10 completed, 6 unknown, 4 recruiting, 2 active not recruiting. 7 Not applicable, 3 Phase 2, 3 Phase 3, 2 Phase 1.
Follow Azoospermia, Nonobstructive: new trials by email Literature Review of Azoospermia, Nonobstructive trials Research Report on Azoospermia, Nonobstructive
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm isotretinoin, Human chorionic gonadotrophin (hCG) - Oligospermia, Azoospermia, Nonobstructive | Phase 2 | Enrolling by invitation | University of Nebraska | 100 | 2026-04-13 | 2026-04-20 |
| Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI) Primary Ovarian Insufficiency, Azoospermia | Recruiting | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 500 | 2026-03-11 | 2026-03-16 | |
| Inhibin B/FSH Ratio as a Predictor of Testicular Pathology in NOA Azoospermia, Nonobstructive, Non-obstructive Azoospermia | Completed | Elazıg Fethi Sekin Sehir Hastanesi | 73 | 2026-01-10 | 2026-02-17 | |
| Interest of Clomiphene Citrate in Patients With Non-obstructive Azoospermia on the Quantity of Sperm Cells Clomifene Citrate, Placebo - Azoospermia, Nonobstructive | Phase 3 | Withdrawn | Hospices Civils de Lyon | 2026-01-01 | 2026-06-17 | |
| Timing of Oocyte Retrieval and Micro Testicular Sperm Extraction Microdissection Testicular Sperm Extraction | Completed | Clinique Ovo | 129 | 2025-11-15 | 2025-12-05 | |
| Study of Tolerability, Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of the Medicinal Product MediReg® Medicinal product MediReg® (Human Mesenchymal Stromal Cell Secretome), lyophilizate for preparation of solution for injection in patients with severe spermatogenesis disorders, Clostilbegit (clomiphene) 50 mg 1 tablet x 1 p a day - 3 months, Triovit - 1 tablet x 1 p a day - 3 months, Folic acid - 1 tablet x 1 p a day - 3 months. - Azoospermia, Nonobstructive, Teratospermia | Phase 1 / Phase 2 | Recruiting | Lomonosov Moscow State University Medical Research and Educational Center | 80 | 2024-11-26 | 2025-03-11 |
| Autologous Transplantation of Human Cryopreserved Testis Tissue Autologous Transplantation of Testis Tissue - Cancer, Hematologic Diseases | Not applicable | Active not recruiting | Herlev and Gentofte Hospital | 5 | 2024-11-04 | 2026-01-23 |
| Platelet Rich Plasma Testis Treatment for Infertile Men Platelet rich plasma - Male Infertility, Nonobstructive Azoospermia | Not applicable | Recruiting | Stanford University | 10 | 2023-01-18 | 2026-01-13 |
| Management of Non Obstructive Azoospermia in Men micro-dissection testicular sperm extraction - Male Infertility, Azoospermia, Nonobstructive | Not applicable | Completed | South Valley University | 300 | 2022-06-01 | 2025-05-25 |
| Machine Learning Based-Personalized Prediction of Sperm Retrieval Success Rate Machine learning-based predictive model - Infertility, Male, Azoospermia, Nonobstructive | Completed | Peking University Third Hospital | 2612 | 2022-06-01 | 2024-04-11 | |
| TeSE (Testicular Sperm Extraction) in Azoospermic Patients: m-TeSE vs. l-TeSE Microscope, Surgical loupes - Azoospermia, Nonobstructive | Not applicable | Completed | A.O.U. Città della Salute e della Scienza | 42 | 2022-03-01 | 2024-11-25 |
| Maternal Inheritance of a Pathogenic MT-ND1 Mutation Causes Mitochondrial Dysfunction and Spermatogenic Failure in Men Azoospermia, Nonobstructive, Cryptozoospermia | Recruiting | The Third Affiliated Hospital of Guangzhou Medical University | 1200 | 2021-04-01 | 2026-07-09 | |
| Hormonal Stimulation of Spermatogenesis Beta-hCG - Azoospermia, Nonobstructive | Phase 1 | Completed | Egymedicalpedia | 100 | 2021-03-01 | 2023-10-19 |
