14 unknown, 12 completed, 7 not yet recruiting, 6 recruiting. 49 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 49 | Unknown 14, Completed 12, Not yet recruiting 7, Recruiting 6, Active not recruiting 4, Terminated 3, Withdrawn 2, Suspended 1 |
Follow Primary Ovarian Insufficiency: new trials by email Literature Review of Primary Ovarian Insufficiency trials Research Report on Primary Ovarian Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ovarian Tissue Allo-transplantation Ovarian tissue allo-transplantation - Ovarian Failure, Ovarian Insufficiency | Not applicable | Not yet recruiting | University Hospitals Cleveland Medical Center | 10 | 2026-09-01 | 2026-07-23 |
| Poi for Mama: a Pilot to Improve Maternal Microbiome and Gestational Diabetes Risk Fermented Poi - Gestational Diabetes Mellitus (GDM), Pregnancy | Not applicable | Recruiting | University of Hawaii | 50 | 2026-06-12 | 2026-07-02 |
| Improving Outcomes in Early Menopause After Cancer Nurse Navigator Intervention, Education Control - Early Menopause, Cancer | Not applicable | Recruiting | Duke University | 117 | 2026-01-20 | 2026-05-14 |
| A RCT Study on Autologous PRP Injection in Patients With POR PRP injection - Poor Ovarian Response, PRP Injection | Not applicable | Not yet recruiting | Peking University Third Hospital | 142 | 2025-12-15 | 2025-12-15 |
| A RCT Study on Autologous Cell Injection Into the Ovaries of Patients With POR PRP injection, SVF injection - Poor Ovarian Response | Not applicable | Not yet recruiting | Peking University Third Hospital | 198 | 2025-12-15 | 2025-12-15 |
| Gynecological Impact of Allogeneic Hematopoietic Stem Cell Transplantation in Adults Questionnaire - Acute Leukemia | Not applicable | Completed | University Hospital, Bordeaux | 51 | 2025-09-19 | 2026-06-25 |
| Efficacy and Safety of Huanjingjian Decoction in Women With Premature Ovarian Insufficiency Huanjingjian decoction, Hormone replacement therapy, Placebo - Premature Ovarian Insufficiency | Not applicable | Not yet recruiting | Shanghai Pulmonary Hospital, Shanghai, China | 276 | 2025-09-01 | 2025-09-08 |
| Safety and Efficacy of Autologous Adipose-Derived Regenerative Cells (ADRCs) Injection for Improving Diminished Ovarian Reserve Autologous Adipose-Derived Regenerative Cells (ADRCs) Intraovarian Injection - Diminished Ovarian Reserve (DOR), Primary Ovarian Insufficiency (Poi) | Not applicable | Not yet recruiting | Cytori Therapeutics | 25 | 2025-08-25 | 2025-08-12 |
| Therapeutic Effect of Vitamin C Supplementation in Patients With Ovarian Aging Vitamin C (Ascorbic Acid), Placebo - Premature Ovarian Insufficiency, Ovarian Reserve Function | Not applicable | Not yet recruiting | Peking University Third Hospital | 354 | 2025-07-02 | 2025-06-26 |
| Exploratory Clinical Study on the Efficacy and Safety of Lactobacillus Johnsonii in the Treatment of Patients with Premature Ovarian Insufficiency Lactobacillus johnsonii, Placebo - Premature Ovarian Insufficiency | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 60 | 2025-03-01 | 2025-03-10 |
| Application of Platelet-rich Plasma (PRP) in Reproductive Medicine Platelet-Rich Plasma (PRP) Injections - Premature Ovarian Insufficiency, Intrauterine Adhesion | Not applicable | Recruiting | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 300 | 2024-10-17 | 2025-02-18 |
| Application of Autologous Adipose Stromal Vascular Fraction in the Treatment of Premature Ovarian Insufficiency Conventional IVF, Lower abdominal liposuction and preparation of SVF, Ovarian injection - Premature Ovarian Insufficiency | Not applicable | Recruiting | Rui Yang | 260 | 2024-07-23 | 2024-11-14 |
| Treatment of Premature Ovarian Insufficiency Using Bone Marrow Cells autologous bone marrow cells injection - Premature Ovarian Insufficiency | Not applicable | Completed | abdulmajeed hammadi | 10 | 2024-03-01 | 2026-09-14 |
| Evolution of Sexual Life Quality of Women With POI Before and After Introduction of Hormone Replacement Therapy questionnaire - Premature Ovarian Failure | Not applicable | Completed | University Hospital, Bordeaux | 72 | 2023-07-17 | 2026-06-29 |
