6 completed, 4 terminated, 3 active not recruiting, 2 recruiting. 16 Phase 2, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 6, Terminated 4, Active not recruiting 3, Recruiting 2, Unknown 1 |
| Phase 1 | 4 | Completed 2, Recruiting 1, Terminated 1 |
Follow Nose Neoplasms: new trials by email Literature Review of Nose Neoplasms trials Research Report on Nose Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer SX-682, DTX - Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 120 | 2026-11-11 | 2026-11-06 |
| Toripalimab With Chemotherapy for Sinus Cancer Toripalimab, Carboplatin, Docetaxel - Sinonasal Cancer, Paranasal Sinus Neoplasms | Phase 2 | Recruiting | Dana-Farber Cancer Institute | 20 | 2025-06-17 | 2026-08-31 |
| Phase 2 Study of Bintrafusp Alfa in Recurrent/Metastatic Olfactory Neuroblastoma (BARON). Bintrafusp alfa/M7824, Ibuprofen, PET scan - Olfactory Neuroblastoma, Esthesioneuroblastoma | Phase 2 | Completed | National Cancer Institute (NCI) | 11 | 2022-06-21 | 2025-08-08 |
| Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study Cisplatin, Intensity-Modulated Proton Therapy, Quality-of-Life Assessment - Head and Neck Carcinoma, Head and Neck Carcinoma of Unknown Primary | Phase 2 | Active not recruiting | Mayo Clinic | 174 | 2022-02-16 | 2026-07-16 |
| Customized 3D Printed Oral Stents During Head and Neck Radiotherapy Best Practice, Medical Device Usage and Evaluation - Head and Neck Carcinoma, Malignant Parotid Gland Neoplasm | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 88 | 2021-05-26 | 2026-10-06 |
| Camrelizumab Plus Chemoradiotherapy for Patients With Locoregional Cancer of Nasal Cavity and Paranasal Sinuses camrelizumab - Nasal Cavity Cancer, Paranasal Sinus Cancer | Phase 2 | Unknown | Sun Yat-sen University | 57 | 2021-04-16 | 2021-11-10 |
| Celecoxib Through Surgery and Radiation Therapy for the Treatment of Advanced Head and Neck Cancer Celecoxib, Placebo, Quality-of-Life Assessment - Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 | Terminated | University of Utah | 13 | 2019-11-27 | 2025-02-12 |
| Tabelecleucel in Combination With Pembrolizumab in Subjects With Epstein-Barr Virus-associated Nasopharyngeal Carcinoma (EBV+ NPC) Tabelecleucel, Pembrolizumab - Nasopharyngeal Carcinoma, Nasopharyngeal Neoplasms | Phase 1 / Phase 2 | Terminated | Atara Biotherapeutics | 12 | 2019-02-19 | 2024-11-14 |
| A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal Passages Cisplatin, Adjuvant Proton Radiotherapy, Endoscopic Resection - Paranasal Sinus Cancer, Nasal Cavity Tumor | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 3 | 2017-09-01 | 2025-05-16 |
| Adaptive Radiotherapy for Head and Neck Cancer Adaptive Radiotherapy - Head and Neck Cancer, Paranasal Sinus Cancer | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 64 | 2017-03-15 | 2021-10-26 |
| Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Biospecimen Collection, Computed Tomography, Echocardiography Test - Acinar Cell Carcinoma, Adenoid Cystic Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 798 | 2017-01-30 | 2026-06-17 |
| Docetaxel, Cisplatin and Fluorouracil in Treating Patients With Previously Untreated Stage II-IV Nasal Cavity and Paranasal Sinus Cancer Carboplatin, Chemoradiotherapy, Cisplatin - Locally Advanced Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma, Nasal Cavity and Paranasal Sinus Poorly Differentiated Carcinoma | Phase 2 | Terminated | M.D. Anderson Cancer Center | 31 | 2008-06-16 | 2026-07-17 |
