68 completed, 26 unknown, 15 recruiting, 9 not yet recruiting. 61 Not applicable, 12 Phase 2, 10 Phase 3, 6 Phase 4, 3 Early Phase 1.
Follow Male Infertility: new trials by email Literature Review of Male Infertility trials Research Report on Male Infertility
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparative Efficacy of Antioxidants Alone Versus Combined Therapy With SERMs or FSH in Normogonadotropic Idiopathic OAT Patients: A Randomized Controlled Trial Antioxidants + Clomiphene Citrate, Antioxidants + FSH, Antioxidants Alone - Oligoasthenoteratozoospermia, Male Infertility | Phase 4 | Not yet recruiting | Hamad Medical Corporation | 360 | 2026-10-15 | 2026-10-07 |
| Nordic Sperm DNA Study Lifestyle change - Male Infertility, Sperm DNA Fragmentation | Not applicable | Not yet recruiting | Regionshospitalet Viborg, Skive | 800 | 2026-09-01 | 2026-08-21 |
| Effect of Varicocelectomy on Spermatogenic Cell Count and Semen Parameters Subinguinal Microsurgical Varicocelectomy - Varicocele, Male Infertility | Not applicable | Not yet recruiting | Assiut University | 40 | 2026-08-01 | 2026-07-06 |
| Effectiveness of Live Motile Sperm Sorting Device on IVF Outcomes in Advanced Paternal Age LensHooke® CA0 sperm sorting device, Density Gradient Centrifugation - Male Infertility, Advanced Paternal Age | Not applicable | Recruiting | Vietnam Military Medical University | 378 | 2026-07-15 | 2026-08-20 |
| Assessing the Correlation Between Phospholipase C Zeta Measurements and Semen Parameters No Intervention: Observational Cohort - Male Infertility, Male Subfertility | Recruiting | Fakih IVF Fertility Center | 200 | 2026-07-01 | 2026-07-06 | |
| Selective Extended Venous Stripping Versus Standard Microsurgical Varicocelectomy for Varicocele-Related Male Infertility Microsurgical Subinguinal Varicocelectomy With Selective Extended Venous Stripping, Standard Microsurgical Subinguinal Varicocelectomy With Conventional Vein Ligation - Varicocele, Male Infertility | Not applicable | Not yet recruiting | Benha University | 160 | 2026-06-15 | 2026-05-22 |
| Single Infrapubic Versus Bilateral Subinguinal Microsurgical Varicocelectomy Single Infrapubic Microsurgical Bilateral Varicocelectomy, Bilateral Subinguinal Microsurgical Varicocelectomy - Bilateral Varicocele, Male Infertility | Not applicable | Recruiting | Beni-Suef University | 40 | 2026-06-08 | 2026-06-16 |
| Intratesticular Artery Resistive Index Changes After Varicocelectomy Microscopic Sub-inguinal Varicocelectomy - Varicocele, Male Infertility | Not applicable | Not yet recruiting | Assiut University | 40 | 2026-05-01 | 2026-04-08 |
| Comparison of Two Types of Calcium (Ca²⁺) Ionophore Treatments for Oocyte Activation in Cases of Suboptimal Fertilization Potential Group 1: Oocyte Activation (OA) CultActive, Group 2: Oocyte Activation (OA) Ionomycin, Group 3: Control - ICSI, Testicular Sperm Extraction in Azoospermic Patients | Not applicable | Not yet recruiting | ART Fertility Clinics LLC | 20 | 2026-04-30 | 2026-05-11 |
| Development of an AI Platform for the Analysis of Sperm and Prediction of Their Clinical Potential Swim-up, Density gradient centrifugation, HyperSperm - Infertility (IVF Patients), ICSI | Recruiting | Fecundis Lab SL | 500 | 2026-03-18 | 2026-06-12 | |
| YO® Smartphone Home Sperm Test Versus Manual Semen Analysis in Egyptian Men YO® Home Sperm Test, Manual Semen Analysis (WHO 6th Edition) - Semen Analysis, Male Infertility | Not applicable | Active not recruiting | Armed Forces College of Medicine, Cairo, Egypt | 20 | 2026-03-10 | 2026-10-19 |
| Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative Stress Standardized Mediterranean Diet, Gazpacho - Male Infertility, Oxidative Stress | Not applicable | Recruiting | Ginefiv | 80 | 2026-03-02 | 2026-03-13 |
| Royal Jelly Supplementation in Unexplained Male Infertility Lyophilized Royal Jelly, Placebo - Unexplained Infertility, Male Infertility | Not applicable | Recruiting | Medipol University | 80 | 2026-02-01 | 2026-08-19 |
