16 completed. 16 Phase 2, 4 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 16 |
| Phase 1 | 4 | Completed 4 |
| Phase 3 | 1 | Completed 1 |
Follow Ichthyosis: new trials by email Literature Review of Ichthyosis trials Research Report on Ichthyosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Rimegepant and Placebo for Pain in IBS Rimegepant 75 MG [Nurtec] - Irritable Bowel Syndrome | Phase 2 | Completed | Mayo Clinic | 39 | 2024-06-06 | 2026-10-15 |
| A 44-week Monocentric Open Study Assessing the Efficacy and Safety of Deucravacitinib in Adults With Inflammatory Genodermatoses deucravacitinib - Epidermolysis Bullosa Simplex, Ichthyosis | Phase 2 | Completed | Centre Hospitalier Universitaire de Nice | 8 | 2024-03-18 | 2026-10-16 |
| ADX-629 Therapy for Sjogren-Larsson Syndrome ADX-629 - Sjogren-Larsson Syndrome | Phase 1 / Phase 2 | Completed | University of Nebraska | 8 | 2023-01-02 | 2026-05-05 |
| A Study to Evaluate Topically Applied SXR1096 Cream in Patients With Netherton Syndrome SXR1096 cream, Placebo cream - Netherton Syndrome | Phase 1 / Phase 2 | Completed | Sixera Pharma | 9 | 2021-12-07 | 2025-12-16 |
| A Vehicle Controlled Study to Evaluate Safety and Efficacy of Topical TMB-001 for Treatment of Congenital Ichthyosis Isotretinoin, Vehicle - Congenital Ichthyosis | Phase 2 | Completed | LEO Pharma | 34 | 2019-12-03 | 2026-05-22 |
| A Six Week Topical Cream Study for Subjects With Ichthyosis Vulgaris 146-9251 cream, Vehicle cream - Ichthyosis Vulgaris | Phase 2 | Completed | Crown Laboratories, Inc. | 80 | 2017-04-25 | 2021-08-10 |
| A Safety and Tolerability Study of Topical PAT-001 in Congenital Ichthyosis PAT-001, 0.1%, PAT-001, 0.2%, Vehicle for PAT-001 0.1% - Congenital Ichthyosis | Phase 2 | Completed | Patagonia Pharmaceuticals, LLC | 19 | 2017-03-08 | 2021-09-29 |
| The Efficacy and Safety of Secukinumab in Patients With Ichthyoses Secukinumab, Placebo - Ichthyosis, Autosomal Recessive Congenital Ichthyosis | Phase 2 | Completed | Northwestern University | 20 | 2016-12-01 | 2021-08-25 |
| A Study of Topical NS2 Cream to Treat Ichthyosis in Sjögren-Larsson Syndrome (SLS) Active topical NS2 1% dermatologic cream, Vehicle placebo 0.0% NS2 dermatologic cream - Sjögren-Larsson Syndrome | Phase 2 | Completed | Aldeyra Therapeutics, Inc. | 12 | 2015-03-01 | 2022-12-13 |
| Efficacy Study on Trabectedin in Retroperitoneal Leiomyosarcoma and Well Differentiated/Dedifferentiated Liposarcoma Trabectedin - Liposarcoma, Leiomyosarcoma | Phase 2 | Completed | Italian Sarcoma Group | 105 | 2014-03-01 | 2021-11-01 |
| Clinical Trial Using Humira in Netherton Syndrome Adalimumab - Netherton Syndrome | Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 11 | 2014-01-27 | 2026-04-08 |
| Effects of ROSE-010 on GI Transit in Constipation Predominant Irritable Bowel Syndrome (C-IBS) Patients ROSE-010, Placebo - Irritable Bowel Syndrome Constipation Predominant | Phase 1 / Phase 2 | Completed | Mayo Clinic | 52 | 2010-01-01 | 2013-05-31 |
