Keratosis: Clinical Trials

372 completed, 52 unknown, 36 recruiting, 27 terminated. 131 Not applicable, 115 Phase 2, 99 Phase 3, 67 Phase 1, 50 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	131	Completed 87, Unknown 19, Recruiting 8, Not yet recruiting 6, Withdrawn 5, Terminated 4, Active not recruiting 2
Phase 2	115	Completed 82, Unknown 9, Terminated 7, Active not recruiting 5, Not yet recruiting 4, Recruiting 4, Withdrawn 4
Phase 3	99	Completed 76, Recruiting 9, Terminated 7, Not yet recruiting 2, Unknown 2, Withdrawn 2, Active not recruiting 1
Phase 1	67	Completed 53, Recruiting 5, Terminated 3, Not yet recruiting 2, Unknown 2, Active not recruiting 1, Withdrawn 1
Phase 4	50	Completed 35, Unknown 7, Terminated 3, Active not recruiting 2, Enrolling by invitation 2, Withdrawn 1
Early Phase 1	8	Completed 3, Recruiting 2, Enrolling by invitation 1, Terminated 1, Withdrawn 1

Follow Keratosis: new trials by email Literature Review of Keratosis trials Research Report on Keratosis

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Epidermal Growth Factor Receptor Inhibition for Keratinopathies Erlotinib - Epidermolytic Ichthyosis, Palmoplantar Keratoderma	Phase 1 / Phase 2	Not yet recruiting	Northwestern University	44	2027-07-01	2026-08-03
Efficacy and Safety of Cryotherapy Followed by Tirbanibulin Ointment for Actinic Keratosis on the Scalp and Forehead Cryotherapy + Tirbanibulin - Keratosis, Actinic Keratoses	Phase 3	Not yet recruiting	University Hospital, Lille	59	2026-11-30	2026-05-22
Therapeutic Induction of Dermal Remodeling in Veterans to Prevent Actinic Neoplasia Caused by Chronic Environmental Exposure to Ultraviolet Radiation Microneedling, Trichloroacetic acid peel - Nonmelanoma Skin Cancer, Actinic Keratosis	Not applicable	Not yet recruiting	VA Office of Research and Development	96	2026-11-01	2026-10-06
Using an Artificial Intelligence (AI) Tool for Melanoma Diagnosis Clinical decision support tool - Malignant Melanoma of Skin, Other and Unspecified Malignant Neoplasm of Skin	Phase 3	Recruiting	Memorial Sloan Kettering Cancer Center	14000	2026-10-15	2026-10-22
Basal Cell Carcinoma Chemoprevention Trial 5% Imiquimod cream, Placebo Vehicle Control Cream - Basal Cell Carcinoma	Phase 3	Recruiting	VA Office of Research and Development	1630	2026-10-06	2026-11-02
AI in SK Histopathological Diagnosis This study doesn't include an intervention. - Seborrheic Keratoses, Artifical Intelligence		Not yet recruiting	Al-Azhar University	30	2026-10-01	2026-08-26
Acupuncture Combined With Transcutaneous Electrical Acupoint Stimulation for Constipation-Predominant Irritable Bowel Syndrome With Anxiety State Acupuncture, Transcutaneous Electrical Acupoint Stimulation, Sham Transcutaneous Electrical Acupoint Stimulation - IBS, Constipation Predominant, Anxiety State	Not applicable	Not yet recruiting	The First Affiliated Hospital of Zhejiang Chinese Medical University	58	2026-10-01	2026-10-28
Patient Study to Evaluate the Safety and Emollient Performance of Doublebase Once in the Treatment of Ichthyosis Doublebase Once - Ichthyosis	Not applicable	Not yet recruiting	Dermal Laboratories Ltd	100	2026-09-07	2026-09-08
