17 completed, 12 unknown, 8 recruiting, 3 not yet recruiting. 20 Not applicable, 6 Phase 2, 3 Phase 1, 2 Phase 3, 1 Early Phase 1.
Follow Azoospermia: new trials by email Literature Review of Azoospermia trials Research Report on Azoospermia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| IntelliWell: An AI-Assisted Imaging Platform for Detection and Location of Ultra-Rare Testicular Sperm in Surgical Specimens Use of IntelliWell to identify and localize sperm for ICSI - Infertility, Azoospermia | Not applicable | Recruiting | Brigham and Women's Hospital | 20 | 2026-04-16 | 2026-06-22 |
| Evaluating the Safety and Clinical Efficacy of the BAIBYS™ System in Intracytoplasmic Sperm Injection (ICSI) BAIBYS Sperm selection, Intra cytoplasmatic sperm injection, Conventional manual sperm selection - Male Infertility, Azoospermia | Not applicable | Not yet recruiting | BAIBYS Fertility | 260 | 2026-03-15 | 2026-01-15 |
| Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI) Primary Ovarian Insufficiency, Azoospermia | Recruiting | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 500 | 2026-03-11 | 2026-03-16 | |
| Male Factor Infertility Across India Using Aphrodite Criteria No Intervention: Observational Cohort - Male Infertility Due to Azoospermia | Not yet recruiting | Indira IVF Hospital Pvt Ltd | 1090 | 2026-01-23 | 2026-01-26 | |
| Interest of Clomiphene Citrate in Patients With Non-obstructive Azoospermia on the Quantity of Sperm Cells Clomifene Citrate, Placebo - Azoospermia, Nonobstructive | Phase 3 | Withdrawn | Hospices Civils de Lyon | 2026-01-01 | 2026-06-17 | |
| Laterality Success Determination of Microscopic Testicular Sperm Extraction in Non Obstructive Azoopsermia Patients Testicular sperm extraction - Testicular Sperm Extraction in Azoospermic Patients | Not yet recruiting | Assiut University | 80 | 2025-12-01 | 2025-12-02 | |
| Fertility Restoration With Autografting of Cryopreserved Immature Testicular Tissue autologous transplantation of cryopreserved testicular tissue - Azoospermia or Severe Oligozoospermia, Infertility | Not applicable | Recruiting | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 20 | 2025-11-19 | 2026-04-21 |
| Testicular Evaluation of Azoospermia Using Micro-Ultrasound Azoospermia | Recruiting | Paul Shin | 40 | 2025-05-01 | 2025-07-11 | |
| Fertility Enhancement Through Regenerative Treatment in Ovaries and Testes Stem cells - Gonadal Dysfunction, Gonadal Failure | Recruiting | Jumeirah American Clinic | 60 | 2025-04-08 | 2025-04-10 | |
| Study of Tolerability, Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of the Medicinal Product MediReg® Medicinal product MediReg® (Human Mesenchymal Stromal Cell Secretome), lyophilizate for preparation of solution for injection in patients with severe spermatogenesis disorders, Clostilbegit (clomiphene) 50 mg 1 tablet x 1 p a day - 3 months, Triovit - 1 tablet x 1 p a day - 3 months, Folic acid - 1 tablet x 1 p a day - 3 months. - Azoospermia, Nonobstructive, Teratospermia | Phase 1 / Phase 2 | Recruiting | Lomonosov Moscow State University Medical Research and Educational Center | 80 | 2024-11-26 | 2025-03-11 |
| Testicular Sperm Aspiration (TESA) vs. Microfluidic Sperm Separation (MSS) Infertility, Male, Azoospermia | Completed | Clinique Ovo | 280 | 2023-05-10 | 2024-07-12 | |
| The Association of Gut Microbiota and Spermatogenic Dysfunction no intervention - Infertility, Male, Azoospermia | Unknown | Zhujiang Hospital | 306 | 2023-02-20 | 2024-07-24 | |
| Platelet Rich Plasma Testis Treatment for Infertile Men Platelet rich plasma - Male Infertility, Nonobstructive Azoospermia | Not applicable | Recruiting | Stanford University | 10 | 2023-01-18 | 2026-01-13 |
| Laser Assisted Sperm Selection of Viable Immotile Testicular Sperm in Azoospermic Infertile Men Laser Assisted Immotile Sperm Selection, Hypo-osmotic Swelling Test - Azoospermia, IVF | Not applicable | Completed | Sohag University | 168 | 2020-10-01 | 2023-11-27 |
