30 completed, 13 unknown, 11 recruiting, 3 terminated. 23 Not applicable, 8 Phase 2, 6 Phase 4, 5 Phase 3, 4 Phase 1.
Follow Oligospermia: new trials by email Literature Review of Oligospermia trials Research Report on Oligospermia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sperm, Exposure and Endocrine Disruptors EDC Education Intervention - Fertility, Male Fertility | Not applicable | Not yet recruiting | Million Marker Wellness, Inc. | 100 | 2026-11-01 | 2026-10-06 |
| Comparative Efficacy of Antioxidants Alone Versus Combined Therapy With SERMs or FSH in Normogonadotropic Idiopathic OAT Patients: A Randomized Controlled Trial Antioxidants + Clomiphene Citrate, Antioxidants + FSH, Antioxidants Alone - Oligoasthenoteratozoospermia, Male Infertility | Phase 4 | Not yet recruiting | Hamad Medical Corporation | 360 | 2026-10-15 | 2026-10-07 |
| Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm isotretinoin, Human chorionic gonadotrophin (hCG) - Oligospermia, Azoospermia, Nonobstructive | Phase 2 | Enrolling by invitation | University of Nebraska | 100 | 2026-04-13 | 2026-04-20 |
| Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI) Primary Ovarian Insufficiency, Azoospermia | Recruiting | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 500 | 2026-03-11 | 2026-03-16 | |
| Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative Stress Standardized Mediterranean Diet, Gazpacho - Male Infertility, Oxidative Stress | Not applicable | Recruiting | Ginefiv | 80 | 2026-03-02 | 2026-03-13 |
| Evaluating Traditional Medicine Syndromes in Male Infertility With Oligoasthenoteratozoospermia Male Infertility With OAT | Completed | University of Medicine and Pharmacy at Ho Chi Minh City | 316 | 2026-03-01 | 2026-09-23 | |
| Identifying Candidates for Limited Dissection at Microdissection TESE. Non Obstructive Azoospermia, Cryptozoospermia | Completed | Clinique Ovo | 248 | 2025-12-15 | 2026-02-27 | |
| Fertility Restoration With Autografting of Cryopreserved Immature Testicular Tissue autologous transplantation of cryopreserved testicular tissue - Azoospermia or Severe Oligozoospermia, Infertility | Not applicable | Recruiting | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 20 | 2025-11-19 | 2026-04-21 |
| Timing of Oocyte Retrieval and Micro Testicular Sperm Extraction Microdissection Testicular Sperm Extraction | Completed | Clinique Ovo | 129 | 2025-11-15 | 2025-12-05 | |
| DHEA Plus Coenzyme Q10 Verus Coenzyme Q10 Alone on Sperm Concentration in Subfertile Male With Oligospermia. Tablet DHEA, Coenzyme Q10 - Oligospermia | Not applicable | Completed | Mst.Sumyara Khatun | 56 | 2025-07-01 | 2026-08-18 |
| A Study to Evaluate the Safety and Tolerability of Single and Multiple Dose of STSP-0902 in Healthy Subjects STSP-0902 injection, Placebo - Oligozoospermia | Phase 1 | Recruiting | Staidson (Beijing) Biopharmaceuticals Co., Ltd | 64 | 2025-05-08 | 2026-05-22 |
| Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for Testicular Injury and Oligospermia AlloRx - Testicular Injury, Oligospermia | Phase 1 | Withdrawn | The Foundation for Orthopaedics and Regenerative Medicine | 2025-04-03 | 2025-04-06 | |
| Efficacy and Safety of a New Sperm Capacitation Method Standard sperm preparation, HyperSperm - Reproductive Issues, Male Infertility | Recruiting | Fecundis Lab SL | 300 | 2025-01-14 | 2026-09-01 | |
| Study of Tolerability, Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of the Medicinal Product MediReg® Medicinal product MediReg® (Human Mesenchymal Stromal Cell Secretome), lyophilizate for preparation of solution for injection in patients with severe spermatogenesis disorders, Clostilbegit (clomiphene) 50 mg 1 tablet x 1 p a day - 3 months, Triovit - 1 tablet x 1 p a day - 3 months, Folic acid - 1 tablet x 1 p a day - 3 months. - Azoospermia, Nonobstructive, Teratospermia | Phase 1 / Phase 2 | Recruiting | Lomonosov Moscow State University Medical Research and Educational Center | 80 | 2024-11-26 | 2025-03-11 |
