20 completed, 13 recruiting, 10 unknown, 7 not yet recruiting. 30 Not applicable, 5 Phase 1, 3 Phase 2, 1 Early Phase 1.
Follow MCI: new trials by email Literature Review of MCI trials Research Report on MCI
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Developing and Testing an AI-Based Cognitive Intervention Program Lifestyle Intervention - Intact Cognitive Function, MCI | Not applicable | Not yet recruiting | National Research Center for Rehabilitation Technical Aids | 100 | 2026-11-01 | 2026-08-18 |
| Personalized Closed-Loop Brain Stimulation for Patients With Mild Cognitive Impairment Active tES, Cognitive Interventions - MCI | Not applicable | Not yet recruiting | Johns Hopkins University | 10 | 2026-11-01 | 2026-10-07 |
| Cognitive-Motor Training for AD/ADRD Prevention Novel CogXergaming Training, Exercise and Education Training Program - MCI, Aging | Not applicable | Not yet recruiting | University of Illinois at Chicago | 46 | 2026-10-01 | 2026-08-18 |
| Tailored Brain Health Insights Through Nurturing Knowledge-based Change - Stakeholder-driven, Human-centered, AI-powered Refinement for Prevention BLAZE (Brain health Lifestyle Action with personaliZed Engagement) - MCI, Dementia | Not applicable | Not yet recruiting | Alexandra Hospital | 350 | 2026-09-01 | 2026-05-29 |
| The Effect of Lavender Aromatherapy on Cognitive Function in Older Adults With Mild Cognitive Impairment aromatherapy - MCI | Not applicable | Not yet recruiting | China Medical University, China | 70 | 2026-09-01 | 2026-07-07 |
| Ketogenic Diet to Reduce Osteoarthritis Pain in MCI Well-formulated ketogenic diet - Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee | Not applicable | Not yet recruiting | University of Kansas Medical Center | 10 | 2026-06-01 | 2026-05-04 |
| Telehealth-Adapted Compensatory Training and Intervention for Cognition Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (ME-CCT-MCI), Brief Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (bME-CCT-MCI) - MCI, Mild Cognitive Impairment | Not applicable | Recruiting | University of Florida | 100 | 2026-05-29 | 2026-06-03 |
| A Phase I Study of [18F]Flortaucipir PET Imaging in Chinese Subjects: Safety, Pharmacokinetics, Biodistribution, Radiation Dosimetry, and Preliminary Diagnostic Efficacy [18F]Flortaucipir Injection - AD - Alzheimer's Disease, MCI | Phase 1 | Recruiting | Eli Radiopharma | 18 | 2026-04-23 | 2026-05-14 |
| Prevalence of Mild Cognitive Impairment and Dementia in Patients Admitted to Non-neurological Rehabilitation Wards Cognitive and clinical screening, Extended neuropsychological assessment, Blood biomarker sampling and APOE genotyping - MCI, Mild Cognitive Impairment (MCI) | Not applicable | Recruiting | Fondazione Don Carlo Gnocchi ETS | 384 | 2026-01-20 | 2026-08-10 |
| Validation of the Montreal Cognitive Assessment (MoCA) Version 8.x and MoCA-MIS in Greece. MCI, Dementia | Not yet recruiting | Aristotle University Of Thessaloniki | 250 | 2026-01-01 | 2025-12-22 | |
| FACE Phase II (a Stage II Trial) Cognitive Remediation, Cognitive Remediation II - MCI, Subjective Cognitive Decline (SCD) | Phase 1 / Phase 2 | Recruiting | Stanford University | 80 | 2025-10-31 | 2026-04-24 |
| Exploring the Utility of [18F]3F4AP for Demyelination Imaging [ 18F]3F4AP, [18F]MK6240, [11C]PIB - Demyelinating Disorders, MCI | Phase 1 | Recruiting | Yale University | 105 | 2025-05-05 | 2026-09-09 |
| Validation Study of a New Digital Diagnostic and Treatment Test Based on Interactive Video Games for Alzheimer's Disease Bgaze Therapy, Bgaze Attention Task - Alzheimer Disease, MCI | Not applicable | Enrolling by invitation | Braingaze | 60 | 2025-05-01 | 2025-05-09 |
| Acute Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity Oral ketone monoester (KME) - MCI, SCD | Not applicable | Completed | University Department of Geriatric Medicine FELIX PLATTER | 15 | 2025-04-12 | 2026-05-18 |
| Omics Sciences for the Identification of Pathogenetic Mechanisms and Biomarkers in Neurodegenerative Diseases Alzheimer Disease, FTD | Recruiting | Ospedale Policlinico San Martino | 1200 | 2025-02-28 | 2025-11-25 | |
