19 unknown, 13 completed, 5 terminated, 4 recruiting. 43 Phase 3, 12 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 43 | Unknown 19, Completed 13, Terminated 5, Recruiting 4, Active not recruiting 1, Withdrawn 1 |
| Phase 2 | 12 | Completed 5, Unknown 5, Recruiting 1, Withdrawn 1 |
Follow Keratoconus: new trials by email Literature Review of Keratoconus trials Research Report on Keratoconus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia Riboflavin 0.1% ophthalmic solution and pulsed light, Riboflavin 0.1% ophthalmic solution and non-pulsed light - Keratoconus, Corneal Ectasia | Phase 2 / Phase 3 | Recruiting | Price Vision Group | 500 | 2025-10-01 | 2026-09-25 |
| Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases Epi-ON corneal cross-linking - Keratoconus, Ectasia of Cornea | Phase 3 | Recruiting | Woolfson Eye Institute | 485 | 2025-08-01 | 2026-02-02 |
| Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome Epi-ON corneal cross-linking (CXL) - Down Syndrome (DS), Keratoconus | Phase 3 | Recruiting | Woolfson Eye Institute | 225 | 2025-08-01 | 2026-02-02 |
| Effects of Topical Insulin on Corneal Epithelium Healing After Corneal Crosslinking in Patients With Keratoconus Insulin, Placebo eye drops of 0.5% Methylcellulose - Keratoconus, Cornea Disease | Phase 3 | Recruiting | University of Campinas, Brazil | 36 | 2024-08-01 | 2025-01-14 |
| Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus Riboflavin and Sodium Iodide solution and Ultraviolet-A treatment, Placebo and sham treatment - Keratoconus | Phase 3 | Completed | Epion Therapeutics | 398 | 2023-11-01 | 2026-06-25 |
| Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus Riboflavin and Sodium Iodide solution and Ultraviolet-A treatment, Placebo and sham treatment - Keratoconus | Phase 3 | Completed | Epion Therapeutics | 396 | 2023-10-30 | 2026-06-25 |
| Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light riboflavin ophthalmic solution - Keratoconus, Corneal Ectasia | Phase 3 | Unknown | Cornea and Laser Eye Institute | 170 | 2021-07-30 | 2023-01-04 |
| Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia Riboflavin - Keratoconus, Corneal Ectasia | Phase 3 | Unknown | Cornea and Laser Eye Institute | 160 | 2021-06-02 | 2023-01-04 |
| Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Riboflavin/Dextran or Riboflavin/Methylcellulose Riboflavin - Keratoconus, Corneal Ectasia | Phase 3 | Unknown | Cornea and Laser Eye Institute | 170 | 2021-04-16 | 2023-01-04 |
| The Additional Role of Supplemental Oxygen Therapy in Accelerated Corneal Collagen Cross-linking in Progressive Keratoconus. A Randomized Clinical Trial perform corneal collagen cross linking accelerated and delivery of systemic oxygen, perform corneal collagen cross linking accelerated and without additional oxygen therapy, perform Conventiona corneal collagen cross linking - Keratoconus | Phase 2 / Phase 3 | Unknown | Shahid Beheshti University of Medical Sciences | 30 | 2020-01-01 | 2020-04-13 |
| Comparison of Standard vs. Accelerated Corneal Crosslinking riboflavin 0.1%, Riboflavin 0.1% - Keratoconus, Ectasia Corneal | Phase 2 / Phase 3 | Completed | Price Vision Group | 508 | 2019-04-16 | 2026-09-17 |
| Corneal Collagen Cross-Linking (CXL) Performed With "Epi-ON" Versus "Epi-OFF" in Eyes With Keratoconus and Other Corneal Ectatic Disorders Ricrolin+, VEGA UV-A system - Keratoconus, Ectasia | Phase 3 | Unknown | Center for Sight, Sacramento, CA | 550 | 2019-03-08 | 2019-02-28 |
| Endothelial Cell Loss After Penetrating Keratoplasty PKP - Keratoconus | Phase 2 / Phase 3 | Completed | Alexandria University | 8 | 2018-07-01 | 2020-07-07 |
