141 completed, 106 recruiting, 43 unknown, 38 terminated. 146 Phase 2, 118 Phase 1, 78 Not applicable, 14 Phase 3, 10 Phase 4.
Follow Meningeal Neoplasms: new trials by email Literature Review of Meningeal Neoplasms trials Research Report on Meningeal Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma JBI-778 - Brain Metastases From Solid Tumors, Leptomeningeal Disease | Phase 1 / Phase 2 | Not yet recruiting | Jubilant Therapeutics Inc. | 113 | 2028-04-01 | 2026-08-07 |
| ctDNA-Guided Intraventricular Therapy for CNS Malignancies CSF ctDNA-Guided Clinical Management - Leptomeningeal Disease, Glioblastoma | Not applicable | Not yet recruiting | Alireza Mansouri | 77 | 2027-01-01 | 2026-07-08 |
| Ceritinib Treatment for Recurrent Meningiomas Ceritinib - Recurrent Meningioma, Grade I and Grade II | Phase 2 | Not yet recruiting | Kevin Petrecca | 10 | 2027-01-01 | 2026-10-23 |
| A Study of ONC201 for Refractory Meningioma ONC201 - Meningioma, Refractory Meningioma | Phase 2 | Withdrawn | University of Nebraska | 2026-12-01 | 2026-01-26 | |
| Wearable-Triggered Digital Safety Net for Real-Time Monitoring & Intervention in Leptomeningeal Metastasis Calibration Phase, Stepped Wedge Intervention Phase - Leptomeningeal Metastasis | Not applicable | Not yet recruiting | Case Comprehensive Cancer Center | 48 | 2026-11-01 | 2026-09-03 |
| China Treatment Trial for Tumor in Sellar Region With Unruptured Intracranial Aneurysm Tumor resection followed by aneurysm treatment, Aneurysm treatment followed by tumor resection, Observation - Unruptured Intracranial Aneurysms, Pituitary Neuroendocrine Tumor | Active not recruiting | Cheng sen | 608 | 2026-10-20 | 2026-10-21 | |
| BRain-AVOidant Proton Craniospinal Irradiation for Leptomeningeal Metastases From Solid Tumor Malignancies Radiation Treatments Using Brain- Avoidant Proton Craniospinal Irradiation (BRAVO- pCSI) - Leptomeningeal Metastasis, Breast Cancer | Not applicable | Recruiting | University of Miami | 40 | 2026-10-13 | 2026-10-23 |
| Preoperative Embolization for Highly Vascular Brain Tumors Preoperative Endovascular Embolization - Brain Neoplasms, Meningioma | Not applicable | Not yet recruiting | Assiut University | 55 | 2026-10-01 | 2026-09-17 |
| Pharmacoscopy for Patients With Refractory Primary Brain Tumors Pharmacoscopy 1.0 - Brain (Nervous System) Cancers, Glioblastoma | Phase 2 | Recruiting | University of Zurich | 40 | 2026-09-11 | 2026-09-21 |
| A Study of SX-682 in Combination With Proton Craniospinal Irradiation (pCSI) in People With Leptomeningeal Disease SX-682, Proton Craniospinal Irradiation (pCSI) - Leptomeningeal Disease (LMD) | Phase 1 | Recruiting | Memorial Sloan Kettering Cancer Center | 40 | 2026-09-04 | 2026-09-11 |
| Combined Intrathecal and Systemic Therapy With Trastuzumab Rezetecan for Leptomeningeal Metastases Intrathecal and systemic administration of Trastuzumab Rezetecan - Leptomeningeal Metastases, Solid Tumors | Phase 2 | Not yet recruiting | Jiuda Zhao | 28 | 2026-09-01 | 2026-09-22 |
| Thiotepa Administration Via Ommaya Reservoir for Leptomeningeal Metastases in Non-Small Cell Lung Cancer Resistant to EGFR-TKI. Thiotepa - Leptomeningeal Metastasis | Phase 2 | Not yet recruiting | Tianjin Medical University Cancer Institute and Hospital | 50 | 2026-09-01 | 2026-08-21 |
| B7-H3.CD28Z.CART in CNS Neoplasms B7-H3.CD28Z.CART, Fludarabine, Cyclophosphamide - Central Nervous System Neoplasms, Brain Tumor | Phase 1 | Recruiting | Robbie Majzner | 70 | 2026-09-01 | 2026-09-03 |
| IN10018 in Combination With Dalpiciclib for Progressive Meningiomas Ifebemtinib, Dalpiciclib - Meningioma, CDK4/6 Inhibitor | Phase 1 | Recruiting | Capital Medical University | 24 | 2026-08-31 | 2026-10-21 |
| Direct Comparison of Ga-68-DOTATATE and Ga-68-DOTATOC Ga-68- DOTATATE, Ga-68-DOTATOC - Meningioma | Phase 2 | Withdrawn | Weill Medical College of Cornell University | 2026-08-01 | 2026-08-31 | |
| Trial of Therapies With IT cDC1s Combined w/ IT Trastuzamab for Her+ or IT Nivolumab for Her- BC LMD cDC1 Vaccine, Trastuzumab, Nivolumab - Breast Cancer, Leptomeningeal Disease | Phase 2 | Recruiting | H. Lee Moffitt Cancer Center and Research Institute | 30 | 2026-08-01 | 2026-07-10 |
| Luvometinib in Combination With Serplulimab for NF2-Related Tumors Luvometinib, Serplulimab - NF2-related Schwannomatosis, NF2 | Phase 1 / Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 30 | 2026-07-31 | 2026-07-16 |
| DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery (DEX-NEURO Trial) Dexmedetomidine, Normal Saline (0.9% NaCl) - Neurosurgery, Brain Cancer | Not applicable | Not yet recruiting | University of Malaya | 60 | 2026-07-22 | 2026-02-09 |
| Platform Research for Innovative Medicines in NF2-SWN (PRIME-NF2) Selumetinib 25mg/m2, Luvometinib, Serplulimab - Neurofibromatosis Type 2, Vestibular Schwannoma | Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 200 | 2026-07-18 | 2026-07-20 |
| A Study of JZP3507 (ONC206) in Recurrent Grade 2 or 3 Meningioma JZP3507 - Meningioma | Phase 2 | Recruiting | Jazz Pharmaceuticals | 30 | 2026-07-16 | 2026-07-30 |
Showing 20 of 412. Sign in to see all of them.