Multimodal Laser Treatment of Photodamaged Skin 1927-nm thulium laser, 1550-nm Er:Glass laser, Intense Pulsed Light - Photo-damage, Actinic Keratosis (AK)	Not applicable	Recruiting	Merete Haedersdal	35	2026-09-01	2026-09-09
5-Fluorouracil and Calcipotriene for Field Treatment of Actinic Keratoses Combination field therapy with 5-fluorouracil and calcipotriene (5FU/C) - Actinic Keratoses	Phase 1	Not yet recruiting	Cedars-Sinai Medical Center	96	2026-09-01	2026-10-05
An Open-Label Pharmacokinetic Study for Patients With Actinic Keratosis on the Upper Extremities or the Face Investigational drug, Photodynamic therapy - Actinic Keratosis (AK)	Phase 1	Recruiting	Sun Pharmaceutical Industries Limited	48	2026-08-04	2026-08-13
PDT vs Peels for Treatment of Actinic Keratoses Photodynamic Therapy, Chemical Peels - Actinic Keratoses	Phase 2	Not yet recruiting	Northwestern University	60	2026-08-01	2026-07-01
A Phase 2 Study of HW211026 HW211026 - Actinic Keratosis	Phase 2	Not yet recruiting	Hubei Bio-Pharmaceutical Industrial Technological Institute Inc.	80	2026-07-01	2026-07-09
Phase III Clinical Trial of Changji'an Capsules in the Treatment of Irritable Bowel Syndrome With Predominant Diarrhea (Liver-Qi Invading Spleen Syndrome) Chang Ji'an capsule, Chang Ji'an capsule mimic - IBS, Diarrhea Predominant	Phase 3	Not yet recruiting	Beijing Hospital of Traditional Chinese Medicine	636	2026-05-31	2026-05-28
Study of Skin and Gut Microbiome in a Skin Condition Involving Skin Barrier Impairment and Allergic Symptoms: Netherton Syndrome Superficial skin swabs, Stool samples, Saliva samples - Netherton Syndrome		Recruiting	Assistance Publique - Hôpitaux de Paris	30	2026-05-26	2026-06-30
A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients Topical niacinamide 5% cream, Sunscreen - Skin Cancer, Cutaneous Squamous Cell Carcinoma (CSCC)	Early Phase 1	Recruiting	Marissa Lobl	20	2026-05-01	2026-06-05
Outcomes Associated With Tirbanibulin for Large Field Application on the Face in the U.S (CLEAR) Tirbanibulin - Actinic Keratosis (AK)		Recruiting	Avant Health LLC	30	2026-04-02	2026-06-18
Lymphocyte Phenotype of Autosomal Recessive Congenital Ichthyoses Mutated NIPAL4 (Nipal4-nEDD) blood sampling - Sezary Syndrome, Ichthyosis, Lamellar		Not yet recruiting	Assistance Publique - Hôpitaux de Paris	10	2026-04-01	2026-03-17
Phase 2/3 Clinical Study of QRX003 Lotion in Subjects With Netherton Syndrome QRX003 - Netherton Syndrome	Phase 2 / Phase 3	Recruiting	Quoin Pharmaceuticals	16	2026-03-19	2026-09-28
Transcutaneous Electrical Acustimulation for IBS-D: A Multicenter Study Portable stimulator - IBS, Diarrhea Predominant	Not applicable	Not yet recruiting	First People's Hospital of Foshan	200	2026-03-01	2026-02-20

Showing 20 of 535. Sign in to see all of them.

Narrower conditions

Keratosis, Actinic (340)  ·  Ichthyosis (30)  ·  Keratosis, Seborrheic (29)  ·  Carcinoma, Basal Cell (24)  ·  Ichthyosis Bullosa of Siemens (24)  ·  Netherton Syndrome (22)  ·  Callosities (21)  ·  Cholesteatoma (20)  ·  Carcinoma, Squamous Cell (18)  ·  Irritable Bowel Syndrome (17)  ·  Precancerous Conditions (17)  ·  Skin Diseases (16)  ·  Skin Neoplasms (14)  ·  Ichthyosis Vulgaris (12)

