3 unknown, 2 active not recruiting, 2 completed, 1 recruiting. 8 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 8 | Unknown 3, Active not recruiting 2, Completed 2, Recruiting 1 |
| Phase 2 | 2 | Unknown 2 |
Follow Malignant Glioma of Brain: new trials by email Literature Review of Malignant Glioma of Brain trials Research Report on Malignant Glioma of Brain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma. Ad5-yCD/mutTKSR39rep-ADP adenovirus and fractionated stereotactic radiosurgery (fSRS) - Malignant Glioma of Brain, Astrocytoma | Phase 1 | Recruiting | Henry Ford Health System | 18 | 2022-11-29 | 2025-12-16 |
| Study of Acetazolamide With Temozolomide in Adults With Newly Diagnosed or Recurrent Malignant Glioma Acetazolamide, Temozolomide - Malignant Glioma of Brain | Phase 1 | Active not recruiting | University of Chicago | 10 | 2018-10-03 | 2026-06-05 |
| Personalized Chimeric Antigen Receptor T Cell Immunotherapy for Patients With Recurrent Malignant Gliomas chimeric antigen receptor T cells - Glioma, Malignant Glioma of Brain | Phase 1 | Unknown | Xuanwu Hospital, Beijing | 100 | 2018-03-02 | 2021-06-15 |
| A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG) ribociclib, Everolimus - Diffuse Intrinsic Pontine Glioma, Malignant Glioma of Brain | Phase 1 | Completed | Children's Hospital Medical Center, Cincinnati | 19 | 2017-11-14 | 2023-01-13 |
| A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2 rQNestin, Cyclophosphamide, Stereotactic biopsy - Malignant Glioma of Brain, Astrocytoma | Phase 1 | Active not recruiting | Dana-Farber Cancer Institute | 62 | 2017-07-18 | 2026-03-04 |
| CAR-pNK Cell Immunotherapy in MUC1 Positive Relapsed or Refractory Solid Tumor anti-MUC1 CAR-pNK cells - Hepatocellular Carcinoma, Non-small Cell Lung Cancer | Phase 1 / Phase 2 | Unknown | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | 10 | 2016-07-01 | 2016-12-06 |
| CAR-T Cell Immunotherapy in MUC1 Positive Solid Tumor anti-MUC1 CAR-T cells - Malignant Glioma of Brain, Colorectal Carcinoma | Phase 1 / Phase 2 | Unknown | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | 20 | 2015-11-01 | 2016-12-06 |
| Pilot Immunotherapy Trial for Recurrent Malignant Gliomas IGF-1R/AS ODN, biodiffusion chamber - Malignant Glioma of Brain | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 13 | 2012-02-09 | 2025-05-02 |
Glioma (4) · Astrocytoma (3) · Brain Neoplasms (3) · Glioblastoma (3) · Colorectal Neoplasms (2) · Stomach Neoplasms (2) · Carcinoma, Hepatocellular (1) · Carcinoma, Non-Small-Cell Lung (1) · Diffuse Intrinsic Pontine Glioma (1) · Disease (1) · Ependymoma (1) · Ganglioglioma (1) · Oligodendroglioma (1) · Pancreatic Neoplasms (1) · Recurrence (1)
Neoplasms (7) · Neoplasms by Site (6) · Neoplasms by Histologic Type (5) · Neoplasms, Glandular and Epithelial (5) · Brain Diseases (4) · Central Nervous System Diseases (4) · Central Nervous System Neoplasms (4) · Neoplasms, Germ Cell and Embryonal (4) · Neoplasms, Nerve Tissue (4) · Neoplasms, Neuroepithelial (4) · Nervous System Diseases (4) · Nervous System Neoplasms (4) · Neuroectodermal Tumors (4) · Colonic Diseases (2) · Digestive System Diseases (2)
Acetazolamide (1) · Cyclophosphamide (1) · Everolimus (1) · Immunotherapy, Adoptive (1) · Sensitivity and Specificity (1) · Temozolomide (1) · ribociclib (1)
PersonGen BioTherapeutics (Suzhou) Co., Ltd. (2) · Children's Hospital Medical Center, Cincinnati (1) · Dana-Farber Cancer Institute (1) · Henry Ford Health System (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · University of Chicago (1) · Xuanwu Hospital, Beijing (1)
United States (5) · China (3)
Lin Yang, Ph.D. (2) · Bakhtiar Yamini, MD (1) · David W Andrews, MD (1) · E. Antonio Chiocca, MD, PhD (1) · Tobias Walbert, MD, PhD (1)
PMID 28054442, PMID 32373649, PMID 34235085, PMID 35022322, PMID 37853118, PMID 38853689, PMID 41121171, PMID 41679299