4 completed, 4 unknown, 2 active not recruiting, 2 withdrawn. 8 Phase 1, 5 Phase 2, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 8 | Unknown 3, Active not recruiting 2, Completed 2, Recruiting 1 |
| Phase 2 | 5 | Unknown 2, Completed 1, Terminated 1, Withdrawn 1 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Malignant Glioma of Brain: new trials by email Literature Review of Malignant Glioma of Brain trials Research Report on Malignant Glioma of Brain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma Biological G207 - Neoplasms, High Grade Glioma | Phase 2 | Withdrawn | Pediatric Brain Tumor Consortium | 2025-09-01 | 2026-02-10 | |
| Photodynamic Diagnosis for Malignant Brain Glioma With 5-Aminolevulinic Acid（5-ALA） 5 Aminolevulinic Acid - 5-aminolevulinic Acid, Malignant Glioma of Brain | Phase 3 | Completed | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | 86 | 2024-06-19 | 2026-03-06 |
| Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma. Ad5-yCD/mutTKSR39rep-ADP adenovirus and fractionated stereotactic radiosurgery (fSRS) - Malignant Glioma of Brain, Astrocytoma | Phase 1 | Recruiting | Henry Ford Health System | 18 | 2022-11-29 | 2025-12-16 |
| Pilot Study Evaluating the Optimization of the ORBEYE Blue Light Filter During Fluorescence-Guided Resection of Gliomas 5ALA exoscopic fluorescence filter - Malignant Glioma of Brain | Phase 4 | Unknown | Northwell Health | 10 | 2021-05-13 | 2021-06-23 |
| LITT Palliative Treatment for Patients With Malignant Gliomas Palliative regimen consisting of LITT - Malignant Glioma of Brain, Glioblastoma | Withdrawn | Duke University | 2019-06-01 | 2019-02-27 | ||
| Study of Acetazolamide With Temozolomide in Adults With Newly Diagnosed or Recurrent Malignant Glioma Acetazolamide, Temozolomide - Malignant Glioma of Brain | Phase 1 | Active not recruiting | University of Chicago | 10 | 2018-10-03 | 2026-06-05 |
| Personalized Chimeric Antigen Receptor T Cell Immunotherapy for Patients With Recurrent Malignant Gliomas chimeric antigen receptor T cells - Glioma, Malignant Glioma of Brain | Phase 1 | Unknown | Xuanwu Hospital, Beijing | 100 | 2018-03-02 | 2021-06-15 |
| A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG) ribociclib, Everolimus - Diffuse Intrinsic Pontine Glioma, Malignant Glioma of Brain | Phase 1 | Completed | Children's Hospital Medical Center, Cincinnati | 19 | 2017-11-14 | 2023-01-13 |
| A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2 rQNestin, Cyclophosphamide, Stereotactic biopsy - Malignant Glioma of Brain, Astrocytoma | Phase 1 | Active not recruiting | Dana-Farber Cancer Institute | 62 | 2017-07-18 | 2026-03-04 |
| CAR-pNK Cell Immunotherapy in MUC1 Positive Relapsed or Refractory Solid Tumor anti-MUC1 CAR-pNK cells - Hepatocellular Carcinoma, Non-small Cell Lung Cancer | Phase 1 / Phase 2 | Unknown | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | 10 | 2016-07-01 | 2016-12-06 |
| CAR-T Cell Immunotherapy in MUC1 Positive Solid Tumor anti-MUC1 CAR-T cells - Malignant Glioma of Brain, Colorectal Carcinoma | Phase 1 / Phase 2 | Unknown | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | 20 | 2015-11-01 | 2016-12-06 |
| Pilot Immunotherapy Trial for Recurrent Malignant Gliomas IGF-1R/AS ODN, biodiffusion chamber - Malignant Glioma of Brain | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 13 | 2012-02-09 | 2025-05-02 |
| Panitumumab and Irinotecan for Malignant Gliomas Irinotecan, Panitumumab - Malignant Glioma of Brain | Phase 2 | Terminated | Annick Desjardins | 16 | 2010-02-01 | 2013-09-04 |
| ADV-TK Improves Outcome of Recurrent High-Grade Glioma ADV-TK/GCV, Surgery, systemic chemotherapy - Malignant Glioma of Brain, Glioblastoma | Phase 2 | Completed | Huazhong University of Science and Technology | 47 | 2008-01-01 | 2013-06-25 |
Glioblastoma (7) · Glioma (6) · Brain Neoplasms (4) · Astrocytoma (3) · Colorectal Neoplasms (2) · Stomach Neoplasms (2) · Carcinoma, Hepatocellular (1) · Carcinoma, Non-Small-Cell Lung (1) · Diffuse Intrinsic Pontine Glioma (1) · Disease (1) · Ependymoma (1) · Ganglioglioma (1) · Gliosarcoma (1) · Herpes Simplex (1) · Neoplasms (1)
Neoplasms (10) · Neoplasms by Histologic Type (9) · Neoplasms, Glandular and Epithelial (9) · Neoplasms, Germ Cell and Embryonal (8) · Neoplasms, Nerve Tissue (8) · Neoplasms, Neuroepithelial (8) · Neuroectodermal Tumors (8) · Neoplasms by Site (7) · Brain Diseases (5) · Central Nervous System Diseases (5) · Central Nervous System Neoplasms (5) · Nervous System Diseases (5) · Nervous System Neoplasms (5) · Astrocytoma (4) · Colonic Diseases (2)
Acetazolamide (1) · Aminolevulinic Acid (1) · Cyclophosphamide (1) · Everolimus (1) · Immunotherapy, Adoptive (1) · Irinotecan (1) · Neoadjuvant Therapy (1) · Panitumumab (1) · Sensitivity and Specificity (1) · Surgical Procedures, Operative (1) · Temozolomide (1) · ribociclib (1)
PersonGen BioTherapeutics (Suzhou) Co., Ltd. (2) · Annick Desjardins (1) · Children's Hospital Medical Center, Cincinnati (1) · Dana-Farber Cancer Institute (1) · Duke University (1) · Henry Ford Health System (1) · Huazhong University of Science and Technology (1) · Northwell Health (1) · Pediatric Brain Tumor Consortium (1) · Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · University of Chicago (1) · Xuanwu Hospital, Beijing (1)
United States (9) · China (5)
Lin Yang, Ph.D. (2) · Annick Desjardins, MD, FRCPC (1) · Bakhtiar Yamini, MD (1) · David W Andrews, MD (1) · E. Antonio Chiocca, MD, PhD (1) · Gregory Friedman, MD (1) · Ma Ding, M.D. (1) · Peter S Fecci, MD, PhD (1) · Tobias Walbert, MD, PhD (1)
PMID 26716896, PMID 28054442, PMID 32373649, PMID 34235085, PMID 35022322, PMID 37853118, PMID 38853689, PMID 41121171, PMID 41679299
UM1CA081457 (1)