8 completed. 8 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 8 | Completed 8 |
| Phase 2 | 1 | Completed 1 |
Follow Multiple System Atrophy: new trials by email Literature Review of Multiple System Atrophy trials Research Report on Multiple System Atrophy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients DaTSCAN™ Ioflupane (123I) Injection - Parkinsonian Syndrome, Parkinson Disease(PD) | Phase 3 | Completed | GE Healthcare | 172 | 2020-06-28 | 2023-10-16 |
| Study of BHV-3241 in Participants With Multiple System Atrophy Verdiperstat, Placebo - Multiple System Atrophy | Phase 3 | Completed | Biohaven Pharmaceuticals, Inc. | 421 | 2019-07-29 | 2023-09-29 |
| Clinical Effect of Ampreloxetine (TD-9855) for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure ampreloxetine, Placebo - Symptomatic Neurogenic Orthostatic Hypotension | Phase 3 | Completed | Theravance Biopharma | 195 | 2019-01-24 | 2022-09-14 |
| Efficacy of L-threo DOPS on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patients With MSA L-Threo DOPS, placebo - Multiple System Atrophy | Phase 2 / Phase 3 | Completed | University Hospital, Toulouse | 107 | 2014-01-21 | 2026-04-08 |
| Progression Rate of MSA Under EGCG Supplementation as Anti-Aggregation-Approach EGCG as putative neuroprotective agent, Placebo - Multiple System Atrophy | Phase 3 | Completed | Dr. Johannes Levin | 92 | 2014-01-01 | 2024-03-12 |
| A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa Placebo, Droxidopa - Symptomatic Neurogenic Orthostatic Hypotension (NOH), Non-diabetic Neuropathy | Phase 3 | Completed | Chelsea Therapeutics | 263 | 2008-09-01 | 2014-05-16 |
| Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Droxidopa, Placebo - Neurogenic Orthostatic Hypotension, Non-Diabetic Autonomic Neuropathy | Phase 3 | Completed | Chelsea Therapeutics | 103 | 2008-01-01 | 2014-05-16 |
| Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Placebo, Droxidopa - Symptomatic Neurogenic Orthostatic Hypotension (NOH), Non-diabetic Neuropathy | Phase 3 | Completed | Chelsea Therapeutics | 181 | 2008-01-01 | 2014-05-20 |
Hypotension, Orthostatic (4) · Pure Autonomic Failure (4) · dopamine beta hydroxylase deficiency (3) · Parkinson Disease (2) · Parkinsonian Disorders (2) · Dizziness (1) · Essential Tremor (1) · Hypotension (1) · Supranuclear Palsy, Progressive (1) · Syncope (1)
Autonomic Nervous System Diseases (8) · Basal Ganglia Diseases (8) · Brain Diseases (8) · Central Nervous System Diseases (8) · Movement Disorders (8) · Nervous System Diseases (8) · Neurodegenerative Diseases (8) · Primary Dysautonomias (8) · Synucleinopathies (8) · Cardiovascular Diseases (5) · Vascular Diseases (5) · Hypotension (4) · Orthostatic Intolerance (4) · Neurologic Manifestations (2) · Pathological Conditions, Signs and Symptoms (2)
Droxidopa (4) · Injections (1) · Iodine-123 (1) · ampreloxetine (1) · epigallocatechin gallate (1) · ioflupane (1)
Chelsea Therapeutics (3) · Biohaven Pharmaceuticals, Inc. (1) · Dr. Johannes Levin (1) · GE Healthcare (1) · Theravance Biopharma (1) · University Hospital, Toulouse (1)
United States (5) · Canada (4) · Australia (3) · France (3) · Germany (3) · New Zealand (3) · Austria (2) · Italy (2) · United Kingdom (2) · Bulgaria (1) · China (1) · Denmark (1) · Estonia (1) · Hungary (1) · Israel (1)
Alberto Vasquez, MD (1) · Alvin McElveen, MD (1) · Brent Goodman, MD (1) · Christopher J Mathias, MD (1) · Christopher J. Mathias, MD (1) · Horacio Kaufmann Kaufmann, MD (1) · Horacio Kaufmann, MD (1) · Johannes Levin, MD (1) · Mazen Dimachkie, MD (1) · Phillip A Low, MD (1) · Richard Hull, MD (1) · Roy Freeman, MD (1)
PMID 27538531, PMID 28494751, PMID 25350981, PMID 31278067, PMID 34115419, PMID 41269291, PMID 42475649
2018 (1)