8 completed, 2 unknown. 4 Phase 2, 3 Phase 4, 2 Not applicable, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 4 |
| Phase 4 | 3 | Completed 2, Unknown 1 |
| Not applicable | 2 | Completed 1, Unknown 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Benzbromarone: new trials by email Literature Review of Benzbromarone trials Research Report on Benzbromarone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluate the Efficacy and Safety of D-0120 in Primary Hyperuricemia Patients D-0120, Benzbromarone - Hyperuricemia | Phase 2 | Completed | InventisBio Co., Ltd | 121 | 2022-09-28 | 2024-10-15 |
| SGLT2 Inhibition: Uric Acid Excretion Study Empagliflozin 25 MG, Benzbromaron, Empagliflozin 25 MG + benzbromarone 100 mg - Type 2 Diabetes | Phase 4 | Completed | Amsterdam UMC, location VUmc | 10 | 2020-10-01 | 2023-05-01 |
| Urate Lowering Therapies and Left Ventricular Diastolic Dysfunction Febuxostat 40 mg, Benzbromarone 50mg, Control - Hyperuricemia, Metabolic Syndrome | Phase 4 | Unknown | National Defense Medical Center, Taiwan | 120 | 2020-02-01 | 2020-04-28 |
| Dose-finding and Safety Study of SHR4640 in Subjects With Hyperuricemia Placebo, SHR4640, benzbromarone - Hyperuricemia | Phase 2 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 198 | 2017-07-20 | 2019-08-07 |
| Benzbromarone-Controlled, Double-Blind, Comparative Study of FYU-981 in Hyperuricemia With or Without Gout FYU-981, Benzbromarone - Hyperuricemia With or Without Gout | Phase 3 | Completed | Fuji Yakuhin Co., Ltd. | 201 | 2017-04-01 | 2018-09-26 |
| Compare the Renal Protective Effects of Febuxostat and Benzbromarone in CKD Chinese Patients Febuxostat, Benzbromarone - Chronic Kidney Disease, Hyperuricemia | Not applicable | Unknown | Shanghai 10th People's Hospital | 800 | 2016-10-01 | 2016-10-25 |
| Acute Effects of Benzbromaron on the Pulmonary Circulation Benzbromarone - Idiopathic Pulmonary Arterial Hypertension | Phase 2 | Completed | Medical University of Graz | 10 | 2015-10-01 | 2016-12-23 |
| Compare the Renal Protective Effects of Febuxostat and Benzbromarone Febuxostat, Benzbromarone - Chronic Kidney Disease, Hyperuricemia | Not applicable | Completed | Shanghai 10th People's Hospital | 160 | 2015-01-01 | 2019-07-24 |
| A PD/Safety Study of RDEA3170 in Combination With Febuxostat for Treating Gout or Asymptomatic Hyperuricemia Patients RDEA3170, Febuxostat, Benzbromarone - Gout and Asymptomatic Hyperuricemia | Phase 1 / Phase 2 | Completed | AstraZeneca | 110 | 2014-12-01 | 2015-06-12 |
| Treatment of Hyperuricemia in Patients With Heart Failure Benzbromarone (drug) - Heart Failure, Hyperuricemia | Phase 4 | Completed | Tottori University Hospital | 2004-01-01 | 2007-01-15 |
Hyperuricemia (6) · Renal Insufficiency, Chronic (2) · Diabetes Mellitus, Type 2 (1) · Familial Primary Pulmonary Hypertension (1) · Gout (1) · Heart Failure (1) · Insulin Resistance (1) · Metabolic Syndrome (1) · Ventricular Dysfunction, Left (1)
Shanghai 10th People's Hospital (2) · Amsterdam UMC, location VUmc (1) · AstraZeneca (1) · Fuji Yakuhin Co., Ltd. (1) · InventisBio Co., Ltd (1) · Jiangsu HengRui Medicine Co., Ltd. (1) · Medical University of Graz (1) · National Defense Medical Center, Taiwan (1) · Tottori University Hospital (1)
China (4) · Japan (3) · Austria (1) · Netherlands (1) · Taiwan (1)
Ai Peng, MD, PhD (1) · Cheng-Wei Liu, M.D. (1) · Chunde Bao (1) · Horst Olschewski, MD (1) · Kazuhide Ogino, MD (1) · Ling Wang, MD, PhD (1) · Xiaofeng Zeng (1)
PMID 19933411, PMID 29868853, PMID 31980978, PMID 32951150, PMID 33693494, PMID 35322793