Meningioma (240) · Meningeal Carcinomatosis (146) · Brain Neoplasms (140) · Glioma (71) · Glioblastoma (61) · Astrocytoma (60) · Central Nervous System Neoplasms (59) · Oligodendroglioma (55) · Medulloblastoma (54) · Ependymoma (52) · Carcinoma, Non-Small-Cell Lung (40) · Breast Neoplasms (39) · Choroid Plexus Neoplasms (34) · Gliosarcoma (34)
Neoplasms by Site (411) · Nervous System Diseases (411) · Nervous System Neoplasms (410) · Neoplasms (384) · Central Nervous System Neoplasms (353) · Neoplasms by Histologic Type (273) · Neoplasms, Nerve Tissue (261) · Neoplasms, Vascular Tissue (240) · Central Nervous System Diseases (164) · Brain Diseases (160) · Neuroectodermal Tumors (140) · Neoplasms, Germ Cell and Embryonal (134) · Neoplasms, Glandular and Epithelial (122) · Neoplasms, Neuroepithelial (116)
Magnetic Resonance Spectroscopy (23) · Pemetrexed (20) · Bevacizumab (17) · Radiotherapy (13) · Specimen Handling (11) · Spinal Puncture (9) · Cyclophosphamide (8) · Everolimus (7) · Methotrexate (7) · Nivolumab (7) · Radiosurgery (7) · Radiotherapy, Intensity-Modulated (7) · Temozolomide (7) · Topotecan (7) · Trastuzumab (7)
National Cancer Institute (NCI) (19) · M.D. Anderson Cancer Center (11) · Memorial Sloan Kettering Cancer Center (10) · Guangzhou Medical University (8) · Wake Forest University Health Sciences (8) · Beijing Tiantan Hospital (7) · City of Hope Medical Center (7) · Duke University (7) · Massachusetts General Hospital (7) · NYU Langone Health (7) · Central Hospital, Nancy, France (6) · Northwestern University (6) · H. Lee Moffitt Cancer Center and Research Institute (5) · The First Hospital of Jilin University (5) · Case Comprehensive Cancer Center (4)
United States (207) · China (70) · France (30) · Canada (13) · Germany (11) · Switzerland (10) · Italy (8) · Netherlands (7) · United Kingdom (6) · Spain (5) · Taiwan (5) · Austria (4) · South Korea (4) · Australia (3) · Denmark (3)
Darell D. Bigner, MD, PhD (4) · Edward G. Shaw, MD (3) · Priscilla Brastianos, MD (3) · Priya Kumthekar, MD (3) · Thomas Kaley, MD (3) · Zhenyu Pan (3) · Zhenyu Pan, Professor (3) · Alexander Dmitriev, MD (2) · Anhua Wu, MD (2) · Barbara J O'Brien, MD (2) · D. Brandsma, MD, PhD (2) · Danielle Eekers (2) · Harry T Whelan, MD (2) · Helen A Shih, MD (2) · Henry S. Friedman, MD (2)
PMID 27243238, PMID 31809241, PMID 15117425, PMID 26334749, PMID 26827696, PMID 29151359, PMID 30059262, PMID 9533527, PMID 10501910, PMID 11273919, PMID 11410496, PMID 11810123, PMID 11937001, PMID 14059058, PMID 1447744, PMID 14750917, PMID 15118073, PMID 15118125, PMID 15844174, PMID 15886314, PMID 15897941, PMID 16127110, PMID 16391300, PMID 16533779, PMID 16549835, PMID 16642476, PMID 16855840, PMID 16914578, PMID 16983123, PMID 17308042, PMID 17312328, PMID 17315026, PMID 17374728, PMID 17894407, PMID 17909804, PMID 18056189, PMID 18172267, PMID 18447671, PMID 18470481, PMID 18633018, PMID 18728566, PMID 19470276, PMID 19738466, PMID 20087963, PMID 20573926, PMID 20627894, PMID 20689429, PMID 21062428, PMID 21599552, PMID 21632855
P30CA033572 (4), P30CA043703 (3), U01CA062399 (3), U10CA032102 (3), U10CA081851 (3), 2009 (2), 2019 (2), P30CA060553 (2), P30CA138292 (2), R01CA167632 (2), U01CA081457 (2), U10CA180868 (2), 2005 (1), 2008 (1), 2014 (1)