140 terminated. 140 Phase 1, 41 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 140 | Terminated 140 |
| Phase 2 | 41 | Terminated 41 |
Follow Nervous System Neoplasms: new trials by email Literature Review of Nervous System Neoplasms trials Research Report on Nervous System Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Re-Administration of C134 in Patients With Recurrent GBM (C134-HSV-1) C134 Re-Administration - Recurrent Malignant Glioma, Glioblastoma Multiforme of Brain | Phase 1 | Terminated | University of Alabama at Birmingham | 1 | 2024-06-21 | 2026-01-22 |
| Tucatinib, Trastuzumab, and Capecitabine With SRS for Brain Metastases From HER-2 Positive Breast Cancer Combined use of SRS with Tucatinib, Trastuzumab, and Capecitabine - Brain Metastases, HER2-positive Breast Cancer | Phase 1 | Terminated | Baptist Health South Florida | 1 | 2024-01-29 | 2025-12-31 |
| Safety and Effectiveness of ABM-168 in Adults with Advanced Solid Tumors. ABM-168 - Advanced Solid Tumor, RAS Mutation | Phase 1 | Terminated | ABM Therapeutics Corporation | 12 | 2023-03-30 | 2024-12-06 |
| RRx-001 Given With Irinotecan and Temozolomide for Pediatric Patients With Recurrent or Progressive Malignant Solid and Central Nervous System Tumors RRx-001, Temozolomide, Irinotecan - Brain Tumor, Recurrent, Brain Tumor, Pediatric | Phase 1 | Terminated | EpicentRx, Inc. | 2 | 2023-01-26 | 2024-10-31 |
| Oral AMXT 1501 Dicaprate in Combination With IV DFMO AMXT1501, DFMO - Cancer, Solid Tumor | Phase 1 / Phase 2 | Terminated | Aminex Therapeutics, Inc. | 15 | 2022-11-29 | 2024-12-24 |
| E6201 and Dabrafenib for the Treatment of Central Nervous System Metastases From BRAF V600 Mutated Metastatic Melanoma Dabrafenib, MEK-1/MEKK-1 Inhibitor E6201, Biospecimen Collection - Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Malignant Neoplasm in the Brain | Phase 1 | Terminated | Mayo Clinic | 13 | 2022-10-20 | 2025-08-19 |
| Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-200M for the Treatment of Melanoma Brain Metastases Ipilimumab, Nivolumab, Pembrolizumab - Clinical Stage IV Cutaneous Melanoma AJCC v8, Melanoma of Unknown Primary | Phase 1 | Terminated | Emory University | 1 | 2022-10-13 | 2026-04-23 |
| Safety and Tolerability of TNG908 in Patients With MTAP-deleted Solid Tumors TNG908 - Locally Advanced Solid Tumor | Phase 1 / Phase 2 | Terminated | Tango Therapeutics, Inc. | 110 | 2022-03-23 | 2026-04-15 |
| (Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations BLU-451, Carboplatin, Pemetrexed - Lung Neoplasm Malignant, Carcinoma, Non-Small-Cell Lung | Phase 1 | Terminated | Blueprint Medicines Corporation | 103 | 2022-03-04 | 2025-02-10 |
| Study of Avelumab in Combination With Lenvatinib for Children With Primary CNS Tumors Avelumab, Lenvatinib - Central Nervous System Tumors | Phase 1 | Terminated | EMD Serono Research & Development Institute, Inc. | 17 | 2021-12-03 | 2026-07-29 |
| A Clinical Trial to Evaluate the Safety and Efficacy of AL2846 Capsules in Chinese Patients With Type I Neurofibromatosis AL2846 capsules - Neurofibromatosis and Malignant Peripheral Nerve Sheath Tumors | Phase 1 / Phase 2 | Terminated | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 22 | 2021-09-07 | 2024-03-21 |
| Non-Invasive Focused Ultrasound (FUS) With Oral Panobinostat in Children With Progressive Diffuse Midline Glioma (DMG) Panobinostat 15 MG, Focused Ultrasound with neuro-navigator-controlled sonication - Diffuse Intrinsic Pontine Glioma, Diffuse Pontine and Thalamic Gliomas | Phase 1 | Terminated | Columbia University | 5 | 2021-07-28 | 2025-06-08 |
| Study of PBI-200 in Subjects With NTRK-Fusion-Positive Solid Tumors PBI-200 - Solid Tumor, Adult, Brain Tumor, Primary | Phase 1 | Terminated | Pyramid Biosciences | 29 | 2021-07-20 | 2024-03-28 |
| A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG) BXQ-350 - Part 1 Dose Escalation: Safety and Tolerance, BXQ-350 - Part 2 BXQ-350 Tumor and Plasma Concentrations - Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant | Phase 1 | Terminated | Bexion Pharmaceuticals, Inc. | 10 | 2021-05-24 | 2024-12-20 |
| Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain Metastases Bintrafusp Alfa, Pimasertib, Quality-of-Life Assessment - Anatomic Stage IV Breast Cancer AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8 | Phase 1 / Phase 2 | Terminated | M.D. Anderson Cancer Center | 8 | 2021-01-15 | 2026-03-18 |
| A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement PF-07284890, Binimetinib, Midazolam - Malignant Melanoma, Carcinoma, Non-Small-Cell Lung | Phase 1 | Terminated | Pfizer | 65 | 2021-01-08 | 2025-10-23 |
| Phase I Study of Marizomib + Panobinostat for Children With DIPG Marizomib, Panobinostat - Diffuse Intrinsic Pontine Glioma, Pediatric Brainstem Glioma | Phase 1 | Terminated | Dana-Farber Cancer Institute | 4 | 2020-08-10 | 2024-02-15 |
| 9-ING-41 in Pediatric Patients With Refractory Malignancies. 9-ING-41, Irinotecan, Temozolomide - Refractory Cancer, Refractory Neoplasm | Phase 1 | Terminated | Actuate Therapeutics Inc. | 40 | 2020-06-05 | 2025-07-17 |
| LITT and Pembrolizumab in Recurrent Brain Metastasis LITT + Pembrolizumab - Melanoma, Non-small Cell Lung Carcinoma (NSCLC) | Phase 1 | Terminated | University of Florida | 10 | 2020-01-10 | 2023-12-27 |
| Mapping Draining Lymph Nodes in CNS Malignancies Tc-99m tilmanocept - Central Nervous System Neoplasms, Central Nervous System Tumor | Phase 1 | Terminated | Washington University School of Medicine | 14 | 2019-12-03 | 2023-12-21 |
Showing 20 of 140. Sign in to see all of them.
