29 completed, 9 recruiting, 5 terminated, 4 active not recruiting. 14 Phase 2, 11 Phase 3, 10 Not applicable, 5 Phase 4, 3 Phase 1.
Follow Common Variable Immunodeficiency: new trials by email Literature Review of Common Variable Immunodeficiency trials Research Report on Common Variable Immunodeficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| IVIG Boya: Safety, Efficacy, and Pharmacokinetics Boya IVIG - Primary Immunodeficiency Disease | Phase 3 | Not yet recruiting | Azidus Brasil | 50 | 2026-09-01 | 2026-06-03 |
| Peripheral Helper T-cells in Common Variable ImmunoDeficiency blood sample - Common Variable Immunodeficiency | Not applicable | Recruiting | University Hospital, Bordeaux | 60 | 2026-07-09 | 2026-08-05 |
| Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD) Hematopoietic stem cell transplant (HSCT) - Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder | Phase 2 | Recruiting | Paul Szabolcs | 25 | 2026-05-04 | 2026-05-15 |
| Immunoglobulin for Hypogammaglobulinemia Due to Chimeric Antigen Receptor T Cell Therapy Immune Globulin Intravenous (Human), 10%, Immune Globulin Subcutaneous (Human), 20% Solution - Hypogammaglobulinemia, Acquired | Recruiting | University of Alberta | 30 | 2025-06-01 | 2026-09-24 | |
| Study of IgPro20 to Prevent Infection in People With Multiple Myeloma and Hypogammaglobulinemia IgPro20 - Multiple Myeloma, Hypogammaglobulinemia | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 100 | 2025-05-08 | 2026-10-05 |
| Leniolisib for Immune Dysregulation in CVID Leniolisib - Common Variable Immunodeficiency (CVID) | Phase 2 | Completed | Pharming Technologies B.V. | 27 | 2025-02-12 | 2026-09-18 |
| Usage of Spirometry in Managing IgG Therapy in CVID With Airway Disease Hizentra - Common Variable Immunodeficiency | Phase 4 | Recruiting | University of Alabama at Birmingham | 22 | 2024-01-15 | 2026-05-04 |
| Prediction of Portal Hypertension in Patients With CVID (CVID-pHT) Ultrasound including color doppler ultrasound - Non-Cirrhotic Portal Hypertension, Common Variable Immunodeficiency | Completed | University Hospital Freiburg | 250 | 2023-11-01 | 2026-05-01 | |
| Senolytics Treatment of Interstitial Lung Disease in Common Variable Immunodeficiency Fisetin, Placebo - Common Variable Immunodeficiency, Interstitial Lung Disease Due to Systemic Disease | Phase 2 | Active not recruiting | Avni Joshi | 20 | 2023-04-12 | 2026-06-30 |
| Bronchiectasis Prevalence in Patients With Primary Humoral Immunodefiency in Champagne-Ardenne Region, France Blood test, chest CT scan - Primary Immunodeficiency, Common Variable Immunodeficiency | Not applicable | Completed | CHU de Reims | 46 | 2022-11-28 | 2025-12-18 |
| Composition and Function of Gut Microbiota in Porto-sinusoidal Vascular Disease Associated With Variable Common Immunodeficiency Stool sample - Common Variable Immunodeficiency, Vascular Diseases | Unknown | Assistance Publique - Hôpitaux de Paris | 40 | 2022-07-01 | 2022-08-01 | |
| COVID-19 Vaccine Responses in PIDD Subjects X-linked Agammaglobulinemia, XLA | Active not recruiting | Duke University | 100 | 2021-09-30 | 2025-06-03 | |
| Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease Abatacept, Placebo - Interstitial Lung Disease, Common Variable Immunodeficiency | Phase 2 | Recruiting | Children's Hospital Medical Center, Cincinnati | 38 | 2021-07-14 | 2026-07-22 |
| Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity Busulfan test dose, Fludarabine, Busulfan - Lymphoproliferative Disorders, Autoimmune Lymphoproliferative | Phase 2 | Recruiting | National Cancer Institute (NCI) | 66 | 2020-09-22 | 2026-10-19 |
| Lymphocyte Immunophenotyping in Common Variable Immunodeficiency Common Variable Immunodeficiency, Granulomatous Disease | Completed | Barts & The London NHS Trust | 210 | 2020-09-01 | 2024-03-26 | |
| Improving the Diagnosis of Common Variable Immune Deficiency CVI - Common Variable Immunodeficiency | Completed | University of California, Los Angeles | 24 | 2019-05-01 | 2026-04-20 | |
| Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation e-ATG, Immunosuppression Only Conditioning, Reduced Intensity Conditioning - Lymphoproliferative Disorders, Autoimmune Lymphoproliferative | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 71 | 2018-09-04 | 2026-03-17 |
| Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation Thiotepa--single daily dose, Thiotepa--escalated dose - Bone Marrow Failure Syndrome, Thalassemia | Phase 1 / Phase 2 | Completed | University of Florida | 6 | 2018-06-15 | 2023-09-15 |
| A Study to Evaluate the Benefit of RUCONEST® in Subjects Who Experience ADRs Related to IVIG Infusions C1-esterase inhibitor [recombinant] (C1-INH-R) - CVI - Common Variable Immunodeficiency | Phase 4 | Completed | IMMUNOe Research Centers | 20 | 2018-06-13 | 2021-02-15 |
| Severe PID With Lymphoproliferation and Neutropenia FACS analyses, Target Sequencing by NGS ( Next-generation sequencing), Whole Exome Sequencing - Primary Immune-Deficiency (PID) Common Variable Immune Deficiency (CVID) | Not applicable | Completed | University Hospital, Strasbourg, France | 27 | 2018-03-13 | 2026-01-08 |
Showing 20 of 53. Sign in to see all of them.
