7 completed, 2 unknown, 1 recruiting, 1 withdrawn. 3 Not applicable, 2 Phase 3, 2 Phase 4, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Completed 3 |
| Phase 3 | 2 | Unknown 1, Withdrawn 1 |
| Phase 4 | 2 | Completed 2 |
| Phase 2 | 1 | Recruiting 1 |
Follow Periodontitis Chronic Generalized Severe: new trials by email Literature Review of Periodontitis Chronic Generalized Severe trials Research Report on Periodontitis Chronic Generalized Severe
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 3-Month Clinical Trial of Liquid S-PRF in Periodontal Debridement for Periodontitis Stages II-IV Normal saline irrigation, Platelet rich fibrin - Periodontitis Stage II, Periodontitis Stage III | Phase 2 | Recruiting | Mahsa University | 14 | 2024-04-01 | 2025-12-19 |
| Contribution of an Antiviral Drug (Valaciclovir) in the Treatment of Generalized Periodontitis (Stage III or IV and Grade A, B or C): Prospective, Randomized and Double Blind Clinical Trial Antiviral treatment with conventional non-surgical treatment, Placebo with conventional non-surgical treatment - Periodontitis Chronic Generalized Severe | Phase 3 | Unknown | Centre Hospitalier Universitaire de Nice | 142 | 2024-02-05 | 2024-02-09 |
| Evaluation of Macrophage Inflammatory Protein-1α as a Periodontal Disease Biomarker Periodontitis Chronic Generalized Severe, Gingivitis | Completed | Postgraduate Institute of Dental Sciences Rohtak | 120 | 2023-09-01 | 2025-01-15 | |
| Regular Home-use of Dual-light Photodynamic Therapy in the Management of Chronic Stage III-IV Periodontitis Lumoral Treatment - Periodontitis Chronic Generalized Moderate, Periodontitis Chronic Generalized Severe | Not applicable | Completed | Koite Health Oy | 56 | 2023-06-06 | 2026-03-19 |
| Flurbiprofen Versus Aloe Vera Gel in the Treatment of Chronic Periodontitis in Smoking Patients. 2.5% flurbiprofen, 98% aloe vera, Placebo - Periodontitis Chronic Generalized Severe | Phase 4 | Completed | Beirut Arab University | 60 | 2022-09-30 | 2023-09-18 |
| Effects of Non-surgical Periodontal Therapy on Severe Periodontitis and Hyperlipidemia non-surgical periodontal therapy - Periodontitis Chronic Generalized Severe, Hyperlipidemia | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 64 | 2022-09-20 | 2022-09-22 | |
| Scaling and Root Planning With Localized Delivery of Autogenous Growth Factors- Platelet Rich Fibrin (PRF) leukocyte platelet rich fibrin (L-PRF), Scaling and Root Planing - Periodontitis Chronic Generalized Severe, Periodontitis Chronic Generalized Moderate | Phase 3 | Withdrawn | Virginia Commonwealth University | 2022-05-01 | 2022-05-12 | |
| Clinical and Radiograhic Evaluation of NIPSA With and Without Allograft Plus Platelet Rich Fibrin in the Treatment of Intraosseous Defects in Stage III Periodontitis Patients Non-Incised Papilla Surgical Approach - Periodontitis Chronic Generalized Severe, Intrabony Periodontal Defect | Not applicable | Completed | Cairo University | 20 | 2021-03-25 | 2026-07-08 |
| Hyaluronic Acid Versus Red Injectable Platelet Rich Fibrin in Treatment of Periodontitis Hyaluronic acid, red injectable platelet rich fibrin (i-prf) - Periodontitis Chronic Generalized Severe | Phase 4 | Completed | Beirut Arab University | 75 | 2021-03-01 | 2023-03-14 |
| Clinical Evaluation of Laser Therapy Used as an Adjunct to Non-Surgical Treatment of Gum Disease Laser Therapy, Non-surgical Scaling and Root Planing - Periodontitis Chronic Generalized Moderate, Periodontitis Chronic Generalized Severe | Not applicable | Completed | University of California, Los Angeles | 23 | 2017-01-01 | 2021-03-05 |
| Effect of Non-surgical Treatment of Periodontitis Patients Focusing on Inflammatory Mediators in Gingival Crevicular Fluid Collecting fluid for biomarker analyses, Hygiene instruction, tooth cleaning, plaque removal - Periodontitis, Periodontitis Chronic Generalized Severe | Completed | Oral Health Centre of Expertise in Western Norway | 30 | 2016-01-08 | 2026-03-31 |
Periodontitis (4) · Chronic Periodontitis (1) · Gingivitis (1) · Hyperlipidemias (1) · Inflammation (1) · Periodontal Diseases (1) · Periodontal Pocket (1) · Plaque, Amyloid (1)
Mouth Diseases (5) · Stomatognathic Diseases (5) · Periodontal Diseases (4) · Pathological Conditions, Signs and Symptoms (3) · Pathologic Processes (2) · Chronic Disease (1) · Disease Attributes (1) · Dyslipidemias (1) · Gingival Diseases (1) · Infections (1) · Lipid Metabolism Disorders (1) · Metabolic Diseases (1) · Nutritional and Metabolic Diseases (1) · Pathological Conditions, Anatomical (1)
Root Planing (2) · Flurbiprofen (1) · Hyaluronic Acid (1) · Laser Therapy (1) · Tooth Exfoliation (1) · proliferation regulatory factors, human urine (1)
Beirut Arab University (2) · Cairo University (1) · Centre Hospitalier Universitaire de Nice (1) · Koite Health Oy (1) · Mahsa University (1) · Oral Health Centre of Expertise in Western Norway (1) · Postgraduate Institute of Dental Sciences Rohtak (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · University of California, Los Angeles (1) · Virginia Commonwealth University (1)
Lebanon (2) · China (1) · Egypt (1) · France (1) · India (1) · Lithuania (1) · Malaysia (1) · Norway (1) · United States (1)
Nayer Aboelsaad, PhD (2) · Ingrida Marija Pacauskiene, Doctor (1) · Omneya Abo-Eldahab, PHD (1) · Omneya K. Tawfeek, PHD (1) · Perry R Klokkevold, DDS, MS (1) · Thomas Waldrop, DDS (1) · Timo Sorsa, Professor (1)