| Warfarin Effects on Male Fertility After Cardiac Surgery Semen analysis, sperm DNA fragmentation and hormonal evaluation - Male Infertility, Heart Valve Disease | Not yet recruiting | Città di Lecce Hospital, GVM Care & Research | 90 | 2026-02-01 | 2026-01-09 | |
| To Investigate if the Harvester® Improves Sperm Motility and Blastocyst Utilization (the Percent of Fertilized Eggs That Develop to the Point That They Are Able to be Transferred) in IVF Cycles. microfludics semen processing device - Infertility, Male Infertility | Not applicable | Active not recruiting | MotilityCount aps | 1600 | 2026-01-20 | 2026-01-27 |
| Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men L-carnitine - Oligoasthenozoospermia, Male Infertility | Phase 3 | Active not recruiting | South Valley University | 50 | 2026-01-01 | 2026-02-11 |
| Identifying Candidates for Limited Dissection at Microdissection TESE. Non Obstructive Azoospermia, Cryptozoospermia | Completed | Clinique Ovo | 248 | 2025-12-15 | 2026-02-27 | |
| A Clinical Evaluation of Semen Quality Using the MiOXSYS™ System 2.0 Diagnostic - Male Infertility | Withdrawn | Aytu BioPharma, Inc. | 2025-09-01 | 2024-03-08 | ||
| Effect of Graminex on Infertility Related to Male Accessory Glands Inflammation Deprox_HP, Peacist - Male Infertility, Prostatitis | Not applicable | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 50 | 2025-09-01 | 2025-08-14 |
| The Efficiency of a New Sperm-Wash Device for Intrauterine Insemination in Couples With Infertility LensHooke CA0, Density Gradient Centrifugation (DGC) - Infertility, Male Infertility | Not applicable | Recruiting | Chung Shan Medical University | 120 | 2025-04-24 | 2025-05-08 |
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Infertility, Male (134) · Infertility (19) · Oligospermia (12) · Asthenozoospermia (6) · Teratozoospermia (6) · Varicocele (6) · Azoospermia (5) · Infertility, Female (4) · Eunuchism (3) · Aneuploidy (2) · Azoospermia, Nonobstructive (2) · Hypogonadism (2) · Inflammation (2) · Obesity (2) · Weight Loss (2)
Genital Diseases (134) · Male Urogenital Diseases (134) · Urogenital Diseases (134) · Genital Diseases, Male (133) · Infertility (115) · Endocrine System Diseases (10) · Gonadal Disorders (10) · Female Urogenital Diseases and Pregnancy Complications (8) · Cardiovascular Diseases (7) · Female Urogenital Diseases (7) · Pathological Conditions, Signs and Symptoms (6) · Vascular Diseases (6) · Genital Diseases, Female (4) · Hypogonadism (4) · Pathologic Processes (4)
Centrifugation, Density Gradient (6) · Blood Specimen Collection (4) · Sperm Injections, Intracytoplasmic (4) · Clomiphene (3) · Semen Analysis (3) · Asian ginseng (2) · Carnitine (2) · Chorionic Gonadotropin (2) · Sugars (2) · Antioxidants (1) · Ascorbic Acid (1) · Calcifediol (1) · Calcitriol (1) · Calcium (1) · Caloric Restriction (1)
IRCCS San Raffaele (5) · Weill Medical College of Cornell University (5) · Assiut University (4) · Assistance Publique - Hôpitaux de Paris (3) · South Valley University (3) · Benha University (2) · Catalysis SL (2) · Fecundis Lab SL (2) · Ganin Fertility Center (2) · HaEmek Medical Center, Israel (2) · Hillel Yaffe Medical Center (2) · National Institute of Environmental Health Sciences (NIEHS) (2) · Pusan National University Hospital (2) · Radboud University Medical Center (2) · Reproductive Medicine Associates of New Jersey (2)
United States (28) · Egypt (13) · Italy (11) · Spain (9) · France (7) · Israel (5) · Turkey (Türkiye) (5) · Canada (4) · Vietnam (4) · Taiwan (3) · Brazil (2) · China (2) · Iran (2) · Iraq (2) · Netherlands (2)
Andrea Salonia, MD (3) · Didi D Braat, Prof. MD PhD (2) · Eman Hasanen (2) · Jan AM Kremer, MD, PhD (2) · John K Amory, MD, MPH (2) · Mariona Rius Mas, PhD (2) · Peter N Schlegel, M.D. (2) · Peter N Schlegel, MD (2) · Richard PT Grol, Prof. PhD (2) · Susan H Benoff, PhD (2) · Ahmad F Al-Sherbiny, MD, PhD (1) · Ahmed Al-Shahed, MD, PhD (1) · Ahmed Kadeh, MSc (1) · Ahmed T Alahmar (1) · Ahmed T Alahmar, MBChB, MSC (1)
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P50HD076210 (1), P50HD096723 (1)