2 completed, 2 recruiting, 1 active not recruiting, 1 unknown. 7 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 2, Recruiting 2, Active not recruiting 1, Unknown 1, Withdrawn 1 |
| Phase 2 | 1 | Unknown 1 |
Follow Primitive Neuroectodermal Tumor: new trials by email Literature Review of Primitive Neuroectodermal Tumor trials Research Report on Primitive Neuroectodermal Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer Etoposide, Fludarabine Phosphate, Hematopoietic Cell Transplantation - Anaplastic Ependymoma, Atypical Teratoid/Rhabdoid Tumor | Phase 1 | Withdrawn | M.D. Anderson Cancer Center | 2021-01-14 | 2024-10-26 | |
| Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors SCRI-CARB7H3(s); B7H3-specific chimeric antigen receptor (CAR) T cel - Central Nervous System Tumor, Diffuse Intrinsic Pontine Glioma | Phase 1 | Recruiting | Seattle Children's Hospital | 90 | 2019-12-11 | 2026-04-13 |
| EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors EGFR806-specific chimeric antigen receptor (CAR) T cell - Central Nervous System Tumor, Pediatric, Glioma | Phase 1 | Completed | Seattle Children's Hospital | 11 | 2019-03-19 | 2025-12-17 |
| HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors HER2-specific chimeric antigen receptor (CAR) T cell - Central Nervous System Tumor, Pediatric, Glioma | Phase 1 | Active not recruiting | Seattle Children's Hospital | 10 | 2018-07-26 | 2025-12-17 |
| SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Gemcitabine, ribociclib, sonidegib - Anaplastic Astrocytoma, Anaplastic Ependymoma | Phase 1 | Completed | St. Jude Children's Research Hospital | 68 | 2018-03-05 | 2024-05-31 |
| Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors TCRαβ+/CD19+ depleted Haploidentical HSCT, Zoledronate - Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia | Phase 1 | Recruiting | University of Wisconsin, Madison | 22 | 2016-02-12 | 2026-10-27 |
| Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Carboplatin, Mannitol, Melphalan - Central Nervous System Embryonal Neoplasm, Embryonal Tumor With Multilayered Rosettes, C19MC-Altered | Phase 1 / Phase 2 | Unknown | OHSU Knight Cancer Institute | 17 | 2009-07-09 | 2021-10-26 |
Neuroectodermal Tumors, Primitive (7) · Medulloblastoma (6) · Brain Neoplasms (5) · Choroid Plexus Carcinoma (5) · Ependymoma (5) · Glioma (5) · Neoplasms, Germ Cell and Embryonal (5) · Rhabdoid Tumor (5) · Central Nervous System Neoplasms (4) · Pinealoma (4) · Astrocytoma (1) · Diffuse Intrinsic Pontine Glioma (1) · Glioblastoma (1) · Hodgkin Disease (1) · Leukemia, Myeloid, Acute (1)
Neoplasms by Histologic Type (7) · Neoplasms, Glandular and Epithelial (7) · Neoplasms, Nerve Tissue (7) · Neuroectodermal Tumors (7) · Neoplasms (6) · Neoplasms, Neuroepithelial (6) · Brain Diseases (5) · Central Nervous System Diseases (5) · Neoplasms by Site (5) · Neoplasms, Complex and Mixed (5) · Nervous System Diseases (5) · Nervous System Neoplasms (5) · Hemic and Lymphatic Diseases (2) · Immune System Diseases (2) · Immunoproliferative Disorders (2)
Automobiles (3) · Melphalan (2) · Antilymphocyte Serum (1) · Carboplatin (1) · Etoposide (1) · Filgrastim (1) · Gemcitabine (1) · Granulocyte Colony-Stimulating Factor (1) · Hematopoietic Stem Cell Transplantation (1) · Mannitol (1) · Mycophenolic Acid (1) · Stem Cell Transplantation (1) · Tacrolimus (1) · Thiotepa (1) · Zoledronic Acid (1)
Seattle Children's Hospital (3) · M.D. Anderson Cancer Center (1) · OHSU Knight Cancer Institute (1) · St. Jude Children's Research Hospital (1) · University of Wisconsin, Madison (1)
United States (6)
Rebecca Ronsley, MD (2) · Christian Capitini, MD (1) · Edward A Neuwelt (1) · Giles W. Robinson, MD (1) · Juliane Gust, MD, PhD (1) · Kris M Mahadeo, MD (1)
PMID 31401903, PMID 34253928, PMID 35468680, PMID 37640679, PMID 39775044, PMID 41798119
R01NS044687 (1)