Brain Neoplasms (87) · Glioblastoma (39) · Central Nervous System Neoplasms (36) · Glioma (31) · Astrocytoma (30) · Oligodendroglioma (21) · Gliosarcoma (18) · Neoplasms (18) · Melanoma (13) · Diffuse Intrinsic Pontine Glioma (12) · Medulloblastoma (12) · Carcinoma, Non-Small-Cell Lung (10) · Breast Neoplasms (9) · Meningeal Carcinomatosis (9) · Recurrence (9)
Nervous System Diseases (140) · Neoplasms by Site (133) · Neoplasms (122) · Central Nervous System Diseases (106) · Brain Diseases (104) · Central Nervous System Neoplasms (96) · Neoplasms by Histologic Type (96) · Neoplasms, Nerve Tissue (91) · Neoplasms, Germ Cell and Embryonal (85) · Neuroectodermal Tumors (84) · Neoplasms, Glandular and Epithelial (78) · Neoplasms, Neuroepithelial (74) · Glioma (42) · Astrocytoma (24)
Temozolomide (17) · Radiotherapy (10) · Bevacizumab (5) · Filgrastim (5) · Radiosurgery (5) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (4) · Cyclophosphamide (4) · Granulocyte Colony-Stimulating Factor (4) · Magnetic Resonance Spectroscopy (4) · Trastuzumab (4) · Carboplatin (3) · Erlotinib Hydrochloride (3) · Melphalan (3) · Panobinostat (3) · Radiation (3)
National Cancer Institute (NCI) (14) · M.D. Anderson Cancer Center (9) · Pediatric Brain Tumor Consortium (6) · H. Lee Moffitt Cancer Center and Research Institute (3) · Masonic Cancer Center, University of Minnesota (3) · OHSU Knight Cancer Institute (3) · Vanderbilt-Ingram Cancer Center (3) · Baylor College of Medicine (2) · Bexion Pharmaceuticals, Inc. (2) · Children's Hospital of Philadelphia (2) · Dana-Farber Cancer Institute (2) · EMD Serono Research & Development Institute, Inc. (2) · Northwestern University (2) · Novartis Pharmaceuticals (2) · UNC Lineberger Comprehensive Cancer Center (2)
United States (128) · Canada (9) · France (5) · United Kingdom (5) · South Korea (4) · Spain (4) · Australia (3) · Denmark (3) · Germany (3) · Belgium (2) · China (2) · Italy (2) · Singapore (2) · Switzerland (2) · Finland (1)
Edward A. Neuwelt, MD (2) · Ian F. Pollack, MD (2) · Jeffrey Yap, PhD (2) · Morris D. Groves, MD (2) · Adrienne C Scheck, PhD (1) · Ajay Niranjan, MD, MBA (1) · Alfredo Quinones, MD (1) · Allen K Sills, MD (1) · Allen Mellemed, MD (1) · Andreas Klein, MD (1) · Annick Desjardins, MD (1) · April Eichler (1) · Asha Das, MD (1)
PMID 12749708, PMID 17293590, PMID 17909804, PMID 18425516, PMID 19065567, PMID 24327518, PMID 24410126, PMID 24792486, PMID 27424289, PMID 28053024, PMID 28357727, PMID 28672195, PMID 29383130, PMID 29846250, PMID 30989436, PMID 31101621, PMID 31533931, PMID 31776899, PMID 31831767, PMID 31882719, PMID 31938892, PMID 32270710, PMID 32354716, PMID 33034839, PMID 33047248, PMID 34321280, PMID 34359048, PMID 35137228, PMID 35191738, PMID 35262780, PMID 35484319, PMID 36371226, PMID 36617554, PMID 36705597, PMID 37553297, PMID 38335473, PMID 39077892, PMID 39756156, PMID 41339822
U01CA081457 (4), U01CA069852 (2), 1RC2CA148491-01 (1), 2009 (1), 2017 (1), N01CM00032 (1), N01CM00039 (1), P30CA014599 (1), P30CA016086 (1), P30CA016672 (1), P30CA033572 (1), P30CA043703 (1), P30CA056036 (1), P30CA068485 (1), P30CA069533 (1)