7 completed, 4 recruiting, 4 terminated, 1 not yet recruiting. 7 Not applicable, 5 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Recruiting 2, Terminated 2, Completed 1, Not yet recruiting 1, Withdrawn 1 |
| Phase 1 | 5 | Completed 4, Recruiting 1 |
| Phase 2 | 3 | Completed 2, Terminated 1 |
Follow Malignant Brain Tumor: new trials by email Literature Review of Malignant Brain Tumor trials Research Report on Malignant Brain Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Listen Aphasia Pilot Study LISTEN (AI-based AAC smartphone app) - Aphasia, Malignant Brain Tumor | Not applicable | Not yet recruiting | Dana-Farber Cancer Institute | 80 | 2027-01-01 | 2026-07-28 |
| Supportive Psychoeducational Intervention for Patients With Brain Tumors (Acceptance and Commitment Therapy-based Supportive Intervention for Patients With Central Nervous System Tumors) Psychosocial intervention, Usual supportive care - Malignant Brain Tumor, Glioma | Not applicable | Recruiting | Massachusetts General Hospital | 100 | 2025-05-15 | 2026-10-07 |
| Evaluation of the Contribution of NODDI Protocol Tractography in Brain Tumor Surgery NODDI TRACT - Malignant Brain Tumor | Not applicable | Withdrawn | GCS Ramsay Santé pour l'Enseignement et la Recherche | 2024-09-01 | 2025-12-03 | |
| NeuroPathways Intervention for Brain Tumor Patients Information and Support Intervention, Usual supportive care - Malignant Brain Tumor, Glioma | Not applicable | Recruiting | Massachusetts General Hospital | 50 | 2023-11-07 | 2026-10-07 |
| Safety Study of the Repeated Opening of the Blood-brain Barrier With the SonoCloud® Device to Treat Malignant Brain Tumors in Pediatric Patients SonoCloud® (9 transducers) - Malignant Brain Tumor, Malignant Glioma | Phase 1 | Recruiting | Assistance Publique - Hôpitaux de Paris | 24 | 2023-02-06 | 2026-05-06 |
| Evaluation of cCeLL-Ex Vivo Confocal Microscopy for Real-time Brain Tumor Diagnosis cCeLL - Ex vivo - Benign Brain Tumor, Malignant Brain Tumor | Not applicable | Terminated | VPIX Medical | 285 | 2023-01-01 | 2025-12-15 |
| Clinical Applicantion of Multi-Tracer PET/MR Imaging in Neurological Disorders/Disease PET/MR - Alzheimer Disease, Parkinson Disease | Recruiting | Xuanwu Hospital, Beijing | 2300 | 2022-10-01 | 2025-07-16 | |
| Magrolimab in Children and Adults With Recurrent or Progressive Malignant Brain Tumors Magrolimab - Brain Cancer, Malignant Brain Tumor | Phase 1 | Completed | University of California, San Francisco | 13 | 2022-04-22 | 2025-07-09 |
| Psychological Intervention For Brain Tumor Caregivers Psychosocial Intervention Group, Usual Care Group - Malignant Glioma, Anxiety | Not applicable | Completed | Massachusetts General Hospital | 120 | 2019-10-09 | 2024-12-05 |
| National Wide Cross-sectional Study in Paediatric Central Nervous System Tumours in China -- the CNOG-MC001 Registry Tumour resection - Tumors, Central Nervous System, Pediatric Brain Tumor | Completed | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 4303 | 2018-10-27 | 2021-09-08 | |
| Pilot Study of Cabozantinib for Recurrent or Progressive Central Nervous System Tumors in Children Cabozantinib - Glioblastoma Multiforme, Anaplastic Astrocytoma | Phase 2 | Terminated | Indiana University | 4 | 2017-05-18 | 2022-10-06 |
| Combination Adenovirus + Pembrolizumab to Trigger Immune Virus Effects DNX-2401, pembrolizumab - Brain Cancer, Brain Neoplasm | Phase 2 | Completed | DNAtrix, Inc. | 49 | 2016-10-06 | 2021-07-15 |
