55 completed, 13 recruiting, 9 terminated, 8 not yet recruiting. 29 Phase 2, 24 Not applicable, 14 Phase 3, 13 Phase 1, 3 Early Phase 1.
Follow Ichthyosis: new trials by email Literature Review of Ichthyosis trials Research Report on Ichthyosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Epidermal Growth Factor Receptor Inhibition for Keratinopathies Erlotinib - Epidermolytic Ichthyosis, Palmoplantar Keratoderma | Phase 1 / Phase 2 | Not yet recruiting | Northwestern University | 44 | 2027-07-01 | 2026-08-03 |
| Acupuncture Combined With Transcutaneous Electrical Acupoint Stimulation for Constipation-Predominant Irritable Bowel Syndrome With Anxiety State Acupuncture, Transcutaneous Electrical Acupoint Stimulation, Sham Transcutaneous Electrical Acupoint Stimulation - IBS, Constipation Predominant, Anxiety State | Not applicable | Not yet recruiting | The First Affiliated Hospital of Zhejiang Chinese Medical University | 58 | 2026-10-01 | 2026-10-28 |
| Patient Study to Evaluate the Safety and Emollient Performance of Doublebase Once in the Treatment of Ichthyosis Doublebase Once - Ichthyosis | Not applicable | Not yet recruiting | Dermal Laboratories Ltd | 100 | 2026-09-07 | 2026-09-08 |
| Phase III Clinical Trial of Changji'an Capsules in the Treatment of Irritable Bowel Syndrome With Predominant Diarrhea (Liver-Qi Invading Spleen Syndrome) Chang Ji'an capsule, Chang Ji'an capsule mimic - IBS, Diarrhea Predominant | Phase 3 | Not yet recruiting | Beijing Hospital of Traditional Chinese Medicine | 636 | 2026-05-31 | 2026-05-28 |
| Study of Skin and Gut Microbiome in a Skin Condition Involving Skin Barrier Impairment and Allergic Symptoms: Netherton Syndrome Superficial skin swabs, Stool samples, Saliva samples - Netherton Syndrome | Recruiting | Assistance Publique - Hôpitaux de Paris | 30 | 2026-05-26 | 2026-06-30 | |
| Lymphocyte Phenotype of Autosomal Recessive Congenital Ichthyoses Mutated NIPAL4 (Nipal4-nEDD) blood sampling - Sezary Syndrome, Ichthyosis, Lamellar | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 10 | 2026-04-01 | 2026-03-17 | |
| Phase 2/3 Clinical Study of QRX003 Lotion in Subjects With Netherton Syndrome QRX003 - Netherton Syndrome | Phase 2 / Phase 3 | Recruiting | Quoin Pharmaceuticals | 16 | 2026-03-19 | 2026-09-28 |
| Transcutaneous Electrical Acustimulation for IBS-D: A Multicenter Study Portable stimulator - IBS, Diarrhea Predominant | Not applicable | Not yet recruiting | First People's Hospital of Foshan | 200 | 2026-03-01 | 2026-02-20 |
| Thera-Clean® Microbubbles System in Patients With Skin Diseases TheraClean - Epidermolysis Bullosa, Ichthyosis | Early Phase 1 | Enrolling by invitation | Northwestern University | 20 | 2026-01-13 | 2026-02-03 |
| Evaluating Whether Intact Fish Skin Graft Can Decrease the Need for Autograft in the Treatment of Deep Partial-Thickness Burns Intact fish skin graft, autograft - Partial-thickness Burn Wounds | Phase 4 | Enrolling by invitation | Kerecis Ltd. | 65 | 2026-01-01 | 2026-01-08 |
| Co-Development and Validation of Colonic Symptom Pictograms for Young People Pictogram comprehension and validation - Constipation - Functional, Abdominal Pain (AP) | Not yet recruiting | University of Auckland, New Zealand | 120 | 2026-01-01 | 2026-01-13 | |
| Saccharomyces Boulardii CNCM I-745 in Irritable Bowel Syndrome Saccharomyces Boulardii 250 MG, Placebo 250 mg - IBS (Irritable Bowel Syndrome), IBS-D (Diarrhea-predominant) | Phase 3 | Recruiting | Biocodex | 406 | 2025-10-22 | 2025-11-18 |
| Clinical Study of QRX003 Lotion in Subjects With Netherton Syndrome QRX003, 4% Lotion - Netherton Syndrome | Phase 2 / Phase 3 | Recruiting | Quoin Pharmaceuticals | 8 | 2025-10-06 | 2026-08-31 |
| The Beneficial Effects on the Intestinal Function of a Food Supplement Based on an Extract of Green Tea and a Pool of Probiotics in Subjects With Irritable Bowel Syndrome With Predominance of Constipation food supplement based on a mixture of green tea extract and a pool of probiotics., Placebo - IBS, Constipation Predominant | Not applicable | Recruiting | Adamas Biotech S.r.l. | 64 | 2025-07-30 | 2025-08-05 |
| Natural History of Sphingosine Phosphate Lyase Insufficiency Syndrome (SPLIS) no intervention - Sphingosine Phosphate Lyase Insufficiency Syndrome (SPLIS) | Recruiting | University of California, San Francisco | 28 | 2025-04-22 | 2026-08-04 | |
| A Clinical Evaluation of Marula-Derived Ceramide Cream on Skin Barrier Function Enhancement Apply a cream containing 0.05% marula oil-derived ceramide NPs - Atopic Dermatitis (AD), Psoriasis | Not applicable | Completed | Shanghai Chicmax Cosmetic Co., Ltd. | 32 | 2025-02-06 | 2025-07-15 |
| Natural History of Netherton Syndrome Netherton Syndrome | Terminated | Boehringer Ingelheim | 4 | 2024-10-09 | 2026-06-24 | |
| A Study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of BCX17725 BCX17725, Placebo - Netherton Syndrome | Phase 1 | Recruiting | BioCryst Pharmaceuticals | 78 | 2024-09-26 | 2026-08-27 |
| Efficacy of Injectable Gentamicin in Hereditary Ichthyosis Gentamicin Injectable Solution - Ichthyosis | Phase 2 | Not yet recruiting | University Hospital, Toulouse | 26 | 2024-09-01 | 2024-09-05 |
| Evaluation of Topical ATR12-351 in Adults With Netherton Syndrome ATR12-351 - Netherton Syndrome | Phase 1 | Completed | Azitra Inc. | 6 | 2024-06-16 | 2026-07-29 |
Showing 20 of 97. Sign in to see all of them.
