81 completed, 9 unknown, 5 withdrawn, 4 recruiting. 28 Phase 4, 26 Phase 2, 23 Phase 3, 17 Phase 1, 15 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ethiopian Antimalarial Therapeutic Efficacy Study 2026 Artemether-Lumefantrine + Primaquine and Chloroquine + Primaquine - Plasmodium Vivax Malaria Without Complication, Plasmodium Falciparum Malaria (Uncomplicated) | Not yet recruiting | Ethiopian Public Health Institute | 1200 | 2026-10-20 | 2026-09-25 | |
| Postpartum 8-aminoquinoline Breast Milk Study Daily primaquine (0.5 mg/kg per day) for 14 days given with food food and water, Daily primaquine 1 mg/kg per day for 7 days given with food and water, Single-dose tafenoquine given with food and water to prevent gastrointestinal discomfort - Drug Pharmacokinetics in Healthy Volunteers | Phase 2 / Phase 3 | Not yet recruiting | Curtin University | 60 | 2026-04-01 | 2026-03-18 |
| Positioning Second-line Therapies for Pneumocystis Jirovecii Pneumonia (PCP Alternatives) Clindamycin + primaquine, Pentamidine, Atovaquone - Pneumocystis, Pneumocystis Infection | Phase 4 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 416 | 2026-03-01 | 2026-01-21 |
| An Interventional Study to Compare the Efficacy and Safety of Tafenoquine (TQ) and Primaquine (PQ) When Either Are Taken Together With Chloroquine (CQ) for the Treatment of P. Vivax Malaria in Indian Participants Aged 2 Years and Older Tafenoquine, Primaquine, Chloroquine - Malaria, Vivax | Phase 3 | Recruiting | GlaxoSmithKline | 324 | 2024-11-13 | 2026-10-01 |
| Southeast Asia Dose Optimization of Tafenoquine Tafenoquine, Chloroquine, Artemether 20 mg-Lumefantrine 120 mg - Plasmodium Vivax Malaria | Phase 4 | Recruiting | University of Oxford | 820 | 2024-07-22 | 2026-10-09 |
| Postpartum Primaquine in Breast Milk Primaquine - Postpartum Women | Phase 4 | Completed | University of Oxford | 12 | 2024-07-09 | 2025-06-10 |
| Primaquine for Vivax Malaria in G6PD Intermediate and Deficient Cases. Patients with G6PD enzyme activities between 30 and <70% of the AMM will be treated with schizontocidal treatment plus high dose primaquine 1mg/kg/day for 7 days, Patients with G6PD enzyme activities <30% of the AMM will be treated with schizontocidal treatment plus 8 weekly primaquine (0.75mg/kg dose). - Vivax Malaria, G6PD Deficiency | Phase 4 | Recruiting | Menzies School of Health Research | 100 | 2024-05-17 | 2026-03-12 |
| A Revised Tafenoquine Dose to Improve Radical Cure for Vivax Malaria Tafenoquine, Primaquine - Vivax Malaria | Phase 3 | Recruiting | Menzies School of Health Research | 1090 | 2024-05-10 | 2025-07-18 |
| A Study to Evaluate Antimalarial Activity and Safety of MK-7602 in Healthy Adults (MK-7602-003) Plasmodium falciparum, MK-7602, Artemether/lumefantrine - Malaria | Phase 1 | Completed | Merck Sharp & Dohme LLC | 16 | 2024-04-18 | 2025-01-13 |
| A Study to Assess the Availability of Oral Primaquine and Its Inert Metabolite, Carboxyprimaquine, in the Body Regimen 1 (Oral primaquine), Regimen 2 (IV primaquine phosphate), Regimen 3 (IV carboxyprimaquine) - Healthy, Pharmacokinetic | Phase 1 | Withdrawn | University of Oxford | 2024-03-01 | 2024-05-06 | |
| Tafenoquine and Primaquine in Colostrum and Breast Milk Primaquine, Tafenoquine - Healthy Lactating Women | Phase 4 | Withdrawn | University of Oxford | 2023-07-01 | 2024-04-04 | |
| Primaquine Double Dose for Radical Cure of Plasmodium Vivax in Colombia Primaquine double dose over 14 days, Primaquine single dose over 14 days - Malaria, Vivax, Relapse | Phase 2 / Phase 3 | Withdrawn | University of California, San Francisco | 2023-01-20 | 2023-05-11 | |
