13 unknown, 11 completed, 3 active not recruiting, 3 not yet recruiting. 35 Phase 1, 23 Phase 2.
Follow Primary Ovarian Insufficiency: new trials by email Literature Review of Primary Ovarian Insufficiency trials Research Report on Primary Ovarian Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oral GDC-0077 in Premature Ovarian Insufficiency GDC-0077 - Primary Ovarian Insufficiency | Phase 1 | Not yet recruiting | Women's Hospital School Of Medicine Zhejiang University | 12 | 2026-10-30 | 2026-10-29 |
| Phase Ⅰ/Ⅱa Trial Evaluating Intravenous hUC-MSCs Injection for Safety, Tolerability and Efficacy in Patients With POI hUC-MSCs Injection (Phase I), hUC-MSCs Injection (Phase IIa), Placebo - Premature Ovarian Insufficiency | Phase 1 / Phase 2 | Recruiting | Shenzhen Wingor Biotechnology Co., Ltd. | 59 | 2026-08-03 | 2026-08-20 |
| Umbilical Cord Mesenchymal Stem Cells (UC-MSC) in the Treatment of Primary Ovarian Insufficiency HS_SW01 cells injection - Primary Ovarian Insufficiency (Poi) | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Huishan Biotechnology Co., Ltd. | 21 | 2026-04-15 | 2026-04-27 |
| A Clinical Study of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Premature Ovarian Insufficiency YT023, Control Arm (Conventional Therapy) - Premature Ovarian Insufficiency | Phase 1 / Phase 2 | Active not recruiting | International Peace Maternity and Child Health Hospital | 60 | 2026-03-20 | 2026-04-03 |
| The Study of Human Chorionic Gonadotropin (HCG) Activating the Dormant Follicles . human chorionic gonadotropin - Premature Ovarian Insufficiency | Phase 1 | Not yet recruiting | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 60 | 2025-04-01 | 2025-03-12 |
| Clinical Study on the Safety and Efficacy of Human Amniotic Mesenchymal Stem Cells in the Treatment of Premature Ovarian Insufficiency Climen 21 Tablets, hA-MSCs - Premature Ovarian Insufficiency | Phase 1 / Phase 2 | Recruiting | Yan Hongli | 50 | 2024-10-15 | 2025-08-11 |
| Phase 1 Clinical Trial of CordSTEM-ST umbilical cord-derived mesenchymal stem cell - Premature Ovarian Insufficiency | Phase 1 | Completed | CHABiotech CO., Ltd | 6 | 2024-08-30 | 2025-11-19 |
| Autologous ADMSC Transplantation in Patients With POI stem cell therapy - Premature Ovarian Failure | Phase 1 | Unknown | Mongolian National University of Medical Sciences | 10 | 2024-01-15 | 2023-11-15 |
| A Proof of Concept Study to Evaluate Exosomes From Human Mesenchymal Stem Cells in Women With Premature Ovarian Insufficiency (POI) VL-PX10 - Premature Ovarian Insufficiency, Diminished Ovarian Reserve | Phase 1 | Suspended | Vitti Labs, LLC | 9 | 2023-10-06 | 2024-09-19 |
| Intra-ovarian Injection of MSC-EVs in Idiopathic Premature Ovarian Failure Intra-ovarian injection of bone marrow mesenchymal stromal cells-derived extracellular vesicles - Premature Ovarian Failure | Phase 1 / Phase 2 | Completed | Royan Institute | 10 | 2023-02-20 | 2026-07-15 |
| Autologous Heterotopic Fresh Ovarian Graft in Woman With LACC Eligible for Pelvic Radiotherapy Treatment. Ovarian graft - Locally Advanced Cervical Carcinoma, Premature Ovarian Failure | Phase 1 / Phase 2 | Active not recruiting | MARILIA ALBANEZI BERTOLAZZI | 22 | 2022-06-08 | 2025-09-05 |
| The Use of Expandeded Mesenchymal Stromal Cells (MSC) in Premature Ovarian Failure (POF) in Adult Humans expanded autologous bone marrow derived MSC Intravaginally, expanded autologous bone marrow derived MSC Laporoscopic, EV - Premature Ovarian Failure | Phase 1 | Active not recruiting | University of Jordan | 10 | 2022-01-01 | 2025-01-28 |
| Ovarian Injection of PRP (Platelet -Rich Plasma) Vs Normal Saline in Premature Ovarian Insufficiency platelet rich plasma, Normal saline - Premature Ovarian Failure | Phase 1 / Phase 2 | Unknown | Ahmed Saad | 60 | 2021-06-20 | 2021-06-10 |
| A Therapeutic Trial of Human Amniotic Epithelial Cells Transplantation for Primary Ovarian Failure human amniotic epithelial cells (hAECs) transplantation - Primary Ovarian Insufficiency, Premature Ovarian Failure | Phase 1 | Completed | International Peace Maternity and Child Health Hospital | 36 | 2020-06-20 | 2023-03-01 |