| Reexamining Her Cardiovascular Risk - Ottawa WomeN's Longitudinal Cohort Study PET scan - Cardiovascular Diseases | Not applicable | Active not recruiting | Ottawa Heart Institute Research Corporation | 176 | 2023-04-25 | 2026-09-08 |
| A Multicenter Open-label Clinical Study on the Prevention of Premature Ovarian Failure After HSCT leuprorelin, normal saline - Hematopoietic Stem Cell Transplantation, Premature Ovarian Failure | Not applicable | Unknown | First Affiliated Hospital Xi'an Jiaotong University | 200 | 2023-03-01 | 2023-02-23 |
| The Danish TURNER Cryopreservation Study laparoscopic cryopreservation of one ovary - Fertility Disorders, Turner Syndrome | Not applicable | Recruiting | University of Aarhus | 100 | 2023-01-01 | 2024-05-24 |
| Effect of NMN (Nicotinamide Mononucleotide) on Diminished Ovarian Reserve (Including Premature Ovarian Insufficiency) NMN intervention, Placebo - Diminished Ovarian Reserve, Premature Ovarian Insufficiency | Not applicable | Unknown | Peking University Third Hospital | 200 | 2022-07-01 | 2022-10-12 |
| Autologous Platelet-rich Plasma (PRP) Infusion to Improve Outcomes in Women With Ovarian Insufficiency: a Pilot Study Autologous Platelet-rich Plasma (PRP) Injection - Diminished Ovarian Reserve, Premature Ovarian Insufficiency | Not applicable | Unknown | KK Women's and Children's Hospital | 30 | 2022-05-01 | 2022-05-23 |
| Ovarian PRP (Platelet Rich Plasma) Injection for Follicular Activation autologous PRP (platelet rich plasma), Saline solution (NaCL) Injection - Premature Ovarian Insufficiency, Infertility, Female | Not applicable | Active not recruiting | University of Luebeck | 114 | 2022-03-17 | 2025-06-04 |
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Menopause, Premature (8) · Infertility (6) · Infertility, Female (4) · Breast Neoplasms (2) · Cardiovascular Diseases (2) · Diabetes, Gestational (2) · Turner Syndrome (2) · Amenorrhea (1) · Arrhythmias, Cardiac (1) · Cognitive Dysfunction (1) · Coronary Disease (1) · Endometriosis (1) · Galactosemias (1) · Gynatresia (1)
Adnexal Diseases (49) · Endocrine System Diseases (49) · Female Urogenital Diseases (49) · Female Urogenital Diseases and Pregnancy Complications (49) · Genital Diseases (49) · Genital Diseases, Female (49) · Gonadal Disorders (49) · Ovarian Diseases (49) · Urogenital Diseases (49) · Heart Diseases (4) · Metabolic Diseases (4) · Nutritional and Metabolic Diseases (4) · Cardiovascular Diseases (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Genetic Diseases, Inborn (3)
Injections (3) · Estradiol (2) · Lisdexamfetamine Dimesylate (2) · Saline Solution (2) · Surveys and Questionnaires (2) · Ascorbic Acid (1) · Blood Specimen Collection (1) · CbsT2 protein, Lactobacillus johnsonii (1) · Electrocardiography (1) · Estrogens (1) · Estrogens, Conjugated (USP) (1) · Follicle Stimulating Hormone (1) · Genetic Testing (1) · Guideline Adherence (1) · Hormone Replacement Therapy (1)
Peking University Third Hospital (4) · Assistance Publique - Hôpitaux de Paris (2) · Radboud University Medical Center (2) · University Hospital, Bordeaux (2) · University of Pennsylvania (2) · Acibadem University (1) · Affiliated Hospital of Nantong University (1) · Cairo University (1) · Center for Human Reproduction (1) · Cytori Therapeutics (1) · Duke University (1) · Equipo Juana Crespo (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · First Affiliated Hospital Xi'an Jiaotong University (1) · Hacettepe University (1)
United States (11) · China (8) · France (5) · Netherlands (4) · Egypt (3) · Canada (2) · Turkey (Türkiye) (2) · Croatia (1) · Denmark (1) · Germany (1) · Iraq (1) · Italy (1) · Russia (1) · Singapore (1) · Spain (1)
C. Neill Epperson, MD (2) · Ahmed Maged, MD (1) · Anne Bachelot, Pr (1) · Ayman Al-Hendy, MD, PhD (1) · Chanyu Zhang (1) · Dan Nayot, MD (1) · Darrell M Wilson (1) · Didi D Braat, Prof. MD PhD (1) · E Adang (1) · E Kirk Neely (1) · Elizabeth Brink, PhD (1) · Estela Rubio-Gozalbo, MD, PhD (1) · G Zielhuis, Prof PhD (1) · Georg Griesing, MD (1)
PMID 18326616, PMID 21134950, PMID 22698640, PMID 24341612, PMID 24982681, PMID 29486615, PMID 30804135, PMID 31125412, PMID 31398245, PMID 31831533, PMID 32680541, PMID 33342535, PMID 37549836, PMID 39433199, PMID 40180397, PMID 41250060
R21CA301298 (1)