8 recruiting, 7 completed, 5 not yet recruiting, 1 active not recruiting. 8 Not applicable, 4 Phase 2, 3 Phase 1, 1 Early Phase 1, 1 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Immune Aging and Advanced Therapy Outcomes in Older Adults With IBD Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Frailty | Not yet recruiting | First Affiliated Hospital, Sun Yat-Sen University | 300 | 2026-10-12 | 2026-10-13 | |
| Precision Microbiota Interventions for Senoreduction Trial Limosilactobacillus reuteri, Blueberry extract - HIV Infections, Alcohol Drinking | Phase 1 / Phase 2 | Not yet recruiting | Louisiana State University Health Sciences Center in New Orleans | 160 | 2026-10-01 | 2026-10-01 |
| Influenza Vaccine Immunogenicity in Repeatedly Vaccinated Older Adults Standard dose influenza vaccine, MF59 adjuvanted influenza vaccine, High dose influenza vaccine - Influenza Vaccination, Older Adults (65 Years and Older) | Phase 4 | Recruiting | Korea University Guro Hospital | 180 | 2026-09-21 | 2026-09-24 |
| Research Project on the Interaction Between Immune Function and Infectious Diseases in Older Adults and the Development of Prevention and Control Strategies Infectious Diseases, Immunosenescence | Not yet recruiting | Huashan Hospital | 23000 | 2026-06-09 | 2026-06-12 | |
| Skin Inflammation in (Peri)Menopause: A Probiotic Intervention Proof of Concept Trial Lactobacillus casei Shirota (LcS) Probiotic Drink, Skimmed Milk Control Drink - Skin Inflammation, Immunosenescence | Not applicable | Recruiting | King's College London | 30 | 2026-04-28 | 2026-05-08 |
| The Impact of Aerobic Exercise Program on Immunosenescence Institutionalized Older Adults Aerobic exercise program - Immunosenescence, Aging | Not applicable | Not yet recruiting | Instituto Politécnico de Castelo Branco | 40 | 2026-03-02 | 2026-03-17 |
| Effect of Oral Supplement on Influenza Vaccine Long-term Response Influenza, Immunosenescence | Not yet recruiting | Tsinghua University | 30 | 2026-03-01 | 2026-01-22 | |
| Interferon Reference for Older People - REFIPA Study Uninfected older adults - Immunosenescence, Uninfected Older | Not applicable | Recruiting | Hospices Civils de Lyon | 62 | 2025-12-02 | 2026-04-08 |
| VITAL: Vaccination, Immunity, Time-restricted Eating, Aging and Lifestyle TRE: Time-restricted eating - Vaccination, Immunosenescence | Not applicable | Recruiting | Charite University, Berlin, Germany | 24 | 2025-09-10 | 2025-09-18 |
| The Impact of Nicotinamide Mononucleotide Sustained-release Tablets on Immunosenescence and Metablism in Middle-aged and Elderly Individuals With Metabolic Disorders. NMN, Placebo - Immunosenescence, Metabolism | Not applicable | Recruiting | Qing Su | 126 | 2025-06-05 | 2025-07-08 |
| Exploratory Study on Infection and Immunosenescence Based on an Elderly Clinical Cohort Immunosenescence | Recruiting | Huashan Hospital | 484 | 2024-11-29 | 2026-08-04 | |
| The Immu-KNEE-ty Study Knee arthroplasty - Immunosenescence, Aging | Completed | Wageningen University | 14 | 2024-03-12 | 2025-03-04 | |
| Biobank and Brain Health in Bordeaux. Questionnaires, Fasting blood sampling., Saliva collection and nasal or nasopharyngeal swab - Brain, Aging | Recruiting | University Hospital, Bordeaux | 2050 | 2022-03-22 | 2025-08-11 | |
| Thymus Regeneration, Immunorestoration, and Insulin Mitigation Extension Trial TRIIM Treatment, Active Control - Epigenetic Aging, Immunosenescence | Phase 2 | Recruiting | Intervene Immune, Inc. | 85 | 2020-11-23 | 2025-05-07 |