Primary Immunodeficiency Diseases (19) · Bruton type agammaglobulinemia (11) · Agammaglobulinemia (9) · Hyper-IgM Immunodeficiency Syndrome (9) · Severe Combined Immunodeficiency (8) · Wiskott-Aldrich Syndrome (8) · Immunologic Deficiency Syndromes (7) · Lymphoproliferative Disorders (7) · Granulomatous Disease, Chronic (6) · Immune System Diseases (6) · Autoimmune Diseases (5) · IgG Deficiency (4) · Lymphohistiocytosis, Hemophagocytic (4) · T cell immunodeficiency primary (4)
Immune System Diseases (47) · Immunologic Deficiency Syndromes (46) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (27) · Genetic Diseases, Inborn (26) · Hemic and Lymphatic Diseases (26) · Hematologic Diseases (22) · Blood Protein Disorders (20) · Lymphatic Diseases (17) · Dysgammaglobulinemia (14) · Leukocyte Disorders (10) · Metabolic Diseases (10) · Nutritional and Metabolic Diseases (10) · Cytopenia (9) · Genetic Diseases, X-Linked (9) · Hemorrhagic Disorders (9)
gamma-Globulins (7) · Immunoglobulins, Intravenous (6) · Busulfan (4) · Cyclophosphamide (4) · Hizentra (3) · Alemtuzumab (2) · Antilymphocyte Serum (2) · Melphalan (2) · Mesna (2) · Mycophenolic Acid (2) · Prednisone (2) · Stem Cell Transplantation (2) · Tacrolimus (2) · fludarabine (2) · leniolisib (2)
CSL Behring (5) · Bio Products Laboratory (4) · National Cancer Institute (NCI) (4) · National Institute of Allergy and Infectious Diseases (NIAID) (4) · Paul Szabolcs (2) · Assistance Publique - Hôpitaux de Paris (1) · Avni Joshi (1) · Azidus Brasil (1) · Barts & The London NHS Trust (1) · BriovaRx Infusion Services (1) · CHU de Reims (1) · Central Hospital, Nancy, France (1) · Children's Hospital Medical Center, Cincinnati (1) · Duke University (1) · FFF Enterprises (1)
United States (34) · France (7) · United Kingdom (5) · Canada (4) · Germany (4) · Italy (4) · Spain (3) · Belarus (1) · Brazil (1) · Chile (1) · Czechia (1) · Hungary (1) · Ireland (1) · Israel (1) · Netherlands (1)
Dimana Dimitrova, M.D. (2) · Eric Wolford (2) · Paul Szabolcs, MD (2) · Akhilesh Chouksey, MD (1) · Albertina RB Pizzamiglio, md MSc (1) · Aparecida T Nagao-Dias (1) · Ashish K Jain, M.D. (1) · Avni Joshi, MD, MS (1) · Beatriz T Costa Carvalho, md PhD (1) · Biljana Horn, MD (1) · Borre Fevang, MD, Phd (1) · Chaim Roifman, MD (1) · Charles K Naspitz, md MSc (1) · Charlotte Cunningham-Rundles (1)
PMID 36818468, PMID 17479360, PMID 18814020, PMID 20217199, PMID 21674136, PMID 21705277, PMID 21932110, PMID 28842786, PMID 28972011, PMID 30713498, PMID 31599480, PMID 33737935, PMID 36399712, PMID 39271296, PMID 39919133, PMID 40720370, PMID 41091701, PMID 41370196, PMID 41773292
2014 (1), R21AI168980 (1)