12 completed, 3 not yet recruiting, 3 recruiting, 3 unknown. 12 Not applicable, 2 Phase 2, 1 Phase 1, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 12 | Completed 6, Not yet recruiting 2, Recruiting 2, Enrolling by invitation 1, Unknown 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Pleural Infection: new trials by email Literature Review of Pleural Infection trials Research Report on Pleural Infection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Role of Medical Thoracoscopy in Pleural Infection (PROMPT Trial) medical thoracoscopy, Standard of Care - Pleural Infection, Pleural Infections | Not applicable | Not yet recruiting | Università Politecnica delle Marche | 170 | 2026-11-01 | 2026-04-24 |
| Study of Medical Thoracoscopy in Early Pleural Infection Medical thoracoscopy plus standard of care, Standard of Care (Investigator Choice) - Pleural Infection | Not applicable | Not yet recruiting | Alexandria University | 128 | 2026-11-01 | 2026-10-05 |
| Evaluating the Use of an App in Pleural Disease: Algorithm-supported Clinical Decision Making Versus Usual Care Clinical decision-making support tool, Usual care - Pleural Diseases, Pneumothorax Spontaneous Primary | Not applicable | Enrolling by invitation | Zealand University Hospital | 828 | 2026-04-01 | 2026-06-04 |
| Intrapleural Alteplase-Tyloxapol vs Intrapleural Alteplase-DNase in Pleural Infection Intrapleural t-PA/Dnase arm, t-PA (Alteplase) 5-10mg and Tyloxapol 200mg - Pleural Infection | Recruiting | National University of Malaysia | 80 | 2026-04-01 | 2026-06-30 | |
| Chemical vs Mechanical Pleural Adhesiolysis for Liberation of Captive Pleura in Stacked Effusion Intrapleural Hydrogen Peroxide (H_2O_2), Intrapleural Corticosteroids, Thoracoscopic Mechanical Pleurolysis - Pleural Infection, Pleural Adhesions | Phase 2 | Completed | Delta University for Science and Technology | 36 | 2026-03-26 | 2026-07-20 |
| Diagnostic Utility of Pleural Infection-specific Multiplex PCR Panel PRISM PCR panel, Conventional bacterial culture - Pleural Infection | Not yet recruiting | Chinese University of Hong Kong | 800 | 2026-01-01 | 2025-07-22 | |
| Pleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema/Complicated Parapneumonic Effusion Saline Irrigation - Pleural Infection | Not applicable | Recruiting | Mayo Clinic | 60 | 2025-03-29 | 2026-03-30 |
| Trial of Reduced Alteplase Dose for Parapneumonic Effusion (TRAPPE) Tissue Plasminogen Activator - Pleural Infection | Phase 2 / Phase 3 | Completed | Chinese University of Hong Kong | 30 | 2024-11-01 | 2026-10-23 |
| Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas Saline Flush - Empyema, Pleural, Pleural Infection | Not applicable | Recruiting | Vanderbilt University Medical Center | 96 | 2024-06-21 | 2026-02-20 |
| Pleural Fluid Neutrophil Extracellular Traps Exacerbate Disease Severity and Risk of One-year Mortality in Pleural Infection (TORPIDS-3) Pleural Infection | Active not recruiting | University of Oxford | 326 | 2024-01-09 | 2025-09-26 | |
| Predictors of Outcome in Patients With Pleural Infection at Sohag University Hospital disease outcome ( mortality and length of stay ) - Pleural Infection | Unknown | Sohag University | 100 | 2023-11-01 | 2023-11-21 | |
| Pleural Irrigation With Normal Saline Versus Intrapleural Fibrinolytic Intrapleural fibrinolytic with alteplase 5mg and pulmozyme 5 mg, Saline irrigation with 250 mls normal saline (over 1 hour) - Pleural Infection | Not applicable | Completed | National University of Malaysia | 40 | 2023-07-10 | 2026-02-24 |
| Fluid Agitation Microbiologic Yield In Pleural Infection Feasibility Study Agitated Pleural Fluid Thoracentesis - Pleural Infection | Not applicable | Completed | Alexandria University | 30 | 2022-12-15 | 2024-07-23 |