| Effects of Corneal Anatomical Match Between Donor and Recipient During DALK Surgery on Final Visual and Refractive Outcomes in Patients With KCN After mechanical trephination, horizontal meridian of donor's cornea sutured to horizontal meridian of recipient cornea, : After mechanical trephination, horizontal meridian of donor's cornea sutured to vertical meridian of recipient cornea - Keratoconus | Phase 2 / Phase 3 | Unknown | Shahid Beheshti University of Medical Sciences | 52 | 2018-06-01 | 2019-10-17 |
| Accelerated Corneal Cross-linking With Different Riboflavin Solutions Riboflavin - Keratoconus | Phase 3 | Completed | Medical University of Vienna | 60 | 2016-09-19 | 2021-03-03 |
| Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia Ricrolin+, Epi-Off - Keratoconus, Ectasia | Phase 3 | Unknown | Icahn School of Medicine at Mount Sinai | 8 | 2016-06-01 | 2018-06-07 |
| Refractive Treatment of Early Keratoconus Crosslinking, Photorefractive keratectomy, iDesign® Advanced WaveScan Studio - Keratoconus | Phase 3 | Unknown | Ottawa Hospital Research Institute | 24 | 2016-01-01 | 2015-12-14 |
| Corneal Cross-Linking Comparing Variables Epithelium-On Riboflavin, Epithelium-Off Riboflavin, UV Light - Continuous Beam - Unstable Corneas | Phase 3 | Unknown | Crowd Health Research, LTD | 500 | 2014-05-01 | 2014-03-26 |
| Safety and Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus riboflavin solution, placebo solution, KXL System - Keratoconus | Phase 3 | Terminated | Glaukos Corporation | 92 | 2013-11-01 | 2021-04-26 |
| Evaluating the Safety and Efficacy of the KXL System for Corneal Collagen Cross-Linking in Eyes Having Keratoconus 0.1% Riboflavin ophthalmic solution (KXL System With vibeX Rapid), simultaneous KXL and topography-guided transepithelial photorefractive keratectomy(PRK) - Keratoconus, Post LASIK Keratectasia | Phase 3 | Unknown | Singapore Eye Research Institute | 66 | 2013-03-01 | 2015-12-23 |
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Corneal Diseases (9) · Dilatation, Pathologic (8) · Down Syndrome (1) · Eye Diseases (1)
Eye Diseases (42) · Corneal Diseases (34) · Pathological Conditions, Anatomical (8) · Pathological Conditions, Signs and Symptoms (8) · Abnormalities, Multiple (1) · Chromosome Disorders (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Genetic Diseases, Inborn (1) · Intellectual Disability (1) · Nervous System Diseases (1) · Neurobehavioral Manifestations (1) · Neurologic Manifestations (1)
Riboflavin (16) · Corneal Cross-Linking (7) · Dextrans (2) · Corneal Transplantation (1) · Flavin Mononucleotide (1) · Insulin (1) · Iontophoresis (1) · Lubricant Eye Drops (1) · Methylcellulose (1) · Ophthalmic Solutions (1) · Photorefractive Keratectomy (1)
Cornea and Laser Eye Institute (7) · Glaukos Corporation (4) · Shahid Beheshti University of Medical Sciences (3) · Epion Therapeutics (2) · Medical University of Vienna (2) · Price Vision Group (2) · Topcon Medical Systems, Inc. (2) · Woolfson Eye Institute (2) · Alexandria University (1) · American-European Congress of Ophthalmic Surgery (1) · Center for Sight, Sacramento, CA (1) · Crowd Health Research, LTD (1) · Emory University (1) · Federal University of São Paulo (1) · Hospital Oftalmologico de Brasilia (1)
United States (28) · Brazil (4) · Iran (3) · Austria (2) · Egypt (1) · Germany (1) · Norway (1) · Puerto Rico (1) · Singapore (1) · Sweden (1)
Peter S Hersh, MD (4) · Peter Hersh, MD (3) · Michael Belin, MD (2) · Peter Hersh, M.D. (2) · Steven A Greenstein, MD (2) · Vineeta Belanger (2) · Aleksandar Stojanovic, MD (1) · Bahram Einollahi, MD (1) · Belquiz A Nassaralla, MD PhD (1) · Denise D Freitas, Professor (1) · Ehab Mossallam, PhD (1) · Ezra Maguen, M.D. (1) · Francis Price, MD (1) · Francis W Price, Jr., MD (1) · James J Reidy, M.D. (1)
PMID 12719068, PMID 16565005, PMID 16765803, PMID 16900027, PMID 16952090, PMID 17258522, PMID 17434435, PMID 17457183, PMID 17457184, PMID 17531694, PMID 17720054, PMID 17721317, PMID 18471635, PMID 22331118, PMID 22692521, PMID 25365551, PMID 26194634, PMID 27388250, PMID 32557558, PMID 33252568