10 completed, 2 withdrawn, 1 recruiting, 1 terminated. 4 Phase 1, 4 Phase 2, 4 Phase 4, 3 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 3, Unknown 1 |
| Phase 2 | 4 | Completed 2, Unknown 1, Withdrawn 1 |
| Phase 4 | 4 | Completed 3, Recruiting 1 |
| Not applicable | 3 | Completed 1, Terminated 1, Withdrawn 1 |
| Phase 3 | 1 | Completed 1 |
Follow this drug Literature Review of Artemether trials Research Report on Artemether
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Southeast Asia Dose Optimization of Tafenoquine Tafenoquine, Chloroquine, Artemether 20 mg-Lumefantrine 120 mg - Plasmodium Vivax Malaria | Phase 4 | Recruiting | University of Oxford | 820 | 2024-07-22 | 2026-10-09 |
| To Evaluate Efficacy, Safety, Tolerability and PK of Intravenous Cipargamin in Participants With Severe Plasmodium Falciparum Malaria Cipargamin, IV Artesunate, Coartem - Severe Malaria | Phase 2 | Completed | Novartis Pharmaceuticals | 254 | 2022-03-07 | 2026-04-09 |
| A Clinical Trial to Evaluate Plasmodium Falciparum 7G8 and NF54 Challenge Strains (PfSPZ) in a Head-to-head Comparative Study - (ECG-CHMI) atovaquone-proguanil - Plasmodium Falciparum | Not applicable | Withdrawn | U.S. Army Medical Research and Development Command | 2020-03-01 | 2020-05-08 | |
| A Study to Assess the Safety and Efficacy of 5-aminolevulinic Acid Hydrochloride (5-ALA HCl) and Sodium Ferrous Citrate (SFC) Added on Artemisinin-based Combination Therapy (ACT) in Adult Patients With Uncomplicated Malaria 5-aminolevulinic acid hydrochloride (5-ALA HCl) 600 mg QD, Sodium ferrous citrate (SFC) 472 mg QD, Artemisinin-based combination (ACT) - Malaria | Phase 2 | Withdrawn | Neopharma Japan Co., Ltd. | 2019-09-06 | 2020-03-03 | |
| Safety, Immunogenicity, and Protective Efficacy of Two Regimens of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) During Natural Transmission Season in Healthy African Adults in Mali PfSPZ Vaccine, Normal Saline, artemether 20mg/lumefantrine 120mg (AL) - Malaria | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 478 | 2018-05-14 | 2021-08-20 |
| A Phase 1/2a Study of LON002 in Subjects With Advanced Solid Tumours Artemether - Solid Tumours | Phase 1 / Phase 2 | Unknown | LondonPharma Ltd. | 87 | 2014-10-01 | 2015-09-07 |
| Effect of ACT-451840 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy Subjects ACT-451840:, Plasmodium falciparum-infected human erythrocytes:, Artemether 20 mg and lumefantrine 120mg combination tablet: - Healthy Subjects | Phase 1 | Completed | Idorsia Pharmaceuticals Ltd. | 8 | 2014-06-01 | 2019-08-22 |
| Artemether/Lumefantrine and Vivax Malaria tablets artemether/lumefantrine - Vivax Malaria | Phase 3 | Completed | University of Khartoum | 38 | 2011-09-01 | 2013-01-17 |
| Evaluation of the Riamet® Versus Malarone® in the Treatment of Uncomplicated Malaria Malarone (atovaquone + proguanil combination), RIAMET (artemether + LUMEFANTRIN combination) - Malaria | Phase 4 | Completed | Assistance Publique - Hôpitaux de Paris | 317 | 2010-07-01 | 2015-12-09 |
| Safety Study on the Effect of Eurartesim™ on QT/QTc Interval Compared to Riamet in Healthy Volunteers Eurartesim™, Riamet®, Placebo and finally Moxifloxacin - Malaria, Falciparum | Phase 1 | Completed | sigma-tau i.f.r. S.p.A. | 287 | 2010-02-01 | 2011-06-17 |
| Efficacy of ArTiMist™ in Children Quinine, Artemether - Falciparum Malaria | Phase 2 | Completed | Proto Pharma Ltd | 31 | 2009-12-01 | 2011-01-27 |
| Randomised Efficacy Study of Two Artemether-Lumefantrine Oral Formulations for the Treatment of Uncomplicated P. Falciparum Malaria Artemether/lumefantrine tablets, Artemether/Lumefantrine suspension - Malaria, Falciparum | Phase 4 | Completed | Dafra Pharma | 267 | 2007-05-01 | 2008-01-18 |
| Efficacy of Chloroquine + Sulfadoxine Pyrimethamine Versus Artemether + Lumefantrine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria in the Philippines artemether/lumafantrine vs chloroquine/sulfadoxine-pyrimethamine - Malaria | Not applicable | Completed | Centers for Disease Control and Prevention | 560 | 2003-07-01 | 2012-09-11 |
| Comparative Evaluation of the Safety and the Efficacy of 2 Antimalarials Depending on HIV Status ARTEMETHER + LUMEFANTRINE VS. SULFADOXINE + PYRIMETHAMINE - Plasmodium Falciparum Malaria | Not applicable | Terminated | Institute of Tropical Medicine, Belgium | 3000 | 2003-03-01 | 2010-09-14 |
| Efficacy of Sulphadoxine-pyrimethamine and Artemisinin-containing Combination Therapy for Malaria Sulfadoxine-pyrimethamine, sulfadoxine-pyrimethamine plus artesunate, lumefantrine plus artemether - Malaria (Uncomplicated) | Phase 4 | Completed | Centers for Disease Control and Prevention | 390 | 2000-01-01 | 2012-09-11 |
Malaria (9) · Malaria, Falciparum (7) · Malaria, Vivax (2) · Neoplasms (1) · Parasitic Diseases (1) · Protozoan Infections (1) · Recurrence (1)
Centers for Disease Control and Prevention (2) · Assistance Publique - Hôpitaux de Paris (1) · Dafra Pharma (1) · Idorsia Pharmaceuticals Ltd. (1) · Institute of Tropical Medicine, Belgium (1) · LondonPharma Ltd. (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Neopharma Japan Co., Ltd. (1) · Novartis Pharmaceuticals (1) · Proto Pharma Ltd (1) · U.S. Army Medical Research and Development Command (1) · University of Khartoum (1) · University of Oxford (1) · sigma-tau i.f.r. S.p.A. (1)
France (2) · Kenya (2) · Australia (1) · Burkina Faso (1) · Cambodia (1) · Côte d’Ivoire (1) · Democratic Republic of the Congo (1) · Indonesia (1) · Laos (1) · Mali (1) · Mozambique (1) · Philippines (1) · Rwanda (1) · Sudan (1) · Tanzania (1)
Cindy Chu, MD, PhD (1) · Daryl Bendel, MBChB MBA Dip Pharm Med MFPM (1) · Daryl Bendel, MD (1) · Debashis Sarker, MD (1) · Dorin Bustos, MD, PhD (1) · Elizabeth A Juma, Dr. (1) · John R MacArthur, MD, MPH (1) · Lionel Hovsepian, MD (1) · Mazhar Ajaz, MD (1) · Michelle Lee (1) · Olivier Bouchaud, MD, PhD (1) · Patrick E Duffy, M.D. (1) · Peter B Bloland, DVM, MPVM (1) · Salim Abdulla, MD, PhD (1)
PMID 16960779, PMID 19102746, PMID 23217037, PMID 26303805, PMID 27062080, PMID 30692558, PMID 33289099, PMID 39153490