12 completed, 4 unknown, 3 recruiting, 2 terminated. 5 Phase 2, 4 Phase 3, 3 Phase 1, 2 Not applicable, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 4, Recruiting 1 |
| Phase 3 | 4 | Completed 4 |
| Phase 1 | 3 | Completed 3 |
| Not applicable | 2 | Active not recruiting 1, Terminated 1 |
| Phase 4 | 2 | Completed 2 |
Follow Hyper-IgM Immunodeficiency Syndrome: new trials by email Literature Review of Hyper-IgM Immunodeficiency Syndrome trials Research Report on Hyper-IgM Immunodeficiency Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD) Hematopoietic stem cell transplant (HSCT) - Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder | Phase 2 | Recruiting | Paul Szabolcs | 25 | 2026-05-04 | 2026-05-15 |
| A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders AMPD3, OMIM*102772, AMP Deaminase Deficiency, AK1, OMIM *103000, Adenylate Kinase Deficiency | Recruiting | National Human Genome Research Institute (NHGRI) | 999 | 2023-12-19 | 2026-08-19 | |
| Immune Response Following COVID-19 Vaccination Rapid antibody test - IgM and IgG in Blood | Unknown | Texas Cardiac Arrhythmia Research Foundation | 500 | 2021-01-15 | 2021-02-03 | |
| Pro-inflammatory Role of Blood Platelets in Critically Ill Patients With Septic Shock. Septic shock, Systemic Inflammatory Response Syndrome - Septic Shock | Completed | University Hospital, Bordeaux | 202 | 2020-11-09 | 2024-04-26 | |
| Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC data collection - Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes | Recruiting | Paul Szabolcs | 50 | 2020-08-20 | 2026-01-13 | |
| A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies CDX-1140, CDX-301, pembrolizumab - Melanoma, Non-small Cell Lung Cancer | Phase 1 | Completed | Celldex Therapeutics | 132 | 2017-12-01 | 2024-03-28 |
| Pharmacokinetics (PK) and Safety of Subgam-VF in Primary Immunodeficiency Diseases Subgam - Primary Immune Deficiency Disorders, Common Variable Immunodeficiency | Phase 3 | Completed | Bio Products Laboratory | 38 | 2015-08-20 | 2018-09-12 |
| Pilot Study Related to the Effect of Clopidogrel on Plasmatic Soluble CD40 Ligand During Systemic Lupus Erythematous Treatment by clopidogrel - Systemic Lupus Erythematous | Phase 1 / Phase 2 | Completed | University Hospital, Bordeaux | 18 | 2015-08-19 | 2026-05-14 |
| Bioequivalence Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Gammaplex® 10 and Gammaplex® 5% in Primary Immunodeficiency Diseases Gammaplex (5%), Gammaplex 10 - Primary Immune Deficiency Disorders, Common Variable Immunodeficiency | Phase 3 | Completed | Bio Products Laboratory | 48 | 2014-02-01 | 2017-03-29 |
| Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204) Hematopoietic Stem Cell Transplant - Hemophagocytic Lymphohistiocytosis, Chronic Active Epstein-Barr Virus Infection | Phase 2 | Completed | Medical College of Wisconsin | 47 | 2013-12-01 | 2022-12-08 |
| Immune Disorder HSCT Protocol Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan - Immune Deficiency Disorders, Severe Combined Immunodeficiency | Phase 2 | Completed | Washington University School of Medicine | 28 | 2013-04-29 | 2026-10-27 |
| Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies Alemtuzumab 0.3 mg, Cyclophosphamide, Busulfan - SCID, Omenn's Syndrome | Not applicable | Active not recruiting | Masonic Cancer Center, University of Minnesota | 57 | 2012-09-04 | 2026-06-17 |
| 300 Antibody Diagnostic Test Kit Acute Bacterial Infections, Acute Viral Infections | Unknown | The Plasma Source | 300 | 2012-08-01 | 2012-07-20 | |
| A Study to Find Out How Safe and Effective Gammaplex® is in Young People With Primary Immunodeficiency Gammaplex - Primary Immune Deficiency Disorders, Common Variable Immunodeficiency | Phase 4 | Completed | Bio Products Laboratory | 25 | 2011-03-01 | 2014-12-23 |
| Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells Hematopoietic stem cell transplantation - Sickle Cell Disease, Thalassemia | Phase 1 / Phase 2 | Completed | Children's Hospital Los Angeles | 25 | 2008-08-01 | 2016-06-23 |
| Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects Flebogamma 5% DIF - Primary Immune Deficiency Disease | Phase 4 | Completed | Instituto Grifols, S.A. | 24 | 2008-05-01 | 2017-02-02 |
| A Clinical Study of Intravenous Immunoglobulin Immune Globulin Intravenous (Human) Omr-IgG-am IGIV - Immunologic Deficiency Syndromes | Phase 3 | Completed | FFF Enterprises | 57 | 2006-11-01 | 2014-08-11 |
| Efficacy, Safety and Pharmacokinetics of Gammaplex in Primary Immunodeficiency Diseases. Gammaplex (Intravenous immunoglobulin) - Primary Immunodeficiency, Common Variable Hypogammaglobulinemia | Phase 3 | Completed | Bio Products Laboratory | 50 | 2006-01-01 | 2013-01-24 |
| Studies of Disorders in Antibody Production and Related Primary Immunodeficiency States Hyper-IgM Syndrome, Ectodermal Dysplasia | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 119 | 2005-12-14 | 2017-10-06 | |
| Molecular and Clinical Studies of Primary Immunodeficiency Diseases Wiskott- Aldrich Syndrome, ADA Deficient SCID | Unknown | National Human Genome Research Institute (NHGRI) | 266 | 2000-10-25 | 2024-09-19 |
Showing 20 of 22. Sign in to see all of them.
Common Variable Immunodeficiency (10) · Wiskott-Aldrich Syndrome (10) · Primary Immunodeficiency Diseases (9) · Bruton type agammaglobulinemia (8) · Granulomatous Disease, Chronic (7) · Chediak-Higashi Syndrome (5) · Lymphohistiocytosis, Hemophagocytic (5) · Severe Combined Immunodeficiency (5) · Hyper-IgM Immunodeficiency Syndrome, Type 1 (4) · Immunologic Deficiency Syndromes (4) · Lymphoproliferative Disorders (4) · Genetic Diseases, Inborn (3) · Immune System Diseases (3) · Anemia (2)
Blood Protein Disorders (22) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (22) · Dysgammaglobulinemia (22) · Hemic and Lymphatic Diseases (22) · Hematologic Diseases (21) · Genetic Diseases, Inborn (19) · Immune System Diseases (19) · Immunologic Deficiency Syndromes (18) · Genetic Diseases, X-Linked (15) · Primary Immunodeficiency Diseases (13) · Leukocyte Disorders (12) · Blood Coagulation Disorders (10) · Blood Coagulation Disorders, Inherited (10) · Cytopenia (10) · Hemorrhagic Disorders (10)
gamma-Globulins (5) · Stem Cell Transplantation (3) · Busulfan (2) · Cyclophosphamide (2) · Melphalan (2) · Alemtuzumab (1) · Antilymphocyte Serum (1) · Cyclosporine (1) · Data Collection (1) · Drug Therapy (1) · Etoposide (1) · Hematopoietic Stem Cell Transplantation (1) · Immunoglobulins, Intravenous (1) · Mesna (1) · Methotrexate (1)
Bio Products Laboratory (4) · National Human Genome Research Institute (NHGRI) (2) · Paul Szabolcs (2) · University Hospital, Bordeaux (2) · Celldex Therapeutics (1) · Children's Hospital Los Angeles (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · FFF Enterprises (1) · Fairview University Medical Center (1) · Instituto Grifols, S.A. (1) · Masonic Cancer Center, University of Minnesota (1) · Medical College of Wisconsin (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Texas Cardiac Arrhythmia Research Foundation (1) · The Plasma Source (1)
United States (20) · Canada (2) · France (2) · Chile (1) · Hungary (1) · Israel (1) · United Kingdom (1)
Eric Wolford (2) · Paul Szabolcs, MD (2) · Akhilesh Chouksey, MD (1) · Andrea Natale (1) · Ashish K Jain, M.D. (1) · Chaim Roifman, MD (1) · Daniel Suez, MD (1) · Don McNeil, MD (1) · Elizabeth K Garabedian, R.N. (1) · Eyal Grunebaum, MD (1) · Gordan L Sussman, MD (1) · Hans D. Ochs (1) · Hisham Abdel-Azim, MD (1) · Isaac R Melamed, MD (1)
PMID 36818468, PMID 21725047, PMID 29635077, PMID 31599480, PMID 33152483, PMID 37042921, PMID 39271296, PMID 39919133, PMID 41773292
2014 (1), U10HL069294 (1), U24CA076518 (1)