171 completed, 84 unknown, 40 recruiting, 17 not yet recruiting. 161 Not applicable, 38 Phase 2, 24 Phase 3, 18 Phase 4, 16 Phase 1.
Follow Infertility, Male: new trials by email Literature Review of Infertility, Male trials Research Report on Infertility, Male
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sperm, Exposure and Endocrine Disruptors EDC Education Intervention - Fertility, Male Fertility | Not applicable | Not yet recruiting | Million Marker Wellness, Inc. | 100 | 2026-11-01 | 2026-10-06 |
| Comparative Efficacy of Antioxidants Alone Versus Combined Therapy With SERMs or FSH in Normogonadotropic Idiopathic OAT Patients: A Randomized Controlled Trial Antioxidants + Clomiphene Citrate, Antioxidants + FSH, Antioxidants Alone - Oligoasthenoteratozoospermia, Male Infertility | Phase 4 | Not yet recruiting | Hamad Medical Corporation | 360 | 2026-10-15 | 2026-10-07 |
| Nordic Sperm DNA Study Lifestyle change - Male Infertility, Sperm DNA Fragmentation | Not applicable | Not yet recruiting | Regionshospitalet Viborg, Skive | 800 | 2026-09-01 | 2026-08-21 |
| Effect of Varicocelectomy on Spermatogenic Cell Count and Semen Parameters Subinguinal Microsurgical Varicocelectomy - Varicocele, Male Infertility | Not applicable | Not yet recruiting | Assiut University | 40 | 2026-08-01 | 2026-07-06 |
| Gonadotropin Therapy in Idiopathic Hypogonadal Non-Obstructive No intervention, hCG + FSH therapy - APHRODITE Group | Not applicable | Not yet recruiting | Indira IVF Hospital Pvt Ltd | 860 | 2026-07-17 | 2026-04-20 |
| Effectiveness of Live Motile Sperm Sorting Device on IVF Outcomes in Advanced Paternal Age LensHooke® CA0 sperm sorting device, Density Gradient Centrifugation - Male Infertility, Advanced Paternal Age | Not applicable | Recruiting | Vietnam Military Medical University | 378 | 2026-07-15 | 2026-08-20 |
| Assessing the Correlation Between Phospholipase C Zeta Measurements and Semen Parameters No Intervention: Observational Cohort - Male Infertility, Male Subfertility | Recruiting | Fakih IVF Fertility Center | 200 | 2026-07-01 | 2026-07-06 | |
| Selective Extended Venous Stripping Versus Standard Microsurgical Varicocelectomy for Varicocele-Related Male Infertility Microsurgical Subinguinal Varicocelectomy With Selective Extended Venous Stripping, Standard Microsurgical Subinguinal Varicocelectomy With Conventional Vein Ligation - Varicocele, Male Infertility | Not applicable | Not yet recruiting | Benha University | 160 | 2026-06-15 | 2026-05-22 |
| Cell Free Preimplantation Genetic Testing Spent media collection - Infertility, Female, Infertility, Male | Not yet recruiting | Genomic Prediction Inc. | 200 | 2026-06-11 | 2025-08-26 | |
| Single Infrapubic Versus Bilateral Subinguinal Microsurgical Varicocelectomy Single Infrapubic Microsurgical Bilateral Varicocelectomy, Bilateral Subinguinal Microsurgical Varicocelectomy - Bilateral Varicocele, Male Infertility | Not applicable | Recruiting | Beni-Suef University | 40 | 2026-06-08 | 2026-06-16 |
| Can Fat-Burning Shots Boost Fertility? Comparing Weight-Loss Injections vs. Healthy Habits for Obese Men With Low Sperm Health Semaglutide (Rybelsus®), Tirzepatide, Standardized Lifestyle Intervention - Obesity-related Male Infertility | Phase 2 | Not yet recruiting | First Affiliated Hospital of Wenzhou Medical University | 180 | 2026-05-01 | 2025-09-17 |
| Intratesticular Artery Resistive Index Changes After Varicocelectomy Microscopic Sub-inguinal Varicocelectomy - Varicocele, Male Infertility | Not applicable | Not yet recruiting | Assiut University | 40 | 2026-05-01 | 2026-04-08 |
| Comparison of Two Types of Calcium (Ca²⁺) Ionophore Treatments for Oocyte Activation in Cases of Suboptimal Fertilization Potential Group 1: Oocyte Activation (OA) CultActive, Group 2: Oocyte Activation (OA) Ionomycin, Group 3: Control - ICSI, Testicular Sperm Extraction in Azoospermic Patients | Not applicable | Not yet recruiting | ART Fertility Clinics LLC | 20 | 2026-04-30 | 2026-05-11 |
| A Novel Aromatase Inhibitor, Leflutrozole, for Treatment of Non-Obstructive Azoospermia Leflutrozole, Dose 2 - Infertility Due to Azoospermia, Infertility, Male | Phase 1 / Phase 2 | Active not recruiting | Martin Blomberg Jensen | 15 | 2026-04-21 | 2026-10-21 |
| IntelliWell: An AI-Assisted Imaging Platform for Detection and Location of Ultra-Rare Testicular Sperm in Surgical Specimens Use of IntelliWell to identify and localize sperm for ICSI - Infertility, Azoospermia | Not applicable | Recruiting | Brigham and Women's Hospital | 20 | 2026-04-16 | 2026-06-22 |
| Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm isotretinoin, Human chorionic gonadotrophin (hCG) - Oligospermia, Azoospermia, Nonobstructive | Phase 2 | Enrolling by invitation | University of Nebraska | 100 | 2026-04-13 | 2026-04-20 |
| Development of an AI Platform for the Analysis of Sperm and Prediction of Their Clinical Potential Swim-up, Density gradient centrifugation, HyperSperm - Infertility (IVF Patients), ICSI | Recruiting | Fecundis Lab SL | 500 | 2026-03-18 | 2026-06-12 | |
| Evaluating the Safety and Clinical Efficacy of the BAIBYS™ System in Intracytoplasmic Sperm Injection (ICSI) BAIBYS Sperm selection, Intra cytoplasmatic sperm injection, Conventional manual sperm selection - Male Infertility, Azoospermia | Not applicable | Not yet recruiting | BAIBYS Fertility | 260 | 2026-03-15 | 2026-01-15 |
| Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI) Primary Ovarian Insufficiency, Azoospermia | Recruiting | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 500 | 2026-03-11 | 2026-03-16 | |
| YO® Smartphone Home Sperm Test Versus Manual Semen Analysis in Egyptian Men YO® Home Sperm Test, Manual Semen Analysis (WHO 6th Edition) - Semen Analysis, Male Infertility | Not applicable | Active not recruiting | Armed Forces College of Medicine, Cairo, Egypt | 20 | 2026-03-10 | 2026-10-19 |
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Infertility (62) · Oligospermia (61) · Azoospermia (45) · Asthenozoospermia (31) · Infertility, Female (19) · Azoospermia, Nonobstructive (17) · Teratozoospermia (14) · Varicocele (11) · Hypogonadism (9) · Neoplasms (7) · Obesity (7) · Eunuchism (5) · Klinefelter Syndrome (5) · Aneuploidy (4)
Genital Diseases (353) · Male Urogenital Diseases (353) · Urogenital Diseases (353) · Genital Diseases, Male (352) · Infertility (291) · Female Urogenital Diseases and Pregnancy Complications (29) · Female Urogenital Diseases (28) · Endocrine System Diseases (25) · Gonadal Disorders (24) · Genital Diseases, Female (21) · Pathological Conditions, Signs and Symptoms (15) · Cardiovascular Diseases (12) · Nutritional and Metabolic Diseases (11) · Vascular Diseases (11)
Sperm Injections, Intracytoplasmic (13) · Centrifugation, Density Gradient (9) · Clomiphene (9) · Blood Specimen Collection (5) · Carnitine (5) · Chorionic Gonadotropin (5) · Zinc Sulfate (5) · Antioxidants (4) · Denosumab (4) · Letrozole (4) · Semen Analysis (4) · Vitamin E (4) · coenzyme Q10 (4) · Injections (3) · Isotretinoin (3)
Assiut University (10) · Weill Medical College of Cornell University (8) · IRCCS San Raffaele (7) · Benha University (5) · Martin Blomberg Jensen (5) · Assistance Publique - Hôpitaux de Paris (4) · Clinique Ovo (4) · Ganin Fertility Center (4) · Hillel Yaffe Medical Center (4) · South Valley University (4) · ART Fertility Clinics LLC (3) · Babylon University (3) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (3) · Hadassah Medical Organization (3) · Instituto Valenciano de Infertilidad, IVI VALENCIA (3)
United States (62) · Egypt (34) · Spain (22) · Italy (17) · China (16) · Denmark (15) · France (15) · Israel (15) · Turkey (Türkiye) (14) · Canada (11) · Iraq (9) · Vietnam (7) · Belgium (6) · Brazil (6) · Bangladesh (4)
Andrea Salonia, MD (4) · Christine Wyns, MD, PhD (3) · Eman Hasanen (3) · Antti Perheentupa, MD,PhD (2) · Ashok Agarwal, PhD (2) · Dan Nayot, BSc, MSc, MD (2) · Didi D Braat, Prof. MD PhD (2) · Hosam Zaki, MSc, FRCOG (2) · Jan AM Kremer, MD, PhD (2) · John K Amory, MD, MPH (2) · Jonathan Gal, MD (2) · Khaled A Gadalla, MD (2) · Kyle Orwig, PhD (2) · Lamia A. Almashhedy, PhD (2) · Marcelle Cedars, MD (2)
PMID 35506389, PMID 22958644, PMID 33790862, PMID 38367592, PMID 10582779, PMID 10647757, PMID 11028927, PMID 11228933, PMID 11756355, PMID 12215343, PMID 12516764, PMID 14501743, PMID 14581508, PMID 14667875, PMID 15465836, PMID 15640258, PMID 16248841, PMID 16291975, PMID 16595231, PMID 16844298, PMID 17376819, PMID 17439440, PMID 17636251, PMID 1794918, PMID 18074014, PMID 18281241, PMID 18983750, PMID 19381855, PMID 19768529, PMID 19779211, PMID 20303873, PMID 20348942, PMID 20884700, PMID 21134950, PMID 21919943, PMID 22057559, PMID 22081410, PMID 22417664, PMID 22791757, PMID 22793260, PMID 23024648, PMID 23040525, PMID 23145537, PMID 23543240, PMID 23714437, PMID 23757979, PMID 23856422, PMID 24383664, PMID 24799882, PMID 24872947
2023 (3), 2016 (2), 2025 (1), K08CA237338 (1), K24HD082231 (1), P50HD076210 (1), P50HD096723 (1), R01HD084380 (1)