28 completed, 6 unknown, 4 terminated, 2 not yet recruiting. 41 Phase 3, 9 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 41 | Completed 28, Unknown 6, Terminated 4, Not yet recruiting 2, Recruiting 1 |
| Phase 2 | 9 | Completed 5, Unknown 3, Terminated 1 |
Follow Leishmaniasis: new trials by email Literature Review of Leishmaniasis trials Research Report on Leishmaniasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study Comparing Several Drugs to Understand Which Work Against Cutaneous Leishmaniasis (CL) Sodium Stibogluconate (SSG), Miltefosine, Miltefosine + Paromomycin - Cutaneous Leihmaniasis | Phase 3 | Not yet recruiting | Institute of Tropical Medicine, Belgium | 900 | 2027-01-01 | 2026-03-10 |
| Arnica Tincture Fot the Treatment of Cutaneous Leishmaniasis II. Arnica Tincture, Meglumine antimoniate. - Leishmaniasis, Cutaneous | Phase 3 | Recruiting | Universidad de Antioquia | 96 | 2026-03-11 | 2026-04-02 |
| Antimicrobial Adjuvants to Revert the Imbalance of Skin Microbiota for Improved Outcomes of Complicated Cutaneous Leishmaniasis Treatment in Ethiopia Fusidic Acid, Vehicle cream - Leishmaniasis, Cutaneous | Phase 3 | Not yet recruiting | Institute of Tropical Medicine, Belgium | 180 | 2025-04-01 | 2024-11-19 |
| Tofacitinib Associated With Meglumine Antimoniate in Cutaneous Leishmaniasis Oral tofacitinib, Parenteral meglumine antimoniate - Cutaneous Leishmaniasis, American | Phase 2 / Phase 3 | Unknown | Hospital Universitário Professor Edgard Santos | 22 | 2023-10-01 | 2023-08-25 |
| Randomised Clinical Trial in Treatment Modalities for Cutaneous Leishmaniasis Caused by Leishmania Tropica, in Pakistan drug: miltefosine with thermotherapy - Old World Cutaneous Leishmaniasis | Phase 3 | Completed | Medecins Sans Frontieres, Netherlands | 645 | 2022-10-07 | 2026-07-30 |
| Pilot Study: Oral Treatment of American Tegumentary Leishmaniasis (Cutaneous and Mucosal Forms) in the Elderly Miltefosine 50mg, Pentoxifylline 400mg, Liposomal Amphotericin B - Leishmaniasis; Brazilian, Leishmaniasis, Mucocutaneous | Phase 2 / Phase 3 | Unknown | University of Brasilia | 100 | 2022-06-22 | 2023-09-15 |
| Intralesional Voriconazole, or Intralesional Cryotherapy, or Oral Doxycycline in the Treatment of Cutaneous Leishmaniasis Intralesional Sodium stibogluconate, Intralesional Cryotherapy, Intralesional Voriconazole - Leishmaniasis, Cutaneous | Phase 3 | Unknown | Zagazig University | 136 | 2022-01-01 | 2023-08-29 |
| Treatment of Mucosal Bolivian Leishmaniasis Group 1: Miltefosine, Group 2: Pentavalent Antimony, Group 3: Liposomal amphotericin B - Mucosal Leishmaniasis | Phase 3 | Unknown | Fundacion Nacional de Dermatologia | 120 | 2021-04-01 | 2024-03-05 |
| Enhancing Protection Against Vector-borne Diseases in Forcibly Displaced Communities: Evaluating the Efficacy of Spatial Repellents for Cutaneous Leishmaniasis Control in North-East Syria Spatial repellant emanator - Leishmaniasis, Cutaneous, Vector Borne Diseases | Phase 3 | Completed | The Mentor Initiative | 18404 | 2021-02-01 | 2025-04-08 |
| Combination, Miltefosine Monotherapy for Cutaneous Leishmaniasis in New World Meglumine Antimoniate, Miltefosine, Thermotherapy machine - Cutaneous Leishmaniases | Phase 3 | Completed | Drugs for Neglected Diseases | 184 | 2021-01-26 | 2025-05-08 |
| Oral Miltefosine Plus Topical Paromomycin In American Cutaneous Leishmaniasis Miltefosine and Paromomycin, miltefosine, paromomycin - Cutaneous Leishmaniasis, American | Phase 2 / Phase 3 | Completed | Fundacion Nacional de Dermatologia | 120 | 2019-02-01 | 2021-02-02 |
| Miltefosine/Paromomycin Phase III Trial for Treatment of Primary Visceral Leishmaniasis (VL) Patients in Eastern Africa Miltefosine, Paromomycin, Sodium stibogluconate - Visceral Leishmaniasis | Phase 3 | Completed | Drugs for Neglected Diseases | 439 | 2018-01-24 | 2024-02-29 |
| Effectiveness, Safety and Feasibility of HECT-CL, in Quetta, Pakistan HECT-CL - Cutaneous Leishmaniases | Phase 3 | Terminated | Medecins Sans Frontieres, Netherlands | 56 | 2017-10-04 | 2019-01-16 |