| The Effects of Some Antihyperglycemic Drugs on Cognitive Function and Risk of Depression of Diabetic Patients SGLT2 Is+METFORMIN, DPP4 Is+metformin, Control group - MCI | Active not recruiting | Beni-Suef University | 300 | 2025-01-01 | 2026-07-24 | |
| Efficacy and Safety of Dimethyl Fumarate Among Patients with Mild Cognitive Impairment and Dementia Due to Alzheimer's Disease dimethyl fumarate - MCI, MCI-AD, Early Stage Alzheimer's Disease | Phase 2 | Recruiting | Medical University of Lodz | 30 | 2024-10-28 | 2025-02-27 |
| ViewMind Atlas Cognition ViewMind Atlas™ - MCI, Cognitive Ability, General | Not applicable | Unknown | ViewMind | 270 | 2024-10-16 | 2024-12-24 |
| Studying the Effects of Digital Interventions on Cognition, Wellbeing, Stress, and Sleep in Older Adults MediTrain, wrist worn multi-sensor watches, Sleep monitor - MCI, Aging | Not applicable | Active not recruiting | University of California, San Francisco | 90 | 2024-09-10 | 2026-08-24 |
| Accelerating Cognitive Gains From Digital Inverventions With Noninvasive Brain Stimulation MediTrain, Worder, noninvasive neurostimulation device - Aging, MCI | Not applicable | Active not recruiting | University of California, San Francisco | 90 | 2024-08-31 | 2026-08-24 |
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Cognitive Dysfunction (22) · Alzheimer Disease (18) · Dementia (12) · Motor Activity (3) · Neurocognitive Disorders (3) · Attention Deficit Disorder with Hyperactivity (2) · Behavior (2) · Disease (2) · Fibromyalgia (2) · Multiple Sclerosis (2) · Nerve Degeneration (2) · Parkinson Disease (2) · Alzheimer Disease 10 (1) · Alzheimer Disease 11 (1) · Alzheimer Disease 12 (1)
Mental Disorders (35) · Neurocognitive Disorders (32) · Nervous System Diseases (30) · Brain Diseases (29) · Central Nervous System Diseases (29) · Cognition Disorders (21) · Neurodegenerative Diseases (19) · Tauopathies (18) · Dementia (16) · Pathological Conditions, Signs and Symptoms (8) · Pathologic Processes (6) · Behavior (4) · Neurologic Manifestations (4) · Signs and Symptoms (4) · Immune System Diseases (3)
Exercise (2) · Physical Examination (2) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (1) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (1) · Aromatherapy (1) · Cognitive Remediation (1) · Control Groups (1) · Dimethyl Fumarate (1) · Indigo Carmine (1) · Methylene Blue (1) · Phenazopyridine (1) · Positron-Emission Tomography (1) · Speech Therapy (1) · Transcranial Magnetic Stimulation (1)
University of California, San Francisco (3) · Braingaze (2) · Chang Gung Memorial Hospital (2) · Johns Hopkins University (2) · QuantalX Neuroscience (2) · University of Illinois at Chicago (2) · iPACES LLC (2) · Accexible (1) · Alexandra Hospital (1) · Altoida (1) · Antalya Training and Research Hospital (1) · Aristotle University Of Thessaloniki (1) · Beni-Suef University (1) · Centre Hospitalier Universitaire de Nice (1) · China Medical University, China (1)
United States (21) · China (6) · Italy (4) · Canada (2) · Israel (2) · Spain (2) · Taiwan (2) · Argentina (1) · Belgium (1) · Colombia (1) · Egypt (1) · France (1) · Greece (1) · Japan (1) · Poland (1)
Cay Anderson-Hanley, PhD (3) · David Ziegler, PhD (2) · Kyrana Tsapkini, PhD (2) · Adam Gazzaley, MD/PhD (1) · Andy Liu, MD (1) · Bob Gillen, PhD (1) · Cameron K Perrin, M.S. (1) · Christine Walsh, PhD (1) · Corinne Fischer, MD (1) · Cristina Polito (1) · David A Ziegler, PhD (1) · David Wolk, MD (1) · Donatienne Van Weehaeghe, MD PhD (1)
PMID 30200183, PMID 30233154, PMID 22261206, PMID 27337738, PMID 29780318, PMID 27369684, PMID 29424560, PMID 30174426, PMID 30258975, PMID 30607981, PMID 31063176, PMID 33031971, PMID 3338459, PMID 33858238, PMID 34612169, PMID 34875098, PMID 35002683, PMID 36448676, PMID 36564192, PMID 36755377, PMID 37287321, PMID 38144923, PMID 38414877, PMID 38942556, PMID 39096926, PMID 39168498, PMID 39713939, PMID 39713957, PMID 40001837, PMID 40129129, PMID 40917768, PMID 41440544, PMID 41518400, PMID 42831056
P41EB022544 (1), R01AG055005 (1), R01AG076153 (1), R01AG076668 (1), R01AG085561 (1), R01DC014475 (1), R01EB033582 (1), R41AG053120 (1), R61AG080528 (1), R61AG083503 (1)