| A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of STSP-0902 in Healthy Subjects STSP-0902 injection, Placebo - Oligozoospermia, Asthenozoospermia | Phase 1 | Completed | Staidson (Beijing) Biopharmaceuticals Co., Ltd | 40 | 2024-07-31 | 2025-05-11 |
| Efficacy and Safety Study of Products Based on Tribulus Terrestris, L. in Men With Oligospermia Tribulus terrestris, Placebo - Oligospermia | Phase 4 | Recruiting | Herbarium Laboratorio Botanico Ltda | 204 | 2024-07-12 | 2025-04-06 |
| Varicocelectomy for Cryptozoospermic Men. Varicoceles ligation - Cryptozoospermia | Not applicable | Completed | Sohag University | 69 | 2024-02-01 | 2026-08-12 |
| Hyperbaric Oxygen Therapy for Men Suffering From Infertility Due to Oligospermia. Hyperbaric oxygen therapy - Oligospermia | Not applicable | Recruiting | Assaf-Harofeh Medical Center | 15 | 2024-01-20 | 2026-04-22 |
| Creatine and Ubiquinol for Sperm Quality Supplement 1, Supplement 2, Placebo - Oligospermia, Sperm Count, Low | Not applicable | Completed | University of Novi Sad, Faculty of Sport and Physical Education | 18 | 2023-12-15 | 2024-12-04 |
| Comparative Evaluation of the Efficacy of Letrozole, L-Carnitine, and Their Combination on Sperm Quality, Oxidative Stress, and ART Outcomes in Men With Idiopathic Oligoasthenoteratozoospermia. Letrozole 2.5mg, L-carnitine - Idiopathic Oligoasthenoteratozoospermia, Male Infertility | Phase 2 / Phase 3 | Completed | Tehran University of Medical Sciences | 90 | 2023-12-01 | 2026-06-30 |
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Infertility, Male (26) · Asthenozoospermia (12) · Azoospermia (11) · Infertility (9) · Teratozoospermia (9) · Azoospermia, Nonobstructive (7) · Varicocele (2) · Abortion, Spontaneous (1) · COVID-19 (1) · Endocrine System Diseases (1) · Fasting (1) · Fibrosis (1) · Insulin Resistance (1) · Non-Muscle Invasive Bladder Neoplasms (1)
Genital Diseases (62) · Genital Diseases, Male (62) · Male Urogenital Diseases (62) · Urogenital Diseases (62) · Infertility (53) · Infertility, Male (36) · Female Urogenital Diseases and Pregnancy Complications (3) · Cardiovascular Diseases (2) · Female Urogenital Diseases (2) · Nutritional and Metabolic Diseases (2) · Pathological Conditions, Signs and Symptoms (2) · Vascular Diseases (2) · Adnexal Diseases (1) · Behavior (1) · Body Weight (1)
Antioxidants (2) · Carnitine (2) · Clomiphene (2) · Diet Therapy (2) · Geritol (2) · Letrozole (2) · Standard of Care (2) · coenzyme Q10 (2) · Anastrozole (1) · Angptl4 protein, mouse (1) · Ascorbic Acid (1) · BCG Vaccine (1) · Blood Specimen Collection (1) · Chorionic Gonadotropin (1) · Diet, Healthy (1)
Clinique Ovo (2) · Reproductive & Genetic Hospital of CITIC-Xiangya (2) · Staidson (Beijing) Biopharmaceuticals Co., Ltd (2) · A.O.U. Città della Salute e della Scienza (1) · AGUNCO Obstetrics and Gynecology Centre (1) · Ain Shams University (1) · Ankara City Hospital Bilkent (1) · Aristotle University Of Thessaloniki (1) · Assaf-Harofeh Medical Center (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Benha University (1) · Charite University, Berlin, Germany (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Duta Wacana Christian University (1)
China (8) · United States (7) · Egypt (6) · Spain (5) · Israel (4) · Indonesia (3) · Canada (2) · Italy (2) · Russia (2) · Taiwan (2) · Turkey (Türkiye) (2) · Antigua and Barbuda (1) · Argentina (1) · Bangladesh (1) · Belgium (1)
Ahmad O Hammoud, MD (1) · Ahmed M Eltaher, professor (1) · Aldo Maina, MD (1) · Anastasia Efimenko, doctor of sciences (1) · Andreas Michalsen, Prof. Dr. (1) · Anees Fatima, MBBS,FCPS (1) · Anthony U Mbah, MD, FMCP (1) · Ariel Revel, MD (1) · Azim Hedayatpour, Professor, PhD (1) · Chadwick Prodromos, MD (1) · Chris Deibert, MD, MPH (1) · Christine Wyns, MD, PhD (1) · Dai-Nhan Tran, Medical Doctor (1) · Dana Irge, DR (1)
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