| Miltefosine and GM-CSF in Cutaneous Leishmaniasis Sbv, Miltefosine plus placebo, Miltefosine plus GM-CSF - Cutaneous Leishmaniasis | Phase 3 | Completed | Hospital Universitário Professor Edgard Santos | 300 | 2017-06-30 | 2020-04-07 |
| Topical Paromomycin for Cutaneous Leishmaniasis in Bolivia Paromomycin Sulfate, Pentamidine Isethionate, Placebo - Leishmaniasis, Cutaneous, Leishmania Braziliensis Complex | Phase 2 / Phase 3 | Completed | Fundacion Nacional de Dermatologia | 80 | 2017-04-15 | 2021-02-02 |
| Efficacy Trial of Ambisome Given Alone and Ambisome Given in Combination With Miltefosine for the Treatment of VL HIV Positive Ethiopian Patients. Liposomal Amphotericin B, Miltefosine - Visceral Leishmaniasis | Phase 3 | Completed | Drugs for Neglected Diseases | 59 | 2014-07-01 | 2019-04-08 |
| Miltefosine for Children With PKDL Miltefosine - Post Kala Azar Dermal Leishmaniasis | Phase 3 | Completed | International Centre for Diarrhoeal Disease Research, Bangladesh | 80 | 2014-07-01 | 2019-08-21 |
| High Dose Fluconazole in Cutaneous Leishmaniasis in Bahia and Manaus Fluconazole, Meglumine Antimoniate - Cutaneous Leishmaniasis | Phase 3 | Terminated | Hospital Universitário Professor Edgard Santos | 53 | 2014-02-01 | 2015-12-02 |
| Phase 3 Study of Walter Reed (WR) 279,396 and Paromomycin Alone for the Treatment of Cutaneous Leishmaniasis in Panama WR 279,396, Paromomycin - Cutaneous Leishmaniasis | Phase 3 | Completed | U.S. Army Medical Research and Development Command | 399 | 2013-05-01 | 2018-02-14 |
| Replacement of Insecticides to Control Visceral Leishmaniasis (VL) IWFPL, IDWL, ITN - Cost-effective and Sustainable Vector Control Methods Will be Established to Reduce VL in India, Bangladesh and Nepal | Phase 3 | Completed | International Centre for Diarrhoeal Disease Research, Bangladesh | 3600 | 2012-05-01 | 2017-08-29 |
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Leishmaniasis, Cutaneous (24) · Leishmaniasis, Visceral (13) · Leishmaniasis, Mucocutaneous (6) · Hyperthermia (3) · Acquired Immunodeficiency Syndrome (1) · Recurrence (1) · Vector Borne Diseases (1)
Euglenozoa Infections (41) · Infections (41) · Parasitic Diseases (41) · Protozoan Infections (41) · Vector Borne Diseases (40) · Skin Diseases (28) · Skin Diseases, Infectious (28) · Skin Diseases, Parasitic (28) · Skin and Connective Tissue Diseases (28) · Leishmaniasis, Cutaneous (4) · Pathological Conditions, Signs and Symptoms (4) · Body Temperature Changes (3) · Heat Stress Disorders (3) · Signs and Symptoms (3)
miltefosine (14) · Meglumine Antimoniate (12) · Paromomycin (11) · liposomal amphotericin B (8) · Antimony Sodium Gluconate (3) · Pentamidine (3) · Pentoxifylline (3) · amphotericin B, deoxycholate drug combination (3) · Hyperthermia, Induced (2) · Amphotericin B (1) · Arnicae flos extract (1) · Azithromycin (1) · Contraceptives, Oral (1) · Doxycycline (1) · Fluconazole (1)
Drugs for Neglected Diseases (7) · Banaras Hindu University (3) · Fundacion Nacional de Dermatologia (3) · Hospital Universitário Professor Edgard Santos (3) · Institute of Tropical Medicine, Belgium (3) · Centro Internacional de Entrenamiento e Investigaciones Médicas (2) · International Centre for Diarrhoeal Disease Research, Bangladesh (2) · Medecins Sans Frontieres, Netherlands (2) · Oswaldo Cruz Foundation (2) · Tehran University of Medical Sciences (2) · U.S. Army Medical Research and Development Command (2) · Universidad de Antioquia (2) · Ana Rabello (1) · Bharat Serums and Vaccines Limited (1) · Fundación Cardiovascular de Colombia (1)
Brazil (9) · Ethiopia (6) · India (6) · Bolivia (4) · Colombia (4) · Bangladesh (3) · Iran (2) · Kenya (2) · Pakistan (2) · Panama (2) · Peru (2) · Sudan (2) · Uganda (2) · Libya (1) · Syria (1)
Shyam Sundar, MD (3) · Armando O. Schubach, MD, PhD (2) · Afif Ben Salah, M.D., Ph.D. (1) · Ahmed M Musa, MD, Prof (1) · Ali Khamesipour (1) · Ali Khamesipour, PhD (1) · Alireza Khatami, MD MSPH (1) · Ana Rabello, MD PhD (1) · Catherine Royce, Dr (1) · Christian F Rueda-Clausen, MD (1) · Daniel J Smith, PhD (1) · Daniel Smith, PhD (1) · Dr. Gautam Daftary, MBBS (1) · Dr. S.K. Bhattacharya (1)
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