| Rates DMBT1 ( Glycoprotein) in Sputum of CF Patients With Pseudomonas Aeruginosa Malignant Brain Tumor | Terminated | University Hospital, Lille | 1 | 2016-03-23 | 2022-10-18 | |
| Study of the IDO Pathway Inhibitor, Indoximod, and Temozolomide for Pediatric Patients With Progressive Primary Malignant Brain Tumors Indoximod, Temozolomide, Conformal Radiation - Glioblastoma Multiforme, Glioma | Phase 1 | Completed | NewLink Genetics Corporation | 81 | 2015-10-01 | 2020-06-04 |
| Study of IDO Inhibitor and Temozolomide for Adult Patients With Primary Malignant Brain Tumors Indoximod, Temozolomide, Bevacizumab - Glioblastoma Multiforme, Glioma | Phase 1 / Phase 2 | Completed | NewLink Genetics Corporation | 160 | 2014-03-01 | 2024-03-27 |
| A Computer-Based Intervention for Distance Caregivers of Parents With Advanced Cancer Usual care, computer-assisted intervention, Distress Thermometer - Stage IV Lung Cancer, Malignant Brain Tumor | Not applicable | Terminated | Case Comprehensive Cancer Center | 7 | 2011-11-01 | 2015-02-18 |
| Safety Study of Tarceva in Children With Refractory and Relapsed Malignant Brain Tumors and Newly Diagnosed Brain Stem Glioma Tarceva (Erlotinib Hydrochloride) - Malignant Brain Tumor, Brain Stem Glioma, | Phase 1 | Completed | Gustave Roussy, Cancer Campus, Grand Paris | 48 | 2005-06-01 | 2009-08-07 |
Brain Neoplasms (17) · Glioma (8) · Glioblastoma (4) · Gliosarcoma (3) · Alzheimer Disease (1) · Anxiety Disorders (1) · Aphasia (1) · Astrocytoma (1) · Caregiver Burden (1) · Central Nervous System Neoplasms (1) · Diffuse Intrinsic Pontine Glioma (1) · Disease (1) · Ependymoma (1) · Epilepsy (1) · Lung Neoplasms (1)
Brain Diseases (17) · Central Nervous System Diseases (17) · Neoplasms by Site (17) · Nervous System Neoplasms (17) · Central Nervous System Neoplasms (16) · Neoplasms (16) · Nervous System Diseases (16) · Neoplasms by Histologic Type (8) · Neoplasms, Glandular and Epithelial (8) · Neoplasms, Germ Cell and Embryonal (7) · Neoplasms, Nerve Tissue (7) · Neoplasms, Neuroepithelial (7) · Neuroectodermal Tumors (7) · Astrocytoma (3) · Mental Disorders (2)
1-methyltryptophan (2) · Temozolomide (2) · Antibodies, Monoclonal (1) · Auscultation (1) · Bevacizumab (1) · Cyclophosphamide (1) · Erlotinib Hydrochloride (1) · Etoposide (1) · Oncolytic Virotherapy (1) · Psychosocial Intervention (1) · Radiosurgery (1) · Spermine Synthase (1) · cabozantinib (1) · magrolimab (1) · pembrolizumab (1)
Massachusetts General Hospital (3) · NewLink Genetics Corporation (2) · Assistance Publique - Hôpitaux de Paris (1) · Case Comprehensive Cancer Center (1) · DNAtrix, Inc. (1) · Dana-Farber Cancer Institute (1) · GCS Ramsay Santé pour l'Enseignement et la Recherche (1) · Gustave Roussy, Cancer Campus, Grand Paris (1) · Indiana University (1) · University Hospital, Lille (1) · University of California, San Francisco (1) · VPIX Medical (1) · Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (1) · Xuanwu Hospital, Beijing (1)
United States (10) · France (4) · Canada (2) · China (2) · South Korea (1)
Deborah A Forst, MD (2) · Deborah Forst, MD (1) · Dominique Turck, MD, PhD (1) · Gene Kennedy, MD (1) · Howard Colman, MD PhD FAAN (1) · Jie Lu, Phd (1) · Jie MA, M.D., Ph.D. (1) · John Rhee, MD, MPH (1) · Nancy Gady, BS (1) · Nicholas Whipple, MD, MPH (1) · Sabine Mueller, MD, PhD (1) · Samuel Cheshier, MD, PhD (1) · Sara Douglas, RN, PhD (1) · Scott Coven, DO (1)
PMID 21653689, PMID 37188783, PMID 37678946, PMID 37715730, PMID 39284103
K08CA279644 (1), P30CA043703 (1)