33 completed, 3 terminated, 2 recruiting, 2 unknown. 43 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 43 | Completed 33, Terminated 3, Recruiting 2, Unknown 2, Withdrawn 2, Active not recruiting 1 |
Follow Open-Angle Glaucoma: new trials by email Literature Review of Open-Angle Glaucoma trials Research Report on Open-Angle Glaucoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Biomarkers of Ocular Surface Damage in the Setting of Topical Ocular Hypotensive Medication Use Durysta, Bimatoprost Intracameral Implant 10 µg - Glaucoma, Open-Angle Glaucoma | Phase 4 | Recruiting | University of Miami | 20 | 2026-02-09 | 2026-03-05 |
| A Study Investigating Oral Semaglutide in People with Open-Angle Glaucoma Oral semaglutide, Placebo - Primary Open Angle Glaucoma (POAG), Open-Angle Glaucoma | Phase 4 | Recruiting | Glostrup University Hospital, Copenhagen | 126 | 2025-01-01 | 2025-01-24 |
| A Study to Evaluate Adverse Events and Change in Disease Activity With the XEN45 Glaucoma Treatment System Implantation In Adult Participants With Open-Angle Glaucoma in China XEN45 Glaucoma Treatment System, Trabeculectomy - Open-angle Glaucoma, OAG | Phase 4 | Active not recruiting | AbbVie | 120 | 2024-01-09 | 2026-04-28 |
| African Glaucoma Laser Trial Selective laser trabeculoplasty (SLT), Latanoprost ophthalmic solution, Timolol ophthalmic solution - Open-angle Glaucoma | Phase 4 | Withdrawn | West Virginia University | 2019-09-01 | 2021-06-21 | |
| Safety and Efficacy of SIMBRINZA® BID as an Adjunctive to DUOTRAV® Brinzolamide 1%/brimonidine tartrate 0.2% ophthalmic suspension, Brinzolamide/brimonidine vehicle, Travoprost 0.004%/timolol 0.5% solution - Open-angle Glaucoma, Ocular Hypertension | Phase 4 | Terminated | Alcon Research | 173 | 2016-06-24 | 2019-05-29 |
| Efficacy and Safety of XEN® Gel Stent and Post-operative Management in Patients With Open Angle Glaucoma 5-fluorouracil, Transconjunctival needling, Transconjunctival revision - Open-angle Glaucoma | Phase 4 | Unknown | Wroclaw Medical University | 100 | 2016-01-01 | 2022-03-29 |
| SIMBRINZA® Suspension BID as an Adjunctive to Prostaglandin Analogue (PGA) Brinzolamide 1%/brimonidine 0.2% tartrate ophthalmic suspension, Brinz/brim vehicle, Prostaglandin analogue - Open-Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon Research | 290 | 2015-08-07 | 2018-11-15 |
| Comparison of Intraocular Pressure (IOP)-Lowering Efficacy and Safety of AZORGA® Ophthalmic Suspension and COSOPT® Ophthalmic Solution Brinzolamide 1%/Timolol maleate 0.5% fixed combination ophthalmic suspension, Dorzolamide hydrochloride 1%/Timolol maleate 0.5% ophthalmic solution, Subject's habitual PGA monotherapy - Open-Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon, a Novartis Company | 218 | 2014-12-01 | 2016-12-08 |
| Evaluation of Intraocular Pressure Using Simbrinza™ in Patients With Open-Angle Glaucoma or Ocular Hypertension Brinzolamide 1%/Brimonidine 0.2% ophthalmic suspension, Timolol Maleate 0.5% - Open-Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon Research | 89 | 2013-10-01 | 2015-04-13 |
| Two Trabecular Micro-bypass Stents & Postoperative Travoprost to Treat Glaucoma Subjects on Two Hypotensive Agents Implantation of two iStent inject micro-bypass stents, Topical travoprost, Two iStent inject micro-bypass stents - Open-angle Glaucoma | Phase 4 | Completed | Glaukos Corporation | 53 | 2013-03-01 | 2022-09-07 |
| Efficacy of Changing to TRAVATAN® From Prior Therapy Travoprost 0.004% BAK-free - Open-angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon Research | 191 | 2012-02-01 | 2014-06-13 |
| Travacom Post Marketing Surveillance Study Travoprost/timolol fixed combination (Travacom) - Open-angle Glaucoma, Ocular Hypertension | Phase 4 | Withdrawn | Alcon Research | 2012-01-01 | 2012-10-18 | |
| Efficacy of Changing to TRAVATAN® From Prior Therapy Travoprost 0.004% - Open-Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon Research | 202 | 2011-12-01 | 2014-05-19 |