| The Oxford Pleural Infection Endotyping Study Pleural Infection, Pleural Diseases | Completed | University of Oxford | 80 | 2021-06-20 | 2024-07-22 | |
| Antiseptic Irrigation for Pleural Infection Povidone-Iodine pleural irrigation - Pleural Infection | Phase 1 | Completed | Alexandria University | 36 | 2021-03-04 | 2022-08-31 |
| Short Versus Long Antibiotic Course for Pleural Infection Management (SLIM Trial) Short course (2-3 weeks) of antibiotics, Standard (long course) of antibiotics - Pleural Infection | Not applicable | Completed | Alexandria University | 50 | 2020-09-28 | 2021-12-21 |
| Prospective Data Collection on Clinical, Radiological and Patient Reported Outcomes After Pleural Intervention Pleural interventions - Pleural Diseases, Pleural Mesothelioma | Unknown | University of Oxford | 2000 | 2020-09-01 | 2023-06-18 | |
| Oral Versus Intravenous Antibiotics for the Treatment of Pleural Space Infection: a Randomized Controlled Pilot Trial Antibiotics - Pleural Infection | Not applicable | Unknown | St. Joseph's Healthcare Hamilton | 40 | 2020-05-01 | 2020-03-10 |
| Pharmacokinetics and Pleural Fluid Penetration of Amoxicillin and Clavulanic Acid in Patients With Pleural Infections chest tube drainage, antibiotic concentration in pleural fluid, Amoxicillin + clavulanic acid - Pleural Infection, Empyema | Not applicable | Completed | Centre Hospitalier Universitaire, Amiens | 11 | 2019-07-18 | 2025-12-08 |
| The Microbiology of Pleural Infection Not applicable. Observational study. Retrospective analysis of samples. - Pleural Infection, Pleural Infection Bacterial | Completed | University of Oxford | 251 | 2019-02-10 | 2020-10-01 |
Showing 20 of 23. Sign in to see all of them.
Pleural Effusion (6) · Empyema (5) · Pleural Diseases (5) · Empyema, Pleural (3) · Inflammation (3) · Pneumothorax (2) · Community-Acquired Pneumonia (1) · Mesothelioma, Malignant (1) · Pleural Effusion, Malignant (1) · Pleural Neoplasms (1)
Respiratory Tract Diseases (10) · Pathologic Processes (8) · Pathological Conditions, Signs and Symptoms (8) · Infections (6) · Suppuration (6) · Inflammation (5) · Pleural Diseases (4) · Respiratory Tract Infections (4) · Adenoma (1) · Community-Acquired Infections (1) · Empyema (1) · Lung Diseases (1) · Lung Neoplasms (1) · Mesothelioma (1) · Neoplasms (1)
Tissue Plasminogen Activator (4) · Anti-Bacterial Agents (3) · Standard of Care (2) · Amoxicillin-Potassium Clavulanate Combination (1) · High-Energy Shock Waves (1) · Length of Stay (1) · Mortality (1) · Povidone-Iodine (1) · Thoracoscopy (1) · Thrombolytic Therapy (1) · dornase alfa (1) · tyloxapol (1)
University of Oxford (5) · Alexandria University (4) · Chinese University of Hong Kong (2) · National University of Malaysia (2) · Beth Israel Deaconess Medical Center (1) · Centre Hospitalier Universitaire, Amiens (1) · Delta University for Science and Technology (1) · Mayo Clinic (1) · Sohag University (1) · St. Joseph's Healthcare Hamilton (1) · Tulane University (1) · Università Politecnica delle Marche (1) · Vanderbilt University Medical Center (1) · Zealand University Hospital (1)
Egypt (5) · United Kingdom (5) · United States (4) · Hong Kong (2) · Malaysia (2) · Denmark (1) · France (1)
Maged Hassan, PhD (2) · Casper Jensen, MD (1) · Dagny Anderson, MD (1) · David SC Hui, MD (1) · Fayez Kheir, MD, MSc (1) · Jennifer D Duke, MD (1) · Mohamed Faisal Abdul Hamid, MBBS (IIUM) (1) · Mohamed Faisal Abdul Hamid, MBBS(IIUM) (1) · Najib Rahman, DPhil (1)
PMID 21830966, PMID 32421353, PMID 12639166, PMID 22398159, PMID 26254467, PMID 27333122, PMID 35581627, PMID 37553157, PMID 39827129, PMID 40251602, PMID 41243095, PMID 41566445, PMID 41785244, PMID 41948066, PMID 5540449