| Very Small Embryonic-like Stem Cells for Ovary very small embryonic-like stem cell - Stem Cell Transplant Complications, Premature Ovarian Failure | Phase 1 / Phase 2 | Withdrawn | Fuda Cancer Hospital, Guangzhou | 2019-07-03 | 2020-10-19 | |
| Stem Cell Therapy and Growth Factor Ovarian in Vitro Activation SEGOVA procedure - Menopause, Menopause Ovarian Failure | Phase 1 / Phase 2 | Unknown | Forever Young d.o.o. | 100 | 2019-06-01 | 2020-08-06 |
| Mesenchymal Stem Cells (MSCs) - Like Cell Transplantation in Women With Primary Ovarian Insufficiency Cell therapy - Primary Ovarian Insufficiency | Phase 1 | Unknown | Chinese Academy of Sciences | 28 | 2019-04-03 | 2021-08-05 |
| Efficacy, Safety, and Tolerability of Higher Doses Estrogen Therapy in Women With Premature Ovarian Insufficiency Transdermal estradiol gel 0.1% 1.5mg/ day, Transdermal estradiol gel 0.1% 2.0mg/ day - Primary Ovarian Insufficiency | Phase 1 / Phase 2 | Unknown | Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare | 80 | 2019-03-01 | 2023-02-28 |
| Effects of UCA-PSCs in Women With POF transplantation of human UCA-PSCs or WJ-MSCs into ovaries of POF patients - Premature Ovarian Failure | Phase 1 | Completed | Li-jun Ding | 20 | 2018-12-01 | 2021-12-01 |
| Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility Human Chorionic Gonadotropin (hCG), Gonadotropins, GNRH-A Triptorelin - Female Infertility, Female Infertility Due to Ovulatory Disorder | Phase 1 / Phase 2 | Completed | Lebanese University | 200 | 2018-02-01 | 2023-05-09 |
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Infertility (3) · Infertility, Female (2) · Menopause, Premature (2) · Ovarian Dysgenesis 2 (2) · Premature Ovarian Failure 2a (2) · Premature Ovarian Failure 3 (2) · Premature Ovarian Failure 5 (2) · Premature Ovarian Failure 6 (2) · Premature Ovarian Failure 7 (2) · Endometriosis (1) · Endometritis (1) · Leiomyoma (1) · Metrorrhagia (1) · Polycystic Ovary Syndrome (1)
Adnexal Diseases (35) · Endocrine System Diseases (35) · Female Urogenital Diseases (35) · Female Urogenital Diseases and Pregnancy Complications (35) · Genital Diseases (35) · Genital Diseases, Female (35) · Gonadal Disorders (35) · Ovarian Diseases (35) · Urogenital Diseases (35) · Uterine Diseases (2) · Cysts (1) · Fallopian Tube Diseases (1) · Hemorrhage (1) · Neoplasms (1) · Neoplasms by Histologic Type (1)
Chorionic Gonadotropin (2) · Dehydroepiandrosterone (2) · Stem Cell Transplantation (2) · Cell- and Tissue-Based Therapy (1) · Clinical Trials, Phase I as Topic (1) · Follicle Stimulating Hormone (1) · Gonadotropins (1) · Growth Hormone (1) · Hormone Replacement Therapy (1) · Human Growth Hormone (1) · Injections (1) · LHRH, Ac-Nal(1)-Cpa(2)-Trp(3)-Arg(6)-Ala(10)- (1) · Menotropins (1) · Saline Solution (1) · Sodium Chloride (1)
Chinese Academy of Sciences (3) · Al-Azhar University (2) · Center for Human Reproduction (2) · International Peace Maternity and Child Health Hospital (2) · Royan Institute (2) · Ahmed Saad (1) · Ascendance Biomedical (1) · CHABiotech CO., Ltd (1) · El-Rayadh Fertility Centre (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare (1) · Forever Young d.o.o. (1) · Fuda Cancer Hospital, Guangzhou (1) · Guangzhou University of Traditional Chinese Medicine (1) · Lebanese University (1)
China (11) · Egypt (5) · United States (5) · Iran (2) · Jordan (2) · Brazil (1) · Japan (1) · Lebanon (1) · Malta (1) · Mongolia (1) · North Macedonia (1) · Russia (1) · Serbia (1) · South Korea (1)
Hala Gabr, MD (2) · Hala N Hosni, Professor (2) · Hongmei Wang, Doctor (2) · Mahmoud Edessy, Professor (2) · Medhat Kamel, Msc (2) · Sayed Bakry, PhD (2) · Aleksandar Ljubic, MD, PhD (1) · Batsuren Choijamts, Ph.D (1) · David H Barad, MD (1) · David H Barad, MD, MS (1) · Dongmei Lai, M.D. (1) · Dr Abdalla Awidi, MD (1) · E Scott Sills, MD PhD (1) · Faezeh Shekari, Ph.D (1)
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