| Assessment of Intraocular Pressure (IOP) Control in Subjects With Open-Angle Glaucoma or Ocular Hypertension Treated With Travoprost 0.004% (TRAVATAN® Z) or Bimatoprost 0.01% (LUMIGAN®) Travoprost 0.004% ophthalmic solution, Bimatoprost 0.01% ophthalmic solution - Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon Research | 84 | 2011-10-01 | 2013-09-13 |
| Subjects With Open-angle Glaucoma, Pseudoexfoliative Glaucoma, or Ocular Hypertension Naïve to Medical and Surgical Therapy, Treated With Two Trabecular Micro-bypass Stents (iStent Inject) or Travoprost iStent inject, Travoprost - Open-angle Glaucoma | Phase 4 | Completed | Glaukos Corporation | 196 | 2011-09-01 | 2022-09-08 |
| Efficacy and Tolerability of AZARGA® as Replacement Therapy in Patients on COMBIGAN® Therapy in Canada Brinzolamide 1% / timolol 0.5% maleate fixed combination - Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon Research | 57 | 2011-09-01 | 2014-07-01 |
| Subjects With Open-angle Glaucoma, Pseudoexfoliative Glaucoma, or Ocular Hypertension Naïve to Medical and Surgical Therapy, Treated With Two Trabecular Micro-bypass Stents (iStent)or Travoprost iStent, Travoprost - Open-angle Glaucoma | Phase 4 | Completed | Glaukos Corporation | 101 | 2011-09-01 | 2017-12-18 |
| Patient Preference Comparison of AZARGA Versus COSOPT Brinzolamide 1.0% + Timolol 0.5% ophthalmic suspension, Dorzolamide 2.0% + Timolol 0.5% ophthalmic solution - Open-Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon Research | 112 | 2011-09-01 | 2014-02-10 |
| Efficacy of Changing to DUOTRAV® From Prior Therapy Travoprost 0.004%+Timolol 0.5% ophthalmic solution - Open-Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon Research | 60 | 2011-08-01 | 2014-02-10 |
| The Effects of Preservative-free Prostaglandin Eye Drops in Sign and Symptoms on the Eyes of Patients With Glaucoma Tafluprost 0.0015% - Ocular Hypertension, Open-Angle Glaucoma | Phase 4 | Completed | FinnMedi Oy | 30 | 2010-08-01 | 2014-10-28 |
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Glaucoma, Open-Angle (43) · Ocular Hypertension (31) · Glaucoma (15) · Hypertension (2) · Cardiovascular Diseases (1) · Cataract (1) · Exfoliation Syndrome (1) · Eye Diseases (1) · Patient Compliance (1) · Vascular Diseases (1)
Eye Diseases (42) · Glaucoma (28) · Ocular Hypertension (12) · Behavior (1) · Cardiovascular Diseases (1) · Health Behavior (1) · Iris Diseases (1) · Lens Diseases (1) · Patient Acceptance of Health Care (1) · Treatment Adherence and Compliance (1) · Uveal Diseases (1) · Vascular Diseases (1)
Timolol (15) · Travoprost (14) · dorzolamide (9) · Brimonidine Tartrate (7) · Latanoprost (6) · brinzolamide (6) · dorzolamide-timolol combination (6) · Duotrav (5) · Ophthalmic Solutions (5) · Azarga (2) · Bimatoprost (2) · Brimonidine Tartrate, Timolol Maleate Drug Combination (2) · Dexamethasone (1) · Fluorouracil (1) · Lubricant Eye Drops (1)
Alcon Research (17) · Glaukos Corporation (6) · Pharmaceutical Research Network (5) · Allergan (2) · Bp Consulting, Inc (2) · AbbVie (1) · Alcon, a Novartis Company (1) · Aristotle University Of Thessaloniki (1) · FinnMedi Oy (1) · Glostrup University Hospital, Copenhagen (1) · Ophthalmic Consultants Centres, Canada (1) · University Hospital, Basel, Switzerland (1) · University of Miami (1) · West Virginia University (1) · Wills Eye (1)
United States (9) · Canada (4) · Spain (4) · Armenia (3) · Germany (3) · China (2) · Poland (2) · Switzerland (2) · Austria (1) · Denmark (1) · Finland (1) · Greece (1) · Italy (1) · Japan (1) · Netherlands (1)
William C. Stewart, MD (5) · Severine Durier, Pharm.D (3) · Elizabeth D. Sharpe, MD (2) · Lilit A Voskanyan, MD, PhD (2) · Sriram Sonty, MD, FACS (2) · Adriana S. Bonadia (1) · Anastasios GP Konstas, MD, PhD (1) · Anna Grau (1) · Anthony D Realini, MD (1) · Barbara Cvenkel, MD (1) · Cindy M. Hutnik, BSc, PhD, MD (1)
PMID 19476406, PMID 11589866, PMID 14736774, PMID 14996520, PMID 17415690, PMID 18826749, PMID 25432143, PMID 26563363, PMID 9098273
2015 (1), 2016 (1)