28 completed, 2 terminated, 1 active not recruiting, 1 recruiting. 7 Phase 1, 6 Phase 2, 6 Phase 3, 5 Not applicable, 4 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 7 |
| Phase 2 | 6 | Completed 6 |
| Phase 3 | 6 | Completed 4, Active not recruiting 1, Recruiting 1 |
| Not applicable | 5 | Completed 4, Withdrawn 1 |
| Phase 4 | 4 | Completed 4 |
| Early Phase 1 | 1 | Terminated 1 |
Follow Plasmodium Falciparum: new trials by email Literature Review of Plasmodium Falciparum trials Research Report on Plasmodium Falciparum
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Serological Testing and Treatment for Plasmodium Vivax Malaria: a Trial in Ethiopia and Madagascar PvSeroTAT, Control - Malaria Vivax, Malaria Falciparum | Phase 3 | Recruiting | London School of Hygiene and Tropical Medicine | 19200 | 2025-05-12 | 2026-09-18 |
| Targeted Antimalarial Drug Administration for Seasonal Migrant Populations in Amhara Region, Ethiopia Dihydroartemisinin-piperaquine - Plasmodium Falciparum, Malaria | Phase 3 | Active not recruiting | PATH | 10350 | 2024-08-21 | 2025-05-06 |
| Clinical Practices for Treating Severe Malaria Caused by P. Falciparum Malaria, Falciparum, Plasmodium Falciparum | Completed | Centre Hospitalier de Saint-Denis | 77 | 2024-05-01 | 2025-06-18 | |
| A Study of the Plasmodium Falciparum Malaria Vaccine Candidate Pfs48/45 in Matrix-M Adjuvant in the UK Pfs48/45 in Matrix-M - Malaria, Plasmodium Falciparum | Early Phase 1 | Terminated | University of Oxford | 17 | 2022-11-02 | 2026-08-07 |
| Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for Treatment of Plasmodium Falciparum Malaria in Liberia Amodiaquine-artesunate (ASAQ), Artemether+Lumefantrine (AL) - Plasmodium Falciparum, Malaria | Phase 4 | Completed | Centers for Disease Control and Prevention | 352 | 2022-08-09 | 2024-05-07 |
| A Study of Blood-stage Controlled Human Plasmodium Falciparum Malaria Infection in Tanzania P. falciparum infected erythrocytes - Malaria, Plasmodium Falciparum | Not applicable | Completed | University of Oxford | 12 | 2022-07-18 | 2023-05-24 |
| Study of Malaria Vaccine RTS,S/AS01E in Plasmodium Falciparum-infected and Uninfected Adults Pre-treated With Anti-malarial Therapy Malaria Vaccine RTS,S/AS01E, Abhayrab rabies vaccine, Dihydroartemisinin-piperaquine (DHA/Pip) - Plasmodium Falciparum | Phase 2 | Completed | PATH | 620 | 2020-11-06 | 2024-07-19 |
| The Malaria Heart Disease Study Assessment of cardiac function - Plasmodium Falciparum, Plasmodium Vivax | Terminated | University Hospital, Gentofte, Copenhagen | 597 | 2020-06-21 | 2022-07-19 | |
| A Clinical Trial to Evaluate Plasmodium Falciparum 7G8 and NF54 Challenge Strains (PfSPZ) in a Head-to-head Comparative Study - (ECG-CHMI) atovaquone-proguanil - Plasmodium Falciparum | Not applicable | Withdrawn | U.S. Army Medical Research and Development Command | 2020-03-01 | 2020-05-08 | |
| Comparison of Arterolane-piperaquine Versus Arterolane-piperaquine+Mefloquine Versus Artemether-lumefantrine in Kenyan Children Arterolane-piperaquine, Arterolane-piperaquine+mefloquine, Artemether-lumefantrine - Plasmodium Falciparum | Phase 3 | Completed | University of Oxford | 219 | 2018-03-07 | 2021-09-29 |
| Clinical Performance of the HRP2 HS-RDT for Malaria Diagnosis in Pregnant Women HS-RDT - Plasmodium Falciparum, Pregnancy Malaria | Completed | Foundation for Innovative New Diagnostics, Switzerland | 880 | 2017-07-25 | 2023-11-30 | |
| ELISA Validation of Hypersensitive Rapid Diagnostic Test Results for Detection of P. Falciparum ELISA validation - Plasmodium Falciparum | Completed | University of Oxford | 1656 | 2017-06-01 | 2018-07-05 | |
| Safety and Protective Efficacy of Pb(PfCS@UIS4) Pb(PfCS@UIS4)-infected mosquitoes, Challenge infection P. falciparum - Malaria,Falciparum, Plasmodium Falciparum | Phase 1 / Phase 2 | Completed | Radboud University Medical Center | 24 | 2017-05-29 | 2022-03-04 |
| Prevalence Survey of Plasmodium Falciparum Antimalarial Drug Resistance Markers Plasmodium Falciparum | Completed | University of Oxford | 399 | 2016-09-16 | 2022-04-07 | |
| Safety and Protective Efficacy of BCG Vaccination Against Controlled Human Malaria Infection BCG vaccination - Malaria, Plasmodium Falciparum | Phase 2 | Completed | Radboud University Medical Center | 20 | 2016-04-01 | 2017-04-20 |
