5 completed, 2 enrolling by invitation, 2 recruiting, 1 not yet recruiting. 6 Not applicable, 4 Phase 2, 3 Phase 1, 1 Early Phase 1, 1 Phase 3.
Follow Noise-Induced Hearing Loss: new trials by email Literature Review of Noise-Induced Hearing Loss trials Research Report on Noise-Induced Hearing Loss
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intervention for Hearing Health Among Native Americans Talking Circle, Diabetes prevention program & delayed TC - Noise-Induced Hearing Loss | Not applicable | Not yet recruiting | University of California, San Francisco | 400 | 2027-04-01 | 2026-08-21 |
| Comparative Efficacy of Earplug Usage Instruction Video-Based Earplug Instruction, Paper-Based Earplug Instruction - Noise-Induced Hearing Loss, Hearing Protection Device Use | Not applicable | Enrolling by invitation | Sirinthorn Chanaveroj | 64 | 2026-06-08 | 2026-07-28 |
| Regenerative Medicine and Stem Cell-Based Interventions for Inner Ear Trauma, Tinnitus, and Sensorineural Hearing Loss Audiologic Monitoring, Investigational Regenerative Pharmacologic Therapy, Stem Cell Regenerative Therapy - Sensorineural Hearing Loss, Tinnitus | Early Phase 1 | Enrolling by invitation | Truway Health, Inc. | 120 | 2026-03-08 | 2026-03-16 |
| A Treatment for a Form of Age-Related Central Auditory Processing Disorder Consisting of Clemastine Fumarate Plus Engineered Sound Clemastine Fumarate Combined With Engineered Sound, Clemastine Fumarate Combined With Pink Noise, Placebo Drug With Engineered Sound - Central Auditory Processing Disorder, Hearing Impaired (Partially) | Phase 1 / Phase 2 | Recruiting | University of Colorado, Denver | 344 | 2025-03-31 | 2026-04-30 |
| Non-Invasive System to Deliver Therapeutic Hypothermia for Protection Against Noise-Induced Hearing Loss Cold pack-delivered mild therapeutic hypothermia - Noise Exposure, Noise-induced Hearing Loss | Not applicable | Recruiting | Restorear Devices LLC | 116 | 2024-12-19 | 2026-07-23 |
| Prevention of Noise-induced Hearing Loss Zonisamide, Methylprednisolone - Noise-induced Hearing Loss | Phase 1 / Phase 2 | Withdrawn | Washington University School of Medicine | 2017-10-31 | 2017-11-06 | |
| Test of Hearing Health Education Programs for Farm and Rural Youth Interactive youth educational program, Internet-based educational booster - Noise-induced Hearing Loss | Not applicable | Completed | University of Michigan | 2093 | 2015-02-17 | 2017-02-27 |
| Protective Effects of EPI-743 on Noise-Induced Hearing Loss EPI-743, Placebo - Noise-induced Hearing Loss | Phase 2 | Completed | Edison Pharmaceuticals Inc | 77 | 2014-10-31 | 2020-11-18 |
| Study to Determine the Safety, Tolerability, and Pharmacokinetic Profile of HPN-07 and HPN-07 Plus NAC HPN-07, NAC, Placebo - Hearing Loss, Sensorineural Hearing Loss | Phase 1 | Completed | Otologic Pharmaceutics, Inc. | 32 | 2014-10-01 | 2015-05-01 |
| Phase 3 Clinical Trial: D-methionine to Reduce Noise-Induced Hearing Loss (NIHL) D-methionine, Placebo - Noise-induced Hearing Loss | Phase 3 | Terminated | Southern Illinois University | 351 | 2013-09-01 | 2022-06-28 |
| Prevention of Noise-induced Damage by Use of Antioxidants Antioxidantia - Noise-induced Tinnitus, Noise-induced Hearing Loss | Not applicable | Unknown | University Hospital, Antwerp | 30 | 2012-11-01 | 2013-11-06 |
| Test of a Web-based Intervention to Promote Hearing Protector Use Sampler of hearing protection devices, Static Web-based information, Interactive Web-based information - Noise-induced Hearing Loss | Not applicable | Completed | Marjorie McCullagh | 498 | 2011-11-01 | 2015-10-05 |
| Micronutrients to Prevent Noise-induced Hearing Loss beta-carotene, vitamins C and E, magnesium, Placebo - Noise-Induced Hearing Loss | Phase 2 | Completed | University of Michigan | 72 | 2008-10-01 | 2017-05-19 |
Hearing Loss, Noise-Induced (13) · Hearing Loss (6) · Hearing Loss, Sensorineural (3) · Tinnitus (3) · Hearing Loss, Hidden (2) · Auditory Diseases, Central (1) · Hearing Disorders (1) · Hearing Loss, Sudden (1) · Language Development Disorders (1) · Presbycusis (1)
Ear Diseases (13) · Nervous System Diseases (13) · Neurologic Manifestations (13) · Otorhinolaryngologic Diseases (13) · Pathological Conditions, Signs and Symptoms (13) · Sensation Disorders (13) · Signs and Symptoms (13) · Hearing Disorders (12) · Hearing Loss, Sensorineural (10) · Hearing Loss (7) · Brain Diseases (1) · Central Nervous System Diseases (1) · Communication Disorders (1) · Language Disorders (1) · Neurobehavioral Manifestations (1)
Acetylcysteine (1) · Clemastine (1) · Magnesium (1) · Methylprednisolone (1) · Methylprednisolone Acetate (1) · Methylprednisolone Hemisuccinate (1) · Placebo Effect (1) · Zonisamide (1) · alpha-tocotrienol quinone (1) · beta Carotene (1) · disufenton sodium (1)
University of Michigan (2) · Edison Pharmaceuticals Inc (1) · Marjorie McCullagh (1) · Otologic Pharmaceutics, Inc. (1) · Restorear Devices LLC (1) · Sirinthorn Chanaveroj (1) · Southern Illinois University (1) · Truway Health, Inc. (1) · University Hospital, Antwerp (1) · University of California, San Francisco (1) · University of Colorado, Denver (1) · Washington University School of Medicine (1)
United States (11) · Belgium (1) · Thailand (1)
Achim Klug, PhD (1) · Colleen G Le Prell, PhD (1) · Colleen Le Prell, Ph.D (1) · Gavin C Solomon, CEO (1) · Josef M Miller, PhD (1) · Judith Lieu, MD (1) · Kathleen Campbell, PhD (1) · Marjorie C McCullagh, PhD (1) · Marjorie C. McCullagh, PhD (1) · Oi Saeng Hong, PhD, RN, FAAN, FAAOHN (1) · Samuel A Budoff, PhD, MS (1) · Suhrud M Rajguru, PhD (1) · Treva Tyson, MD (1)
PMID 21974483, PMID 22122960, PMID 24708640, PMID 24975234, PMID 25927191, PMID 26475373, PMID 26766172
R01DC013885 (1), R01NR021182 (1), R44DC018760 (1), U01DC008423 (1)