| Therapeutic Efficacy of Chloroquine Plus Primaquine in the Treatment of Uncomplicated Plasmodium Vivax Chloroquine, Primaquine - Efficacy, Malaria | Phase 4 | Completed | Dinka Dugassa | 100 | 2022-12-19 | 2023-09-22 |
| Momordica Charantia and Dihydroartemisinin-piperaquined-primaquine for Uncomplicated Plasmodium Falciparum Malaria Patients in Southwest Sumba Regency Dihydroartemisinin, Piperaquine, Primaquine - Uncomplicated Plasmodium Falciparum | Phase 2 | Completed | Syamsudin Abdillah,Ph.D, Pharm D | 36 | 2022-11-01 | 2023-05-16 |
| Gametocytocidal and Transmission-blocking Efficacy of ASAQ and ALAQ With or Without PQ in Mali Artesunate-amodiaquine combination, Primaquine Phosphate, Artemether-lumefantrine - Malaria,Falciparum | Phase 2 | Completed | London School of Hygiene and Tropical Medicine | 100 | 2022-10-17 | 2024-10-01 |
| Radical CUREfor MAlaria Among Highly Mobile and Hard-to-reach Populations in the Guyanese Shield PART, Malakit, CROSS-SECTIONAL PRE- AND POST-INTERVENTION SURVEYS - Malaria, Vivax | Not applicable | Completed | Centre Hospitalier de Cayenne | 1991 | 2022-09-12 | 2025-07-24 |
| Controlled Human Malaria Infection Transmission Model - Phase A PfSPZ Challenge, Sulfadoxine-Pyrimethamine, Piperaquine - Malaria,Falciparum | Phase 1 / Phase 2 | Suspended | University of Oxford | 44 | 2022-08-22 | 2024-05-23 |
| Operational Feasibility of Appropriate Plasmodium Vivax Radical Cure After G6PD Testing in Thailand Tafenoquine, Primaquine - Malaria, Vivax, G6PD Deficiency | Completed | Dr. Prayuth Sudathip | 187 | 2022-05-23 | 2023-10-26 | |
| Short Course Radical Cure of P. Vivax Malaria in Nepal primaquine - Malaria, Malaria, Vivax | Phase 4 | Completed | Menzies School of Health Research | 27 | 2021-10-27 | 2024-08-29 |
| Gametocytocidal and Transmission-blocking Efficacy of PQ in Combination With AL and TQ in Combination With SPAQ in Mali Artemether-lumefantrine, Primaquine Phosphate, Sulphadoxine-pyrimethamine with amodiaquine - Malaria,Falciparum | Phase 2 | Completed | London School of Hygiene and Tropical Medicine | 80 | 2021-10-12 | 2022-01-18 |
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Malaria (51) · Malaria, Vivax (45) · Malaria, Falciparum (25) · Glucosephosphate Dehydrogenase Deficiency (9) · Recurrence (9) · Pneumonia, Pneumocystis (4) · Acquired Immunodeficiency Syndrome (3) · Hemolysis (3) · Infections (3) · HIV Infections (2) · Parasitic Diseases (2) · Pneumonia (2) · AIDS-Related Opportunistic Infections (1) · Breast Feeding (1) · Drug-Related Side Effects and Adverse Reactions (1)
University of Oxford (18) · London School of Hygiene and Tropical Medicine (12) · Menzies School of Health Research (10) · University of California, San Francisco (6) · GlaxoSmithKline (5) · Research Institute for Tropical Medicine, Philippines (4) · Centers for Disease Control and Prevention (3) · Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (3) · PATH (3) · Universitas Indonesia (3) · Armed Forces Research Institute of Medical Sciences, Thailand (2) · Heidelberg University (2) · Muhimbili University of Health and Allied Sciences (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Papua New Guinea Institute of Medical Research (2)
Thailand (19) · Indonesia (12) · Brazil (11) · Ethiopia (11) · United States (9) · Cambodia (8) · Mali (6) · Papua New Guinea (5) · Tanzania (5) · Kenya (4) · Laos (4) · Vietnam (4) · Afghanistan (3) · Australia (3) · Burkina Faso (3)
Teun Bousema, PhD (3) · Alassane Dicko (2) · Alassane Dicko, MD (2) · Andreas Martensson, PhD (2) · Black JR (2) · Francois Nosten, MD (2) · Ivo Mueller, PhD (2) · Norman Waters, PhD (2) · Roland Gosling, MD, PhD (2) · Rose McGready, Ph.D (2) · Abduallah S Ali (1) · Abdullah S Ali, Programme Manager (1)
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