1050 completed, 322 recruiting, 319 terminated, 208 unknown. 2212 Phase 1, 773 Phase 2.
Follow Intestinal Diseases: new trials by email Literature Review of Intestinal Diseases trials Research Report on Intestinal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CCR5 Targeting Leronlimab in Combination With Hepatic Arterial Infusion Floxuridine and Systemic Therapy for the Treatment of Colorectal Cancer Liver Metastases, CHAMP Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 1 | Not yet recruiting | City of Hope Medical Center | 36 | 2027-05-06 | 2026-09-25 |
| LMT503 First-in-human SAD, MAD, and FE Study LMT503, Placebo - Inflammatory Bowel Disease, Colitis, Ulcerative | Phase 1 | Not yet recruiting | Lmito Therapeutics Inc. | 72 | 2027-03-01 | 2026-09-01 |
| A Safety Study of ST316 in Participants With Familial Adenomatous Polyposis (FAP). ST316 IV - Familial Adenomatous Polyposis (FAP) | Phase 1 | Not yet recruiting | Sapience Therapeutics | 40 | 2027-01-04 | 2026-08-12 |
| Safety, Tolerability and PK of ATTO 1091 in Healthy Adult Volunteers and Patients With Ulcerative Colitis ATTO-1091, Placebo - Ulcerative Colitis (UC) | Phase 1 | Not yet recruiting | Attovia Therapeutics Inc | 96 | 2026-12-14 | 2026-09-15 |
| A Study of DES-1357 in People With Deficient Mismatch Repair (dMMR)/Microsatellite Instability-High (MSI-H) Metastatic Colorectal Cancer (mCRC) DES-1357 - Metastatic Colorectal Cancer (CRC) | Phase 1 / Phase 2 | Not yet recruiting | D. E. Shaw Research, LLC | 88 | 2026-12-03 | 2026-09-08 |
| COQ10 and Vitamin E for Off-Target Radiation Toxicity Coenzyme Q10 Cap/Tab, Vitamin E Cap/Tab - Prostate Cancer, Uterine Cancer | Phase 1 / Phase 2 | Not yet recruiting | University of Nebraska | 200 | 2026-12-01 | 2026-10-08 |
| Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal Cancer Biospecimen Collection, Computed Tomography, Fluorouracil - Advanced Microsatellite Stable Colorectal Carcinoma, Metastatic Microsatellite Stable Colorectal Carcinoma | Phase 1 | Not yet recruiting | City of Hope Medical Center | 30 | 2026-12-01 | 2026-09-02 |
| A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation LG00313112 - Ovarian Cancer, Small Cell Lung Cancer | Phase 1 / Phase 2 | Not yet recruiting | LG Chem | 250 | 2026-12-01 | 2026-08-07 |
| TCR1188-ABC Cells in KRAS-mutated Cancers TCR1188-ABC cells, Fludarabine + Cyclophosphamide combination, Tocilizumab - Cholangiocarcinoma, Colorectal Cancer | Phase 1 | Recruiting | University of Pennsylvania | 30 | 2026-12-01 | 2026-10-14 |
| SND002 Cell Injection in Participants With Advanced Malignant Solid Tumors SND002 Cell Injection - Colorectal Neoplasms, Stomach Neoplasms | Phase 1 | Not yet recruiting | Guizhou Sinorda Pharmaceutical Co., Ltd. | 78 | 2026-12-01 | 2026-11-04 |
| Study of Varsetatug Masetecan in Combination With Anti-Cancer Therapies in Colorectal Cancer varsetatug masetecan, bevacizumab + 5-FU + leucovorin, bevacizumab - Colo-rectal Cancer | Phase 1 / Phase 2 | Not yet recruiting | CytomX Therapeutics | 368 | 2026-12-01 | 2026-10-28 |
| A Study to Evaluate the Safety and Activity of GDC-7035 With Anti-Cancer Therapies in Participants With KRAS G12D-Mutated Unresectable Advanced or Metastatic Colorectal Cancer or Pancreatic Ductal Adenocarcinoma GDC-7035, Panitumumab, mFOLFOX6 - Colorectal Neoplasms, Pancreatic Ductal Adenocarcinoma | Phase 1 | Not yet recruiting | Genentech, Inc. | 388 | 2026-11-30 | 2026-11-10 |
| Safety and Efficacy Study in Adults With Advanced Solid Tumors Receiving REGN13089-M404-M2980, an Antibody-drug Conjugate That Targets MET Protein on Tumors REGN13089-M404-M2980 - Advanced Solid Tumors | Phase 1 / Phase 2 | Not yet recruiting | Regeneron Pharmaceuticals | 320 | 2026-11-23 | 2026-10-07 |
| Hepatic Artery Infusion of Carfilzomib in Participants With Liver Metastatic Disease Previously Treated With Hepatic Artery Infusion Pump Therapy Carfilzomib - Colorectal Neoplasms, Neoplasms | Phase 1 | Not yet recruiting | National Cancer Institute (NCI) | 20 | 2026-11-17 | 2026-11-12 |
| A Study to Learn About the Study Medicine Called PF-08165784 in People With PIK3CA-Mutated Advanced or Metastatic Solid Tumors PF-08165784, Fulvestrant, Atirmociclib - Advanced Breast Cancer, Advanced or Metastatic Breast Cancer | Phase 1 | Not yet recruiting | Pfizer | 268 | 2026-11-09 | 2026-10-28 |