| Phase 1b Food Based Modulation of Biomarkers in Human Tissues at High-Risk for Oral Cancer. placebo, laboratory biomarker analysis, questionnaire administration - Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Salivary Gland Squamous Cell Carcinoma | Phase 1 / Phase 2 | Completed | Ohio State University Comprehensive Cancer Center | 70 | 2007-09-04 | 2020-02-20 |
| Erlotinib, Celecoxib and Reirradiation for Recurrent Head and Neck Cancer erlotinib + celecoxib - Cancer of the Pharynx, Cancer of the Larynx | Phase 1 / Phase 2 | Completed | Johnny Kao | 15 | 2007-02-01 | 2017-04-10 |
| Fluorouracil, Hydroxyurea, Cetuximab and Twice-daily Intensity Radiation Therapy for Advanced Head and Neck Cancer Cetuximab, Hydroxyurea, Fluorouracil - Head and Neck Cancer, Cancer of the Pharynx | Phase 2 | Completed | Johnny Kao | 33 | 2007-02-01 | 2018-03-13 |
| Antineoplaston Therapy in Treating Patients With Advanced Head and Neck Cancer Antineoplaston therapy (Atengenal + Astugenal) - Head and Neck Cancer | Phase 2 | Terminated | Burzynski Research Institute | 7 | 1996-05-06 | 2017-11-21 |
Paranasal Sinus Neoplasms (13) · Laryngeal Neoplasms (8) · Head and Neck Neoplasms (7) · Mouth Neoplasms (7) · Hypopharyngeal Neoplasms (6) · Oropharyngeal Neoplasms (5) · Nasopharyngeal Neoplasms (4) · Salivary Gland Neoplasms (4) · Carcinoma (3) · Carcinoma, Adenoid Cystic (3) · Nasopharyngeal Carcinoma (3) · Pharyngeal Neoplasms (3) · Carcinoma, Squamous Cell (2) · Esthesioneuroblastoma, Olfactory (2)
Nose Diseases (16) · Respiratory Tract Diseases (16) · Respiratory Tract Neoplasms (16) · Neoplasms (15) · Neoplasms by Site (15) · Otorhinolaryngologic Diseases (15) · Otorhinolaryngologic Neoplasms (15) · Paranasal Sinus Diseases (14) · Pharyngeal Diseases (10) · Stomatognathic Diseases (10) · Head and Neck Neoplasms (9) · Laryngeal Diseases (8) · Mouth Diseases (8) · Pharyngeal Neoplasms (8)
Cisplatin (4) · Radiotherapy (3) · 1,2-diaminocyclohexaneplatinum II citrate (2) · Carboplatin (2) · Celecoxib (2) · Docetaxel (2) · Fluorouracil (2) · Magnetic Resonance Spectroscopy (2) · Platinum (2) · Specimen Handling (2) · CTLA-4 Antigen (1) · Cetuximab (1) · Chemoprevention (1) · Chemoradiotherapy (1) · Electrocardiography (1)
National Cancer Institute (NCI) (3) · Johnny Kao (2) · M.D. Anderson Cancer Center (2) · Memorial Sloan Kettering Cancer Center (2) · Atara Biotherapeutics (1) · Burzynski Research Institute (1) · Dana-Farber Cancer Institute (1) · Mayo Clinic (1) · Ohio State University Comprehensive Cancer Center (1) · Sun Yat-sen University (1) · University of Utah (1)
United States (15) · China (1) · Guam (1)
Charalampos Floudas, M.D. (2) · Aditi Mehta, DO (1) · Amit Agrawal (1) · Anna Lee (1) · C. Jillian Tsai, MD (1) · Ehab Y Hanna (1) · Johnny Kao, M.D. (1) · Johnny Kao, MD (1) · Kartik Sehgal, MD (1) · Marc Cohen, MD (1) · Richard Cannon, MD (1) · Sandip P Patel (1) · Scott C. Lester, M.D. (1) · Stanislaw R. Burzynski, MD, PhD (1)
PMID 20830768, PMID 21246519, PMID 31969335, PMID 33362722, PMID 33882143, PMID 34380663, PMID 34716198, PMID 38243705, PMID 38358334, PMID 39067873, PMID 39343510, PMID 39417692, PMID 39500789, PMID 39583952, PMID 39856213, PMID 40402690, PMID 40588371, PMID 41672597, PMID 41892875, PMID 41995270, PMID 42307670, PMID 42499790
P30CA042014 (1), U10CA180888 (1)