| Safety and Immunogenicity of Direct Venous Inoculation of a Radiation-attenuated PfSPZ Vaccine in Equatoguinean Adults PfSPZ Vaccine, Normal Saline - Malaria, Plasmodium Falciparum | Phase 1 | Completed | Sanaria Inc. | 33 | 2015-03-01 | 2016-03-02 |
| Dihydroartemisinin-piperaquine With Low Dose Primaquine to Reduce Malaria Transmission Dihydroartemisinin-piperaquine combination (Artekin), Primaquine - Malaria, Asymptomatic Malaria | Phase 3 | Completed | London School of Hygiene and Tropical Medicine | 120 | 2014-10-01 | 2016-01-14 |
| A Phase Ia Clinical Trial to Assess the Safety and Immunogenicity of New Plasmodium Falciparum Malaria Vaccine Candidates ChAd63 RH5 Alone and With MVA RH5 ChAd63 RH5 low dose, ChAd63 RH5 full dose, MVA RH5 low dose - Malaria, Plasmodium Falciparum | Phase 1 | Completed | University of Oxford | 26 | 2014-08-01 | 2015-12-03 |
| Efficacy and Safety of a Single Low-dose Primaquine for the Clearance of Gametocytes Primaquine (For artemether-lumefantrine+primaquine arm), Placebo (For artemether-lumefantrine arm) - Plasmodium Falciparum | Phase 4 | Completed | Muhimbili University of Health and Allied Sciences | 220 | 2014-07-01 | 2014-12-08 |
| Safety, Tolerability, Pharmacokinetics and Efficacy of ARCO artemisinin/naphthoquine, dihydroartemisinin/piperaquine phosphate - Plasmodium Falciparum, Malaria, Falciparum | Phase 4 | Completed | Ifakara Health Institute | 60 | 2014-01-07 | 2018-03-14 |
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Malaria, Falciparum (33) · Malaria (15) · Malaria, Vivax (3) · Acquired Immunodeficiency Syndrome (1) · Adenoviridae Infections (1) · Cardiovascular Diseases (1) · Diarrhea (1) · Disease (1) · HIV Infections (1) · Heart Diseases (1) · Parasitic Diseases (1) · Protozoan Infections (1)
Infections (33) · Mosquito-Borne Diseases (33) · Vector Borne Diseases (33) · Parasitic Diseases (32) · Protozoan Infections (32) · Malaria (18) · Pathological Conditions, Signs and Symptoms (2) · Virus Diseases (2) · Blood-Borne Infections (1) · Communicable Diseases (1) · DNA Virus Infections (1) · Genital Diseases (1) · Immune System Diseases (1) · Immunologic Deficiency Syndromes (1) · Lentivirus Infections (1)
Artemether, Lumefantrine Drug Combination (5) · Primaquine (4) · Saline Solution (2) · Vaccines (2) · artenimol (2) · atovaquone, proguanil drug combination (2) · piperaquine (2) · Amodiaquine (1) · Artemether (1) · Immunization (1) · Lumefantrine (1) · Matrix-M (1) · Proguanil (1) · Pyrimethamine (1) · RTS malaria vaccine (1)
University of Oxford (7) · Radboud University Medical Center (4) · London School of Hygiene and Tropical Medicine (3) · Sanaria Inc. (3) · U.S. Army Medical Research and Development Command (3) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · PATH (2) · Centers for Disease Control and Prevention (1) · Centre Hospitalier de Saint-Denis (1) · Foundation for Innovative New Diagnostics, Switzerland (1) · Ifakara Health Institute (1) · Muhimbili University of Health and Allied Sciences (1) · National Institute of Malariology, Parasitology and Entomology, Vietnam (1) · Tropical Medicine Research Institute (1) · University Hospital, Gentofte, Copenhagen (1)
Kenya (5) · Netherlands (5) · Tanzania (3) · United Kingdom (3) · United States (3) · Ethiopia (2) · Brazil (1) · Burkina Faso (1) · Chad (1) · Colombia (1) · Equatorial Guinea (1) · France (1) · Liberia (1) · Madagascar (1) · Mali (1)
Salim Abdulla, MD, PhD (2) · Adam Bennett, PhD (1) · Adrian VS Hill, DPhil FRCP (1) · Alfred Tiono, PhD, MD (1) · Andreas Martensson, PhD (1) · Angela M Minassian, DPhil FRCP (1) · Angela Minassian, Dr (1) · Annette Erhart, MD, PhD (1) · Badria B El Sayed, PhD,MSc,BSc (1) · Benson Singa, MBChB MPH (1) · Chris Drakeley (1) · Cindy Tamminga, MD, MPH (1) · Fitsum G Tadesse (1) · Gudissa Assefa Bayissa (1)
PMID 18612426, PMID 19649245, PMID 21903775, PMID 22003383, PMID 22003411, PMID 23186785, PMID 23823332, PMID 23899517, PMID 25211344, PMID 25224002, PMID 25396417, PMID 26292027, PMID 26292257, PMID 26952094, PMID 27287612, PMID 27565897, PMID 27695088, PMID 27790201, PMID 28031267, PMID 28081133, PMID 28289025, PMID 29141739, PMID 30860013, PMID 32434846, PMID 32736543, PMID 34111412, PMID 34321001, PMID 34585740, PMID 34775497, PMID 34807316, PMID 34906368, PMID 35065154, PMID 35405640, PMID 35465706, PMID 36041756, PMID 40439411, PMID 41176969
2015 (1)