5 unknown, 3 completed, 2 not yet recruiting, 2 recruiting. 6 Phase 2, 5 Early Phase 1, 3 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 2, Not yet recruiting 2, Recruiting 1, Terminated 1 |
| Early Phase 1 | 5 | Unknown 5 |
| Phase 1 | 3 | Completed 2, Recruiting 1 |
| Phase 3 | 1 | Terminated 1 |
Follow Oncolytic Virotherapy: new trials by email Literature Review of Oncolytic Virotherapy trials Research Report on Oncolytic Virotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oncolytic Virus Plus PD-1 Inhibitor to Patients With Advanced Pancreatic Cancer H101, Camrelizumab - Pancreatic Cancer | Phase 2 | Not yet recruiting | Fudan University | 30 | 2026-12-01 | 2025-08-07 |
| Oncolytic Virus (H101) + SBRT + Chemotherapy + Targeted Therapy + Immunotherapy for Unresectable CRLM SBRT, PD-1 Antibody, H101 - CRC, Liver Metastasis Colon Cancer | Phase 2 | Not yet recruiting | Jun Huang | 114 | 2026-06-01 | 2026-04-28 |
| Clinical Study of Oncolytic Virus in Glioblastoma oncolytic virus - Glioblastoma (GBM) | Phase 1 / Phase 2 | Recruiting | Mianyang Central Hospital | 20 | 2023-11-02 | 2025-12-19 |
| A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Advanced Solid Tumors Recombinant oncolytic herpes simplex virus type 1 (R130) - Sarcoma, Carcinoma | Early Phase 1 | Unknown | Shanghai Yunying Medical Technology | 20 | 2023-06-24 | 2023-07-27 |
| A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Advanced Solid Tumors Recombinant oncolytic herpes simplex virus type 1 (R130) - Lung Cancer, Bronchial Cancer | Early Phase 1 | Unknown | Shanghai Yunying Medical Technology | 24 | 2023-03-30 | 2023-06-02 |
| A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Relapsed/Refractory Head and Neck Cancer Recombinant oncolytic herpes simplex virus type 1 (R130) - Head and Neck Cancer, Esophageal Cancer | Early Phase 1 | Unknown | Shanghai Yunying Medical Technology | 9 | 2023-03-27 | 2023-04-26 |
| A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Advanced Solid Tumors Recombinant oncolytic herpes simplex virus type 1 (R130) - Sarcoma, Carcinoma | Early Phase 1 | Unknown | Shanghai Yunying Medical Technology | 20 | 2023-03-02 | 2023-05-16 |
| The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302) Re-resection, Temozolomide, Lomustine - Glioblastoma, Glioblastoma Multiforme | Recruiting | Jasper Gerritsen | 464 | 2023-01-01 | 2024-02-28 | |
| Safety and Efficacy of Recombinant Oncolytic Adenovirus L-IFN Injection in Relapsed/Refractory Solid Tumors Clinical Study Recombinant L-IFN adenovirus injection - Head and Neck Cancer, Melanoma | Early Phase 1 | Unknown | Shanghai Fengxian District Central Hospital | 28 | 2021-11-30 | 2022-02-01 |
| Clinical Study on the Safety and Efficacy of Novel Oncolytic Virus in the Treatment of Recurrent Malignant Glioma ON-01, ONF - Glioblastoma Multiforme, Gliomas, Malignant | Phase 1 / Phase 2 | Completed | Beijing Neurosurgical Institute | 38 | 2018-08-01 | 2024-08-20 |
| Combination Adenovirus + Pembrolizumab to Trigger Immune Virus Effects DNX-2401, pembrolizumab - Brain Cancer, Brain Neoplasm | Phase 2 | Completed | DNAtrix, Inc. | 49 | 2016-10-06 | 2021-07-15 |
| DNX-2401 With Interferon Gamma (IFN-γ) for Recurrent Glioblastoma or Gliosarcoma Brain Tumors Single intratumoral injection of DNX-2401, Interferon-gamma - Glioblastoma or Gliosarcoma | Phase 1 | Completed | DNAtrix, Inc. | 37 | 2014-09-11 | 2018-07-16 |
| Efficacy Study of Recombinant Adenovirus for Non Muscle Invasive Bladder Cancer CG0070 Adenovirus Vector, Control Arm: Quadruple Choice - Transitional Cell Carcinoma, Bladder Cancer | Phase 2 / Phase 3 | Terminated | CG Oncology, Inc. | 22 | 2014-03-01 | 2021-04-14 |
Glioblastoma (5) · Breast Neoplasms (4) · Head and Neck Neoplasms (4) · Lung Neoplasms (4) · Brain Neoplasms (3) · Glioma (3) · Pancreatic Neoplasms (3) · Sarcoma (3) · Carcinoma (2) · Colorectal Neoplasms (2) · Gliosarcoma (2) · Liver Neoplasms (2) · Melanoma (2) · Neoplasms (2) · Neoplasms, Nerve Tissue (2)
Shanghai Yunying Medical Technology (4) · DNAtrix, Inc. (2) · Beijing Neurosurgical Institute (1) · CG Oncology, Inc. (1) · Fudan University (1) · Jasper Gerritsen (1) · Jun Huang (1) · Mianyang Central Hospital (1) · Shanghai Fengxian District Central Hospital (1)
China (8) · United States (4) · Belgium (1) · Canada (1) · Germany (1) · Netherlands (1) · Switzerland (1)
Alex W Yeung, MBBS (1) · Frederick Lang, MD (1) · Haitao Wu, Phd (1) · Jasper Gerritsen, MD PhD (1) · Jun Huang (1) · Karen Fink, MD, PhD (1) · Nam Tran, MD, PhD (1) · Nancy Gady, BS (1) · Rong Zhang, MD (1) · Vinay Puduvalli, MBBS (1)