12 completed. 12 Phase 2, 7 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 12 | Completed 12 |
| Phase 1 | 7 | Completed 7 |
Follow Lymphopenia: new trials by email Literature Review of Lymphopenia trials Research Report on Lymphopenia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation Thiotepa--single daily dose, Thiotepa--escalated dose - Bone Marrow Failure Syndrome, Thalassemia | Phase 1 / Phase 2 | Completed | University of Florida | 6 | 2018-06-15 | 2023-09-15 |
| Immune Disorder HSCT Protocol Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan - Immune Deficiency Disorders, Severe Combined Immunodeficiency | Phase 2 | Completed | Washington University School of Medicine | 28 | 2013-04-29 | 2026-10-27 |
| Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies fludarabine phosphate, melphalan, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Roswell Park Cancer Institute | 94 | 2012-02-28 | 2019-09-24 |
| Pilot and Feasibility Study of Hematopoietic Stem Cell Gene Transfer for the Wiskott-Aldrich Syndrome Retrovirus-mediated gene transfer - Wiskott-Aldrich Syndrome | Phase 1 / Phase 2 | Completed | David Williams | 5 | 2011-07-01 | 2025-08-14 |
| Study Evaluating Impact of IL-7 on CD4 Lymphopenia, Risks of Severe Haematological Toxicity and Tumor Progression in Metastatic Breast Cancer Patients placebo, interleukin 7 - Metastatic Breast Cancer | Phase 2 | Completed | Centre Leon Berard | 24 | 2011-06-01 | 2015-02-09 |
| Gene Therapy for WAS Autologous CD34 positive cells transduced with a lentiviral vector containing human WAS gene - Wiskott-Aldrich Syndrome | Phase 1 / Phase 2 | Completed | Genethon | 5 | 2011-05-01 | 2018-05-22 |
| Gene Therapy for Wiskott-Aldrich Syndrome (WAS) Autologous CD34 positive cells transduced with a lentiviral vector containing human WAS gene - Wiskott-Aldrich Syndrome | Phase 1 / Phase 2 | Completed | Genethon | 6 | 2011-03-01 | 2021-06-03 |
| Gene Therapy for Wiskott-Aldrich Syndrome TLT003 - Wiskott-Aldrich Syndrome (WAS) | Phase 1 / Phase 2 | Completed | Fondazione Telethon | 8 | 2010-04-20 | 2025-04-04 |
| Treosulfan and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Nonmalignant Inherited Disorders Allogeneic Bone Marrow Transplantation, Anti-Thymocyte Globulin, Cyclosporine - Non-Neoplastic Hematologic and Lymphocytic Disorder | Phase 2 | Completed | Fred Hutchinson Cancer Center | 98 | 2009-07-31 | 2021-08-13 |
| Study of Drug to Reduce Thrombocytopenia in Patients Receiving Chemo for Ovarian, Fallopian Tube or Peritoneal Cancer TXA127, Placebo - Thrombocytopenia, Neutropenia | Phase 2 | Completed | Tarix Pharmaceuticals | 34 | 2008-10-01 | 2017-11-13 |
| Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells Hematopoietic stem cell transplantation - Sickle Cell Disease, Thalassemia | Phase 1 / Phase 2 | Completed | Children's Hospital Los Angeles | 25 | 2008-08-01 | 2016-06-23 |
| Study of Reduced Toxicity Myeloablative Conditioning Regimen for Wiskott-Aldrich Syndrome (WAS) Fludarabine, Busulfan, Thymoglobulin - Wiskott-Aldrich Syndrome | Phase 1 / Phase 2 | Completed | The Korean Society of Pediatric Hematology Oncology | 5 | 2007-02-01 | 2014-07-14 |
Wiskott-Aldrich Syndrome (10) · Anemia, Diamond-Blackfan (3) · Anemia, Sickle Cell (3) · Granulomatous Disease, Chronic (3) · Lymphohistiocytosis, Hemophagocytic (3) · Lymphoproliferative Disorders (3) · Primary Immunodeficiency Diseases (3) · Severe Combined Immunodeficiency (3) · Thalassemia (3) · Anemia (2) · Bone Marrow Failure Disorders (2) · Chediak-Higashi Syndrome (2) · Common Variable Immunodeficiency (2) · Congenital amegakaryocytic thrombocytopenia (2) · Hyper-IgM Immunodeficiency Syndrome (2)
Hematologic Diseases (12) · Hemic and Lymphatic Diseases (12) · Leukocyte Disorders (12) · Leukopenia (12) · Cytopenia (11) · Immune System Diseases (11) · Immunologic Deficiency Syndromes (11) · Blood Coagulation Disorders (10) · Blood Coagulation Disorders, Inherited (10) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (10) · Genetic Diseases, X-Linked (10) · Hemorrhagic Disorders (10) · Genetic Diseases, Inborn (9) · Primary Immunodeficiency Diseases (7)
Melphalan (2) · Methotrexate (2) · Mycophenolic Acid (2) · Peripheral Blood Stem Cell Transplantation (2) · Tacrolimus (2) · Whole-Body Irradiation (2) · fludarabine (2) · fludarabine phosphate (2) · merphos (2) · thymoglobulin (2) · Antilymphocyte Serum (1) · Busulfan (1) · Cord Blood Stem Cell Transplantation (1) · Cyclosporine (1) · Cyclosporins (1)
Genethon (2) · Centre Leon Berard (1) · Children's Hospital Los Angeles (1) · David Williams (1) · Fondazione Telethon (1) · Fred Hutchinson Cancer Center (1) · Roswell Park Cancer Institute (1) · Tarix Pharmaceuticals (1) · The Korean Society of Pediatric Hematology Oncology (1) · University of Florida (1) · Washington University School of Medicine (1)
United States (7) · France (2) · Italy (1) · South Korea (1) · United Kingdom (1)
Biljana Horn, MD (1) · George Chen (1) · Hisham Abdel-Azim, MD (1) · Hyo Seop Ahn, Ph. D (1) · Isabelle Ray Coquart (1) · Jennifer Whangbo, M.D. (1) · Lauri M. Burroughs (1)
PMID 35075289, PMID 10561360, PMID 10737767, PMID 12010786, PMID 12411295, PMID 12610500, PMID 12759326, PMID 12816983, PMID 14615453, PMID 15503313, PMID 15569976, PMID 15629410, PMID 15841203, PMID 15905493, PMID 16557261, PMID 16699374, PMID 17135638, PMID 17320482, PMID 18573906, PMID 19244125, PMID 19287090, PMID 19380868, PMID 19396174, PMID 19549917, PMID 19808962, PMID 19933849, PMID 22550117, PMID 28716862, PMID 30981783, PMID 31599480, PMID 37244942, PMID 37478401, PMID 38446574, PMID 42777242, PMID 8636781, PMID 9215626, PMID 9657738
2009 (2), P30CA015704 (1)