3 completed, 2 recruiting, 2 unknown, 1 enrolling by invitation. 4 Phase 2, 2 Phase 3, 1 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 1, Enrolling by invitation 1, Recruiting 1, Unknown 1 |
| Phase 3 | 2 | Completed 2 |
| Not applicable | 1 | Recruiting 1 |
| Phase 1 | 1 | Recruiting 1 |
Follow Monotherapy: new trials by email Literature Review of Monotherapy trials Research Report on Monotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tamsulosin Monotherapy Versus Combination Therapy With Tadalafil (2.5 mg vs 5 mg) in Managing Male LUTS Secondary to BPH Tamsulosin 0.4 mg + Tadalafil 2.5 mg, Tamsulosin 0.4 mg + Tadalafil 5 mg, Tamsulosin 0.4 mg - Safety, Efficacy | Not applicable | Recruiting | Ain Shams University | 90 | 2026-07-01 | 2026-07-23 |
| Clinical Study on the Early Bactericidal Activity of Contezolid Against Mycobacterium Abscessus Disease Contezolid, linezolid - Monotherapy, Mycobacterium Abscessus Infection | Phase 2 | Enrolling by invitation | Beijing Chest Hospital | 24 | 2026-01-01 | 2026-01-28 |
| Mirdametinib Monotherapy in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF). Mirdametinib - NF1, Cutaneous Neurofibroma | Phase 1 / Phase 2 | Recruiting | Johns Hopkins University | 24 | 2024-02-12 | 2026-04-13 |
| Analysis of Factors Influencing the Efficacy of Levamlodipine Benzoate and Its Population Pharmacodynamic Modeling Hypertensive Patients, Monotherapy | Unknown | The Second Affiliated Hospital of Chongqing Medical University | 150 | 2022-12-15 | 2023-09-14 | |
| Early Simplified: A Trial to Compare the Efficacy of Standard of Care Combination Antiretroviral Therapy With a Simplified Dolutegravir Monotherapy in Patients With a Primary HIV-1 Infection Dolutegravir, Standard of care combinational antiretroviral therapy - Monotherapy, Dolutegravir | Phase 2 | Unknown | University of Zurich | 101 | 2016-11-01 | 2018-10-12 |
| A Pilot Study of MONOtherapy of DOlutegravir in HIV-1 Virologically Suppressed Patients Dolutegravir - Human Immunodeficiency Virus, Dolutegravir | Phase 2 | Completed | Calmy Alexandra | 8 | 2016-06-01 | 2017-11-01 |
| Evaluating Long Term Safety of Lacosamide (LCM) to Carbamazepine Controlled-release (CBZ-CR); Initial Monotherapy in Epilepsy Subjects 16 Years and Older Lacosamide, Carbamazepine-Controlled Release (CBZ-CR) - Epilepsy, Monotherapy | Phase 3 | Completed | UCB BIOSCIENCES GmbH | 551 | 2012-05-01 | 2018-07-18 |
| Trial Comparing the Efficacy and Safety of Lacosamide (LCM) to Carbamazepine Controlled-Release (CBZ-CR); Initial Monotherapy in Epilepsy; Subjects Aged 16 and Older Lacosamide, Carbamazepine-Controlled Release - Epilepsy, Monotherapy | Phase 3 | Completed | UCB BIOSCIENCES GmbH | 888 | 2011-04-01 | 2021-02-02 |
Epilepsy (2) · Acquired Immunodeficiency Syndrome (1) · HIV Infections (1) · Lower Urinary Tract Symptoms (1) · Mycobacterium Infections, Nontuberculous (1) · Prostatic Hyperplasia (1)
Brain Diseases (2) · Central Nervous System Diseases (2) · Genital Diseases (2) · Infections (2) · Nervous System Diseases (2) · Urogenital Diseases (2) · Actinomycetales Infections (1) · Bacterial Infections (1) · Bacterial Infections and Mycoses (1) · Blood-Borne Infections (1) · Communicable Diseases (1) · Genital Diseases, Male (1) · Gram-Positive Bacterial Infections (1) · Immune System Diseases (1) · Immunologic Deficiency Syndromes (1)
Lacosamide (2) · dolutegravir (2) · Linezolid (1) · Oxazolidinones (1) · Tadalafil (1) · Tamsulosin (1) · contezolid (1) · mirdametinib (1)
UCB BIOSCIENCES GmbH (2) · Ain Shams University (1) · Beijing Chest Hospital (1) · Calmy Alexandra (1) · Johns Hopkins University (1) · The Second Affiliated Hospital of Chongqing Medical University (1) · University of Zurich (1)
Switzerland (4) · United States (3) · Australia (2) · Belgium (2) · Bulgaria (2) · Canada (2) · China (2) · Czechia (2) · Finland (2) · France (2) · Germany (2) · Greece (2) · Hungary (2) · Italy (2) · Japan (2)
Carlos Romo, MD (1) · Delphine Sculier, MD (1) · Dominique L Braun, MD (1) · Wenjuan Nie, Director (1) · Xian Yu (1)
PMID 27889312, PMID 28290119, PMID 30601950, PMID 33200428, PMID 34265173