-12-04 |
Pulmonary Disease, Chronic Obstructive (13) · Emphysema (11) · Lung Diseases (5) · Pathologic Processes (4) · Respiratory Tract Diseases (4) · Bronchitis, Chronic (3) · Respiratory Aspiration (3) · Lung Diseases, Obstructive (2) · alpha 1-Antitrypsin Deficiency (2) · Digestive System Diseases (1) · Genetic Diseases, Inborn (1) · Hypoxia (1) · Inflammation (1) · Liver Diseases (1)
Chronic Disease (17) · Disease Attributes (17) · Pathological Conditions, Signs and Symptoms (17) · Lung Diseases, Obstructive (15) · Pathologic Processes (13) · Respiratory Tract Diseases (13) · Lung Diseases (12) · Pulmonary Disease, Chronic Obstructive (4) · Bronchial Diseases (3) · Bronchitis (3) · Infections (3) · Respiration Disorders (3) · Respiratory Tract Infections (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Digestive System Diseases (1)
Pneumonectomy (2) · 15-keto-17-phenyl-18,19,20-trinorprostaglandin F2 alpha-1-isopropyl ester (1) · Hydrogels (1) · Yoga (1) · remestemcel-l (1)
Aeris Therapeutics (7) · Federal Research Clinical Center of Federal Medical & Biological Agency, Russia (1) · Grifols Therapeutics LLC (1) · Heidelberg University (1) · Kamada, Ltd. (1) · Leiden University Medical Center (1) · Mansoura University (1) · Mesoblast, Inc. (1) · National Center for Complementary and Integrative Health (NCCIH) (1) · ROX Medical, Inc. (1) · University of Rome Tor Vergata (1)
United States (7) · Israel (4) · Germany (2) · Netherlands (2) · Austria (1) · Egypt (1) · France (1) · Italy (1) · Russia (1)
Charlie Strange, MD (2) · Gerard Criner, MD (2) · Mark Gotfried, MD (2) · Ahmad Saad El-Morsi, Prof (1) · Alexander V Averyanov, MD, PhD (1) · Christopher James, PA (1) · Eugenio Pompeo, MD (1) · Felix JF Herth, MD (1) · Geoffrey McLennan, MD (1) · Issahar Ben-Dov, MD (1) · Mark Dransfield, MD (1) · Mark Krasna, MD (1) · Robert A Sandhaus, M.D. (1) · Sanjiv Tewari, MD (1) · Thomas Gildea, MD (1)
PMID 19179484, PMID 22374920, PMID 22056369, PMID 22292600, PMID 22459779, PMID 23172272, PMID 23822603, PMID 24484754, PMID 33964910, PMID 38536165