| An Open-label, DDI Study to Investigate the Effects of Duvakitug on the PK of Selected Cytochrome P450 Substrates Duvakitug - Ulcerative Colitis, Crohn's Disease | Phase 1 | Not yet recruiting | Sanofi | 25 | 2026-11-03 | 2026-11-06 |
| R-3750 in Patients With Crohn's Disease R-3750, Placebo - Crohn Disease (CD) | Phase 1 | Not yet recruiting | Rise Therapeutics LLC | 40 | 2026-11-01 | 2026-08-28 |
| S-Adenosylmethionine (SAMe) for Chemoprevention of Colorectal Adenomas S-Adenosylmethionine (SAMe) - Colorectal Cancer (Diagnosis), Adenoma | Phase 1 | Not yet recruiting | Jun Gong, MD | 18 | 2026-11-01 | 2026-08-04 |
| Study Evaluating the Safety Feasibility and Efficacy of ODI-2001 Vaccine, a Personnalized Immunotherapy in Patients With Metastatic or Locally Advanced Colon Cancer or Pancreatic Cancer Personalized cancer vaccine including : DNA neoantigen vaccine, MVA viral vector and Ipilimumab (anti-CTLA4) - Metastatic Colorectal Cancer (CRC), Locally Advanced Colorectal Cancer | Phase 1 | Not yet recruiting | Centre Georges Francois Leclerc | 77 | 2026-11-01 | 2026-05-14 |
| IKS04 Regimen in Advanced Solid Tumors That Express CA242 IKS04 antibody drug conjugate ADC + Isumab04 monoclonal antibody - Colorectal Cancer, Gastro Esophageal Junctional Cancer | Phase 1 | Not yet recruiting | Iksuda Therapeutics Ltd. | 120 | 2026-11-01 | 2026-07-31 |
Showing 20 of 2212. Sign in to see all of them.
Colorectal Neoplasms (1247) · Colonic Neoplasms (432) · Carcinoma, Non-Small-Cell Lung (368) · Pancreatic Neoplasms (328) · Rectal Neoplasms (312) · Breast Neoplasms (282) · Stomach Neoplasms (265) · Ovarian Neoplasms (219) · Neoplasms (209) · Neoplasm Metastasis (198) · Colitis, Ulcerative (185) · Lung Neoplasms (179) · Melanoma (179) · Crohn Disease (167) · Squamous Cell Carcinoma of Head and Neck (142)
Digestive System Diseases (2199) · Gastrointestinal Diseases (2193) · Colonic Diseases (1713) · Neoplasms by Site (1615) · Digestive System Neoplasms (1607) · Intestinal Neoplasms (1599) · Gastrointestinal Neoplasms (1561) · Rectal Diseases (1495) · Neoplasms (1422) · Neoplasms by Histologic Type (549) · Respiratory Tract Diseases (489) · Respiratory Tract Neoplasms (488) · Thoracic Neoplasms (487) · Lung Diseases (486)
Fluorouracil (140) · Oxaliplatin (129) · Cetuximab (125) · pembrolizumab (117) · Bevacizumab (115) · Irinotecan (113) · Leucovorin (112) · Capecitabine (109) · Nivolumab (53) · Cyclophosphamide (48) · Gemcitabine (42) · Radiotherapy (38) · IFL protocol (37) · Cisplatin (36) · Folfox protocol (34)
National Cancer Institute (NCI) (100) · Pfizer (35) · GlaxoSmithKline (34) · M.D. Anderson Cancer Center (34) · Novartis Pharmaceuticals (24) · Memorial Sloan Kettering Cancer Center (23) · AstraZeneca (22) · Eli Lilly and Company (21) · City of Hope Medical Center (20) · Bristol-Myers Squibb (19) · National Institute of Allergy and Infectious Diseases (NIAID) (18) · Mayo Clinic (17) · Incyte Corporation (15) · Genentech, Inc. (14) · Hoffmann-La Roche (14)
United States (1276) · China (262) · Spain (174) · Australia (169) · Canada (160) · United Kingdom (152) · France (136) · Germany (126) · South Korea (120) · Netherlands (96) · Belgium (95) · Italy (89) · Japan (74) · Denmark (47) · Taiwan (47)
Amy Lightner, MD (7)
PMID 40056080, PMID 17560413, PMID 22607579, PMID 27490698, PMID 28735965, PMID 30277655, PMID 31527168, PMID 34017343, PMID 35537408, PMID 36897458, PMID 36977960, PMID 37082579, PMID 37590355, PMID 37917289, PMID 37934000, PMID 38267790, PMID 38580386, PMID 39462179, PMID 40443562, PMID 42201333, PMID 10496568, PMID 11743810, PMID 11919232, PMID 11919233, PMID 12196376, PMID 12393999, PMID 12576903, PMID 12750250, PMID 14981738, PMID 15160338, PMID 15169795, PMID 15199546, PMID 15289858, PMID 1544146, PMID 15530127, PMID 1559306, PMID 16009951, PMID 16062074, PMID 16413414, PMID 16452248, PMID 16564913, PMID 16600928, PMID 16600979, PMID 17026790, PMID 17045238, PMID 17216531, PMID 17520255, PMID 17697209, PMID 17761300, PMID 17956350
2023 (32), 2025 (24), 2016 (22), 2017 (22), 2019 (17), 2018 (13), 2015 (12), P30CA033572 (12), 2009 (10), 2014 (7), P30CA016672 (7), P30CA015083 (6), P30CA016056 (6), UM1CA186690 (6), 2008 (5)