| Using BCG to Protect Senior Citizens During the COVID-19 Pandemic BCG-Denmark, Saline - Covid19, Non-specific Effects of Vaccines | Phase 3 | Completed | Bandim Health Project | 1700 | 2020-09-15 | 2024-08-22 |
| COVID-19 Serology and Immunosenescence blood sample - Covid19, Geriatric Medicine | Not applicable | Active not recruiting | Centre Hospitalier Universitaire, Amiens | 98 | 2020-08-29 | 2026-06-15 |
| Fasting-mimicking Diet and Immunosenescence Seasonal influenza (flu) vaccine, Diet - Immunosenescence | Phase 2 | Withdrawn | University of Southern California | 2019-05-01 | 2019-10-30 | |
| Effect of Milk Protein and Prebiotics in Combination With Vitamin D on Innate Immunity in Elderly People Milk protein, prebiotics, vitamin D, Placebo product - Immunosenescence, Inflammation | Not applicable | Completed | NIZO Food Research | 30 | 2016-11-01 | 2018-09-05 |
| Nutritional Supplementation and Muscle Health: A Pilot Study on Immune Function Muscle Armor Supplement, Placebo - Immunosenescence, Sarcopenia | Not applicable | Completed | Central Arkansas Veterans Healthcare System | 12 | 2013-01-01 | 2013-11-13 |
| Pilot Study on Effect Size of Non-digestible Polysaccharides (NPS) on Immunity NPS - Immunosenescence | Phase 1 / Phase 2 | Completed | Clinical Research Center Kiel GmbH | 239 | 2012-08-01 | 2016-11-17 |
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Influenza, Human (5) · COVID-19 (2) · Inflammation (2) · Acne Vulgaris (1) · Alcohol Drinking (1) · Alzheimer Disease (1) · Anxiety Disorders (1) · Behavioral Symptoms (1) · Brain Diseases (1) · Chickenpox (1) · Colitis, Ulcerative (1) · Communicable Diseases (1) · Dementia (1) · Depression (1) · Dermatitis (1)
Infections (10) · Virus Diseases (9) · RNA Virus Infections (8) · Respiratory Tract Diseases (7) · Respiratory Tract Infections (7) · Orthomyxoviridae Infections (5) · Pathological Conditions, Signs and Symptoms (5) · Pathologic Processes (4) · Behavior (3) · Blood-Borne Infections (2) · Communicable Diseases (2) · Coronaviridae Infections (2) · Coronavirus Infections (2) · Genital Diseases (2) · Immune System Diseases (2)
Influenza Vaccines (2) · 4'-galactooligosaccharide (1) · Arthroplasty, Replacement, Knee (1) · Blood Specimen Collection (1) · Dextrins (1) · Diet (1) · Herpes Zoster Vaccine (1) · Milk Proteins (1) · Neuroimaging (1) · Prebiotics (1) · Sodium Chloride (1) · Surveys and Questionnaires (1) · Urination (1) · Vaccines (1) · Vitamin D (1)
Huashan Hospital (2) · Bandim Health Project (1) · Central Arkansas Veterans Healthcare System (1) · Centre Hospitalier Universitaire, Amiens (1) · Charite University, Berlin, Germany (1) · Clasado (1) · Clinical Research Center Kiel GmbH (1) · First Affiliated Hospital, Sun Yat-Sen University (1) · Hospices Civils de Lyon (1) · Instituto Politécnico de Castelo Branco (1) · Intervene Immune, Inc. (1) · King's College London (1) · Korea University Guro Hospital (1) · Louisiana State University Health Sciences Center in New Orleans (1) · NIZO Food Research (1)
United States (4) · China (3) · France (3) · Netherlands (2) · United Kingdom (2) · Denmark (1) · Germany (1) · South Korea (1)
Adit A Ginde, MD, MPH (1) · Andrea Du Preez (1) · Anna Katharina Simon, Prof. Dr. (1) · Anne Marie Rosendahl Madsen, MD (1) · Christiane Laue, MD (1) · Christine Stabell Benn, DMSc (1) · Cong Tian, Master (1) · David A Welsh, MD (1) · Elizabeth Zelinski, PhD (1) · Els van Hoffen, PhD (1) · Glenn Gibson, PhD (1) · Joon Young Song, MD, PhD (1) · Richard Dennis, PhD (1) · Sebastian Hofer, Dr. rer. nat. (1)
PMID 30515164, PMID 33011177, PMID 39423874, PMID 40081635, PMID 41723029, PMID 41795627
K23AG040708 (1)