Broader conditions

Skin and Connective Tissue Diseases (535)  ·  Skin Diseases (519)  ·  Neoplasms (362)  ·  Precancerous Conditions (329)  ·  Congenital, Hereditary, and Neonatal Diseases and Abnormalities (117)  ·  Genetic Diseases, Inborn (104)  ·  Congenital Abnormalities (99)  ·  Skin Abnormalities (98)  ·  Skin Diseases, Genetic (98)  ·  Infant, Newborn, Diseases (86)  ·  Ichthyosis (67)  ·  Neoplasms by Histologic Type (53)  ·  Neoplasms, Glandular and Epithelial (41)  ·  Pathological Conditions, Signs and Symptoms (41)

Interventions

3-ingenyl angelate (42)  ·  Aminolevulinic Acid (34)  ·  Imiquimod (29)  ·  Fluorouracil (24)  ·  Photochemotherapy (23)  ·  methyl 5-aminolevulinate (15)  ·  Cryotherapy (12)  ·  Diclofenac (12)  ·  Gels (12)  ·  Solutions (10)  ·  tirbanibulin (8)  ·  Petrolatum (7)  ·  BF-200 ALA (6)  ·  Ointments (6)  ·  calcipotriene (6)

Sponsors

LEO Pharma (33)  ·  Peplin (21)  ·  Northwestern University (15)  ·  Almirall, S.A. (14)  ·  Galderma R&D (11)  ·  Maastricht University Medical Center (11)  ·  DUSA Pharmaceuticals, Inc. (10)  ·  University of California, Davis (9)  ·  Aclaris Therapeutics, Inc. (8)  ·  Graceway Pharmaceuticals, LLC (8)  ·  University Hospital, Toulouse (7)  ·  Actavis Inc. (6)  ·  Biofrontera Bioscience GmbH (6)  ·  Bispebjerg Hospital (5)  ·  Dong-A University (5)

Countries

United States (242)  ·  Germany (59)  ·  France (51)  ·  Australia (24)  ·  Netherlands (23)  ·  Canada (20)  ·  United Kingdom (20)  ·  Italy (19)  ·  Spain (16)  ·  Denmark (13)  ·  China (12)  ·  Brazil (10)  ·  Switzerland (10)  ·  Austria (8)  ·  Sweden (8)

Top investigators

Stuart Marcus, MD, PhD (9)  ·  Murad Alam, MD (6)  ·  Amy Paller, MD (4)  ·  Klara Mosterd, prof.dr. (4)  ·  Mir Misbahuddin, MBBS, PhD (4)  ·  Stuart D Shanler, MD (4)  ·  Antonio Martorell, PhD (3)  ·  C. William Hanke, MD (3)  ·  Edward Maytin, MD, PhD (3)  ·  Eugene Bauer, MD (3)  ·  Gary Goldenberg, MD (3)  ·  Jane Fang, MD (3)  ·  Michael Hambidge, MD (3)  ·  Sharon Levy, MD (3)  ·  Adeline Vanderver, MD (2)

Results publications

PMID 22417254, PMID 23553119, PMID 38125671, PMID 24765228, PMID 25584134, PMID 25950503, PMID 26300464, PMID 30365590, PMID 33196758, PMID 33567191, PMID 35314199, PMID 10607349, PMID 11493098, PMID 11511292, PMID 11912510, PMID 11966728, PMID 12533168, PMID 12648223, PMID 14734878, PMID 15097955, PMID 15168956, PMID 15238912, PMID 16250204, PMID 17151593, PMID 17488399, PMID 17488400, PMID 17822489, PMID 17916094, PMID 18067627, PMID 18571597, PMID 18948357, PMID 18955209, PMID 19221274, PMID 19241467, PMID 19467365, PMID 19638214, PMID 20083693, PMID 20133013, PMID 20231500, PMID 20514316, PMID 20518784, PMID 20691689, PMID 20725550, PMID 20729935, PMID 21115882, PMID 21283921, PMID 21753882, PMID 21866055, PMID 22025453, PMID 22055282

NIH funding

2014 (4), 2015 (2), P01CA027502 (2), P30CA023074 (2), UL1RR024150 (2), 1RC1DK086182 (1), 2005 (1), 2008 (1), 2016 (1), 2017 (1), 2023 (1), 2025 (1), P30CA043703 (1), R01AT007137 (1), R01CA293974 (1)