| Testicular Elastography for Microscopic Testicular Sperm Extraction testicular elastography - Azoospermia, Elasticity Imaging Techniques | Not applicable | Completed | Uşak University | 84 | 2020-01-01 | 2024-07-29 |
| Seminal TEX101 as a Predictor of Recovery of Spermatogenesis in Azoospermic Men With Palpable Varicocele micro-surgical varicocelectomy - Azoospermia, Nonobstructive, Varicocele | Not applicable | Completed | Cairo University | 40 | 2019-01-01 | 2020-05-21 |
| Testis Needle Aspiration of Sperm in Men With Azoospermia Sperm cell aspiration and TEFNA - Azoospermia | Not applicable | Recruiting | Hadassah Medical Organization | 150 | 2018-07-28 | 2025-03-04 |
| Autologous Adipose-Derived Adult Stromal Vascular Cell Administration for Male Patients With Infertility Lipoaspiration and SVF introduction., Standard therapy. - Azoospermia, Oligozoospermia | Phase 2 | Unknown | State-Financed Health Facility "Samara Regional Medical Center Dinasty" | 40 | 2018-03-12 | 2020-10-22 |
| Detection of Microdeletions in the Azoospermia Factor (AZF) Regions in Infertile Male Patients Azoospermia or Severe Oligozoospermia | Terminated | Reproductive & Genetic Hospital of CITIC-Xiangya | 5000 | 2017-12-04 | 2022-01-26 | |
| TESE and Non Obstructive Azoospermia Conventional TESE, Microdissection TESE - Azoospermia, Nonobstructive | Not applicable | Unknown | Assiut University | 148 | 2017-09-01 | 2017-09-29 |
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Infertility, Male (15) · Oligospermia (11) · Infertility (10) · Azoospermia, Nonobstructive (9) · Klinefelter Syndrome (3) · Asthenozoospermia (2) · Eunuchism (2) · Primary Ovarian Insufficiency (2) · Teratozoospermia (2) · Cryptorchidism (1) · Erectile Dysfunction (1) · Gonadal Disorders (1) · Hypogonadism (1) · Insulin Resistance (1)
Genital Diseases (45) · Genital Diseases, Male (45) · Male Urogenital Diseases (45) · Urogenital Diseases (45) · Infertility (35) · Infertility, Male (30) · Endocrine System Diseases (7) · Gonadal Disorders (6) · Female Urogenital Diseases (5) · Female Urogenital Diseases and Pregnancy Complications (5) · Hypogonadism (5) · Chromosome Disorders (3) · Congenital Abnormalities (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Disorders of Sex Development (3)
Clomiphene (3) · Chorionic Gonadotropin (2) · Injections (2) · Sperm Injections, Intracytoplasmic (2) · Urofollitropin (2) · Blood Specimen Collection (1) · Diet, Healthy (1) · Goserelin (1) · Isotretinoin (1) · Standard of Care (1)
Assiut University (2) · Hadassah Medical Organization (2) · Hospices Civils de Lyon (2) · Igenomix (2) · Man Clinic for Andrology, Male Infertility and Sexual Dysfunction (2) · Sheba Medical Center (2) · Turku University Hospital (2) · ANDROFERT - Clinica de Andrologia e Reproducao Humana (1) · Al-Azhar University (1) · Azienda Sanitaria Locale Bari (1) · BAIBYS Fertility (1) · Brigham and Women's Hospital (1) · Cairo University (1) · Clinic and Research Center in Human Reproduction Roger Abdelmassih (1) · Clinique Ovo (1)
Egypt (7) · United States (6) · Israel (5) · China (4) · France (3) · Spain (3) · Brazil (2) · Canada (2) · Denmark (2) · Finland (2) · Russia (2) · Belgium (1) · India (1) · Sweden (1) · Taiwan (1)
Antti Perheentupa, MD,PhD (2) · Khaled A Gadalla, MD (2) · Sayed Bakry, PhD (2) · Ahmed Kadeh, MSc (1) · Alayman Hussein, MD (1) · Anastasia Efimenko, doctor of sciences (1) · Ariel Revel, MD (1) · Armand Zini, MD (1) · Benjamin E. Reubinoff, MD PhD (1) · Bing Yao, MD (1) · Carlos Simon, MDPhD (1) · Carmen Rubio, PhD (1) · Christine Wyns, MD, PhD (1)
PMID 22958644, PMID 14501743, PMID 14667875, PMID 16291975, PMID 16595231, PMID 1794918, PMID 24919724, PMID 25423570, PMID 30243299, PMID 32374923, PMID 33790862, PMID 36112034, PMID 38367592, PMID 38909671, PMID 43278, PMID 7637066, PMID 9230450
K24HD082231 (1)