| Cheno Effect on Transit in Health and IBS-C Sodium chenodeoxycholate (NaCDC), Placebo - Constipation-predominant Irritable Bowel Syndrome | Phase 2 | Completed | Mayo Clinic | 36 | 2009-04-01 | 2012-07-02 |
| Efficacy and Safety of Two Doses of Liarozole vs. Placebo for the Treatment of Lamellar Ichthyosis Liarozole - Ichthyosis, Lamellar | Phase 2 / Phase 3 | Completed | Stiefel, a GSK Company | 98 | 2006-01-01 | 2011-09-26 |
| 8 Weeks Treatment With DDP225 in Patients With Diarrhea Predominant IBS DDP225 - Irritable Bowel Syndrome | Phase 2 | Completed | Dynogen Pharmaceuticals | 88 | 2005-09-01 | 2007-10-15 |
| Safety Study of Elidel (Pimecrolimus) 1% Cream to Treat Netherton Syndrome Pimecrolimus 1% Cream - Netherton Syndrome | Phase 1 / Phase 2 | Completed | Children's Hospital of Philadelphia | 3 | 2005-09-01 | 2019-08-14 |
Ichthyosis Bullosa of Siemens (4) · Netherton Syndrome (4) · Ichthyosis Vulgaris (3) · Irritable Bowel Syndrome (3) · Constipation (2) · Ichthyosis, Lamellar (2) · Sjogren-Larsson Syndrome (2) · Cerebral Palsy (1) · Epidermolysis Bullosa Simplex (1) · Hyperkeratosis, Epidermolytic (1) · Ichthyosiform Erythroderma, Congenital (1) · Ichthyosis, X-Linked (1) · Intellectual Disability (1) · Leiomyosarcoma (1)
Congenital Abnormalities (16) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (16) · Genetic Diseases, Inborn (16) · Keratosis (16) · Skin Abnormalities (16) · Skin Diseases (16) · Skin and Connective Tissue Diseases (16) · Skin Diseases, Genetic (15) · Infant, Newborn, Diseases (13) · Abnormalities, Multiple (4) · Ichthyosiform Erythroderma, Congenital (4) · Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4) · Colonic Diseases (3)
ADX-629 (1) · Adalimumab (1) · Chenodeoxycholic Acid (1) · Glucagon-Like Peptide 1 (1) · Isotretinoin (1) · Trabectedin (1) · WAS protein, human (1) · deucravacitinib (1) · glucagon-like peptide (7-37), valyl(10)- (1) · liarozole (1) · pimecrolimus (1) · rimegepant sulfate (1) · secukinumab (1)
Mayo Clinic (3) · Aldeyra Therapeutics, Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Centre Hospitalier Universitaire de Nice (1) · Children's Hospital of Philadelphia (1) · Crown Laboratories, Inc. (1) · Dynogen Pharmaceuticals (1) · Italian Sarcoma Group (1) · LEO Pharma (1) · Northwestern University (1) · Patagonia Pharmaceuticals, LLC (1) · Sixera Pharma (1) · Stiefel, a GSK Company (1) · University of Nebraska (1)
United States (11) · France (4) · Canada (2) · Germany (2) · Italy (2) · Sweden (2) · Australia (1) · Austria (1) · Belgium (1) · Dominican Republic (1) · Netherlands (1) · Norway (1)
Albert C Yan, MD (1) · Amy Paller, MD (1) · Christine Bodemer, MD, PhD (1) · Christine Chiaverini (1) · Emma Guttman-Yassky, MD, PhD (1) · Koen van Rossem, MD, PhD (1) · Maarten de Chateau, MD PhD (1) · Michael Camilleri (1) · Michael Camilleri, MD (1) · Michael L. Camilleri, M.D. (1) · Paolo G. Casali, MD (1) · William B Rizzo, MD (1) · William B. Rizzo, MD (1) · William Patterson, MD (1) · Zachary Rome, BS (1)
PMID 20083693, PMID 20691689, PMID 22517769, PMID 24102348, PMID 35218370, PMID 37170057, PMID 41637861
UL1RR024150 (2), 1RC1DK086182 (1), R01DK054681 (1), R01DK079866 (1)