| Seminal Level of Clusterin Before Testicular Sperm Extraction semen sample - Azoospermia, Nonobstructive | Unknown | Assiut University | 88 | 2020-12-16 | 2020-12-21 | |
| The Effects of Intratesticular PRP Injection in Men With Azoospermia or Cryptozoospermia PRP injection into at least one testis - Azoospermia, Nonobstructive | Not applicable | Completed | Acibadem University | 200 | 2020-01-27 | 2020-11-24 |
| Evaluation of Assisted Reproductive Technology (ART) Outcomes in Couples With Nonobstructive Azoospermia, Cryptozoospermia, and Severe Oligozoospermia Beta-hCG Positivity, Clinical Pregnancy | Completed | Duzce University | 80 | 2019-11-01 | 2026-10-27 | |
| Retrieval of Sperm From Men With Azoospermia Using Ultrasound-guided Rete Testis Aspiration Ultrasound-guided rete testis flushing and aspiration - Azoospermia, Nonobstructive, Infertility, Male | Active not recruiting | University of Pittsburgh | 50 | 2019-05-10 | 2025-12-10 | |
| Seminal TEX101 as a Predictor of Recovery of Spermatogenesis in Azoospermic Men With Palpable Varicocele micro-surgical varicocelectomy - Azoospermia, Nonobstructive, Varicocele | Not applicable | Completed | Cairo University | 40 | 2019-01-01 | 2020-05-21 |
| TESE and Non Obstructive Azoospermia Conventional TESE, Microdissection TESE - Azoospermia, Nonobstructive | Not applicable | Unknown | Assiut University | 148 | 2017-09-01 | 2017-09-29 |
| 2015-Metabolomics&Microbiome-infertility Analysis of microbiome and metabolomics - Azoospermia, Nonobstructive | Unknown | IRCCS San Raffaele | 45 | 2016-06-01 | 2023-12-26 |
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Azoospermia (9) · Infertility, Male (8) · Oligospermia (7) · Infertility (2) · Abortion, Spontaneous (1) · Cryptorchidism (1) · Hematologic Diseases (1) · Klinefelter Syndrome (1) · Neoplasms (1) · Primary Ovarian Insufficiency (1) · Teratozoospermia (1) · Varicocele (1)
Genital Diseases (18) · Genital Diseases, Male (18) · Male Urogenital Diseases (18) · Urogenital Diseases (18) · Infertility (16) · Infertility, Male (10) · Female Urogenital Diseases and Pregnancy Complications (3) · Endocrine System Diseases (2) · Female Urogenital Diseases (2) · Gonadal Disorders (2) · Adnexal Diseases (1) · Cardiovascular Diseases (1) · Chromosome Disorders (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1)
Chorionic Gonadotropin (2) · Clomiphene (2) · Injections (2) · Urofollitropin (2) · Chorionic Gonadotropin, beta Subunit, Human (1) · Goserelin (1) · Isotretinoin (1) · Letrozole (1)
Assiut University (2) · A.O.U. Città della Salute e della Scienza (1) · Acibadem University (1) · Azienda Sanitaria Locale Bari (1) · Cairo University (1) · Clinique Ovo (1) · Duzce University (1) · Egymedicalpedia (1) · Elazıg Fethi Sekin Sehir Hastanesi (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Herlev and Gentofte Hospital (1) · Hospices Civils de Lyon (1) · IRCCS San Raffaele (1) · Jinling Hospital, China (1) · KK Women's and Children's Hospital (1)
United States (4) · China (3) · Egypt (3) · Turkey (Türkiye) (3) · Denmark (2) · Italy (2) · Canada (1) · France (1) · Russia (1) · Singapore (1)
Alayman Hussein, MD (1) · Anastasia Efimenko, doctor of sciences (1) · Bing Yao, MD (1) · Chris Deibert, MD, MPH (1) · Craig Niederberger, MD (1) · Dmitry Okhobotov, doctor of sciences (1) · Elena von Rohden, MD (1) · Ettore Caroppo, MD (1) · Isaac-Jacques Kadoch, MD (1) · Kyle Orwig, PhD (1) · Merve Tepecik (1) · Plotton Ingrid (1)
PMID 14667875, PMID 22958644, PMID 24919724, PMID 29883240, PMID 30243299