Ichthyosis Bullosa of Siemens (24) · Netherton Syndrome (22) · Irritable Bowel Syndrome (17) · Ichthyosis Vulgaris (12) · Ichthyosis, Lamellar (7) · Dermatitis, Atopic (6) · Sjogren-Larsson Syndrome (6) · Ichthyosis, X-Linked (5) · Keratoderma, Palmoplantar (5) · Epidermolysis Bullosa (4) · Hyperkeratosis, Epidermolytic (4) · Psoriasis (4) · Albinism (3) · Charcot-Marie-Tooth Disease (3)
Congenital Abnormalities (97) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (97) · Skin Abnormalities (97) · Skin and Connective Tissue Diseases (97) · Keratosis (96) · Skin Diseases (94) · Infant, Newborn, Diseases (86) · Genetic Diseases, Inborn (85) · Skin Diseases, Genetic (81) · Abnormalities, Multiple (28) · Ichthyosiform Erythroderma, Congenital (28) · Digestive System Diseases (19) · Colonic Diseases (17) · Colonic Diseases, Functional (17)
Blood Specimen Collection (3) · Doxorubicin (2) · Trabectedin (2) · Ustekinumab (2) · dupilumab (2) · secukinumab (2) · ADI PEG20 (1) · ADX-629 (1) · Acupuncture Therapy (1) · Adalimumab (1) · Biopsy (1) · Chenodeoxycholic Acid (1) · Curcumin (1) · Data Collection (1) · Diet (1)
Northwestern University (8) · University Hospital, Toulouse (5) · Assistance Publique - Hôpitaux de Paris (4) · Maastricht University Medical Center (4) · Quoin Pharmaceuticals (4) · Children's Hospital of Philadelphia (3) · Daiichi Sankyo (3) · Kerecis Ltd. (3) · Mayo Clinic (3) · Aldeyra Therapeutics, Inc. (2) · Boehringer Ingelheim (2) · Centre Hospitalier Universitaire de Nice (2) · Institut National de la Santé Et de la Recherche Médicale, France (2) · LEO Pharma (2) · National Cancer Institute (NCI) (2)
United States (51) · France (21) · Netherlands (8) · Germany (6) · Italy (6) · United Kingdom (5) · Australia (4) · Canada (4) · China (4) · Spain (4) · Finland (2) · Israel (2) · Portugal (2) · Russia (2) · Sweden (2)
Amy Paller, MD (4) · Adeline Vanderver, MD (2) · Amy Paller (2) · Antoni Gostynski, MD, PhD (2) · Tony Andrasfay (2) · William B Rizzo, MD (2) · Alain Hovnanian, MD, PhD (1) · Alan Irvine (1) · Albert C Yan, MD (1) · Amy S Paller, MD (1) · Andres Poveda, Ph.M. (1) · Antoni C Gostynski, MD, PhD (1) · Antoni H Gostynski, MD, PhD (1)
PMID 11511292, PMID 11912510, PMID 12648223, PMID 14734878, PMID 15238912, PMID 16250204, PMID 18571597, PMID 18948357, PMID 19241467, PMID 19638214, PMID 20083693, PMID 20691689, PMID 22517769, PMID 24102348, PMID 24329107, PMID 24920311, PMID 27144627, PMID 31327218, PMID 32153925, PMID 32342562, PMID 32749716, PMID 34543653, PMID 35088760, PMID 35218370, PMID 35260030, PMID 35663767, PMID 35973183, PMID 36052114, PMID 37170057, PMID 39365895, PMID 40908106, PMID 41637861, PMID 9804339, PMID 9843209
UL1RR024150 (2), 1RC1DK086182 (1), 2008 (1), 2014 (1), 2025 (1), R01AT007137 (1), R01DK054681 (1), R01DK079866 (1), R01HD113778 (1), R21AT003619 (1), U01NS106845 (1), U54NS115052 (1), UL1TR001436 (1)